BG104452A - New derivatives of the methylenebisphosphonic acid - Google Patents

New derivatives of the methylenebisphosphonic acid

Info

Publication number
BG104452A
BG104452A BG104452A BG10445200A BG104452A BG 104452 A BG104452 A BG 104452A BG 104452 A BG104452 A BG 104452A BG 10445200 A BG10445200 A BG 10445200A BG 104452 A BG104452 A BG 104452A
Authority
BG
Bulgaria
Prior art keywords
new derivatives
anhydrides
methylenebisphosphonic acid
methylenebisphosphonic
acid
Prior art date
Application number
BG104452A
Other languages
Bulgarian (bg)
English (en)
Inventor
Esko Pohjala
Jouko Vepsalainen
Heikki Nupponen
Jouni Kahkoenen
Leena Lauren
Ritva Hannuniemi
Tomi Jarvinen
Marko Ahlmark
Original Assignee
Leiras Oy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Leiras Oy filed Critical Leiras Oy
Publication of BG104452A publication Critical patent/BG104452A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se)
    • C07F9/40—Esters thereof
    • C07F9/4071—Esters thereof the ester moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/409—Compounds containing the structure P(=X)-X-acyl, P(=X) -X-heteroatom, P(=X)-X-CN (X = O, S, Se)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se)
    • C07F9/40—Esters thereof
    • C07F9/4071—Esters thereof the ester moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/409—Compounds containing the structure P(=X)-X-acyl, P(=X) -X-heteroatom, P(=X)-X-CN (X = O, S, Se)
    • C07F9/4093—Compounds containing the structure P(=X)-X-C(=X)- (X = O, S, Se)
BG104452A 1997-10-20 2000-05-17 New derivatives of the methylenebisphosphonic acid BG104452A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FI974001A FI104901B (fi) 1997-10-20 1997-10-20 Uudet metyleenibisfosfonihappojohdannaiset
PCT/FI1998/000814 WO1999020634A1 (en) 1997-10-20 1998-10-20 Novel methylenebisphosphonic acid derivatives

Publications (1)

Publication Number Publication Date
BG104452A true BG104452A (en) 2000-12-29

Family

ID=8549759

Family Applications (1)

Application Number Title Priority Date Filing Date
BG104452A BG104452A (en) 1997-10-20 2000-05-17 New derivatives of the methylenebisphosphonic acid

Country Status (19)

Country Link
US (1) US6326363B1 (no)
EP (1) EP1032578A1 (no)
JP (1) JP2001520232A (no)
KR (1) KR20010031269A (no)
CN (1) CN1147497C (no)
AU (1) AU740355B2 (no)
BG (1) BG104452A (no)
BR (1) BR9813102A (no)
CA (1) CA2306080A1 (no)
EE (1) EE04061B1 (no)
FI (1) FI104901B (no)
HU (1) HUP0004386A3 (no)
IL (1) IL135639A0 (no)
NO (1) NO20002006L (no)
NZ (1) NZ504390A (no)
PL (1) PL340055A1 (no)
RU (1) RU2205833C2 (no)
TR (1) TR200001055T2 (no)
WO (1) WO1999020634A1 (no)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO313180B1 (no) * 2000-07-04 2002-08-26 Anticancer Therapeutic Inv Sa Bensökende alfapartikkel emitterende radiofarmasöytika
US7862552B2 (en) 2005-05-09 2011-01-04 Boston Scientific Scimed, Inc. Medical devices for treating urological and uterine conditions
US8288545B2 (en) * 2006-07-21 2012-10-16 Glsynthesis Inc. Reactive pyrophosphoric and bisphosphonic acid derivatives and methods of their use
US8575127B2 (en) 2008-11-20 2013-11-05 Glsynthesis Inc. Antithrombotic diadenosine tetraphosphates and related analogs
CN107011380A (zh) * 2016-01-28 2017-08-04 臧伟 一种二膦酸衍生物及含二膦酸衍生物的组合物治疗骨折的应用

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4447256A (en) 1977-07-20 1984-05-08 Nissan Chemical Industries, Ltd. N-(Unsubstituted or substituted pyridyl)aminomethylene-diphosphonic acids, herbicidal compositions containing same, their use for herbicides, and process for preparing same
DE2758580A1 (de) 1977-12-29 1979-07-05 Hoechst Ag Verfahren zur herstellung von phosphin- und phosphonsaeure-anhydriden
US4973576A (en) 1987-03-10 1990-11-27 Yamanouchi Pharmaceutical Co., Ltd. Bisphophonic acid derivatives and pharmaceutical compositions containing the same
US4933472A (en) 1988-04-08 1990-06-12 Yamanouchi Pharmaceutical Co., Ltd. Substituted aminomethylenebis(phosphonic acid) derivatives
EP0356866A3 (en) 1988-08-29 1991-03-27 E.R. SQUIBB & SONS, INC. Phosphorus-containing squalene synthetase inhibitors and method
FI83421C (fi) * 1989-06-21 1991-07-10 Huhtamaeki Oy Foerfarande foer framstaellning av farmakologiskt anvaendbara metylenbisfosfonsyraderivat.
DE69023844T2 (de) * 1989-09-06 1996-06-20 Merck & Co Inc Acyloxymethylester der Bisphonsäuren als Knochenresorptions-Inhibitoren.
FI89364C (fi) * 1990-12-20 1993-09-27 Leiras Oy Foerfarande foer framstaellning av nya, farmakologiskt anvaendbara metylenbisfosfonsyraderivat
FI89365C (fi) * 1990-12-20 1993-09-27 Leiras Oy Foerfarande foer framstaellning av nya farmakologiskt anvaendbara metylenbisfosfonsyraderivat
FI89366C (fi) * 1990-12-20 1993-09-27 Leiras Oy Foerfarande foer framstaellning av nya farmakologiskt anvaendbara metylenbisfosfonsyraderivat
ES2078654T3 (es) 1991-04-06 1995-12-16 Astra Pharma Prod Analogos de atp.
TW237386B (no) 1992-04-15 1995-01-01 Ciba Geigy
ES2108425T3 (es) * 1993-02-10 1997-12-16 Astra Pharma Prod Analogos de atp sustituidos con n-alquilo-2.
US5462932A (en) 1994-05-17 1995-10-31 Merck & Co., Inc. Oral liquid alendronate formulations

Also Published As

Publication number Publication date
US6326363B1 (en) 2001-12-04
PL340055A1 (en) 2001-01-15
KR20010031269A (ko) 2001-04-16
FI104901B (fi) 2000-04-28
EE04061B1 (et) 2003-06-16
AU740355B2 (en) 2001-11-01
NO20002006D0 (no) 2000-04-17
TR200001055T2 (tr) 2000-09-21
JP2001520232A (ja) 2001-10-30
AU9543798A (en) 1999-05-10
BR9813102A (pt) 2000-08-22
NO20002006L (no) 2000-06-15
EP1032578A1 (en) 2000-09-06
NZ504390A (en) 2001-10-26
FI974001A (fi) 1999-04-21
HUP0004386A3 (en) 2002-08-28
RU2205833C2 (ru) 2003-06-10
WO1999020634A1 (en) 1999-04-29
CA2306080A1 (en) 1999-04-29
CN1147497C (zh) 2004-04-28
FI974001A0 (fi) 1997-10-20
EE200000239A (et) 2001-08-15
IL135639A0 (en) 2001-05-20
CN1276793A (zh) 2000-12-13
HUP0004386A2 (hu) 2001-04-28

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