BE881049A - Procede de granulation de la trans-dl-1-hydroxy-3-(1', 1'-dimethylheptyl)-6,6-dimethyl-6a, 7, 8, 9, 10, 10a-hexahy-drobenzo (b,d) pyran-9-one (nabilone) - Google Patents

Procede de granulation de la trans-dl-1-hydroxy-3-(1', 1'-dimethylheptyl)-6,6-dimethyl-6a, 7, 8, 9, 10, 10a-hexahy-drobenzo (b,d) pyran-9-one (nabilone)

Info

Publication number: BE881049A
Authority: BE; Belgium
Prior art keywords: drobenzo; hexahy; nabilone; dimethylheptyl; pyran
Prior art date: 1979-03-09

Application number

BE1/9675A

Other languages

English (en)

Inventor

J W Conine

Original Assignee

Lilly Co Eli

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1979-03-09

Filing date

1980-01-09

Publication date

1980-07-09

1980-01-09 Application filed by Lilly Co Eli filed Critical Lilly Co Eli

1980-07-09 Publication of BE881049A publication Critical patent/BE881049A/fr

Links

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics

Landscapes

Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Organic Chemistry (AREA)
Otolaryngology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Hospice & Palliative Care (AREA)
Chemical Kinetics & Catalysis (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Pyrane Compounds (AREA)

BE1/9675A 1979-03-09 1980-01-09 Procede de granulation de la trans-dl-1-hydroxy-3-(1', 1'-dimethylheptyl)-6,6-dimethyl-6a, 7, 8, 9, 10, 10a-hexahy-drobenzo (b,d) pyran-9-one (nabilone) BE881049A (fr)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US06/019,810 US4195078A (en)	1979-03-09	1979-03-09	Nabilone granulation

Publications (1)

Publication Number	Publication Date
BE881049A true BE881049A (fr)	1980-07-09

Family

ID=21795156

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BE1/9675A BE881049A (fr)	1979-03-09	1980-01-09	Procede de granulation de la trans-dl-1-hydroxy-3-(1', 1'-dimethylheptyl)-6,6-dimethyl-6a, 7, 8, 9, 10, 10a-hexahy-drobenzo (b,d) pyran-9-one (nabilone)

Country Status (16)

Country	Link
US (1)	US4195078A (fr)
EP (1)	EP0015635A1 (fr)
JP (1)	JPS55133309A (fr)
AU (1)	AU531805B2 (fr)
BE (1)	BE881049A (fr)
CA (1)	CA1124178A (fr)
CH (1)	CH643840A5 (fr)
DK (1)	DK8080A (fr)
FR (1)	FR2450606A1 (fr)
GB (1)	GB2045080B (fr)
IE (1)	IE49243B1 (fr)
IL (1)	IL59098A (fr)
IT (1)	IT1193886B (fr)
LU (1)	LU82072A1 (fr)
NZ (1)	NZ192557A (fr)
ZA (1)	ZA80104B (fr)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4327080A (en) *	1981-07-13	1982-04-27	E. R. Squibb & Sons, Inc.	Novel Bendroflumethiazide formulations and method
JPS59155309A (ja) *	1983-02-22	1984-09-04	Teijin Ltd	活性型ビタミンｄ↓３類組成物
NZ211545A (en) *	1984-04-11	1987-09-30	Ici Australia Ltd	Composition having particulate trace element suspended in matrix of solid polyethylene glycol
US4790991A (en) *	1985-02-05	1988-12-13	Warner-Lambert Company	Ingestible aggregate and delivery system prepared therefrom
US4851392A (en) *	1985-02-05	1989-07-25	Warner-Lambert Company	Ingestible aggregate and delivery system prepared therefrom
US4843098A (en) *	1985-02-05	1989-06-27	Warner-Lambert Company	Ingestible aggregate and delivery system prepared therefrom
US4747881A (en) *	1985-02-05	1988-05-31	Warner-Lambert Company	Ingestible aggregate and delivery system prepared therefrom
US4818539A (en) *	1985-02-05	1989-04-04	Warner-Lambert Company	Ingestible aggregate and delivery system prepared therefrom
US4844908A (en) *	1986-11-27	1989-07-04	Duphar International Research B.V.	Method of preparing tablets with clovoxamine fumarate and tablets thus prepared
EP0547796A1 (fr) *	1991-12-17	1993-06-23	Konica Corporation	Composés chimique sous forme solide utilisé dans la traitement d'un matériau photographique à l'halogénure d'argent sensible à la lumière
US6566560B2 (en)	1999-03-22	2003-05-20	Immugen Pharmaceuticals, Inc.	Resorcinolic compounds
AU2002213429A1 (en) *	2000-09-28	2002-04-08	Immugen Pharmaceuticals, Inc.	Antiviral methods and compounds
WO2002026224A2 (fr) *	2000-09-28	2002-04-04	Immugen Pharmaceuticals, Inc.	Procedes et composes pour inhiber le metabolisme des eicosanoides et l'agregation plaquettaire
AU2003214226A1 (en) *	2002-03-18	2003-10-08	Immugen Pharmaceuticals, Inc.	Topical formulations of resorcinols and cannibinoids and methods of use
CA2845443A1 (fr) *	2014-03-04	2015-09-04	Pharmascience Inc.	Comprime de nabilone se desintegrant en bouche et methode de fabrication associee

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR886435A (fr) *	1941-09-29	1943-10-14		Aiguille à tricoter perfectionnée
US3136692A (en) *	1961-06-30	1964-06-09	Strong Cobb Arner Inc	Effervescent composition containing polyvinylpyrrolidone
DE1467792A1 (de) *	1965-05-21	1968-12-12	Brunnengraeber & Co Gmbh Dr Ch	Sprengmittel fuer pharmazeutische Presslinge
CA885974A (en) *	1968-04-02	1971-11-16	R. Telfer William	Ferrous fumarate capsule and preparation
IL32673A (en) *	1968-08-05	1973-11-28	Ciba Geigy Ag	A granular material containing oily or liquid therapeutically usable furanosides and a process for its manufacture
US3632778A (en) *	1970-06-10	1972-01-04	Hoffmann La Roche	Tablets containing l-dopa
NL7112288A (fr) *	1970-09-16	1972-03-20
JPS5418330B2 (fr) *	1973-03-16	1979-07-06
US3851032A (en) *	1973-04-23	1974-11-26	Sterling Drug Inc	Process of preparing a solid fine crystalline paracetamol polymer complex composition
US3864492A (en) *	1973-08-01	1975-02-04	Abbott Lab	Method of treating depression using 1,4{40 -dihydroxy-3-n-pentyl-6,6,9-trimethyl-6a,7,10,10a-tetra-hydrodibenzo{8 b,d{9 pyran
US3920809A (en) *	1973-11-05	1975-11-18	Lilly Co Eli	Dibenzo(b,d)pyranone dispersions
US3987188A (en) *	1973-11-05	1976-10-19	Eli Lilly And Company	Hexahydro-dibenzo[b,d]pyran-9-ones as sedative drugs
US3953603A (en) *	1973-11-05	1976-04-27	Eli Lilly And Company	Hexahydro-dibenzo[b,d,]pyran-9-ones as psychotropic, particularly anti-depressant drugs
US4024275A (en) *	1973-11-05	1977-05-17	Eli Lilly And Company	Method of reducing elevated blood pressure with dihydroxy-hexahydrodibenzo(b,d)pyrans
US3944673A (en) *	1973-11-05	1976-03-16	Eli Lilly And Company	Hexahydro-dibenzo[b,d]pyran-9-ones as analgesic drugs
IE39678B1 (en) *	1973-11-05	1978-12-06	Lilly Co Eli	A polymorphic form of a dibenzopyranone
AT329556B (de) *	1974-10-24	1976-05-25	Lilly Co Eli	Verfahren zur herstellung einer neuen stabilen polymorphen kristallinen form von 1-hydroxy-3-(1',1'-dimethylheptyl)-6,6-dimethyl-6,6a,7,8,10,10a-hexahydro-9h-dibenzo(b,d)pyran-9-on
US4143129A (en) *	1975-10-11	1979-03-06	Lilly Industries Limited	Cephalexin tablets
US4088777A (en) *	1976-02-17	1978-05-09	Eli Lilly And Company	Hexahydro-dibenzo[b,d]pyran-9-ones as anticonvulsant drugs
US4087546A (en) *	1976-02-17	1978-05-02	Eli Lilly And Company	Hexahydro-dibenzo[b,d]pyran-9-ones as antiasthmatic drugs
US4087545A (en) *	1976-02-17	1978-05-02	Eli Lilly And Company	Hexahydro-dibenzo[b,d]pyran-9-ones as antiemetic drugs
US4087547A (en) *	1976-02-17	1978-05-02	Eli Lilly And Company	Hexahydro-dibenzo[b,d]pyran-9-ones in treatment of glaucoma

1979
- 1979-03-09 US US06/019,810 patent/US4195078A/en not_active Expired - Lifetime
1980
- 1980-01-08 DK DK8080A patent/DK8080A/da not_active Application Discontinuation
- 1980-01-08 ZA ZA00800104A patent/ZA80104B/xx unknown
- 1980-01-08 CA CA343,252A patent/CA1124178A/fr not_active Expired
- 1980-01-08 NZ NZ192557A patent/NZ192557A/xx unknown
- 1980-01-09 IL IL59098A patent/IL59098A/xx not_active IP Right Cessation
- 1980-01-09 BE BE1/9675A patent/BE881049A/fr not_active IP Right Cessation
- 1980-01-09 FR FR8000430A patent/FR2450606A1/fr active Granted
- 1980-01-09 IT IT19114/80A patent/IT1193886B/it active
- 1980-01-09 CH CH13880A patent/CH643840A5/fr not_active IP Right Cessation
- 1980-01-10 EP EP80300094A patent/EP0015635A1/fr not_active Ceased
- 1980-01-10 JP JP172880A patent/JPS55133309A/ja active Granted
- 1980-01-10 LU LU82072A patent/LU82072A1/fr unknown
- 1980-01-10 GB GB8000871A patent/GB2045080B/en not_active Expired
- 1980-01-10 IE IE42/80A patent/IE49243B1/en not_active IP Right Cessation
- 1980-01-11 AU AU54554/80A patent/AU531805B2/en not_active Ceased

Also Published As

Publication number	Publication date
NZ192557A (en)	1981-05-01
CH643840A5 (fr)	1984-06-29
DK8080A (da)	1980-09-10
AU531805B2 (en)	1983-09-08
IL59098A (en)	1983-09-30
IE49243B1 (en)	1985-09-04
LU82072A1 (fr)	1980-04-23
CA1124178A (fr)	1982-05-25
US4195078A (en)	1980-03-25
FR2450606A1 (fr)	1980-10-03
IE800042L (en)	1980-09-09
JPH0142923B2 (fr)	1989-09-18
ZA80104B (en)	1981-08-26
JPS55133309A (en)	1980-10-17
IL59098A0 (en)	1980-05-30
IT8019114A0 (it)	1980-01-09
IT1193886B (it)	1988-08-31
FR2450606B1 (fr)	1983-04-15
EP0015635A1 (fr)	1980-09-17
GB2045080A (en)	1980-10-29
AU5455480A (en)	1980-09-11
GB2045080B (en)	1983-05-25

Legal Events

Date

Code

Title

Description

1997-07-31

RE

Patent lapsed

Owner name: ELI LILLY AND CY

Effective date: 19970131

Publication	Publication Date	Title
BE882325A (fr)	1980-09-19	Procede de preparation de la monacoline k.
BE881049A (fr)	1980-07-09	Procede de granulation de la trans-dl-1-hydroxy-3-(1', 1'-dimethylheptyl)-6,6-dimethyl-6a, 7, 8, 9, 10, 10a-hexahy-drobenzo (b,d) pyran-9-one (nabilone)
BE856411A (fr)	1978-01-04	Procede de transformation de cis-hexahydrodibenzo (b,d) pyran-9-ones en trans-hexahydrodibenzo (b,d) pyran-9-ones
BE896830A (fr)	1983-09-16	Procede de preparation du 26, 26, 26, 27, 27, 27-hexafluoro-1 alpha, 25-dihydroxycholesterol.
MA19783A1 (fr)	1983-12-31	Procede de preparation de benzoazacycloalkyl-spiro-imidazolidines.
BE866839A (fr)	1978-11-09	Procede de preparation de triazines 1,3,5-s-hexahydrotrisubstituees
BE880509A (fr)	1980-06-10	Procede de preparation de 2',6'-dialkyl-n-alcoxymethyl-2-chloro-acetanilides
FR2455568B1 (fr)	1986-06-13	Procede de preparation du 2,3-dimethylbutene-2
BE865532A (fr)	1978-10-02	Procede de preparation de 2,2-dimethylolalcanals
LU78874A1 (fr)	1979-09-06	Procede de preparation de nouvelles sulfonylhydrazones de 1,4-dioxo-et 4-oxoquinoxaline-2-carboxaldehyde
FR2465752B1 (fr)	1985-11-15	Procede de production de 2,2,4-trimethyl-1,2-dihydroquinoleine polymerisee
RO77442A (fr)	1982-10-26	Procede de preparation des octahydro-2h-pyrolo(3,4-g) quinoleines
BE866662A (fr)	1978-11-03	Procede de preparation de 3,5-dihalogenanilines
BE852760A (fr)	1977-09-22	Procede d'obtention de 2,6-di-terbutylphenol
FR2653774B1 (fr)	1992-02-14	Procede de granulation des polysaccharides.
BE886470A (fr)	1981-04-01	Procede de preparation catalytique de la thieno (3,2-c) pyridine
BE884784A (fr)	1980-12-01	Procede de purification de solutions de cobalt (ii)
FR2614218B1 (fr)	1989-08-04	Procede de granulation d'engrais mineraux.
FR2521556B1 (fr)	1986-04-04	Procede de preparation de 3, 3'-diamino-diphenylsulfones
BE848346A (fr)	1977-05-16	Procede de preparation de l'antibiotique 924a1,
BE885416A (fr)	1981-01-16	Procede de preparation de 2-oxo-dihydrobenzo d 1,3 oxazines
FR2652768B1 (fr)	1994-02-25	Procede de fabrication de moules.
RO77115A2 (fr)	1981-06-22	Procede d'obtenir 2,4,6-trichloroalkyle-1,5,5-triazines
RO77055A2 (fr)	1981-06-22	Procede d'obtenir 2,4,6-trichlorhydrazine
MA19345A1 (fr)	1982-07-01	Procede de transformation de nitrate de calcium .