BR0011160A - Produção de vacinas de vìrus sinciciais respiratórios quiméricos atenuados a partiir de sequências de nucleotìdeos clonados - Google Patents

Produção de vacinas de vìrus sinciciais respiratórios quiméricos atenuados a partiir de sequências de nucleotìdeos clonados

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Publication number
BR0011160A
BR0011160A BR0011160-0A BR0011160A BR0011160A BR 0011160 A BR0011160 A BR 0011160A BR 0011160 A BR0011160 A BR 0011160A BR 0011160 A BR0011160 A BR 0011160A
Authority
BR
Brazil
Prior art keywords
rsv
chimeric
attenuated
offspring
nucleotide sequences
Prior art date
Application number
BR0011160-0A
Other languages
English (en)
Inventor
Peter L Collins
Brian R Murphy
Stephen S Whitehead
Original Assignee
Us Health
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/291,894 external-priority patent/US6689367B1/en
Application filed by Us Health filed Critical Us Health
Publication of BR0011160A publication Critical patent/BR0011160A/pt

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    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
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    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C12N7/04—Inactivation or attenuation; Producing viral sub-units
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/155—Paramyxoviridae, e.g. parainfluenza virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5254—Virus avirulent or attenuated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A61K2039/541—Mucosal route
    • A61K2039/543—Mucosal route intranasal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
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    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • C12N2760/18511—Pneumovirus, e.g. human respiratory syncytial virus
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    • C12N2760/18011—Paramyxoviridae
    • C12N2760/18511—Pneumovirus, e.g. human respiratory syncytial virus
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    • C12N2760/18011—Paramyxoviridae
    • C12N2760/18511—Pneumovirus, e.g. human respiratory syncytial virus
    • C12N2760/18541—Use of virus, viral particle or viral elements as a vector
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    • C12N2760/00011—Details
    • C12N2760/18011—Paramyxoviridae
    • C12N2760/18511—Pneumovirus, e.g. human respiratory syncytial virus
    • C12N2760/18561—Methods of inactivation or attenuation

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  • Health & Medical Sciences (AREA)
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Abstract

"PRODUçãO DE VACINAS DE VìRUS SINCICIAIS RESPIRATóRIOS QUIMéRICOS ATENUADOS A PARTIR DE SEQuêNCIAS DE NUCLEOTìDEOS CLONADOS". Vírus sincicial respiratório quimérico (RSV ) e composições de vacina do mesmo são produzidos introduzindo um ou mais genes ou segmentos de genes heterólogos a partir de um subgrupo ou descendência de RSV em um fundo de RSV recipiente de um subgrupo ou descendência diferente. O vírus RSV quimérico ou partícula subviral resultante é infeccioso e atenuado, preferivelmente pela introdução de mutações selecionadas especificando fenótipos atenuados em um genoma ou antigenoma quimérico para produzir, por exemplo, descendências de vacina sensível à temperatura (ts) e/ou adaptadas ao frio (ca). Alternativamente, RSV quimérico e composições de vacina do mesmo incorporam outras mutações especificando características estruturais e/ou fenotípicas desejadas em um RSV quimérico infeccioso. Tal RSV quimérico incorpora mutações desejadas especificadas pela inserção, eliminação, substituição ou rearranjo de uma ou mais seq³ências de nucleotídeo, gene(s), ou segmento(s) de gene selecionados em um clone de RSV quimérico. Isto provê um método para desenvolvimento de novas vacinas contra descendências diversas de RSV usando uma cadeia principal atenuada comum como um vetor para expressar antígenos protetores de descendências heterólogas. O sistema imunológico de um individuo é estimulado para induzir proteção contra infecção de RSV natural, preferivelmente de uma maneira multivalente para conseguir proteção contra múltiplas descendências e/ou subgrupos de RSV.
BR0011160-0A 1999-04-13 2000-03-31 Produção de vacinas de vìrus sinciciais respiratórios quiméricos atenuados a partiir de sequências de nucleotìdeos clonados BR0011160A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/291,894 US6689367B1 (en) 1995-09-27 1999-04-13 Production of attenuated chimeric respiratory syncytial virus vaccines from cloned nucleotide sequences
PCT/US2000/008802 WO2000061611A2 (en) 1999-04-13 2000-03-31 Production of attenuated chimeric respiratory syncytial virus vaccines from cloned nucleotide sequences

Publications (1)

Publication Number Publication Date
BR0011160A true BR0011160A (pt) 2002-10-08

Family

ID=23122324

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0011160-0A BR0011160A (pt) 1999-04-13 2000-03-31 Produção de vacinas de vìrus sinciciais respiratórios quiméricos atenuados a partiir de sequências de nucleotìdeos clonados

Country Status (10)

Country Link
EP (2) EP1690940A1 (pt)
JP (1) JP2002541785A (pt)
KR (1) KR100746979B1 (pt)
CN (1) CN100491530C (pt)
AU (1) AU4065500A (pt)
BR (1) BR0011160A (pt)
CA (1) CA2369200A1 (pt)
IL (1) IL145796A0 (pt)
MX (1) MXPA01010320A (pt)
WO (1) WO2000061611A2 (pt)

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US7485440B2 (en) 1995-09-27 2009-02-03 The United States Of America As Represented By The Department Of Health And Human Services Production of attenuated respiratory syncytial virus vaccines involving modification of M2 ORF2
EP0859831B1 (en) * 1995-09-27 2010-03-03 THE UNITED STATES OF AMERICA, as represented by the Secretary of the Department of Health and Human Services Production of infectious respiratory syncytial virus from cloned nucleotide sequences
US6699476B1 (en) 1996-07-15 2004-03-02 Peter L. Collins Production of recombinant respiratory syncytial viruses expressing immune modulatory molecules
EP2112220A3 (en) 1996-07-15 2010-01-06 The Government of the United States of America, as represented by The Department of Health and Human Services Production of attenuated respiratory syncytial virus vaccines from cloned nucleotide sequences
US7951383B2 (en) 1997-05-23 2011-05-31 The United States Of America As Represented By The Department Of Health And Human Services Attenuated parainfluenza virus (PIV) vaccines
US7632508B2 (en) 1997-05-23 2009-12-15 The United States Of America Attenuated human-bovine chimeric parainfluenza virus (PIV) vaccines
US7201907B1 (en) 1997-05-23 2007-04-10 The United States Of America, Represented By The Secretary, Department Of Health And Human Services Attenuated human-bovine chimeric parainfluenza virus(PIV) vaccines
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AU2006200619B2 (en) * 1997-09-26 2007-12-13 Medimmune, Llc Recombinant RSV virus expression systems and vaccines
AU5918100A (en) * 1999-07-09 2001-01-30 Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The Production of attenuated respiratory syncytial virus vaccines involving modification of M2 ORF2
EP1287152B1 (en) 1999-07-09 2008-12-31 THE GOVERNMENT OF THE UNITED STATES OF AMERICA, represented by THE DEPARTMENT OF HEALTH & HUMAN SERVICES Human-bovine chimeric respiratory syncytial virus vaccines
AU2003270824B2 (en) 2002-09-18 2009-02-19 The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services Recovery of recombinant human parainfluenza virus type 2 (HPIV2) from cDNA and use of recombinant HPIV2 in immunogenic compositions and as vectors to elicit immune responses against PIV and other human pathogens
CA2517394A1 (en) 2003-02-28 2005-02-17 The Government Of The United States Of America As Represented By The Sec Retary Of The Department Of Health And Human Services Recombinant human metapneumovirus and its use
EP1633860A2 (en) 2003-06-09 2006-03-15 Wyeth IMPROVED METHOD FOR THE RECOVERY OF NON-SEGMENTED, NEGATIVE-STRANDED RNA VIRUSES FROM cDNA
US8597637B1 (en) * 2010-05-18 2013-12-03 Weidong Zhang Breast cancer therapy using an engineered respiratory syncytial virus
EP4190895A1 (en) 2013-02-08 2023-06-07 The U.S.A. As Represented By The Secretary, Department Of Health And Human Services Attenuation of human respiratory syncytial virus by genome scale codon-pair deoptimization
WO2018057950A1 (en) 2016-09-23 2018-03-29 The Usa, As Represented By The Secretary, Dept. Of Health And Human Services Vaccine candidates for human respiratory syncytial virus (rsv) having attenuated phenotypes
CN107384958B (zh) * 2017-07-14 2020-04-10 北京交通大学 基于反向遗传学构建的rsv反基因组质粒及其应用
CN113462656B (zh) * 2021-03-24 2022-09-30 兰州生物制品研究所有限责任公司 一种人三型副流感病毒冷适应温度敏感株及其应用

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Also Published As

Publication number Publication date
EP1690940A1 (en) 2006-08-16
EP1169457A2 (en) 2002-01-09
KR100746979B1 (ko) 2007-08-07
IL145796A0 (en) 2002-07-25
WO2000061611A9 (en) 2002-03-28
AU4065500A (en) 2000-11-14
KR20020013526A (ko) 2002-02-20
MXPA01010320A (es) 2003-09-15
WO2000061611A2 (en) 2000-10-19
CA2369200A1 (en) 2000-10-19
JP2002541785A (ja) 2002-12-10
CN100491530C (zh) 2009-05-27
CN1364195A (zh) 2002-08-14
WO2000061611A3 (en) 2001-01-04

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