BE1003256A5 - Derives de la butynylamine. - Google Patents

Derives de la butynylamine. Download PDF

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Publication number
BE1003256A5
BE1003256A5 BE8900977A BE8900977A BE1003256A5 BE 1003256 A5 BE1003256 A5 BE 1003256A5 BE 8900977 A BE8900977 A BE 8900977A BE 8900977 A BE8900977 A BE 8900977A BE 1003256 A5 BE1003256 A5 BE 1003256A5
Authority
BE
Belgium
Prior art keywords
alkyl group
hydrogen atom
group
butynylamine
different
Prior art date
Application number
BE8900977A
Other languages
English (en)
Inventor
Kimura Kiyoshi
Kise Masahiro
Morita Iwao
Original Assignee
Nippon Shinyaku Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nippon Shinyaku Co Ltd filed Critical Nippon Shinyaku Co Ltd
Application granted granted Critical
Publication of BE1003256A5 publication Critical patent/BE1003256A5/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C219/00—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C219/02—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C219/20—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C219/00—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C219/24—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups or amino groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/32—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C07C235/34—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Dérivés de la butynylamine représentés par la formule générale (I) suivante et leurs sels pharmacologiquement acceptables, dans laquelle R1 et R2 sont des groupes cycloalkyle, phényle ou 2-thiényle identiques ou différents; R3 et R4 sont un atome d'hydrogène ou un groupe alkyle identiques ou différents ou forment ensemble un groupe cycloalkyle conjointement avec l'atome de carbone adjecent;R5 et R6 sont un atome d'hydrogène ou un groupe alkyle identiques ou différents, ou forment ensemble un groupe amino cyclique conjointement avec l'atome d'azote adjacent, et A désigne O ou NR (où R est un atome d'hydrogène ou un groupe alkyle), à l'exclusion du cas où R3 et R4 sont tous deux des atomes d'hydrogène, A est O et, au moins l'un ou l'outre des symboles R1 et R2 est un groupe phényle.
BE8900977A 1988-09-14 1989-09-14 Derives de la butynylamine. BE1003256A5 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP23127288 1988-09-14

Publications (1)

Publication Number Publication Date
BE1003256A5 true BE1003256A5 (fr) 1992-02-11

Family

ID=16921002

Family Applications (1)

Application Number Title Priority Date Filing Date
BE8900977A BE1003256A5 (fr) 1988-09-14 1989-09-14 Derives de la butynylamine.

Country Status (13)

Country Link
US (1) US5036098B1 (fr)
EP (1) EP0359311B1 (fr)
KR (1) KR0154325B1 (fr)
CN (1) CN1038410C (fr)
BE (1) BE1003256A5 (fr)
CA (1) CA1317943C (fr)
CH (1) CH680440A5 (fr)
DE (1) DE68927657T2 (fr)
ES (1) ES2016060A6 (fr)
FR (1) FR2639044B1 (fr)
GB (2) GB8919320D0 (fr)
HU (2) HUT58045A (fr)
IL (1) IL91377A (fr)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5192779A (en) * 1989-02-14 1993-03-09 Fujisawa Pharmaceutical Co., Ltd. Substituted-acetamide compound and a process for the preparation thereof
US5066680A (en) * 1989-02-14 1991-11-19 Fujisawa Pharmaceutical Co., Ltd. Novel substituted-acetamide compound and a process for the preparation thereof
AU725577B2 (en) * 1996-07-01 2000-10-12 Bridge Pharma, Inc. Smooth muscle spasmolytic agents, compositions and methods of use thereof
US6541479B1 (en) * 1997-12-02 2003-04-01 Massachusetts College Of Pharmacy Calcium channel blockers
US6013830A (en) * 1998-03-30 2000-01-11 Sepracor Inc. Asymmetric grignard synthesis with cyclic 1,2 aminoalcohols
US6140529A (en) * 1998-10-22 2000-10-31 Sepracor Inc. Synthesis of optically active cyclohexylphenylglycolate esters
US6890920B2 (en) * 2001-10-26 2005-05-10 Pharmacia & Upjohn Company Quaternary ammonium compounds
MXPA04003806A (es) * 2001-11-05 2005-04-08 Upjohn Co Aerosol antimuscarinico.
TW200412945A (en) * 2002-10-25 2004-08-01 Upjohn Co Quaternary ammonium compounds
JP2006511494A (ja) * 2002-10-29 2006-04-06 ファルマシア・アンド・アップジョン・カンパニー・エルエルシー 抗ムスカリン剤としてのキヌクリジニウム誘導体
CA2502532A1 (fr) * 2002-10-29 2004-05-13 Pharmacia & Upjohn Company Llc Composes d'ammonium quaternaire utiles en tant qu'antagonistes du recepteur muscarinique
US7887431B2 (en) * 2008-05-16 2011-02-15 Taylor Made Golf Company, Inc. Golf club
EP1622606A1 (fr) * 2003-04-15 2006-02-08 Pharmacia & Upjohn Company LLC Composes d'ammonium quaternaire et leur utilisation comme agents antimuscariniques
WO2004091597A2 (fr) * 2003-04-15 2004-10-28 Pharmacia & Upjohn Company Llc Procede pour traiter le syndrome du colon irritable
CA2796877A1 (fr) 2010-04-30 2011-11-03 Merck Sharp & Dohme Corp. Nouveaux agonistes du recepteur beta 3 adrenergique

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB940540A (en) * 1960-07-26 1963-10-30 Mead Johnson & Co Aminoacetylenes and process for preparing the same
EP0383256A2 (fr) * 1989-02-14 1990-08-22 Fujisawa Pharmaceutical Co., Ltd. Composé acétamide substitué et un procédé pour sa préparation

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL122610C (fr) * 1959-02-18
JPH0755904B2 (ja) * 1986-05-14 1995-06-14 小玉株式会社 膀胱疾患治療剤

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB940540A (en) * 1960-07-26 1963-10-30 Mead Johnson & Co Aminoacetylenes and process for preparing the same
EP0383256A2 (fr) * 1989-02-14 1990-08-22 Fujisawa Pharmaceutical Co., Ltd. Composé acétamide substitué et un procédé pour sa préparation

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
ACTA PHARM. SUECICA, vol. 6, 1969, pages 349-358, Stockholm, SE; R. DAHLBOM et al.: "Acetylene compounds of potential pharmacological value" *

Also Published As

Publication number Publication date
CA1317943C (fr) 1993-05-18
DE68927657D1 (de) 1997-02-27
FR2639044A1 (fr) 1990-05-18
GB2222828B (en) 1992-04-29
CN1041582A (zh) 1990-04-25
HUT58045A (en) 1992-01-28
KR0154325B1 (ko) 1998-12-01
US5036098B1 (en) 1993-11-02
HU211134A9 (en) 1995-10-30
CN1038410C (zh) 1998-05-20
KR900004728A (ko) 1990-04-12
GB8919320D0 (en) 1989-10-11
CH680440A5 (fr) 1992-08-31
EP0359311A2 (fr) 1990-03-21
ES2016060A6 (es) 1990-10-01
EP0359311B1 (fr) 1997-01-15
EP0359311A3 (fr) 1991-07-03
IL91377A (en) 1996-09-12
FR2639044B1 (fr) 1993-08-06
DE68927657T2 (de) 1997-07-03
US5036098A (en) 1991-07-30
GB2222828A (en) 1990-03-21
GB8920766D0 (en) 1989-10-25
IL91377A0 (en) 1990-04-29

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Effective date: 20070930