BE905200A - Procede de preparation d'une forme granulaire a liberation retardee d'un principe actif et forme granulaire obtenue. - Google Patents
Procede de preparation d'une forme granulaire a liberation retardee d'un principe actif et forme granulaire obtenue.Info
- Publication number
- BE905200A BE905200A BE0/216995A BE216995A BE905200A BE 905200 A BE905200 A BE 905200A BE 0/216995 A BE0/216995 A BE 0/216995A BE 216995 A BE216995 A BE 216995A BE 905200 A BE905200 A BE 905200A
- Authority
- BE
- Belgium
- Prior art keywords
- granular form
- preparation
- delayed
- active ingredient
- dispersible
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
- A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
- A61K9/5047—Cellulose ethers containing no ester groups, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
Landscapes
- Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Procédé de préparation d'une forme granulaire à libération retardée d'une substance pharmaceutiquement active, ou de leurs mélanges, où l'on enrobe une substance pharmaceutiquement active granulée ou cristalline, ou leurs mélanges, avec un mélange de matières enrobantes constitué essentiellement d'un mélange homogène d'un (méthyl+éthyl) ester de l'acide poly(H + méth)-acrylique qui est insoluble mais dispersable dans l'eau et d'une éthyl-cellulose qui est insoluble mais dispersable dans l'eau dans un rapport pondéral de 20:1 à 1:5, caractérisé en ce qu'on chauffe les granules enrobés pendant au moins 5 minutes à des températures élevées allant de 50 degrés à 12 degrés C ainsi que la forme granulaire obtenue.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB858519310A GB8519310D0 (en) | 1985-07-31 | 1985-07-31 | Granular active substances |
Publications (1)
Publication Number | Publication Date |
---|---|
BE905200A true BE905200A (fr) | 1987-01-30 |
Family
ID=10583125
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BE0/216995A BE905200A (fr) | 1985-07-31 | 1986-07-30 | Procede de preparation d'une forme granulaire a liberation retardee d'un principe actif et forme granulaire obtenue. |
Country Status (23)
Country | Link |
---|---|
US (1) | US4728513A (fr) |
JP (1) | JPS6229514A (fr) |
AT (1) | AT392901B (fr) |
AU (1) | AU596804B2 (fr) |
BE (1) | BE905200A (fr) |
CH (1) | CH670566A5 (fr) |
DE (1) | DE3625458A1 (fr) |
DK (1) | DK361786A (fr) |
ES (1) | ES2000577A6 (fr) |
FI (1) | FI863074A (fr) |
FR (1) | FR2585570B1 (fr) |
GB (2) | GB8519310D0 (fr) |
GR (1) | GR862017B (fr) |
HU (1) | HU196304B (fr) |
IL (1) | IL79537A (fr) |
IT (1) | IT1195985B (fr) |
LU (1) | LU86523A1 (fr) |
NL (1) | NL8601961A (fr) |
NZ (1) | NZ217028A (fr) |
PH (1) | PH23531A (fr) |
PT (1) | PT83093B (fr) |
SE (1) | SE8603247L (fr) |
ZA (1) | ZA865691B (fr) |
Families Citing this family (73)
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US4726952A (en) * | 1983-08-11 | 1988-02-23 | Mission Pharmacal | Slow-release sodium fluoride tablet, method of making, and method of treatment of osteoporosis |
JPH0830005B2 (ja) * | 1985-09-25 | 1996-03-27 | ゲルゲリイ、ゲルハルト | 崩壊性錠剤とその製造方法 |
CH669523A5 (fr) * | 1986-06-25 | 1989-03-31 | Mepha Ag | |
US4859467A (en) * | 1986-09-25 | 1989-08-22 | Colgate-Palmotive Company | Sustained release fluoride composition |
GB8707421D0 (en) * | 1987-03-27 | 1987-04-29 | Wellcome Found | Pharmaceutical formulations |
GB8707416D0 (en) * | 1987-03-27 | 1987-04-29 | Wellcome Found | Pharmaceutical formulations |
DE3712095A1 (de) * | 1987-04-10 | 1988-10-20 | Lentia Gmbh | Bindemittelfreies granulat mit verzoegerter wirkstoffabgabe |
US5178868A (en) * | 1988-10-26 | 1993-01-12 | Kabi Pharmacia Aktiebolaq | Dosage form |
IT1227899B (it) * | 1988-12-23 | 1991-05-14 | Poli Ind Chimica Spa | Rivestimento totale o parziale di principi attivi farmaceutici e relative composizioni |
AU622254B2 (en) * | 1989-01-03 | 1992-04-02 | Sterling Drug Inc. | Controlled-release, low dose aspirin |
US4970081A (en) * | 1989-01-03 | 1990-11-13 | Sterling Drug Inc. | Controlled-release, low-dose aspirin formulation and method of treating vascular occlusive disease therewith |
US5084287A (en) * | 1990-03-15 | 1992-01-28 | Warner-Lambert Company | Pharmaceutically useful micropellets with a drug-coated core and controlled-release polymeric coat |
US5013728A (en) * | 1990-05-04 | 1991-05-07 | Colgate - Palmolive Company | Composition for treating osteoporosis and hormonal imbalance |
US5153005A (en) * | 1990-12-11 | 1992-10-06 | Colgate-Palmolive Company | Composition and method for preventing fluorosis |
US6613332B1 (en) | 1991-06-21 | 2003-09-02 | The University Of Cincinnati | Oral administration of therapeutic proteins |
EP0590060B1 (fr) * | 1991-06-21 | 1997-09-17 | University Of Cincinnati | Proteines therapeutiques administrables par voie orale et leur procede de production |
US5266331A (en) * | 1991-11-27 | 1993-11-30 | Euroceltique, S.A. | Controlled release oxycodone compositions |
US5286493A (en) * | 1992-01-27 | 1994-02-15 | Euroceltique, S.A. | Stabilized controlled release formulations having acrylic polymer coating |
US5968551A (en) * | 1991-12-24 | 1999-10-19 | Purdue Pharma L.P. | Orally administrable opioid formulations having extended duration of effect |
US5580578A (en) * | 1992-01-27 | 1996-12-03 | Euro-Celtique, S.A. | Controlled release formulations coated with aqueous dispersions of acrylic polymers |
US5681585A (en) * | 1991-12-24 | 1997-10-28 | Euro-Celtique, S.A. | Stabilized controlled release substrate having a coating derived from an aqueous dispersion of hydrophobic polymer |
US5958459A (en) * | 1991-12-24 | 1999-09-28 | Purdue Pharma L.P. | Opioid formulations having extended controlled released |
US5478577A (en) * | 1993-11-23 | 1995-12-26 | Euroceltique, S.A. | Method of treating pain by administering 24 hour oral opioid formulations exhibiting rapid rate of initial rise of plasma drug level |
US5273760A (en) * | 1991-12-24 | 1993-12-28 | Euroceltigue, S.A. | Stabilized controlled release substrate having a coating derived from an aqueous dispersion of hydrophobic polymer |
US7070806B2 (en) * | 1992-01-27 | 2006-07-04 | Purdue Pharma Lp | Controlled release formulations coated with aqueous dispersions of acrylic polymers |
FI101039B (fi) * | 1992-10-09 | 1998-04-15 | Eeva Kristoffersson | Menetelmä lääkepellettien valmistamiseksi |
US20080075781A1 (en) * | 1992-11-25 | 2008-03-27 | Purdue Pharma Lp | Controlled release oxycodone compositions |
ES2095001T5 (es) * | 1992-12-22 | 2001-03-16 | Univ Cincinnati | Una composicion terapeutica administrable oralmente y su metodo de obtencion. |
DE4319649A1 (de) * | 1993-03-18 | 1994-09-22 | Asta Medica Ag | Feste Flupirtin enthaltende orale Darreichungsformen mit kontrollierter Wirkstoffabgabe |
US20070275062A1 (en) * | 1993-06-18 | 2007-11-29 | Benjamin Oshlack | Controlled release oxycodone compositions |
IL110014A (en) * | 1993-07-01 | 1999-11-30 | Euro Celtique Sa | Solid controlled-release oral dosage forms of opioid analgesics |
US7740881B1 (en) | 1993-07-01 | 2010-06-22 | Purdue Pharma Lp | Method of treating humans with opioid formulations having extended controlled release |
US5879705A (en) * | 1993-07-27 | 1999-03-09 | Euro-Celtique S.A. | Sustained release compositions of morphine and a method of preparing pharmaceutical compositions |
US5843480A (en) * | 1994-03-14 | 1998-12-01 | Euro-Celtique, S.A. | Controlled release diamorphine formulation |
US20020006438A1 (en) * | 1998-09-25 | 2002-01-17 | Benjamin Oshlack | Sustained release hydromorphone formulations exhibiting bimodal characteristics |
US5674529A (en) * | 1995-06-06 | 1997-10-07 | Church & Dwight Co., Inc. | Alkalinizing potassium salt controlled release preparations |
FR2760190B1 (fr) * | 1997-02-28 | 1999-04-09 | Adir | Composition pharmaceutique pour la liberation programmee de dexfenfluramine |
CA2270975C (fr) | 1997-07-02 | 2003-04-01 | Euro-Celtique, S.A. | Formulations de tramadol stabilisees a liberation prolongee |
US6806294B2 (en) | 1998-10-15 | 2004-10-19 | Euro-Celtique S.A. | Opioid analgesic |
FR2785539B1 (fr) * | 1998-11-06 | 2004-04-09 | Prographarm Laboratoires | Particules enrobees d'ibuprofene cristallin granule |
DE19928312A1 (de) * | 1999-06-16 | 2000-12-21 | Schering Ag | Arzneimittelzubereitung mit verzögerter Wirkstoffabgabe |
US6475493B1 (en) | 1999-09-02 | 2002-11-05 | Norstrum Pharmaceuticals, Inc. | Controlled release pellet formulation |
US10179130B2 (en) | 1999-10-29 | 2019-01-15 | Purdue Pharma L.P. | Controlled release hydrocodone formulations |
BRPI0015284B8 (pt) | 1999-10-29 | 2021-05-25 | Euro Celtique S/A | formulações de hidrocodona de liberação controlada |
KR101045144B1 (ko) | 2000-10-30 | 2011-06-30 | 유로-셀티크 소시에떼 아노뉨 | 서방성 하이드로코돈 제형 |
US20110104214A1 (en) | 2004-04-15 | 2011-05-05 | Purdue Pharma L.P. | Once-a-day oxycodone formulations |
UA81224C2 (uk) * | 2001-05-02 | 2007-12-25 | Euro Celtic S A | Дозована форма оксикодону та її застосування |
US6884619B2 (en) | 2001-07-17 | 2005-04-26 | Yale University | Inhibition of BEHAB cleavage and primary central nervous system (CNS) tumors |
PE20030527A1 (es) | 2001-10-24 | 2003-07-26 | Gruenenthal Chemie | Formulacion farmaceutica con liberacion retardada que contiene 3-(3-dimetilamino-1-etil-2-metil-propil) fenol o una sal farmaceuticamente aceptable del mismo y tabletas para administracion oral que la contienen |
US7410965B2 (en) * | 2002-05-29 | 2008-08-12 | Gruenenthal Gmbh | Delayed release pharmaceutical composition containing 1-dimethyl-amino-3-(3-methoxyphenyl)-2-methyl-pentan-3-ol |
US20050100577A1 (en) * | 2003-11-10 | 2005-05-12 | Parker Theodore L. | Expandable medical device with beneficial agent matrix formed by a multi solvent system |
US7387793B2 (en) | 2003-11-14 | 2008-06-17 | Eurand, Inc. | Modified release dosage forms of skeletal muscle relaxants |
EP1730516A1 (fr) * | 2004-03-30 | 2006-12-13 | Pfizer Products Incorporated | Procede et dispositif pour l'evaluation de compositions pharmaceutiques |
DE102004035938A1 (de) * | 2004-07-23 | 2006-02-16 | Röhm GmbH & Co. KG | Verfahren zur Herstellung von überzogenen Arzneiformen mit stabilem Wirkstofffreigabeprofil |
EP1825866A4 (fr) * | 2004-12-03 | 2008-03-12 | Takeda Pharmaceutical | Preparation solide |
EP1852100B1 (fr) * | 2005-02-25 | 2018-05-09 | Takeda Pharmaceutical Company Limited | Procédé de fabrication de granulés enrobés du benzimidazole |
CA2671197A1 (fr) * | 2006-07-21 | 2008-01-24 | Lab International Srl | Systeme de delivrance hydrophobe empechant les utilisations abusives |
DE102006051020A1 (de) * | 2006-10-26 | 2008-04-30 | Evonik Röhm Gmbh | Verwendung von (Meth)acrylat-Copolymeren in Retard-Arzneiformen zur Verringerung des Einflusses von Ethanol auf die Wirkstofffreisetzung |
WO2008065502A1 (fr) * | 2006-11-29 | 2008-06-05 | Pfizer Products Inc. | Compositions pharmaceutiques constituées a) de nanoparticules comprenant des polymères entériques et b) de la caséine |
US20100119612A1 (en) * | 2007-04-17 | 2010-05-13 | Bend Research, Inc | Nanoparticles comprising non-crystalline drug |
US8703204B2 (en) * | 2007-05-03 | 2014-04-22 | Bend Research, Inc. | Nanoparticles comprising a cholesteryl ester transfer protein inhibitor and anon-ionizable polymer |
US20100080852A1 (en) * | 2007-05-03 | 2010-04-01 | Ronald Arthur Beyerinck | Phamaceutical composition comprising nanoparticles and casein |
WO2008135828A2 (fr) * | 2007-05-03 | 2008-11-13 | Pfizer Products Inc. | Nanoparticules comprenant un médicament, de l'éthylcellulose et un sel biliaire |
US20080279930A1 (en) * | 2007-05-07 | 2008-11-13 | Bernd Terhaag | Controlled-Release Flupirtine Compositions, Compacts, Kits and Methods of Making and Use Thereof |
EP2162120B1 (fr) * | 2007-06-04 | 2016-05-04 | Bend Research, Inc | Nanoparticules comportant un polymère cellulosique non ionisable et un copolymère bloc amphiphile non ionisable |
WO2008149230A2 (fr) | 2007-06-04 | 2008-12-11 | Pfizer Products Inc. | Nanoparticules comprenant un médicament, un polymère cellulosique non ionisable et du tocophéryl polyéthylène glycol succinate |
EP2178518A2 (fr) * | 2007-07-13 | 2010-04-28 | Bend Research, Inc | Nanoparticules comprenant des polymères cellulosiques ionisables faiblement solubles dans l'eau |
WO2009011367A1 (fr) * | 2007-07-17 | 2009-01-22 | Asahi Kasei Chemicals Corporation | Composition aqueuse |
WO2009073215A1 (fr) * | 2007-12-06 | 2009-06-11 | Bend Research, Inc. | Compositions pharmaceutiques comprenant des nanoparticules et une matière de remise en suspension |
US9233078B2 (en) * | 2007-12-06 | 2016-01-12 | Bend Research, Inc. | Nanoparticles comprising a non-ionizable polymer and an Amine-functionalized methacrylate copolymer |
CN103432093B (zh) * | 2013-08-31 | 2015-03-25 | 西南大学 | 甲磺酸普立地诺骨架缓释片及其制备方法 |
CA2936741C (fr) | 2014-10-31 | 2018-11-06 | Purdue Pharma | Methodes et compositions destinees au traitement du trouble de deficit d'attention |
US10722473B2 (en) | 2018-11-19 | 2020-07-28 | Purdue Pharma L.P. | Methods and compositions particularly for treatment of attention deficit disorder |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US904848A (en) * | 1908-05-27 | 1908-11-24 | William W Devore | Artificial whirlpool. |
AT64577B (de) * | 1913-04-28 | 1914-04-25 | Carl Georg Rodeck | Volksbelustigungsvorrichtung mit sich drehenden Plattformen. |
US1689138A (en) * | 1927-10-15 | 1928-10-23 | Playground & Gymnasium Equipme | Bathers' inclined rotary water platform |
BE634668A (fr) * | 1962-07-11 | |||
DE2010110A1 (de) * | 1970-03-04 | 1971-09-16 | Farbenfabriken Bayer Ag, 5090 Leverkusen | Verfahren zur Herstellung von Mikrokapseln mit Hilfe von synthetischen Koazervaten |
DE2336218C3 (de) * | 1973-07-17 | 1985-11-14 | Byk Gulden Lomberg Chemische Fabrik Gmbh, 7750 Konstanz | Orale Arzneiform |
JPS52139715A (en) * | 1976-05-14 | 1977-11-21 | Nippon Kayaku Co Ltd | Coated granules of alkali polyacrylate |
EP0052075A1 (fr) * | 1980-11-12 | 1982-05-19 | Ciba-Geigy Ag | Granule pharmaceutique à action retardée |
JPS5867616A (ja) * | 1981-10-15 | 1983-04-22 | Tanabe Seiyaku Co Ltd | 腸溶性マイクロカプセル |
US4543886A (en) * | 1983-03-09 | 1985-10-01 | Intamin Inc. | Amusement ride including a rotating loading terminal |
DK62184D0 (da) * | 1984-02-10 | 1984-02-10 | Benzon As Alfred | Diffusionsovertrukket polydepotpraeparat |
CH658188A5 (de) * | 1984-03-23 | 1986-10-31 | Ciba Geigy Ag | Lagerstabile schnellzerfallende pharmazeutische presslinge. |
CH666405A5 (de) * | 1985-06-24 | 1988-07-29 | Ciba Geigy Ag | Feste, haltbare darreichungsformen mit elastischem filmueberzug. |
GB8521494D0 (en) * | 1985-08-29 | 1985-10-02 | Zyma Sa | Controlled release tablet |
-
1985
- 1985-07-31 GB GB858519310A patent/GB8519310D0/en active Pending
-
1986
- 1986-07-22 PH PH34052A patent/PH23531A/en unknown
- 1986-07-23 US US06/888,610 patent/US4728513A/en not_active Expired - Fee Related
- 1986-07-23 LU LU86523A patent/LU86523A1/fr unknown
- 1986-07-24 CH CH3001/86A patent/CH670566A5/de not_active IP Right Cessation
- 1986-07-25 GB GB8618153A patent/GB2178313B/en not_active Expired
- 1986-07-28 IL IL79537A patent/IL79537A/xx unknown
- 1986-07-28 DE DE19863625458 patent/DE3625458A1/de not_active Withdrawn
- 1986-07-28 FI FI863074A patent/FI863074A/fi not_active Application Discontinuation
- 1986-07-29 ES ES8600694A patent/ES2000577A6/es not_active Expired
- 1986-07-29 FR FR868610952A patent/FR2585570B1/fr not_active Expired - Lifetime
- 1986-07-29 SE SE8603247A patent/SE8603247L/ not_active Application Discontinuation
- 1986-07-29 IT IT48323/86A patent/IT1195985B/it active
- 1986-07-29 PT PT83093A patent/PT83093B/pt not_active IP Right Cessation
- 1986-07-30 BE BE0/216995A patent/BE905200A/fr not_active IP Right Cessation
- 1986-07-30 DK DK361786A patent/DK361786A/da not_active Application Discontinuation
- 1986-07-30 AU AU60685/86A patent/AU596804B2/en not_active Ceased
- 1986-07-30 JP JP61177897A patent/JPS6229514A/ja active Pending
- 1986-07-30 AT AT2056/86A patent/AT392901B/de not_active IP Right Cessation
- 1986-07-30 GR GR862017A patent/GR862017B/el unknown
- 1986-07-30 ZA ZA865691A patent/ZA865691B/xx unknown
- 1986-07-30 HU HU863240A patent/HU196304B/hu not_active IP Right Cessation
- 1986-07-30 NL NL8601961A patent/NL8601961A/nl not_active Application Discontinuation
- 1986-07-30 NZ NZ217028A patent/NZ217028A/xx unknown
Also Published As
Publication number | Publication date |
---|---|
PT83093A (en) | 1986-08-01 |
FR2585570A1 (fr) | 1987-02-06 |
HUT41630A (en) | 1987-05-28 |
DE3625458A1 (de) | 1987-02-12 |
IT1195985B (it) | 1988-11-03 |
LU86523A1 (fr) | 1987-02-04 |
GR862017B (en) | 1986-12-23 |
HU196304B (en) | 1988-11-28 |
AU596804B2 (en) | 1990-05-17 |
FI863074A (fi) | 1987-02-01 |
US4728513A (en) | 1988-03-01 |
SE8603247L (sv) | 1987-02-01 |
FI863074A0 (fi) | 1986-07-28 |
GB2178313A (en) | 1987-02-11 |
PH23531A (en) | 1989-08-25 |
AU6068586A (en) | 1987-02-05 |
IL79537A0 (en) | 1986-10-31 |
GB8519310D0 (en) | 1985-09-04 |
DK361786A (da) | 1987-02-01 |
AT392901B (de) | 1991-07-10 |
IL79537A (en) | 1991-01-31 |
PT83093B (pt) | 1989-01-30 |
NL8601961A (nl) | 1987-02-16 |
CH670566A5 (fr) | 1989-06-30 |
ZA865691B (en) | 1987-03-25 |
IT8648323A0 (it) | 1986-07-29 |
GB2178313B (en) | 1989-08-23 |
JPS6229514A (ja) | 1987-02-07 |
ES2000577A6 (es) | 1988-03-01 |
NZ217028A (en) | 1989-08-29 |
FR2585570B1 (fr) | 1990-03-23 |
GB8618153D0 (en) | 1986-09-03 |
DK361786D0 (da) | 1986-07-30 |
ATA205686A (de) | 1990-12-15 |
SE8603247D0 (sv) | 1986-07-29 |
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Date | Code | Title | Description |
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RE | Patent lapsed |
Owner name: ZYMA S.A. Effective date: 19910731 |