BE757336A - 5-butyl-and5-pentyl-picolinic acids active - as dopamene-b-hydroxylase inhibitors - Google Patents

5-butyl-and5-pentyl-picolinic acids active - as dopamene-b-hydroxylase inhibitors

Info

Publication number
BE757336A
BE757336A BE757336DA BE757336A BE 757336 A BE757336 A BE 757336A BE 757336D A BE757336D A BE 757336DA BE 757336 A BE757336 A BE 757336A
Authority
BE
Belgium
Prior art keywords
pentyl
butyl
dopamene
and5
hydroxylase inhibitors
Prior art date
Application number
Other languages
French (fr)
Inventor
H Umezawa
T Nagatsu
Original Assignee
Zaidan Hotin Biseibutsu Kagaku
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Publication date
Publication of BE757336A publication Critical patent/BE757336A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

5-n.Butyl- and 5-n.pentyl-picolinic acids active as dopamine-beta-hydroxylase inhibitors The title cpds. are hypotensives. They may be administered with 3-(3,4-dihydroxyphenyl) L-alanine (I) for the treatment of Parkinsons disease. They reduce the necessary dose of (I) and suppress the hypertension normally associated with use of (I).
BE757336D 1970-10-09 5-butyl-and5-pentyl-picolinic acids active - as dopamene-b-hydroxylase inhibitors BE757336A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
BE757336 1970-10-09

Publications (1)

Publication Number Publication Date
BE757336A true BE757336A (en) 1971-03-16

Family

ID=3857127

Family Applications (1)

Application Number Title Priority Date Filing Date
BE757336D BE757336A (en) 1970-10-09 5-butyl-and5-pentyl-picolinic acids active - as dopamene-b-hydroxylase inhibitors

Country Status (1)

Country Link
BE (1) BE757336A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2181735A1 (en) * 1972-02-17 1973-12-07 Ciba Geigy Ag

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2181735A1 (en) * 1972-02-17 1973-12-07 Ciba Geigy Ag

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Legal Events

Date Code Title Description
RE Patent lapsed

Owner name: ZAIDAN HOJIN BISEIBUTSU KAGAKU KENKYU KAI

Effective date: 19851031