BR0103887C1 - Composições imunogênicas contendo microesferas biodegradáveis encapsulando antìgenos, vetores gênicos e adjuvantes - Google Patents

Composições imunogênicas contendo microesferas biodegradáveis encapsulando antìgenos, vetores gênicos e adjuvantes

Info

Publication number
BR0103887C1
BR0103887C1 BR0103887-7A BR0103887A BR0103887C1 BR 0103887 C1 BR0103887 C1 BR 0103887C1 BR 0103887 A BR0103887 A BR 0103887A BR 0103887 C1 BR0103887 C1 BR 0103887C1
Authority
BR
Brazil
Prior art keywords
antigens
compositions containing
immunogenic compositions
adjuvants
microspheres
Prior art date
Application number
BR0103887-7A
Other languages
English (en)
Other versions
BR0103887A (pt
Inventor
Jose Maciel Junior Rodrigues
Celio Lopes Silva
Original Assignee
Univ Minas Gerais
Celio Lopes Silva
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Minas Gerais, Celio Lopes Silva filed Critical Univ Minas Gerais
Priority to BR0103887-7A priority Critical patent/BR0103887C1/pt
Priority to PCT/BR2002/000099 priority patent/WO2003007869A2/en
Priority to CA002453959A priority patent/CA2453959A1/en
Priority to EP02744957A priority patent/EP1420823A2/en
Priority to AU2002317056A priority patent/AU2002317056A1/en
Priority to CNA028171861A priority patent/CN1549728A/zh
Publication of BR0103887A publication Critical patent/BR0103887A/pt
Publication of BR0103887C1 publication Critical patent/BR0103887C1/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/04—Mycobacterium, e.g. Mycobacterium tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55583—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55588—Adjuvants of undefined constitution
    • A61K2039/55594—Adjuvants of undefined constitution from bacteria

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Oncology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

"COMPOSIçõES IMUNOGêNICAS CONTENDO MICROESFERAS BIODEGRADáVEIS ENCAPSULANDO ANTìGENOS, VETORES GêNICOS E ADJUVANTES". A presente invenção diz respeito a composições capazes de estimular uma resposta imune em um hospedeiro inoculado com um antígeno de interesse ou o vetor gênico que o codifica, onde dita composição compreende microesferas baseadas em copolímeros derivados do ácido lático e do ácido glicólico encapsulando antígenos, vetores gênicos e/ou adjuvantes estimuladores da resposta imune obtidos de frações de micobactérias. Uma concretização da presente invenção é o uso do dimicolato de trealose associado a uma proteína de choque térmico ou ao plasmídeo contendo o gene que a codifica encapsulados em microesferas com um tamanho de partícula inferior a 10 <109>m, capaz de induzir a secreção de citocinas implicadas na proteção de doenças infecciosas, após administração de uma única dose ou várias doses.
BR0103887-7A 2001-07-17 2001-07-17 Composições imunogênicas contendo microesferas biodegradáveis encapsulando antìgenos, vetores gênicos e adjuvantes BR0103887C1 (pt)

Priority Applications (6)

Application Number Priority Date Filing Date Title
BR0103887-7A BR0103887C1 (pt) 2001-07-17 2001-07-17 Composições imunogênicas contendo microesferas biodegradáveis encapsulando antìgenos, vetores gênicos e adjuvantes
PCT/BR2002/000099 WO2003007869A2 (en) 2001-07-17 2002-07-17 Immunogenic compositions containing antigens, gene vectors and adjuvants-loaded biodegradable microspheres
CA002453959A CA2453959A1 (en) 2001-07-17 2002-07-17 Immunogenic compositions containing antigens, gene vectors and adjuvants-loaded biodegradable microspheres
EP02744957A EP1420823A2 (en) 2001-07-17 2002-07-17 Immunogenic compositions containing antigens, gene vectors and adjuvants-loaded biodegradable microspheres
AU2002317056A AU2002317056A1 (en) 2001-07-17 2002-07-17 Immunogenic compositions containing antigens, gene vectors and adjuvants-loaded biodegradable microspheres
CNA028171861A CN1549728A (zh) 2001-07-17 2002-07-17 在可生物降解的微球体中含有抗原、基因载体和佐剂的免疫组合物

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
BR0103887-7A BR0103887C1 (pt) 2001-07-17 2001-07-17 Composições imunogênicas contendo microesferas biodegradáveis encapsulando antìgenos, vetores gênicos e adjuvantes

Publications (2)

Publication Number Publication Date
BR0103887A BR0103887A (pt) 2003-08-05
BR0103887C1 true BR0103887C1 (pt) 2005-11-08

Family

ID=3947962

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0103887-7A BR0103887C1 (pt) 2001-07-17 2001-07-17 Composições imunogênicas contendo microesferas biodegradáveis encapsulando antìgenos, vetores gênicos e adjuvantes

Country Status (5)

Country Link
EP (1) EP1420823A2 (pt)
CN (1) CN1549728A (pt)
BR (1) BR0103887C1 (pt)
CA (1) CA2453959A1 (pt)
WO (1) WO2003007869A2 (pt)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007001448A2 (en) 2004-11-04 2007-01-04 Massachusetts Institute Of Technology Coated controlled release polymer particles as efficient oral delivery vehicles for biopharmaceuticals
CN1317560C (zh) * 2005-10-19 2007-05-23 华中科技大学 一种提高量子点编码微球的编码稳定性的方法
US9267937B2 (en) 2005-12-15 2016-02-23 Massachusetts Institute Of Technology System for screening particles
CA2648099C (en) 2006-03-31 2012-05-29 The Brigham And Women's Hospital, Inc System for targeted delivery of therapeutic agents
CN101573141B (zh) 2006-05-15 2016-05-04 麻省理工学院 用于功能性颗粒的聚合物
WO2007150030A2 (en) 2006-06-23 2007-12-27 Massachusetts Institute Of Technology Microfluidic synthesis of organic nanoparticles
WO2008098165A2 (en) 2007-02-09 2008-08-14 Massachusetts Institute Of Technology Oscillating cell culture bioreactor
EP2144600A4 (en) 2007-04-04 2011-03-16 Massachusetts Inst Technology POLY (AMINIC ACID) TARGET MOLECULES
EP2620157A3 (en) 2007-10-12 2013-10-16 Massachusetts Institute of Technology Vaccine nanotechnology
CN101376023B (zh) * 2008-10-10 2011-12-28 山西海森生物制品有限公司 一种禽用疫苗缓释剂及其制备与接种方法
US8277812B2 (en) 2008-10-12 2012-10-02 Massachusetts Institute Of Technology Immunonanotherapeutics that provide IgG humoral response without T-cell antigen
US8591905B2 (en) * 2008-10-12 2013-11-26 The Brigham And Women's Hospital, Inc. Nicotine immunonanotherapeutics
US8343497B2 (en) 2008-10-12 2013-01-01 The Brigham And Women's Hospital, Inc. Targeting of antigen presenting cells with immunonanotherapeutics
US8343498B2 (en) 2008-10-12 2013-01-01 Massachusetts Institute Of Technology Adjuvant incorporation in immunonanotherapeutics
JP6096675B2 (ja) * 2011-01-04 2017-03-15 アルチベル・ファルマ，ソシエダッド・リミターダ 結核の治療又は予防に適切なリポソーム製剤
CN104411326B (zh) 2012-01-12 2018-02-02 阿尔西维尔法尔玛公司 抗哮喘的mtb‑c疫苗
PL2897620T3 (pl) 2012-09-21 2020-11-02 Intensity Therapeutics, Inc Sposób leczenia nowotworu złośliwego
CN106457692B (zh) 2014-05-14 2020-03-17 迪卡尔公司 包括有图案的背衬的防护罩

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH01207237A (ja) * 1988-02-15 1989-08-21 Sawai Seiyaku Kk 腫瘍壊死因子誘起剤
US6048551A (en) * 1997-03-27 2000-04-11 Hilfinger; John M. Microsphere encapsulation of gene transfer vectors

Also Published As

Publication number Publication date
BR0103887A (pt) 2003-08-05
WO2003007869A2 (en) 2003-01-30
CA2453959A1 (en) 2003-01-30
WO2003007869A3 (en) 2004-03-18
EP1420823A2 (en) 2004-05-26
CN1549728A (zh) 2004-11-24

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