BE817878A - Nouveaux derives du benzamido-2 nitro-5 thiazole - Google Patents

Nouveaux derives du benzamido-2 nitro-5 thiazole

Info

Publication number
BE817878A
BE817878A BE146759A BE146759A BE817878A BE 817878 A BE817878 A BE 817878A BE 146759 A BE146759 A BE 146759A BE 146759 A BE146759 A BE 146759A BE 817878 A BE817878 A BE 817878A
Authority
BE
Belgium
Prior art keywords
benzamido
thiazole
nitro
new derivatives
derivatives
Prior art date
Application number
BE146759A
Other languages
English (en)
Inventor
J-F Rossignol
R Cavier
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of BE817878A publication Critical patent/BE817878A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/44—Acylated amino or imino radicals
    • C07D277/46—Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/58—Nitro radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
BE146759A 1973-08-08 1974-07-19 Nouveaux derives du benzamido-2 nitro-5 thiazole BE817878A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB3760873A GB1437800A (en) 1973-08-08 1973-08-08 Derivatives of 2-benzamido-5-nitro-thiazoles

Publications (1)

Publication Number Publication Date
BE817878A true BE817878A (fr) 1975-01-20

Family

ID=10397712

Family Applications (1)

Application Number Title Priority Date Filing Date
BE146759A BE817878A (fr) 1973-08-08 1974-07-19 Nouveaux derives du benzamido-2 nitro-5 thiazole

Country Status (14)

Country Link
US (1) US3950351A (fr)
JP (1) JPS5041858A (fr)
AR (1) AR201880A1 (fr)
BE (1) BE817878A (fr)
CA (1) CA1041519A (fr)
CH (1) CH583215A5 (fr)
DE (1) DE2438037C2 (fr)
ES (1) ES428906A1 (fr)
FR (1) FR2240010B1 (fr)
GB (1) GB1437800A (fr)
IL (1) IL45194A (fr)
NL (1) NL176779C (fr)
OA (1) OA04761A (fr)
ZA (1) ZA744409B (fr)

Families Citing this family (72)

* Cited by examiner, † Cited by third party
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FR2435905A1 (fr) * 1978-09-13 1980-04-11 Anvar Nouveaux agents molluscicides derives du benzamido-2 nitro-5 thiazole
US4315018A (en) * 1978-12-07 1982-02-09 Rossignol Jean F Specific parasiticidal use of 2-benzamido-5-nitro-thiazole derivatives
IT1144025B (it) * 1979-12-21 1986-10-29 Wellcome Found Derivati nitrotiazolinici e relativo procedimento di produzione
US5387598A (en) * 1994-04-13 1995-02-07 Rossignol; Jean-Francois Composition and galenic formulation suitable for combatting affections of the lower abdomen
CZ287002B6 (en) * 1994-04-13 2000-08-16 Rossignol Jean Franaois Benzamide derivative, pharmaceutical preparation containing thereof and use of the derivative
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AU756451B2 (en) * 1997-05-07 2003-01-16 Romark Laboratories, L.C. Pharmaceutical compositions of tizoxanide and nitazoxanide
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US5925622A (en) * 1998-07-13 1999-07-20 Romark Laboratories, L.C. Synthesis of aryl glucuronide of 2-hydroxy-N- (5-nitro-2-thiazolyl) benzamide, and pharmaceutical compositions comprising same
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US7125568B2 (en) 2001-08-23 2006-10-24 Sung Michael T Lipophilic drug compositions
GB0226930D0 (en) 2002-11-19 2002-12-24 Astrazeneca Ab Chemical compounds
GB0325402D0 (en) * 2003-10-31 2003-12-03 Astrazeneca Ab Compounds
GB0327761D0 (en) * 2003-11-29 2003-12-31 Astrazeneca Ab Compounds
GB0328178D0 (en) * 2003-12-05 2004-01-07 Astrazeneca Ab Compounds
EP1718625A1 (fr) * 2004-02-18 2006-11-08 AstraZeneca AB Composes
DE602005013491D1 (de) * 2004-02-18 2009-05-07 Astrazeneca Ab Benzamidderivate und deren verwendung als glucokinaseaktivierende mittel
TW200600086A (en) * 2004-06-05 2006-01-01 Astrazeneca Ab Chemical compound
UA90864C2 (en) * 2004-09-09 2010-06-10 Ромарк Лебораториз, Л.К. Halogenated benzamide derivatives
US20060194853A1 (en) * 2004-10-08 2006-08-31 Rossignol Jean F Alkyl benzamides
KR20070085371A (ko) 2004-10-16 2007-08-27 아스트라제네카 아베 페녹시 벤즈아미드 화합물의 제조 방법
GB0423044D0 (en) * 2004-10-16 2004-11-17 Astrazeneca Ab Compounds
GB0423043D0 (en) * 2004-10-16 2004-11-17 Astrazeneca Ab Compounds
US20070015803A1 (en) * 2005-04-12 2007-01-18 Romark Laboratories L.C. Methods for treating diseases through interruption of protein maturation, compounds that inhibit the function of molecular chaperones such as protein disulfide isomerases or interfere with glycosylation, pharmaceutical compositions comprising them, and screening methods for identifying therapeutic agents
EP1891069A1 (fr) * 2005-05-24 2008-02-27 AstraZeneca AB Derives d'imidazol[4,5b]pyridine/pyrazine et purine substitues en 2-phenyl en tant que modulateurs de la glucokinase
TW200714597A (en) * 2005-05-27 2007-04-16 Astrazeneca Ab Chemical compounds
EP2027113A1 (fr) * 2005-07-09 2009-02-25 AstraZeneca AB Dérivés d'hétéroaryl benzamide utilisés en tant qu'activateurs de la glk dans le traitement du diabète
BRPI0622261A2 (pt) * 2005-07-09 2011-08-09 Astrazeneca Ab composto, composição farmacêutica, uso de um composto ou um sal farmaceuticamente aceitável do mesmo, e, processo para a preparação de um composto
US20110053910A1 (en) * 2005-07-09 2011-03-03 Mckerrecher Darren 2 -heterocyclyloxybenzoyl amino heterocyclyl compounds as modulators of glucokinase for the treatment of type 2 diabetes
US9202182B2 (en) * 2005-08-11 2015-12-01 International Business Machines Corporation Method and system for analyzing business architecture
TW200738621A (en) * 2005-11-28 2007-10-16 Astrazeneca Ab Chemical process
EP1976516B9 (fr) 2006-01-09 2013-10-30 Romark Laboratories, L.C. Traitement de l'hépatite virale
US7678791B2 (en) * 2006-07-12 2010-03-16 Cumbre Ip Ventures, L.P. Nitroheteroaryl-containing rifamycin derivatives
CN100465169C (zh) * 2006-08-02 2009-03-04 杭州欣阳三友精细化工有限公司 硝唑尼特的制备方法
TW200825063A (en) * 2006-10-23 2008-06-16 Astrazeneca Ab Chemical compounds
TW200825060A (en) * 2006-10-26 2008-06-16 Astrazeneca Ab Chemical compounds
US20100094009A1 (en) * 2006-12-21 2010-04-15 Mccabe James Novel crystalline compound useful as glk activator
CN101007792B (zh) * 2007-01-31 2010-05-26 浙江大学 一种合成硝基噻唑苯酰胺化合物的方法
MX2010001358A (es) 2007-08-03 2010-04-09 Romark Lab Lc Compuestos de tiazolida sustituidos con alquilsulfonilo.
MX2011001333A (es) * 2008-08-04 2011-03-15 Astrazeneca Ab Derivados de pirazolo [3, 4] pirimidin-4-ilo y sus usos para tratar la diabetes y obesidad.
CN102272134B (zh) 2008-12-09 2013-10-16 吉里德科学公司 Toll样受体调节剂
GB0902434D0 (en) * 2009-02-13 2009-04-01 Astrazeneca Ab Chemical process
LT2395840T (lt) 2009-02-13 2020-07-10 Romark Laboratories, L.C. Nitazoksanido kontroliuojamo atpalaidavimo farmacinės kompozicijos
GB0902406D0 (en) * 2009-02-13 2009-04-01 Astrazeneca Ab Crystalline polymorphic form
WO2010116176A1 (fr) * 2009-04-09 2010-10-14 Astrazeneca Ab Dérivé de pyrazolo [4, 5-e] pyrimidine et son utilisation pour traiter le diabète et l'obésité
WO2010116177A1 (fr) 2009-04-09 2010-10-14 Astrazeneca Ab Dérivé de pyrazolo [4,5-e] pyrimidine et son utilisation pour traiter le diabète et l'obésité
CA2761876C (fr) 2009-05-12 2017-01-03 Romark Laboratories L.C. Composes haloalkyl heteroaryl benzamide
KR20170141830A (ko) * 2009-06-26 2017-12-26 로마크 레버러토리즈, 엘.씨. 인플루엔자를 치료하기 위한 화합물 및 방법
CN101602744B (zh) * 2009-06-30 2011-06-01 青岛康地恩药业有限公司 一种硝唑尼特的制备方法
BR112014018149B1 (pt) 2012-01-27 2020-09-29 Siegfried Rhein S.A. De C.V Composição farmacêutica de nitazoxanida
MX340272B (es) 2012-09-27 2016-06-30 Rhein Siegfried Sa De Cv Composicion sinergica de nitazoxanida y mebendazol, procesos para prepararla y el uso de dicha composicion para el tratamiento de la parasitosis humana.
US20160244435A1 (en) * 2013-06-21 2016-08-25 The Scripps Research Institute Expanded therapeutic potential in nitroheteroaryl antimicrobials
KR20190104438A (ko) 2014-07-11 2019-09-09 길리애드 사이언시즈, 인코포레이티드 Hiv의 치료를 위한 톨-유사 수용체의 조정제
EA201790369A1 (ru) 2014-09-16 2017-10-31 Джилид Сайэнс, Инк. Твердые формы модулятора толл-подобного рецептора
CN107105660A (zh) 2014-11-11 2017-08-29 罗马克实验室有限公司 使用替唑尼特、其类似物或盐的前药的治疗组合物和治疗方法
CN105175352A (zh) * 2015-10-27 2015-12-23 杭州澳医保灵药业有限公司 一种硝唑尼特的制备方法
CN106831640A (zh) * 2015-12-03 2017-06-13 江苏正大丰海制药有限公司 一种硝唑尼特晶体的制备方法
PL3436074T3 (pl) 2016-03-31 2020-11-02 Romark Laboratories, L.C. Związki z grupą tiazolidynową do leczenia zakażeń wirusowych
US20170290812A1 (en) 2016-04-11 2017-10-12 Genfit Methods of treatment for cholestatic and fibrotic diseases
EP3573614A1 (fr) 2017-01-27 2019-12-04 Genfit Compositions pharmaceutiques pour polythérapie
WO2018195035A1 (fr) 2017-04-18 2018-10-25 Romark Laboratories L.C. Inhibition de la protéine disulfure-isomérase a3
WO2020208208A1 (fr) 2019-04-12 2020-10-15 Genfit Nitazoxanide et thiazolides destinés à être utilisés dans le traitement de maladies associées au stress oxydatif
CN114630660A (zh) 2019-10-28 2022-06-14 基恩菲特公司 具有抗氧化特性的联合疗法
CA3186666A1 (fr) 2020-07-20 2022-01-27 Jean-Francois Rossignol Sels cristallins de tizoxanide et de 2-hydroxy-n-(5-chloro-1,3-thiazol-2-yl)benzamide (rm-4848) avec de l'ethanolamine, de la morpholine, de la propanolamine, de la piperazine et de la n-methylpiperazin
AU2021333566A1 (en) 2020-08-24 2023-03-16 Romark Laboratories L.C. Use of thiazolides against coronaviruses
CN114044761B (zh) * 2021-02-24 2022-05-17 成都贝诺科成生物科技有限公司 一种新的硝基噻唑衍生物及其应用
CN115197164A (zh) * 2021-04-12 2022-10-18 杜心赟 新型噻唑类化合物及其制备方法和用途
CN116898846A (zh) * 2022-04-12 2023-10-20 成都贝诺科成生物科技有限公司 一种硝基噻唑衍生物在制备抑制幽门螺杆菌的抑菌剂中的用途

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US2735798A (en) * 1956-02-21 Acyl amevo-nitrothiazole compositions
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Also Published As

Publication number Publication date
OA04761A (fr) 1980-08-31
GB1437800A (en) 1976-06-03
ES428906A1 (es) 1976-08-16
ZA744409B (en) 1975-07-30
IL45194A0 (en) 1974-10-22
FR2240010A1 (fr) 1975-03-07
JPS5041858A (fr) 1975-04-16
CH583215A5 (fr) 1976-12-31
DE2438037A1 (de) 1975-02-20
AR201880A1 (es) 1975-04-24
US3950351A (en) 1976-04-13
NL176779B (nl) 1985-01-02
DE2438037C2 (de) 1982-06-09
CA1041519A (fr) 1978-10-31
IL45194A (en) 1977-10-31
NL7409321A (nl) 1975-02-11
FR2240010B1 (fr) 1978-03-24
NL176779C (nl) 1985-06-03
AU7135574A (en) 1976-01-22

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Legal Events

Date Code Title Description
RE Patent lapsed

Owner name: ROSSIGNOL JEAN-FRANCOIS

Effective date: 19850731