BE899073A - NOVEL AZOLIC COMPOUNDS, THEIR PREPARATION AND THEIR USE AS ANTIFUNGALS AND FUNGICIDES - Google Patents

NOVEL AZOLIC COMPOUNDS, THEIR PREPARATION AND THEIR USE AS ANTIFUNGALS AND FUNGICIDES

Info

Publication number
BE899073A
BE899073A BE1/10974A BE1010974A BE899073A BE 899073 A BE899073 A BE 899073A BE 1/10974 A BE1/10974 A BE 1/10974A BE 1010974 A BE1010974 A BE 1010974A BE 899073 A BE899073 A BE 899073A
Authority
BE
Belgium
Prior art keywords
fungicides
antifungals
novel
preparation
compounds
Prior art date
Application number
BE1/10974A
Other languages
French (fr)
Original Assignee
Sandoz Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz Sa filed Critical Sandoz Sa
Publication of BE899073A publication Critical patent/BE899073A/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/70—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/63—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/192—Radicals derived from carboxylic acids from aromatic carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
    • C07D295/215—Radicals derived from nitrogen analogues of carbonic acid

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

L'invention a pour objet les composés azoliques de formule (I) dans laquelle R1 et R2 représentent un groupe aliphatique, arylique ou hétéroarylique éventuellement substitués, R1 pouvant aussi représenter l'hydrogène, R3 et R4 représentent l'hydrogène, un halogène, un groupe nitro, un groupe aliphatique éventuellement substitué qui est éventuellement lié par l'intermédiaire de S, O, SO ou SO2, ou un groupe phényle ou phénoxy éventuellement substitués et X représente N ou CH. Ces composés peuvent etre utilisés en thérapeutique comme anti-fongiques et en agriculture comme fongicides.The subject of the invention is the azole compounds of formula (I) in which R1 and R2 represent an optionally substituted aliphatic, aryl or heteroaryl group, R1 can also represent hydrogen, R3 and R4 represent hydrogen, a halogen, a nitro group, an optionally substituted aliphatic group which is optionally linked via S, O, SO or SO2, or an optionally substituted phenyl or phenoxy group and X represents N or CH. These compounds can be used therapeutically as anti-fungals and in agriculture as fungicides.

BE1/10974A 1983-03-11 1984-03-05 NOVEL AZOLIC COMPOUNDS, THEIR PREPARATION AND THEIR USE AS ANTIFUNGALS AND FUNGICIDES BE899073A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH1332/83A CH655103A5 (en) 1983-03-11 1983-03-11 AZOLE DERIVATIVES, METHOD FOR THEIR PRODUCTION AND THEIR USE.

Publications (1)

Publication Number Publication Date
BE899073A true BE899073A (en) 1984-09-05

Family

ID=4207992

Family Applications (1)

Application Number Title Priority Date Filing Date
BE1/10974A BE899073A (en) 1983-03-11 1984-03-05 NOVEL AZOLIC COMPOUNDS, THEIR PREPARATION AND THEIR USE AS ANTIFUNGALS AND FUNGICIDES

Country Status (24)

Country Link
JP (1) JPS59175472A (en)
KR (1) KR890000377B1 (en)
AU (1) AU571494B2 (en)
BE (1) BE899073A (en)
CA (1) CA1242723A (en)
CH (1) CH655103A5 (en)
DE (1) DE3408127A1 (en)
DK (1) DK149784A (en)
ES (1) ES8506639A1 (en)
FI (1) FI840968A (en)
FR (1) FR2542315B1 (en)
GB (1) GB2136801B (en)
GR (1) GR81869B (en)
HU (1) HUT36098A (en)
IL (1) IL71203A (en)
IT (1) IT1199085B (en)
LU (1) LU85245A1 (en)
NL (1) NL8400730A (en)
NZ (1) NZ207453A (en)
PH (1) PH24667A (en)
PL (1) PL146072B1 (en)
PT (1) PT78226B (en)
SE (1) SE8401321L (en)
ZA (1) ZA841782B (en)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8618188D0 (en) * 1986-07-25 1986-09-03 Ici Plc Diamine compounds
DE3644615A1 (en) * 1986-12-29 1988-07-07 Lentia Gmbh IMIDAZOLE AND TRIAZOLE DERIVATIVES FOR USE AS AN ANTIMYCOTIC AGENTS
DE3644616A1 (en) * 1986-12-29 1988-07-07 Lentia Gmbh IMIDAZOLE DERIVATIVES, METHOD FOR THE PRODUCTION AND USE THEREOF
US5252594A (en) * 1992-06-17 1993-10-12 Rohm And Haas Company Fungicidal (2-aryl-2-substituted)ethyl-1,2,4-triazoles
US5358939A (en) * 1992-06-25 1994-10-25 Rohm And Haas Company Fungicidal 2-aryl-2,2-disubstituted ethyl-1,2,4-triazoles
DE4412358A1 (en) * 1994-04-11 1995-10-12 Bayer Ag Cyclopropyl ethyl azoles
GB9409882D0 (en) * 1994-05-18 1994-07-06 Sandoz Ltd Organic compounds
JP3214987B2 (en) * 1994-09-05 2001-10-02 日本碍子株式会社 Semiconductor device and method of manufacturing the same
AU2003299750A1 (en) * 2002-12-20 2004-07-22 Irm Llc Differential tumor cytotoxocity compounds and compositions
WO2004056744A1 (en) 2002-12-23 2004-07-08 Janssen Pharmaceutica N.V. Adamantyl acetamides as hydroxysteroid dehydrogenase inhibitors
CA2565630C (en) 2004-05-07 2013-05-28 Janssen Pharmaceutica N.V. Pyrrolidin-2-one and piperidin-2-one derivatives as 11-beta hydroxysteroid dehydrogenase inhibitors
WO2006024628A1 (en) 2004-08-30 2006-03-09 Janssen Pharmaceutica N.V. Tricyclic lactam derivatives as 11-beta hydroxysteroid dehydrogenase inhibitors
JP5208505B2 (en) 2004-08-30 2013-06-12 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ N-2 adamantanyl-2-phenoxy-acetamide derivatives as 11-beta hydroxysteroid dehydrogenase inhibitors
DE602005017159D1 (en) 2004-08-30 2009-11-26 Janssen Pharmaceutica Nv OXYSTEROID DEHYDROGENASE INHIBITORS
AU2005286793A1 (en) 2004-09-20 2006-03-30 Xenon Pharmaceuticals Inc. Heterocyclic derivatives for the treatment of diseases mediated by stearoyl-CoA desaturase enzymes
AU2005286728A1 (en) 2004-09-20 2006-03-30 Xenon Pharmaceuticals Inc. Heterocyclic derivatives and their use as mediators of stearoyl-CoA desaturase
EP1804799B1 (en) 2004-09-20 2013-08-21 Xenon Pharmaceuticals Inc. Heterocyclic derivatives and their use as stearoyl-coa desaturase inhibitors
MX2007003325A (en) 2004-09-20 2007-06-05 Xenon Pharmaceuticals Inc Heterocyclic derivatives and their use as stearoyl-coa desaturase inhibitors.
AU2005286731A1 (en) 2004-09-20 2006-03-30 Xenon Pharmaceuticals Inc. Pyridazine derivatives for inhibiting human stearoyl-CoA-desaturase
US7777036B2 (en) 2004-09-20 2010-08-17 Xenon Pharmaceuticals Inc. Heterocyclic derivatives and their use as therapeutic agents
CA2580856A1 (en) 2004-09-20 2006-03-30 Xenon Pharmaceuticals Inc. Heterocyclic derivatives and their use as stearoyl-coa desaturase inhibitors
EP2029138A1 (en) 2005-06-03 2009-03-04 Xenon Pharmaceuticals Inc. Aminothiazole derivatives as human stearoyl-coa desaturase inhibitors
CN104530038A (en) * 2014-12-10 2015-04-22 沈阳药科大学 Amide imidazole derivative and application thereof
CN112142673B (en) * 2020-09-18 2023-06-30 聊城大学 Aryl alkene azole derivative and preparation method and application thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU557755A3 (en) * 1968-08-19 1977-05-05 Янссен Фармасьютика Н.В. (Фирма) Method for preparing imidazole derivatives
CA1189857A (en) * 1981-03-27 1985-07-02 Janssen Pharmaceutica Naamloze Vennootschap Antimicrobial triazole derivatives
AU8314482A (en) * 1981-05-19 1982-11-25 Imperial Chemical Industries Plc 3-triazolyl(imidazolyl)-2,2 bis phenyl-propionamides
EP0117462A3 (en) * 1983-02-28 1986-08-20 American Cyanamid Company N-(2-4-(1h-imidazol-1-yl)alkyl)arylamides

Also Published As

Publication number Publication date
PH24667A (en) 1990-09-07
DE3408127A1 (en) 1984-09-13
PL146072B1 (en) 1988-12-31
AU571494B2 (en) 1988-04-21
GB2136801B (en) 1987-03-04
FR2542315A1 (en) 1984-09-14
KR890000377B1 (en) 1989-03-15
DK149784D0 (en) 1984-02-29
CA1242723A (en) 1988-10-04
CH655103A5 (en) 1986-03-27
GR81869B (en) 1984-12-12
ZA841782B (en) 1985-10-30
DK149784A (en) 1984-09-12
FR2542315B1 (en) 1986-02-07
IT1199085B (en) 1988-12-30
SE8401321L (en) 1984-09-12
IT8447817A0 (en) 1984-03-08
GB2136801A (en) 1984-09-26
PL246600A1 (en) 1985-03-12
KR850006386A (en) 1985-10-05
FI840968A (en) 1984-09-12
NZ207453A (en) 1987-09-30
GB8405900D0 (en) 1984-04-11
NL8400730A (en) 1984-10-01
ES530461A0 (en) 1985-07-16
AU2547584A (en) 1984-09-13
IL71203A (en) 1988-10-31
JPS59175472A (en) 1984-10-04
PT78226B (en) 1986-07-15
ES8506639A1 (en) 1985-07-16
HUT36098A (en) 1985-08-28
LU85245A1 (en) 1984-11-14
FI840968A0 (en) 1984-03-09
SE8401321D0 (en) 1984-03-09
IL71203A0 (en) 1984-06-29
PT78226A (en) 1984-04-01

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Legal Events

Date Code Title Description
RE Patent lapsed

Owner name: SANDOZ S.A.

Effective date: 19910331