BR0012068A - Vla-4 inhibitory compounds - Google Patents

Vla-4 inhibitory compounds

Info

Publication number
BR0012068A
BR0012068A BR0012068-5A BR0012068A BR0012068A BR 0012068 A BR0012068 A BR 0012068A BR 0012068 A BR0012068 A BR 0012068A BR 0012068 A BR0012068 A BR 0012068A
Authority
BR
Brazil
Prior art keywords
vla
compounds
methods
mediated cell
cell adhesion
Prior art date
Application number
BR0012068-5A
Other languages
Portuguese (pt)
Inventor
John J Baldwin
Edward Mcdonald
Kevin Joseph Moriarty
Christopher Ronald Sarko
Nobuo Machinaga
Atsushi Nakayama
Jun Chiba
Shin Iimura
Yoshiyuki Yoneda
Original Assignee
Daiichi Seiyaku Co
Pharmacopeia Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Daiichi Seiyaku Co, Pharmacopeia Inc filed Critical Daiichi Seiyaku Co
Publication of BR0012068A publication Critical patent/BR0012068A/en

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    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
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Abstract

"COMPOSTOS INIBIDORES DE VLA-4". São revelados compostos que inibem seletivamente a ligação de ligandos à integrina <244>4<225>1 (VLA-4) e métodos para sua preparação. Em uma modalidade, compostos da invenção são representados pela fórmula (1). Como inibidores seletivos de adesão de células mediada por VLA-4, os compostos da presente invenção são úteis no tratamento de condições associadas a tal adesão, incluindo, porém não limitados a, condições como respostas auto-imunes e inflamatórias, diabetes, asma, psoríase, doença inflamatória do intestino, rejeição de transplante e metástase de tumor. São também revelados métodos de inibir adesão de células mediada por VLA- 4 e métodos de tratar condições associadas à adesão de células mediada por LA-4."VLA-4 INHIBITING COMPOUNDS". Compounds that selectively inhibit ligand binding to integrin <244> 4 <225> 1 (VLA-4) and methods for its preparation are disclosed. In one embodiment, compounds of the invention are represented by formula (1). As selective inhibitors of VLA-4 mediated cell adhesion, the compounds of the present invention are useful in the treatment of conditions associated with such adhesion, including, but not limited to, conditions such as autoimmune and inflammatory responses, diabetes, asthma, psoriasis , inflammatory bowel disease, transplant rejection and tumor metastasis. Methods of inhibiting VLA-4-mediated cell adhesion and methods of treating conditions associated with LA-4-mediated cell adhesion are also disclosed.

BR0012068-5A 1999-06-30 2000-06-30 Vla-4 inhibitory compounds BR0012068A (en)

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