BE855405A - Nouvelles 4-amino-4-arylcyclohexanones, leur procede de preparation et medicament les contenant - Google Patents
Nouvelles 4-amino-4-arylcyclohexanones, leur procede de preparation et medicament les contenantInfo
- Publication number
- BE855405A BE855405A BE178211A BE178211A BE855405A BE 855405 A BE855405 A BE 855405A BE 178211 A BE178211 A BE 178211A BE 178211 A BE178211 A BE 178211A BE 855405 A BE855405 A BE 855405A
- Authority
- BE
- Belgium
- Prior art keywords
- arylcyclohexanones
- amino
- new
- preparation process
- product containing
- Prior art date
Links
- 229940126601 medicinal product Drugs 0.000 title 1
- 238000002360 preparation method Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
- C07D295/112—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
- C07D295/116—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings with the doubly bound oxygen or sulfur atoms directly attached to a carbocyclic ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/72—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 spiro-condensed with carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
- C07D319/08—1,3-Dioxanes; Hydrogenated 1,3-dioxanes condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
- C07D333/16—Radicals substituted by singly bound hetero atoms other than halogen by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Neurosurgery (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pain & Pain Management (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US05/692,589 US4065573A (en) | 1976-06-03 | 1976-06-03 | 4-Amino-4-phenylcyclohexanone ketal compositions and process of use |
Publications (1)
Publication Number | Publication Date |
---|---|
BE855405A true BE855405A (fr) | 1977-12-05 |
Family
ID=24781200
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BE178211A BE855405A (fr) | 1976-06-03 | 1977-06-03 | Nouvelles 4-amino-4-arylcyclohexanones, leur procede de preparation et medicament les contenant |
Country Status (13)
Country | Link |
---|---|
US (1) | US4065573A (fr) |
JP (1) | JPS5318546A (fr) |
AU (1) | AU511781B2 (fr) |
BE (1) | BE855405A (fr) |
CA (1) | CA1093553A (fr) |
CH (6) | CH641177A5 (fr) |
DE (1) | DE2723937A1 (fr) |
ES (1) | ES459429A1 (fr) |
FR (1) | FR2354992A1 (fr) |
GB (2) | GB1561206A (fr) |
IL (1) | IL52131A (fr) |
NL (1) | NL7706051A (fr) |
ZA (1) | ZA772819B (fr) |
Families Citing this family (48)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4460604A (en) * | 1976-06-03 | 1984-07-17 | The Upjohn Company | 4-Amino-4-aryl-cyclohexanones |
US4180584A (en) * | 1976-06-03 | 1979-12-25 | The Upjohn Company | 4-Pyrrolidino-cyclohexanone ketals |
US4115589A (en) * | 1977-05-17 | 1978-09-19 | The Upjohn Company | Compounds, compositions and method of use |
US4212878A (en) * | 1978-01-26 | 1980-07-15 | The Upjohn Company | Phenylacetamide derivative analgesics |
US4260606A (en) * | 1979-07-19 | 1981-04-07 | A. H. Robins Company, Inc. | 3-Methyleneazetidine derivatives |
US4346101A (en) * | 1980-12-08 | 1982-08-24 | The Upjohn Company | Benzamide derivative analgesics |
US4460600A (en) * | 1981-04-09 | 1984-07-17 | The Upjohn Company | Adjacently substituted ketal derivatives of cycloalkane-amide analgesics |
US4360531A (en) * | 1981-04-09 | 1982-11-23 | The Upjohn Company | Substituted cycloalkanes |
US4359476A (en) * | 1981-04-09 | 1982-11-16 | The Upjohn Company | Adjacently substituted cycloalkane-amide analgesics |
US4466977A (en) * | 1981-04-09 | 1984-08-21 | The Upjohn Company | N-[2-Amino(oxy- or thia- group-substituted-cycloaliphatic)]benzeneacetamides and -benzamide analgesics |
US4508911A (en) * | 1982-06-21 | 1985-04-02 | The Upjohn Company | Amine intermediates for analgesic compounds |
ZA842753B (en) * | 1983-05-18 | 1984-11-28 | Upjohn Co | 2-dihydropyrrolyl-cycloalkyl-amide analgesics |
US4598088A (en) * | 1983-05-18 | 1986-07-01 | The Upjohn Company | 2-pyrrolyl-cycloalkyl-amide analgesics |
US4560767A (en) * | 1983-06-17 | 1985-12-24 | The Upjohn Company | N-(2-amino-cycloalkenyl)benzeneacetamide and -benzamide analgesics and tritiated kappa agonists therefrom |
US4588591A (en) * | 1984-05-25 | 1986-05-13 | The Upjohn Company | Analgesic 2-oxa-spirocyclic compounds |
US4632935A (en) * | 1984-05-30 | 1986-12-30 | The Upjohn Company | Omega-(hydroxy-, ether and ester)-alkyl-2-amino-cycloalkyl- and cycloalkenyl amides as analgesics |
US4737493A (en) * | 1985-07-01 | 1988-04-12 | Warner-Lambert Company | 7-((substituted)amino)-8-((substituted)carbonyl)-methylamino)-1-oxaspiro(4,5)decanes as analgesic agents |
GR920100520A (el) * | 1992-11-26 | 1994-07-29 | Smithkline Beecham Corp | Ενώσεις. |
GR920100521A (el) * | 1992-11-26 | 1994-07-29 | Smithkline Beecham Corp | Ενώσεις. |
GR920100523A (el) * | 1992-11-26 | 1994-07-29 | Smithkline Beecham Corp | Ενώσεις. |
DE9320479U1 (de) * | 1993-06-25 | 1994-08-25 | Claas Saulgau Gmbh | Frei schwenkbare Nachlaufräder für landwirtschaftliche Arbeitsmaschinen, insbesondere Kreiselheumaschinen |
US6013827A (en) * | 1994-03-11 | 2000-01-11 | Smithkline Beecham Corporation | Compounds |
USRE38133E1 (en) * | 1996-03-08 | 2003-06-03 | Adolor Corporation | Kappa agonist compounds and pharmaceutical formulations thereof |
US5763445A (en) * | 1996-03-08 | 1998-06-09 | Adolor Corporation | Kappa agonist compounds pharmaceutical formulations and method of prevention and treatment of pruritus therewith |
US6750216B2 (en) * | 1996-03-08 | 2004-06-15 | Adolor Corporation | Kappa agonist compounds and pharmaceutical formulations thereof |
US5688955A (en) * | 1996-03-08 | 1997-11-18 | Adolor Corporation | Kappa agonist compounds and pharmaceutical formulations thereof |
US6303611B1 (en) | 1996-03-08 | 2001-10-16 | Adolor Corporation | Kappa agonist compounds and pharmaceutical formulations thereof |
US6057323A (en) * | 1996-03-08 | 2000-05-02 | Adolor Corporation | Kappa agonist compounds pharmaceutical formulations and method of prevention and treatment of pruritus therewith |
US6239154B1 (en) | 1996-03-08 | 2001-05-29 | Adolor Corporation | Kappa agonist compounds pharmaceutical formulations and method of prevention and treatment of pruritus therewith |
US5646151A (en) * | 1996-03-08 | 1997-07-08 | Adolor Corporation | Kappa agonist compounds and pharmaceutical formulations thereof |
GB0012240D0 (en) * | 2000-05-19 | 2000-07-12 | Merck Sharp & Dohme | Therapeutic agents |
JP4735915B2 (ja) * | 2001-03-30 | 2011-07-27 | Dic株式会社 | ジオンモノアセタール類の製造方法 |
DE10123163A1 (de) * | 2001-05-09 | 2003-01-16 | Gruenenthal Gmbh | Substituierte Cyclohexan-1,4-diaminderivate |
US6852713B2 (en) * | 2003-04-16 | 2005-02-08 | Adolor Corporation | Lactam derivatives and methods of their use |
US6992193B2 (en) | 2003-06-10 | 2006-01-31 | Adolor Corporation | Sulfonylamino phenylacetamide derivatives and methods of their use |
US7034051B2 (en) * | 2003-08-28 | 2006-04-25 | Adolor Corporation | Fused bicyclic carboxamide derivatives and methods of their use |
US7160902B2 (en) * | 2003-11-14 | 2007-01-09 | Adolor Corporation | Amide derivatives and methods of their use |
AU2007205114B2 (en) * | 2006-01-06 | 2012-11-08 | Sunovion Pharmaceuticals Inc. | Cycloalkylamines as monoamine reuptake inhibitors |
DE102006033114A1 (de) | 2006-07-18 | 2008-01-24 | Grünenthal GmbH | Spirocyclische Azaindol-Derivate |
CA2719743A1 (fr) | 2008-03-27 | 2009-10-01 | Gruenenthal Gmbh | Cyclohexyldiamines substituees |
NZ600207A (en) | 2008-03-27 | 2013-09-27 | Gruenenthal Chemie | Substituted 4-aminocyclohexane derivatives |
PT2257526E (pt) * | 2008-03-27 | 2012-01-24 | Gruenenthal Gmbh | Derivados de espiro(5,5)undecano |
US7977370B2 (en) * | 2008-03-27 | 2011-07-12 | Gruenenthal Gmbh | (Hetero)aryl cyclohexane derivatives |
EP2271613B1 (fr) * | 2008-03-27 | 2014-06-18 | Grünenthal GmbH | Hydroxyméthyle-cyclohexylamine |
MX2010009955A (es) * | 2008-03-27 | 2010-09-30 | Gruenenthal Gmbh | Derivados de ciclohexano espirociclicos sustituidos. |
US8602341B2 (en) | 2010-11-24 | 2013-12-10 | Lincoln Global, Inc. | Multi-spool adapter |
CA3165903A1 (fr) | 2019-12-26 | 2021-07-01 | Gilgamesh Pharmaceuticals, Inc. | Derives arylcyclohexylamine et leur utilisation dans le traitement de troubles psychiatriques |
BR112022016382A2 (pt) | 2020-02-18 | 2022-10-25 | Gilgamesh Pharmaceuticals Inc | Triptaminas específicas para o uso no tratamento de doenças do humor |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3901920A (en) * | 1974-04-19 | 1975-08-26 | Sterling Drug Inc | 1,5-dioxaspiro(5.5)+0 undecanes |
-
1976
- 1976-06-03 US US05/692,589 patent/US4065573A/en not_active Expired - Lifetime
-
1977
- 1977-05-11 ZA ZA00772819A patent/ZA772819B/xx unknown
- 1977-05-16 CA CA278,494A patent/CA1093553A/fr not_active Expired
- 1977-05-20 IL IL52131A patent/IL52131A/xx unknown
- 1977-05-24 AU AU25425/77A patent/AU511781B2/en not_active Expired
- 1977-05-26 DE DE19772723937 patent/DE2723937A1/de not_active Withdrawn
- 1977-06-02 GB GB35783/78A patent/GB1561206A/en not_active Expired
- 1977-06-02 CH CH681777A patent/CH641177A5/de not_active IP Right Cessation
- 1977-06-02 FR FR7716901A patent/FR2354992A1/fr not_active Withdrawn
- 1977-06-02 GB GB23366/77A patent/GB1561205A/en not_active Expired
- 1977-06-02 NL NL7706051A patent/NL7706051A/xx not_active Application Discontinuation
- 1977-06-02 ES ES459429A patent/ES459429A1/es not_active Expired
- 1977-06-03 BE BE178211A patent/BE855405A/fr not_active IP Right Cessation
- 1977-06-03 JP JP6568577A patent/JPS5318546A/ja active Pending
-
1981
- 1981-09-08 CH CH578781A patent/CH638802A5/de not_active IP Right Cessation
- 1981-09-08 CH CH578881A patent/CH638775A5/de not_active IP Right Cessation
- 1981-09-08 CH CH579081A patent/CH638803A5/de not_active IP Right Cessation
- 1981-09-08 CH CH578981A patent/CH638513A5/de not_active IP Right Cessation
- 1981-09-08 CH CH579181A patent/CH638806A5/de not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
GB1561205A (en) | 1980-02-13 |
FR2354992A1 (fr) | 1978-01-13 |
CH638513A5 (de) | 1983-09-30 |
DE2723937A1 (de) | 1977-12-15 |
CH638802A5 (de) | 1983-10-14 |
CH638775A5 (de) | 1983-10-14 |
CA1093553A (fr) | 1981-01-13 |
CH641177A5 (de) | 1984-02-15 |
IL52131A (en) | 1984-01-31 |
ES459429A1 (es) | 1978-11-16 |
NL7706051A (nl) | 1977-12-06 |
CH638803A5 (de) | 1983-10-14 |
IL52131A0 (en) | 1977-07-31 |
JPS5318546A (en) | 1978-02-20 |
ZA772819B (en) | 1978-07-26 |
CH638806A5 (de) | 1983-10-14 |
GB1561206A (en) | 1980-02-13 |
AU2542577A (en) | 1978-11-30 |
US4065573A (en) | 1977-12-27 |
AU511781B2 (en) | 1980-09-04 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
BE855405A (fr) | Nouvelles 4-amino-4-arylcyclohexanones, leur procede de preparation et medicament les contenant | |
BE860726A (fr) | Nouveaux aryl-acylamides n-(2-aminocy-cloaliphatiques), leur procede de preparation et medicament les contenant | |
BE860727A (fr) | Nouveaux benzamides trans-n-(2-aminocycloaliphatiques), leur procede de preparation et medicament les contenant | |
BE829052A (fr) | Nouvelles phenylguanidines substituees, leur procede de preparation et medicament les contenant | |
BE865015A (fr) | Pseudotrisaccharides, leur procede de preparation et medicament les contenant | |
FR2338936A1 (fr) | Nouvelles 1,2-benzisothiazolinones-3, leur procede de preparation et medicament les contenant | |
BE858269A (fr) | Nouvelles aminoalkylidenamino-1,4-dihydropyridines, leur procede de preparation et medicament les contenant | |
FR2346324A1 (fr) | Nouvelles amidino-urees, procede pour leur preparation et medicaments les renfermant | |
LU77557A1 (fr) | Nouveau 2-deoxystreptamine-aminoglycoside,son procede de preparation et medicament le contenant | |
BE868943A (fr) | Nouveaux 3-indolyl-tertiobutylaminopropanols, leur procede de production et medicament les contenant | |
BE829417A (fr) | Nouveaux pyrimidinols, leur procede de preparation et medicament les contenant | |
FR2342069A1 (fr) | Nouvelles benzodiazepinones, leur procede de preparation et medicament les contenant | |
BE862278A (fr) | Nouveaux composes heterocycliques, leur procede de preparation et medicament les contenant | |
FR2346354A1 (fr) | Nouvelles as-triazinobenzodiazepine-1-ones, leur procede de preparation et medicament les contenant | |
FR2278330A1 (fr) | Nouvelles phenylisothiourees substituees, leur procede de preparation et medicament les contenant | |
BE861697A (fr) | Nouveaux antibiotiques polycycliques, leur procede de preparation et medicament les contenant | |
BE825245A (fr) | Nouvelles 2-amino-6-dialkylaminodihydropyridines leur procede de preparation et medicament les contenant | |
BE790839A (fr) | Nouvelles benzodiazepines, leur procede de preparation et medicament les contenant | |
BE843341A (fr) | Nouvelles penicillines, leur procede de preparation et medicament les contenant | |
FR2346352A1 (fr) | Nouvelles triazinobenzodiazepines, leur procede de preparation et medicament les contenant | |
FR2348924A1 (fr) | Nouvelles carbonylpiperazinylquinazolines azoliques,leur procede de preparation et medicament les contenant | |
FR2292474A1 (fr) | Nouveaux diaryloxy-imidazolyl-o,n-acetals, leur procede de preparation et medicament les contenant | |
BE849047A (fr) | Nouvelles 2-(p-naphtyloxy)-ethylpyrazolones, leur procede de preparation et medicament les contenant | |
BE863851A (fr) | 2,4-dichlorophenyl-imidazolyl-ethanones ou -ethanols, leur procede de preparation et medicament les contenant | |
FR2311544A1 (fr) | Nouvelles pyridoquinoleines, leur procede de preparation et medicament les contenant |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
RE | Patent lapsed |
Owner name: THE UPJOHN CY Effective date: 19840603 |