BE901274A - NOVEL CYCLIC AMINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS MEDICAMENTS. - Google Patents

NOVEL CYCLIC AMINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS MEDICAMENTS.

Info

Publication number
BE901274A
BE901274A BE1/11152A BE1011152A BE901274A BE 901274 A BE901274 A BE 901274A BE 1/11152 A BE1/11152 A BE 1/11152A BE 1011152 A BE1011152 A BE 1011152A BE 901274 A BE901274 A BE 901274A
Authority
BE
Belgium
Prior art keywords
medicaments
preparation
cyclic amine
amine derivatives
novel cyclic
Prior art date
Application number
BE1/11152A
Other languages
French (fr)
Original Assignee
Sandoz Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz Sa filed Critical Sandoz Sa
Publication of BE901274A publication Critical patent/BE901274A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • C07D207/09—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/14—Nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/14—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing 9-azabicyclo [3.3.1] nonane ring systems, e.g. granatane, 2-aza-adamantane; Cyclic acetals thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/06—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing isoquinuclidine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

Les composés de formule dans laquelle A représente un groupe de formule II ou III dans lesquelles la valence libre dans la formule II est située sur l'un des cycles condensés, Y signifie -CH2-, -NR3-, -O- ou -S-, R1 à R7 sont des substituants variables, B signifie -O- ou -NH- et D représente un hétérocycle azoté. Les composés peuvent etre utilisés en thérapeutique comme antagonistes des récépteurs sérotoninergiques M pour le traitement des algies, spécialement la migraine et des troubles de la circulation cardiaque.The compounds of formula in which A represents a group of formula II or III in which the free valence in formula II is located on one of the condensed rings, Y signifies -CH2-, -NR3-, -O- or -S -, R1 to R7 are variable substituents, B means -O- or -NH- and D represents a nitrogen heterocycle. The compounds can be used therapeutically as antagonists of the serotonergic M receptors for the treatment of pain, especially migraine and cardiac circulation disorders.

BE1/11152A 1983-12-23 1984-12-14 NOVEL CYCLIC AMINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS MEDICAMENTS. BE901274A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH687683 1983-12-23
CH687983 1983-12-23

Publications (1)

Publication Number Publication Date
BE901274A true BE901274A (en) 1985-06-14

Family

ID=25700317

Family Applications (1)

Application Number Title Priority Date Filing Date
BE1/11152A BE901274A (en) 1983-12-23 1984-12-14 NOVEL CYCLIC AMINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS MEDICAMENTS.

Country Status (19)

Country Link
US (1) US5001133A (en)
AU (2) AU586414B2 (en)
BE (1) BE901274A (en)
CH (1) CH666268A5 (en)
DE (1) DE3445377A1 (en)
DK (1) DK624784A (en)
ES (1) ES8704490A1 (en)
FI (1) FI845075L (en)
FR (1) FR2557110B1 (en)
GB (1) GB2152049B (en)
GR (1) GR82578B (en)
HU (1) HU193725B (en)
IL (1) IL73904A (en)
IT (1) IT1199243B (en)
LU (1) LU85687A1 (en)
NL (1) NL8403823A (en)
PT (1) PT79726A (en)
SE (1) SE8406585L (en)
WO (1) WO1985002847A1 (en)

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US4910193A (en) * 1985-12-16 1990-03-20 Sandoz Ltd. Treatment of gastrointestinal disorders

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NZ203861A (en) * 1982-04-14 1986-07-11 Beecham Group Plc Bicyclic heterocyclic compounds and pharmaceutical compositions containing such
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DE69310737T2 (en) * 1992-07-10 1997-11-20 Du Pont AZEOTROPIC COMPOSITIONS BASED ON PERFLUORETHANE AND TRIFLUORMETHANE

Cited By (5)

* Cited by examiner, † Cited by third party
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EP0226266A3 (en) * 1985-06-25 1990-01-24 Glaxo Group Limited Use of tetrahydrocarbazolone derivatives for the manufacture of medicaments
EP0431443A3 (en) * 1985-06-25 1991-09-18 Glaxo Group Limited Use of tetrahydrocarbazolone derivatives for the manufacture of medicaments
US4910193A (en) * 1985-12-16 1990-03-20 Sandoz Ltd. Treatment of gastrointestinal disorders
FR2602142A1 (en) * 1986-07-30 1988-02-05 Sandoz Sa THERAPEUTIC USE OF 5HT3 SEROTONINERGIC RECEPTOR ANTAGONISTS
BE1005921A4 (en) * 1986-07-30 1994-03-15 Sandoz Sa THERAPEUTIC USE OF serotonin 5HT3 RECEPTOR ANTAGONISTS.

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FR2557110A1 (en) 1985-06-28
IL73904A (en) 1989-09-10
IT8449339A0 (en) 1984-12-21
NL8403823A (en) 1985-07-16
DK624784D0 (en) 1984-12-21
GR82578B (en) 1985-04-23
SE8406585D0 (en) 1984-12-21
HUT38341A (en) 1986-05-28
IT1199243B (en) 1988-12-30
GB2152049A (en) 1985-07-31
DE3445377A1 (en) 1985-07-04
ES538958A0 (en) 1987-04-01
CH666268A5 (en) 1988-07-15
FR2557110B1 (en) 1989-11-24
DK624784A (en) 1985-06-24
ES8704490A1 (en) 1987-04-01
HU193725B (en) 1987-11-30
IL73904A0 (en) 1985-03-31
AU3409089A (en) 1989-09-21
WO1985002847A1 (en) 1985-07-04
GB8432184D0 (en) 1985-01-30
AU586414B2 (en) 1989-07-13
US5001133A (en) 1991-03-19
AU3707384A (en) 1985-07-04
GB2152049B (en) 1988-06-15
LU85687A1 (en) 1985-09-12
FI845075A0 (en) 1984-12-20
PT79726A (en) 1985-01-01
SE8406585L (en) 1985-06-24
FI845075L (en) 1985-06-24

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