BR0012767A - Sample arrangement, processes for measuring or detecting an interaction between components, for testing or optimizing one or more properties of a formulation of an active component, and for measuring or detecting an interaction between a sensory material in another component, and, system for measure or detect an interaction between components - Google Patents

Sample arrangement, processes for measuring or detecting an interaction between components, for testing or optimizing one or more properties of a formulation of an active component, and for measuring or detecting an interaction between a sensory material in another component, and, system for measure or detect an interaction between components

Info

Publication number
BR0012767A
BR0012767A BR0012767-1A BR0012767A BR0012767A BR 0012767 A BR0012767 A BR 0012767A BR 0012767 A BR0012767 A BR 0012767A BR 0012767 A BR0012767 A BR 0012767A
Authority
BR
Brazil
Prior art keywords
interaction
components
measure
detect
measuring
Prior art date
Application number
BR0012767-1A
Other languages
Portuguese (pt)
Inventor
David Putnam
Hongming Chen
Nicholas Galakatos
Robert S Langer
Original Assignee
Transform Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Transform Pharmaceuticals Inc filed Critical Transform Pharmaceuticals Inc
Publication of BR0012767A publication Critical patent/BR0012767A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q3/00—Condition responsive control processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/0061—The surface being organic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00614—Delimitation of the attachment areas
    • B01J2219/00621—Delimitation of the attachment areas by physical means, e.g. trenches, raised areas
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00623—Immobilisation or binding
    • B01J2219/0063—Other, e.g. van der Waals forces, hydrogen bonding
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00639—Making arrays on substantially continuous surfaces the compounds being trapped in or bound to a porous medium
    • B01J2219/00644—Making arrays on substantially continuous surfaces the compounds being trapped in or bound to a porous medium the porous medium being present in discrete locations, e.g. gel pads
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068—Means for controlling the apparatus of the process
    • B01J2219/00686—Automatic
    • B01J2219/00689—Automatic using computers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068—Means for controlling the apparatus of the process
    • B01J2219/00702—Processes involving means for analysing and characterising the products
    • B01J2219/00707—Processes involving means for analysing and characterising the products separated from the reactor apparatus
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/00756—Compositions, e.g. coatings, crystals, formulations
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Preparation (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

"ARRANJO DE AMOSTRA, PROCESSOS PARA MEDIR OU DETECTAR UMA INTERAçãO ENTRE COMPONENTES, PARA TESTAR OU OTIMIZAR UMA OU MAIS PROPRIEDADES DE UMA FORMULAçãO DE UM COMPONENTE ATIVO, E PARA MEDIR OU DETECTAR UMA INTERAçãO ENTRE UM MATERIAL SENSóRIO EM UM OUTRO COMPONENTE, E, SISTEMA PARA MEDIR OU DETECTAR UMA INTERAçãO ENTRE COMPONENTES". A invenção diz respeito a processos de alta produção para preparar um arranjo que compreenda um grande número de amostras, cada amostra consistindo de uma combinação de componentes, em concentrações e identidades variáveis, e processos de alta produção para ensaiar cada amostra quanto a uma ou mais propriedades. Tais processos permitem a detecção ou medição de interações ou a detecção da falta de interações entre componentes inativos e componentes ativos; entre componentes inativos múltiplos; ou entre componentes ativos múltiplos. A invenção é particularmente adequada para produzir um grande número de amostras de excipientes farmacêuticos ao mesmo tempo, depois rapidamente ensaiar cada amostra para detectar ou medir uma interação. Uma vez tal interação seja detectada ou medida, ela pode ser explorada para desenvolver formulações otimizadas para administração farmacêutica."SAMPLE ARRANGEMENT, PROCESSES TO MEASURE OR DETECT AN INTERACTION BETWEEN COMPONENTS, TO TEST OR OPTIMIZE ONE OR MORE PROPERTIES OF A FORMULATION OF AN ACTIVE COMPONENT, AND TO MEASURE OR DETECT AN INTERACTION BETWEEN A SENSORY MATERIAL IN ANOTHER COMPONENT, AND, A SYSTEM TO MEASURE OR DETECT AN INTERACTION BETWEEN COMPONENTS ". The invention relates to high production processes for preparing an arrangement comprising a large number of samples, each sample consisting of a combination of components, in varying concentrations and identities, and high production processes for testing each sample for one or more properties. Such processes allow the detection or measurement of interactions or the detection of the lack of interactions between inactive components and active components; between multiple inactive components; or between multiple active components. The invention is particularly suitable for producing a large number of samples of pharmaceutical excipients at the same time, then quickly testing each sample to detect or measure an interaction. Once such an interaction is detected or measured, it can be exploited to develop formulations optimized for pharmaceutical administration.

BR0012767-1A 1999-07-28 2000-07-28 Sample arrangement, processes for measuring or detecting an interaction between components, for testing or optimizing one or more properties of a formulation of an active component, and for measuring or detecting an interaction between a sensory material in another component, and, system for measure or detect an interaction between components BR0012767A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US14601999P 1999-07-28 1999-07-28
US54046200A 2000-03-31 2000-03-31
PCT/US2000/020717 WO2001009391A1 (en) 1999-07-28 2000-07-28 Sample arrays and high-throughput testing thereof to detect interactions

Publications (1)

Publication Number Publication Date
BR0012767A true BR0012767A (en) 2002-07-23

Family

ID=26843497

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0012767-1A BR0012767A (en) 1999-07-28 2000-07-28 Sample arrangement, processes for measuring or detecting an interaction between components, for testing or optimizing one or more properties of a formulation of an active component, and for measuring or detecting an interaction between a sensory material in another component, and, system for measure or detect an interaction between components

Country Status (11)

Country Link
EP (1) EP1204766A4 (en)
JP (1) JP2003509657A (en)
KR (1) KR20020034168A (en)
AU (1) AU6502300A (en)
BR (1) BR0012767A (en)
CA (1) CA2379160A1 (en)
CZ (1) CZ2002334A3 (en)
IL (1) IL147646A0 (en)
MX (1) MXPA02000890A (en)
SK (1) SK1112002A3 (en)
WO (1) WO2001009391A1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7006928B2 (en) 2001-06-13 2006-02-28 Rpd Tool Ag Device and method for determining the stability of substances and formulations
US20030119060A1 (en) 2001-08-10 2003-06-26 Desrosiers Peter J. Apparatuses and methods for creating and testing pre-formulations and systems for same
EP1351053A1 (en) * 2002-04-05 2003-10-08 Quest International Fragrance Company Method for preparing fragrance composition with plurality of sampling ports

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4399687A (en) * 1980-12-23 1983-08-23 Carter Collins Apparatus for analyzing and identifying odorants
US5985214A (en) * 1997-05-16 1999-11-16 Aurora Biosciences Corporation Systems and methods for rapidly identifying useful chemicals in liquid samples
CN1263473A (en) * 1997-05-21 2000-08-16 利兰·斯坦福青年大学托管委员会 Composition and method for enhancing transport across biological membranes
CZ20013606A3 (en) * 1999-04-05 2002-04-17 Millennium Pharmaceuticals, Inc. Formulation arrays

Also Published As

Publication number Publication date
EP1204766A4 (en) 2003-09-17
MXPA02000890A (en) 2003-10-15
IL147646A0 (en) 2002-08-14
JP2003509657A (en) 2003-03-11
WO2001009391A1 (en) 2001-02-08
CA2379160A1 (en) 2001-02-08
SK1112002A3 (en) 2002-06-04
EP1204766A1 (en) 2002-05-15
CZ2002334A3 (en) 2002-06-12
AU6502300A (en) 2001-02-19
KR20020034168A (en) 2002-05-08

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Legal Events

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FA10 Dismissal: dismissal - article 33 of industrial property law
B11Y Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette]