BE808377A - Coronary dilatory 2,6-diaminonebularine derivs - reaction of 2-halo adenosines and amine; agglomeration-inhibitory - Google Patents
Coronary dilatory 2,6-diaminonebularine derivs - reaction of 2-halo adenosines and amine; agglomeration-inhibitoryInfo
- Publication number
- BE808377A BE808377A BE138648A BE138648A BE808377A BE 808377 A BE808377 A BE 808377A BE 138648 A BE138648 A BE 138648A BE 138648 A BE138648 A BE 138648A BE 808377 A BE808377 A BE 808377A
- Authority
- BE
- Belgium
- Prior art keywords
- agglomeration
- inhibitory
- diaminonebularine
- adenosines
- derivs
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Biochemistry (AREA)
- Diabetes (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Cpds. of formula (I): where R = phenyl- or cyclohexyl, opt. substd. with lower alkyl, lower alkoxy or halogen; including acceptable salts of (I) are prepd. by reacting 2-haloadenosin or a cpd. (III): with a cpd. (II); R-Nh2 at 110-150 degrees C in inert solvent such as methylcellosolve or dioxan. In (III) A = a gp. which can form amino with ammonia such as halogen or -SOnR"; R" = H, alkyl or aralkyl; n = 0, 1 or 2; R' = H or acyl. (I) have high-and long-lasting dilatory activity on coronary vessels, and also have inhibitory activity on agglomeration of platelets in mammals.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP12360272A JPS5549594B2 (en) | 1972-12-08 | 1972-12-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BE808377A true BE808377A (en) | 1974-06-07 |
Family
ID=14864659
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BE138648A BE808377A (en) | 1972-12-08 | 1973-12-07 | Coronary dilatory 2,6-diaminonebularine derivs - reaction of 2-halo adenosines and amine; agglomeration-inhibitory |
Country Status (3)
| Country | Link |
|---|---|
| JP (1) | JPS5549594B2 (en) |
| BE (1) | BE808377A (en) |
| HK (1) | HK15179A (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5461195A (en) * | 1977-10-21 | 1979-05-17 | Takeda Chem Ind Ltd | N2-substituted phenyl-2,6-diaminonebularin |
| JPH0477219U (en) * | 1990-11-20 | 1992-07-06 | ||
| GB0228723D0 (en) | 2002-12-09 | 2003-01-15 | Cambridge Biotechnology Ltd | Treatment of pain |
| SG144146A1 (en) * | 2004-03-05 | 2008-07-29 | Cambridge Biotechnology Ltd | Adenosine receptor agonists |
-
1972
- 1972-12-08 JP JP12360272A patent/JPS5549594B2/ja not_active Expired
-
1973
- 1973-12-07 BE BE138648A patent/BE808377A/en unknown
-
1979
- 1979-03-22 HK HK151/79A patent/HK15179A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HK15179A (en) | 1979-03-30 |
| JPS5549594B2 (en) | 1980-12-12 |
| JPS4980096A (en) | 1974-08-02 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| GB1182803A (en) | 0,2,4-Triazin-5-Ones | |
| ES8401019A1 (en) | Herbicidal sulfonamides. | |
| ES418887A1 (en) | 1-(4-Phenoxyphenyl)-1,3,5-triazines | |
| BE808377A (en) | Coronary dilatory 2,6-diaminonebularine derivs - reaction of 2-halo adenosines and amine; agglomeration-inhibitory | |
| GB1188378A (en) | Dibenzonaphthacridine-5,11,16-Trione Derivatives and processes for their manufacture and use | |
| GB1267324A (en) | s-TRIAZINE DERIVATIVES | |
| GB1191808A (en) | Preparation of Streptozotocin | |
| ES375079A1 (en) | 3-alkoxy-or 3-aryloxy-2-(diaryl-hydroxy)-methyl-propylamines | |
| FR2027230A1 (en) | Imidazolidin-2-ones herbicides | |
| FR2047462A5 (en) | 1-hydroxy-benzimidazole-z-carbpxy acid - amides and esters | |
| ES332773A1 (en) | Method for selective herbicidal treatment of cereal and carrot cultures | |
| GB1409554A (en) | Thieno-diazepin derivatives | |
| FR2078729A5 (en) | Herbicidal 2,4-bis-trifluoromethyl-6-nitro-anilines | |
| BE816076A (en) | N-cyclohexyl-N'-substd-phenyl-benzamides - having anti-inflammatory and analgesic activity with low toxicity | |
| FR2099833A5 (en) | Alkylamino-oxaniloximes - useful as herbicides | |
| ES377679A1 (en) | Fungicidal and fungistatic thiocarbonates | |
| ES384875A1 (en) | Herbicidal para-tert-butylphenyl urea | |
| ES429127A1 (en) | Acylated urea compounds and herbicidal compositions | |
| FR2128097A1 (en) | Guanidinoalkyl-dibenzo-heterocyclics - useful as ataractics sedatives and hypotensives | |
| FR2291971A1 (en) | 6-Oxo-1,6-dihydro-pyrimidine derivs and prepn. - from beta-alkoxy-beta-amino-acrylic cpds. and iso(thio)cyanates, for dyes etc. | |
| FR2016782A1 (en) | Herbicidal compositions | |
| SU639252A1 (en) | PHOSPHORYLATED THIOSEMICARBAZONES WITH ANTI-VIRUS ACTIVITY | |
| ES267026A1 (en) | Procedure for the preparation of benzotriazines (Machine-translation by Google Translate, not legally binding) | |
| NL7108780A (en) | 2-oxo-1-(polyhaloalkyl)-4-phenyl-1,2-dihydro-quinazolines-as anti - inflammatory agents from-2-(trihalo acetyl) amino-benzophenones | |
| FR2141574A1 (en) | 2-oxo-1-(polyhaloalkyl)-4-phenyl-1,2-dihydro-quinazolines-as anti - inflammatory agents from-2-(trihalo acetyl) amino-benzophenones |