BR0011743A - Método para modular a atividade de receptor de fxr - Google Patents
Método para modular a atividade de receptor de fxrInfo
- Publication number
- BR0011743A BR0011743A BR0011743-9A BR0011743A BR0011743A BR 0011743 A BR0011743 A BR 0011743A BR 0011743 A BR0011743 A BR 0011743A BR 0011743 A BR0011743 A BR 0011743A
- Authority
- BR
- Brazil
- Prior art keywords
- fxr receptor
- receptor activity
- modulate fxr
- activity
- modulate
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/695—Silicon compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/554—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one sulfur as ring hetero atoms, e.g. clothiapine, diltiazem
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Gastroenterology & Hepatology (AREA)
- Obesity (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
Patente de Invenção: "MéTODOS PARA MODULAR A ATIVIDADE DE RECEPTOR DE FXR". Métodos para modular a atividade de receptor de FXR de mamíferos. Os métodos incluem métodos de tratamento de um mamíferos hiper- ou hipocolesterolêmico compreendendo contatar o mamíferos com compostos sintéticos tendo atividade de receptor de FXR.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US13896899P | 1999-06-11 | 1999-06-11 | |
PCT/US2000/015912 WO2000076523A1 (en) | 1999-06-11 | 2000-06-09 | Methods for modulating fxr receptor activity |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0011743A true BR0011743A (pt) | 2002-03-05 |
Family
ID=22484498
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0011743-9A BR0011743A (pt) | 1999-06-11 | 2000-06-09 | Método para modular a atividade de receptor de fxr |
Country Status (10)
Country | Link |
---|---|
EP (1) | EP1185277B1 (pt) |
JP (1) | JP2003501477A (pt) |
CN (1) | CN1368884A (pt) |
AT (1) | ATE307595T1 (pt) |
AU (1) | AU768806B2 (pt) |
BR (1) | BR0011743A (pt) |
CA (1) | CA2377320A1 (pt) |
DE (1) | DE60023493T2 (pt) |
HK (1) | HK1047705A1 (pt) |
WO (1) | WO2000076523A1 (pt) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20020132223A1 (en) * | 1999-03-26 | 2002-09-19 | City Of Hope | Methods for modulating activity of the FXR nuclear receptor |
US20020119958A1 (en) * | 2001-02-13 | 2002-08-29 | Shinichiro Tojo | Therapeutic agent for hyperlipidemia |
CA2440680C (en) | 2001-03-12 | 2010-06-01 | Roberto Pellicciari | Steroids as agonists for fxr |
US20030144360A1 (en) * | 2001-11-19 | 2003-07-31 | Allergan Sales, Inc. | Composition and method for modulating BAR/FXR receptor activity |
EP1465882B1 (en) | 2001-12-21 | 2011-08-24 | X-Ceptor Therapeutics, Inc. | Hetrocyclic modulators of nuclear receptors |
US7482366B2 (en) | 2001-12-21 | 2009-01-27 | X-Ceptor Therapeutics, Inc. | Modulators of LXR |
US20050143449A1 (en) * | 2002-11-15 | 2005-06-30 | The Salk Institute For Biological Studies | Non-steroidal farnesoid X receptor modulators and methods for the use thereof |
US10987362B2 (en) | 2004-03-12 | 2021-04-27 | Intercept Pharmaceuticals, Inc. | Treatment of fibrosis using FXR ligands |
JP5094384B2 (ja) | 2004-03-12 | 2012-12-12 | インターセプト ファーマシューティカルズ, インコーポレイテッド | Fxrリガンドを使用する線維症の処置 |
ITMI20050912A1 (it) | 2005-05-19 | 2006-11-20 | Erregierre Spa | Processo di preparazione di acidi 3-a-ya(b)-diidrossi-6-a(b)-alchil-5b-colanici |
AU2008209566C1 (en) | 2007-01-19 | 2013-02-14 | Intercept Pharmaceuticals, Inc. | 23-substituted bile acids as TGR5 modulators and methods of use thereof |
CA2732323C (en) | 2008-07-30 | 2017-06-27 | Intercept Pharmaceuticals, Inc. | Tgr5 modulators and methods of use thereof |
JP5535233B2 (ja) | 2008-11-19 | 2014-07-02 | インターセプト ファーマシューティカルズ, インコーポレイテッド | Tgr5モジュレーターおよびその使用方法 |
EP2379081B1 (en) | 2008-12-19 | 2013-03-20 | Royal College of Surgeons in Ireland | Treatment of diarrhoea |
US9982008B2 (en) | 2012-06-19 | 2018-05-29 | Intercept Pharmaceuticals, Inc. | Preparation and uses of obeticholic acid |
CA3047776C (en) | 2012-06-19 | 2022-10-18 | Intercept Pharmaceuticals, Inc. | Preparation, uses and solid forms of obeticholic acid |
CN105764569B (zh) | 2013-09-11 | 2019-09-13 | 国家医疗保健研究所 | 治疗乙型肝炎病毒感染的方法和药物组合物 |
US20210085662A1 (en) | 2017-03-30 | 2021-03-25 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for reducing persistence and expression of episomal viruses |
CN114173784B (zh) | 2019-07-18 | 2023-12-01 | 埃尼奥制药公司 | 降低干扰素的副作用的方法 |
EP4090327A1 (en) | 2020-01-15 | 2022-11-23 | Institut National de la Santé et de la Recherche Médicale (INSERM) | Use of fxr agonists for treating an infection by hepatitis d virus |
CA3204800A1 (en) | 2021-01-14 | 2022-07-21 | Raphael Darteil | Synergistic effect of a fxr agonist and ifn for the treatment of hbv infection |
CA3213217A1 (en) | 2021-04-28 | 2022-11-03 | Raphael Darteil | Strong potentiation of tlr3 agonists effects using fxr agonists as a combined treatment |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4588715A (en) * | 1984-06-04 | 1986-05-13 | Sandoz, Inc. | Heptenoic acid derivatives |
FR2707989B1 (fr) * | 1993-07-22 | 1995-10-13 | Pf Medicament | Nouveaux dérivés de benzylamines silylées, leurs sels, leurs procédés de fabrication et les compositions pharmaceutiques les renfermant. |
-
2000
- 2000-06-09 JP JP2001502856A patent/JP2003501477A/ja active Pending
- 2000-06-09 BR BR0011743-9A patent/BR0011743A/pt not_active IP Right Cessation
- 2000-06-09 AT AT00941312T patent/ATE307595T1/de not_active IP Right Cessation
- 2000-06-09 EP EP00941312A patent/EP1185277B1/en not_active Expired - Lifetime
- 2000-06-09 WO PCT/US2000/015912 patent/WO2000076523A1/en active IP Right Grant
- 2000-06-09 AU AU56032/00A patent/AU768806B2/en not_active Ceased
- 2000-06-09 CN CN00811519A patent/CN1368884A/zh active Pending
- 2000-06-09 CA CA002377320A patent/CA2377320A1/en not_active Abandoned
- 2000-06-09 DE DE60023493T patent/DE60023493T2/de not_active Expired - Fee Related
-
2002
- 2002-12-27 HK HK02109359.4A patent/HK1047705A1/zh unknown
Also Published As
Publication number | Publication date |
---|---|
HK1047705A1 (zh) | 2003-03-07 |
AU5603200A (en) | 2001-01-02 |
CN1368884A (zh) | 2002-09-11 |
WO2000076523A1 (en) | 2000-12-21 |
DE60023493D1 (de) | 2005-12-01 |
JP2003501477A (ja) | 2003-01-14 |
CA2377320A1 (en) | 2000-12-21 |
EP1185277B1 (en) | 2005-10-26 |
EP1185277A1 (en) | 2002-03-13 |
ATE307595T1 (de) | 2005-11-15 |
DE60023493T2 (de) | 2006-07-20 |
AU768806B2 (en) | 2004-01-08 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B25A | Requested transfer of rights approved |
Free format text: ALLERGAN SALES, LLC (US) |
|
B25A | Requested transfer of rights approved |
Free format text: ALLERGAN, INC (US) |
|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 7O, 8O E 9O ANUIDADES. |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 DA RPI 2008 DE 30/06/2009. |