BR0012068A - Vla-4 inhibitory compounds - Google Patents
Vla-4 inhibitory compoundsInfo
- Publication number
- BR0012068A BR0012068A BR0012068-5A BR0012068A BR0012068A BR 0012068 A BR0012068 A BR 0012068A BR 0012068 A BR0012068 A BR 0012068A BR 0012068 A BR0012068 A BR 0012068A
- Authority
- BR
- Brazil
- Prior art keywords
- vla
- compounds
- methods
- mediated cell
- cell adhesion
- Prior art date
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- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
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Abstract
"COMPOSTOS INIBIDORES DE VLA-4". São revelados compostos que inibem seletivamente a ligação de ligandos à integrina <244>4<225>1 (VLA-4) e métodos para sua preparação. Em uma modalidade, compostos da invenção são representados pela fórmula (1). Como inibidores seletivos de adesão de células mediada por VLA-4, os compostos da presente invenção são úteis no tratamento de condições associadas a tal adesão, incluindo, porém não limitados a, condições como respostas auto-imunes e inflamatórias, diabetes, asma, psoríase, doença inflamatória do intestino, rejeição de transplante e metástase de tumor. São também revelados métodos de inibir adesão de células mediada por VLA- 4 e métodos de tratar condições associadas à adesão de células mediada por LA-4."VLA-4 INHIBITING COMPOUNDS". Compounds that selectively inhibit ligand binding to integrin <244> 4 <225> 1 (VLA-4) and methods for its preparation are disclosed. In one embodiment, compounds of the invention are represented by formula (1). As selective inhibitors of VLA-4 mediated cell adhesion, the compounds of the present invention are useful in the treatment of conditions associated with such adhesion, including, but not limited to, conditions such as autoimmune and inflammatory responses, diabetes, asthma, psoriasis , inflammatory bowel disease, transplant rejection and tumor metastasis. Methods of inhibiting VLA-4-mediated cell adhesion and methods of treating conditions associated with LA-4-mediated cell adhesion are also disclosed.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US14160299P | 1999-06-30 | 1999-06-30 | |
US14160199P | 1999-06-30 | 1999-06-30 | |
US14169299P | 1999-06-30 | 1999-06-30 | |
PCT/US2000/018079 WO2001000206A1 (en) | 1999-06-30 | 2000-06-30 | Vla-4 inhibitor compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0012068A true BR0012068A (en) | 2002-05-14 |
Family
ID=27385682
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0012068-5A BR0012068A (en) | 1999-06-30 | 2000-06-30 | Vla-4 inhibitory compounds |
Country Status (13)
Country | Link |
---|---|
EP (1) | EP1189612A4 (en) |
JP (1) | JP2003503350A (en) |
CN (1) | CN1391473A (en) |
AR (1) | AR035011A1 (en) |
AU (1) | AU781438B2 (en) |
BR (1) | BR0012068A (en) |
CA (1) | CA2369308A1 (en) |
HK (1) | HK1043318A1 (en) |
IL (1) | IL146288A0 (en) |
MX (1) | MXPA01013406A (en) |
NO (1) | NO324892B1 (en) |
TW (1) | TWI283240B (en) |
WO (1) | WO2001000206A1 (en) |
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US6864219B2 (en) | 2000-01-17 | 2005-03-08 | Bayer Aktiengesellschaft | Substituted aryl ketones |
DE10006453A1 (en) * | 2000-02-14 | 2001-08-16 | Bayer Ag | New piperidylcarboxylic acid derivatives, are integrin antagonists useful for treating inflammatory, autoimmune or immunological diseases, e.g. atherosclerosis, asthma, diabetes, rheumatoid arthritis or transplant rejection |
CA2413418A1 (en) | 2000-06-21 | 2001-12-27 | Joseph B. Santella | Piperidine amides as modulators of chemokine receptor activity |
JP4212358B2 (en) | 2000-12-28 | 2009-01-21 | 第一三共株式会社 | VLA-4 inhibitor |
HUP0400321A2 (en) | 2001-06-27 | 2004-08-30 | Smithkline Beecham Corp. | Fluoropyrrolidines as dipeptidyl peptidase inhibitors and pharmaceutical compositions containing them |
GB0123765D0 (en) * | 2001-10-03 | 2001-11-21 | Bayer Ag | Para-amino benzoic acids |
US7956219B2 (en) * | 2002-05-09 | 2011-06-07 | Baker IDI Heart and Diabetes | Amino acid analogues |
WO2004002481A1 (en) | 2002-06-27 | 2004-01-08 | Novo Nordisk A/S | Aryl carbonyl derivatives as therapeutic agents |
RU2340605C2 (en) | 2002-06-27 | 2008-12-10 | Ново Нордиск А/С | Arylcarbonyl derivatives as therapeutic agents |
EP2565178A1 (en) * | 2002-10-03 | 2013-03-06 | Ono Pharmaceutical Co., Ltd. | LPA Receptor Antagonists |
GB0225944D0 (en) * | 2002-11-06 | 2002-12-11 | Glaxo Group Ltd | Novel compounds |
US7345179B2 (en) | 2003-05-09 | 2008-03-18 | Daiichi Pharmaceutical Co., Ltd. | Process for producing pyrrolidine derivative |
JP4676884B2 (en) | 2003-07-24 | 2011-04-27 | 第一三共株式会社 | Cyclohexanecarboxylic acids |
JP4667384B2 (en) * | 2003-10-07 | 2011-04-13 | レノビス, インコーポレイテッド | Amide derivatives and pharmaceutical compositions as ion channel ligands and methods of using them |
BRPI0506662B8 (en) | 2004-01-06 | 2021-05-25 | Novo Nordisk As | glucokinase activating compounds |
JP2005350417A (en) * | 2004-06-11 | 2005-12-22 | Dai Ichi Seiyaku Co Ltd | Method for producing pyrrolidine derivative using reductive etherification method |
CA2576647C (en) * | 2004-08-16 | 2011-12-13 | Merck & Co., Inc. | Vla-4 antagonists |
WO2007069635A1 (en) | 2005-12-13 | 2007-06-21 | Daiichi Sankyo Company, Limited | Vla-4 inhibitory drug |
AR068875A1 (en) | 2007-10-16 | 2009-12-09 | Novartis Ag | DERIVATIVES OF 4-5-DIHIDRO-5-OXO-IMIDAZOL, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, PROCESS OF PREPARATION AND USE OF THE SAME AS INHIBITORS OF NPY AND 2 NON-PEPTIDIC RECEPTORS, FOR THE TREATMENT OF METHODOLOSTIC ANXIETRICS, DEPRESSIONS AND ENDOCRINS. |
EP2628726A1 (en) * | 2008-03-26 | 2013-08-21 | Novartis AG | Hydroxamate-based inhibitors of deacetylases b |
CA2773409C (en) * | 2009-11-18 | 2015-06-16 | Suven Life Sciences Limited | Bicyclic compounds as .alpha.4.beta.2 nicotinic acetylcholine receptor ligands |
US9527807B2 (en) | 2011-04-05 | 2016-12-27 | Takeda Pharmaceutical Company Limited | Sulfonamide derivative and use thereof |
MX2020008905A (en) | 2018-06-12 | 2020-12-03 | Vtv Therapeutics Llc | Therapeutic uses of glucokinase activators in combination with insulin or insulin analogs. |
CA3115820A1 (en) | 2018-10-30 | 2020-05-07 | Gilead Sciences, Inc. | Compounds for inhibition of .alpha.4.beta.7 integrin |
WO2020092394A1 (en) | 2018-10-30 | 2020-05-07 | Gilead Sciences, Inc. | Imidazopyridine derivatives as alpha4beta7 integrin inhibitors |
JP7189369B2 (en) | 2018-10-30 | 2022-12-13 | ギリアード サイエンシーズ, インコーポレイテッド | Compounds for inhibition of alpha4beta7 integrin |
JP7192139B2 (en) | 2018-10-30 | 2022-12-19 | ギリアード サイエンシーズ, インコーポレイテッド | Quinoline derivatives as α4β7 integrin inhibitors |
WO2020173861A1 (en) | 2019-02-26 | 2020-09-03 | Bayer Aktiengesellschaft | Condensed bicyclic heterocyclic derivatives as pest control agents |
EP4013499A1 (en) | 2019-08-14 | 2022-06-22 | Gilead Sciences, Inc. | Compounds for inhibition of alpha 4 beta 7 integrin |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
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US6306840B1 (en) * | 1995-01-23 | 2001-10-23 | Biogen, Inc. | Cell adhesion inhibitors |
US6248713B1 (en) * | 1995-07-11 | 2001-06-19 | Biogen, Inc. | Cell adhesion inhibitors |
JP2002512625A (en) * | 1997-05-29 | 2002-04-23 | メルク エンド カンパニー インコーポレーテッド | Heterocyclic amide compounds as cell adhesion inhibitors |
WO1999020272A1 (en) * | 1997-10-21 | 1999-04-29 | Merck & Co., Inc. | Azapeptide acids as cell adhesion inhibitors |
AU748041B2 (en) * | 1997-10-31 | 2002-05-30 | Aventis Pharma Limited | Substituted anilides |
WO1999054321A1 (en) * | 1998-04-21 | 1999-10-28 | Aventis Pharma Limited | Substituted diamines and their use as cell adhesion inhibitors |
YU77600A (en) * | 1998-06-30 | 2004-03-12 | Pfizer Products Inc. | Non-peptidyl inhibitors of vla-4 dependent cell binding useful in treating inflammatory, autoimmune and respiratory diseases |
-
2000
- 2000-06-30 JP JP2001505915A patent/JP2003503350A/en active Pending
- 2000-06-30 CN CN00809510A patent/CN1391473A/en active Pending
- 2000-06-30 CA CA002369308A patent/CA2369308A1/en not_active Abandoned
- 2000-06-30 BR BR0012068-5A patent/BR0012068A/en not_active Application Discontinuation
- 2000-06-30 AR ARP000103363A patent/AR035011A1/en unknown
- 2000-06-30 EP EP00945035A patent/EP1189612A4/en not_active Withdrawn
- 2000-06-30 IL IL14628800A patent/IL146288A0/en not_active IP Right Cessation
- 2000-06-30 WO PCT/US2000/018079 patent/WO2001000206A1/en active IP Right Grant
- 2000-06-30 AU AU59031/00A patent/AU781438B2/en not_active Ceased
- 2000-06-30 MX MXPA01013406A patent/MXPA01013406A/en active IP Right Grant
- 2000-06-30 TW TW089112968A patent/TWI283240B/en not_active IP Right Cessation
-
2001
- 2001-12-21 NO NO20016319A patent/NO324892B1/en unknown
-
2002
- 2002-07-09 HK HK02105102.2A patent/HK1043318A1/en unknown
Also Published As
Publication number | Publication date |
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CN1391473A (en) | 2003-01-15 |
NO20016319D0 (en) | 2001-12-21 |
EP1189612A4 (en) | 2005-02-16 |
MXPA01013406A (en) | 2003-09-04 |
WO2001000206A1 (en) | 2001-01-04 |
AU781438B2 (en) | 2005-05-26 |
TWI283240B (en) | 2007-07-01 |
CA2369308A1 (en) | 2001-01-04 |
NO324892B1 (en) | 2007-12-27 |
HK1043318A1 (en) | 2002-09-13 |
AR035011A1 (en) | 2004-04-14 |
IL146288A0 (en) | 2002-07-25 |
JP2003503350A (en) | 2003-01-28 |
AU5903100A (en) | 2001-01-31 |
EP1189612A1 (en) | 2002-03-27 |
NO20016319L (en) | 2002-02-28 |
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