BE757336A - 5-butyl-and5-pentyl-picolinic acids active - as dopamene-b-hydroxylase inhibitors - Google Patents
5-butyl-and5-pentyl-picolinic acids active - as dopamene-b-hydroxylase inhibitorsInfo
- Publication number
- BE757336A BE757336A BE757336DA BE757336A BE 757336 A BE757336 A BE 757336A BE 757336D A BE757336D A BE 757336DA BE 757336 A BE757336 A BE 757336A
- Authority
- BE
- Belgium
- Prior art keywords
- pentyl
- butyl
- dopamene
- and5
- hydroxylase inhibitors
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
5-n.Butyl- and 5-n.pentyl-picolinic acids active as dopamine-beta-hydroxylase inhibitors The title cpds. are hypotensives. They may be administered with 3-(3,4-dihydroxyphenyl) L-alanine (I) for the treatment of Parkinsons disease. They reduce the necessary dose of (I) and suppress the hypertension normally associated with use of (I).
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
BE757336 | 1970-10-09 |
Publications (1)
Publication Number | Publication Date |
---|---|
BE757336A true BE757336A (en) | 1971-03-16 |
Family
ID=3857127
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BE757336D BE757336A (en) | 1970-10-09 | 5-butyl-and5-pentyl-picolinic acids active - as dopamene-b-hydroxylase inhibitors |
Country Status (1)
Country | Link |
---|---|
BE (1) | BE757336A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2181735A1 (en) * | 1972-02-17 | 1973-12-07 | Ciba Geigy Ag |
-
0
- BE BE757336D patent/BE757336A/en not_active IP Right Cessation
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2181735A1 (en) * | 1972-02-17 | 1973-12-07 | Ciba Geigy Ag |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
RE | Patent lapsed |
Owner name: ZAIDAN HOJIN BISEIBUTSU KAGAKU KENKYU KAI Effective date: 19851031 |