BR0108007A - Pyrrole-isoquinoline derivatives and tetrahydropyrrole-isoquinoline and their uses as mediators of the 5-ht7 receptor - Google Patents

Pyrrole-isoquinoline derivatives and tetrahydropyrrole-isoquinoline and their uses as mediators of the 5-ht7 receptor

Info

Publication number
BR0108007A
BR0108007A BR0108007-5A BR0108007A BR0108007A BR 0108007 A BR0108007 A BR 0108007A BR 0108007 A BR0108007 A BR 0108007A BR 0108007 A BR0108007 A BR 0108007A
Authority
BR
Brazil
Prior art keywords
isoquinoline
mediators
receptor
tetrahydropyrrole
pyrrole
Prior art date
Application number
BR0108007-5A
Other languages
Portuguese (pt)
Inventor
Michael Gerard Kelly
Young Hee Kang
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of BR0108007A publication Critical patent/BR0108007A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Anesthesiology (AREA)
  • Urology & Nephrology (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

"DERIVADOS DA PIRROLO-ISOQUINOLINA E TETRAIDROPIRROLO-ISOQUINOLINA E SEUS USOS COMO MEDIADORES DO RECEPTOR DA 5-HT7". A invenção refere-se aos compostos de fórmula I que são úteis no tratamento da ansiedade, depressão e distúrbios relacionados do sistema nervoso central e outras condições tais como esquizofrenia, distúrbios do sono, incluindo casos de ritmo circadiano, no tratamento da abstinência do álcool e drogas e na disfunção sexual."PIRROLO-ISOQUINOLINE AND TETRAHYDROPIRROLO-ISOQUINOLIN DERIVATIVES AND THEIR USES AS MEDIATORS OF THE 5-HT7 RECEPTOR". The invention relates to compounds of formula I which are useful in the treatment of anxiety, depression and related disorders of the central nervous system and other conditions such as schizophrenia, sleep disorders, including cases of circadian rhythm, in the treatment of alcohol withdrawal and drugs and sexual dysfunction.

BR0108007-5A 2000-02-04 2001-02-02 Pyrrole-isoquinoline derivatives and tetrahydropyrrole-isoquinoline and their uses as mediators of the 5-ht7 receptor BR0108007A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US49737900A 2000-02-04 2000-02-04
PCT/US2001/003430 WO2001057039A1 (en) 2000-02-04 2001-02-02 Pyrrolo-isoquinoline and tetrahydropyrrolo-isoquinoline derivatives and their use as mediators of the 5-ht7 receptor

Publications (1)

Publication Number Publication Date
BR0108007A true BR0108007A (en) 2002-10-29

Family

ID=23976619

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0108007-5A BR0108007A (en) 2000-02-04 2001-02-02 Pyrrole-isoquinoline derivatives and tetrahydropyrrole-isoquinoline and their uses as mediators of the 5-ht7 receptor

Country Status (8)

Country Link
EP (1) EP1252161A1 (en)
JP (1) JP2003522178A (en)
CN (1) CN1168728C (en)
AU (1) AU2001231287A1 (en)
BR (1) BR0108007A (en)
CA (1) CA2399545A1 (en)
MX (1) MXPA02007521A (en)
WO (1) WO2001057039A1 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103788089A (en) 2003-09-17 2014-05-14 詹森药业有限公司 Fused heterocyclic compounds as serotonin receptor modulators
US7598255B2 (en) 2005-08-04 2009-10-06 Janssen Pharmaceutica Nv Pyrimidine compounds as serotonin receptor modulators
WO2007053353A2 (en) * 2005-10-28 2007-05-10 Wyeth Pyrrolo[2,3-f] and [3,2-f]isoquinolinone derivatives as 5-hydroxytryptamine-6 ligands
EP2676954A1 (en) * 2012-06-19 2013-12-25 Laboratorios del Dr. Esteve S.A. Heterocyclyl-substituted-phenyl derivatives as vasodilators

Also Published As

Publication number Publication date
EP1252161A1 (en) 2002-10-30
CN1168728C (en) 2004-09-29
WO2001057039A1 (en) 2001-08-09
AU2001231287A1 (en) 2001-08-14
MXPA02007521A (en) 2002-12-13
CN1396921A (en) 2003-02-12
JP2003522178A (en) 2003-07-22
CA2399545A1 (en) 2001-08-09

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Legal Events

Date Code Title Description
B08F Application fees: dismissal - article 86 of industrial property law

Free format text: REFERENTE A 6O, 7O E 8O ANUIDADES.

B08H Application fees: decision cancelled

Free format text: REFERENTE AO DESPACHO 8.6 DA RPI 2016 DE 25/08/2009 POR TER SIDO INDEVIDO.

B08F Application fees: dismissal - article 86 of industrial property law

Free format text: REFERENTE 7A,8A E 9A ANUIDADES.

B08K Lapse as no evidence of payment of the annual fee has been furnished to inpi (acc. art. 87)

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2047 DE 30/03/2010.