BG44707A3 - Метод за получаване на 6-деметил-6-дезокси-6-метилен-5- окситетрациклин и негови 11а-хлорни производни - Google Patents
Метод за получаване на 6-деметил-6-дезокси-6-метилен-5- окситетрациклин и негови 11а-хлорни производниInfo
- Publication number
- BG44707A3 BG44707A3 BG066763A BG6676384A BG44707A3 BG 44707 A3 BG44707 A3 BG 44707A3 BG 066763 A BG066763 A BG 066763A BG 6676384 A BG6676384 A BG 6676384A BG 44707 A3 BG44707 A3 BG 44707A3
- Authority
- BG
- Bulgaria
- Prior art keywords
- demethyl
- oxytetracycline
- methylene
- derivatives
- chlorino
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- KEQGZUUPPQEDPF-UHFFFAOYSA-N 1,3-dichloro-5,5-dimethylimidazolidine-2,4-dione Chemical compound CC1(C)N(Cl)C(=O)N(Cl)C1=O KEQGZUUPPQEDPF-UHFFFAOYSA-N 0.000 abstract 1
- OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 abstract 1
- 239000004098 Tetracycline Substances 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 230000003115 biocidal effect Effects 0.000 abstract 1
- 239000003638 chemical reducing agent Substances 0.000 abstract 1
- XTHPWXDJESJLNJ-UHFFFAOYSA-N chlorosulfonic acid Substances OS(Cl)(=O)=O XTHPWXDJESJLNJ-UHFFFAOYSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 235000019253 formic acid Nutrition 0.000 abstract 1
- 230000003993 interaction Effects 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 229960002180 tetracycline Drugs 0.000 abstract 1
- 229930101283 tetracycline Natural products 0.000 abstract 1
- 235000019364 tetracycline Nutrition 0.000 abstract 1
- 150000003522 tetracyclines Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/12—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by halogen atoms or by nitro or nitroso groups
- C07C233/14—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by halogen atoms or by nitro or nitroso groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a ring other than a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
- C07C237/26—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton of a ring being part of a condensed ring system formed by at least four rings, e.g. tetracycline
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/63—Esters of sulfonic acids
- C07C309/72—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C309/73—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton to carbon atoms of non-condensed six-membered aromatic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU833061A HU188367B (en) | 1983-09-02 | 1983-09-02 | Process for preparing 6-demethy-6-deoxy-6-methylene-5-exytetracycline and 11a-chloro-derivative thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BG44707A3 true BG44707A3 (bg) | 1989-01-16 |
Family
ID=10962342
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BG066763A BG44707A3 (bg) | 1983-09-02 | 1984-08-31 | Метод за получаване на 6-деметил-6-дезокси-6-метилен-5- окситетрациклин и негови 11а-хлорни производни |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US4659515A (xx) |
| JP (1) | JPS6094950A (xx) |
| KR (1) | KR910004668B1 (xx) |
| BG (1) | BG44707A3 (xx) |
| DD (1) | DD219186A5 (xx) |
| DE (1) | DE3431009A1 (xx) |
| FR (1) | FR2551435B1 (xx) |
| GB (1) | GB2145722B (xx) |
| HU (1) | HU188367B (xx) |
| IT (1) | IT1207343B (xx) |
| PL (1) | PL143307B1 (xx) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5686634A (en) * | 1994-07-01 | 1997-11-11 | Pfizer, Inc. | Process for producing 5-hydroxy-6-demethyl-6-desoxy-6-methylene-11A-chlorotetracycline |
| CN104163773B (zh) * | 2013-08-30 | 2016-04-27 | 郑州后羿制药有限公司 | 一种四环素的精制方法 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB887671A (en) * | 1958-03-05 | 1962-01-24 | American Cyanamid Co | Preparation of members of the tetracycline series |
| US2984686A (en) * | 1960-12-19 | 1961-05-16 | Pfizer & Co C | 6-deoxy-6-demethyl-6-methylene-5-oxytetracyclines |
| FR1430859A (xx) * | 1960-05-23 | 1966-05-25 | ||
| US3842123A (en) * | 1969-08-08 | 1974-10-15 | L Bernardi | Methylenetetracycline formate ester |
| BE755678R (fr) * | 1969-09-04 | 1971-03-03 | Farmaceutici Italia | Esters de la methylenetetracycline et procede de leur fabrication |
| CA942743A (en) * | 1970-07-03 | 1974-02-26 | Ivan Villax | Process for producing 6-methylenetetracyclines and 6-deoxytetracyclines |
| FR2136137A5 (en) * | 1971-04-05 | 1972-12-22 | Pliva Pharm & Chem Works | Tetracycline derivs prepn - by bromination followed by dehydration |
| GB1333900A (en) * | 1971-07-08 | 1973-10-17 | Farmaceutici Italia | 6-deimethyl-6-deoxytetracycline |
| ATA571275A (de) * | 1974-08-09 | 1976-06-15 | Pliva Pharm & Chem Works | Verfahren zur herstellung von 11a-chlor-6-methylen-5-hydroxy-tetracyclin-p-toluolsulfonat |
-
1983
- 1983-09-02 HU HU833061A patent/HU188367B/hu not_active IP Right Cessation
-
1984
- 1984-08-23 DE DE19843431009 patent/DE3431009A1/de active Granted
- 1984-08-30 IT IT8467863A patent/IT1207343B/it active
- 1984-08-31 PL PL1984249429A patent/PL143307B1/pl unknown
- 1984-08-31 GB GB08422041A patent/GB2145722B/en not_active Expired
- 1984-08-31 DD DD84266854A patent/DD219186A5/de not_active IP Right Cessation
- 1984-08-31 JP JP59180882A patent/JPS6094950A/ja active Granted
- 1984-08-31 FR FR8413504A patent/FR2551435B1/fr not_active Expired
- 1984-08-31 KR KR1019840005370A patent/KR910004668B1/ko not_active IP Right Cessation
- 1984-08-31 US US06/646,574 patent/US4659515A/en not_active Expired - Fee Related
- 1984-08-31 BG BG066763A patent/BG44707A3/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| KR910004668B1 (ko) | 1991-07-09 |
| FR2551435A1 (fr) | 1985-03-08 |
| JPH0344066B2 (xx) | 1991-07-04 |
| HUT35632A (en) | 1985-07-29 |
| GB2145722B (en) | 1987-07-08 |
| IT1207343B (it) | 1989-05-17 |
| IT8467863A0 (it) | 1984-08-30 |
| DD219186A5 (de) | 1985-02-27 |
| PL143307B1 (en) | 1988-02-29 |
| JPS6094950A (ja) | 1985-05-28 |
| HU188367B (en) | 1986-04-28 |
| GB8422041D0 (en) | 1984-10-03 |
| US4659515A (en) | 1987-04-21 |
| GB2145722A (en) | 1985-04-03 |
| FR2551435B1 (fr) | 1989-01-20 |
| KR850002457A (ko) | 1985-05-13 |
| PL249429A1 (en) | 1985-05-07 |
| DE3431009C2 (xx) | 1990-07-26 |
| DE3431009A1 (de) | 1985-03-21 |
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