BE1000468A7 - Procede d'extraction de la silymarine. - Google Patents

Procede d'extraction de la silymarine. Download PDF

Info

Publication number: BE1000468A7
Authority: BE; Belgium
Prior art keywords: chloroform; silymarin; precipitated; acetone; extraction
Prior art date: 1987-04-10

Application number

BE8800376A

Other languages

English (en)

French (fr)

Original Assignee

Lampugnani Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-04-10

Filing date

1988-03-31

Publication date

1988-12-13

1988-03-31 Application filed by Lampugnani Spa filed Critical Lampugnani Spa

1988-12-13 Application granted granted Critical

1988-12-13 Publication of BE1000468A7 publication Critical patent/BE1000468A7/fr

Links

SEBFKMXJBCUCAI-UHFFFAOYSA-N NSC 227190 Natural products C1=C(O)C(OC)=CC(C2C(OC3=CC=C(C=C3O2)C2C(C(=O)C3=C(O)C=C(O)C=C3O2)O)CO)=C1 SEBFKMXJBCUCAI-UHFFFAOYSA-N 0.000 title claims abstract description 17
SEBFKMXJBCUCAI-HKTJVKLFSA-N silibinin Chemical compound C1=C(O)C(OC)=CC([C@@H]2[C@H](OC3=CC=C(C=C3O2)[C@@H]2[C@H](C(=O)C3=C(O)C=C(O)C=C3O2)O)CO)=C1 SEBFKMXJBCUCAI-HKTJVKLFSA-N 0.000 title claims abstract description 17
229960004245 silymarin Drugs 0.000 title claims abstract description 17
235000017700 silymarin Nutrition 0.000 title claims abstract description 17
238000000605 extraction Methods 0.000 title description 15
HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 claims abstract description 36
CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims abstract description 16
235000013399 edible fruits Nutrition 0.000 claims abstract description 9
239000000843 powder Substances 0.000 claims abstract description 7
230000008030 elimination Effects 0.000 claims abstract 2
238000003379 elimination reaction Methods 0.000 claims abstract 2
238000000034 method Methods 0.000 claims description 13
239000002904 solvent Substances 0.000 claims description 12
238000005119 centrifugation Methods 0.000 claims description 7
OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 4
238000001035 drying Methods 0.000 claims description 3
238000002803 maceration Methods 0.000 claims description 2
239000011877 solvent mixture Substances 0.000 claims description 2
239000007788 liquid Substances 0.000 claims 1
239000000203 mixture Substances 0.000 abstract description 7
244000272459 Silybum marianum Species 0.000 abstract description 6
235000010841 Silybum marianum Nutrition 0.000 abstract description 6
239000002244 precipitate Substances 0.000 abstract description 3
XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 15
OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 12
238000005238 degreasing Methods 0.000 description 8
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 6
229930195733 hydrocarbon Natural products 0.000 description 5
150000002430 hydrocarbons Chemical class 0.000 description 5
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
238000001704 evaporation Methods 0.000 description 4
230000008020 evaporation Effects 0.000 description 4
150000002576 ketones Chemical class 0.000 description 4
239000004215 Carbon black (E152) Substances 0.000 description 3
YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 3
VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 3
238000001556 precipitation Methods 0.000 description 3
238000000746 purification Methods 0.000 description 3
238000004064 recycling Methods 0.000 description 3
ZHNUHDYFZUAESO-UHFFFAOYSA-N Formamide Chemical compound NC=O ZHNUHDYFZUAESO-UHFFFAOYSA-N 0.000 description 2
ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 2
NEHMKBQYUWJMIP-UHFFFAOYSA-N chloromethane Chemical compound ClC NEHMKBQYUWJMIP-UHFFFAOYSA-N 0.000 description 2
239000003925 fat Substances 0.000 description 2
238000011084 recovery Methods 0.000 description 2
238000003756 stirring Methods 0.000 description 2
241000132536 Cirsium Species 0.000 description 1
ZAFNJMIOTHYJRJ-UHFFFAOYSA-N Diisopropyl ether Chemical compound CC(C)OC(C)C ZAFNJMIOTHYJRJ-UHFFFAOYSA-N 0.000 description 1
238000013019 agitation Methods 0.000 description 1
239000003708 ampul Substances 0.000 description 1
230000001929 anti-hepatotoxic effect Effects 0.000 description 1
238000009835 boiling Methods 0.000 description 1
239000003610 charcoal Substances 0.000 description 1
150000008280 chlorinated hydrocarbons Chemical class 0.000 description 1
239000002026 chloroform extract Substances 0.000 description 1
239000012141 concentrate Substances 0.000 description 1
239000010779 crude oil Substances 0.000 description 1
-1 dimethyl oxysulfide Chemical compound 0.000 description 1
238000004090 dissolution Methods 0.000 description 1
150000002148 esters Chemical class 0.000 description 1
239000000284 extract Substances 0.000 description 1
150000008282 halocarbons Chemical class 0.000 description 1
150000002596 lactones Chemical class 0.000 description 1
238000004519 manufacturing process Methods 0.000 description 1
238000003801 milling Methods 0.000 description 1
238000012986 modification Methods 0.000 description 1
230000004048 modification Effects 0.000 description 1
239000008194 pharmaceutical composition Substances 0.000 description 1
238000005191 phase separation Methods 0.000 description 1
229920000151 polyglycol Polymers 0.000 description 1
239000010695 polyglycol Substances 0.000 description 1
238000002360 preparation method Methods 0.000 description 1
238000003825 pressing Methods 0.000 description 1
239000000047 product Substances 0.000 description 1
230000001681 protective effect Effects 0.000 description 1
238000005507 spraying Methods 0.000 description 1
229910001220 stainless steel Inorganic materials 0.000 description 1
239000010935 stainless steel Substances 0.000 description 1
239000007858 starting material Substances 0.000 description 1
239000006228 supernatant Substances 0.000 description 1
230000004580 weight loss Effects 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

Health & Medical Sciences (AREA)
Natural Medicines & Medicinal Plants (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Microbiology (AREA)
Animal Behavior & Ethology (AREA)
Botany (AREA)
Medical Informatics (AREA)
Medicinal Chemistry (AREA)
Alternative & Traditional Medicine (AREA)
Mycology (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Biotechnology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Medicines Containing Plant Substances (AREA)
Laminated Bodies (AREA)
Absorbent Articles And Supports Therefor (AREA)

BE8800376A 1987-04-10 1988-03-31 Procede d'extraction de la silymarine. BE1000468A7 (fr)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
IT20073/87A IT1203878B (it)	1987-04-10	1987-04-10	Procedimento di estrazione della silimarina

Publications (1)

Publication Number	Publication Date
BE1000468A7 true BE1000468A7 (fr)	1988-12-13

Family

ID=11163584

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BE8800376A BE1000468A7 (fr)	1987-04-10	1988-03-31	Procede d'extraction de la silymarine.

Country Status (2)

Country	Link
BE (1)	BE1000468A7 (it)
IT (1)	IT1203878B (it)

1987
- 1987-04-10 IT IT20073/87A patent/IT1203878B/it active
1988
- 1988-03-31 BE BE8800376A patent/BE1000468A7/fr not_active IP Right Cessation

Also Published As

Publication number	Publication date
IT8720073A0 (it)	1987-04-10
IT1203878B (it)	1989-02-23

Legal Events

Date

Code

Title

Description

1994-01-01

RE20

Patent expired

Owner name: LAMPUGNANI FARMACEUTICI S.P.A.

Effective date: 19940331

Publication	Publication Date	Title
AT395319B (de)	1992-11-25	Verfahren zur gewinnung eines polyhydroxyalkanoates aus dem zellmaterial eines mikroorganismus und polyhydroxyalkanoatflocken
CA1155113A (en)	1983-10-11	Process for recovery of polyol fatty acid polyesters
JPH029036B2 (it)	1990-02-28
US4052441A (en)	1977-10-04	Separation of acids and esters in the processing of waste salt solution of cyclohexanone manufacture
BE1000468A7 (fr)	1988-12-13	Procede d'extraction de la silymarine.
JP4085200B2 (ja)	2008-05-14	杜仲ゴムの抽出方法
EP3847152B1 (en)	2022-11-02	Fish oil cholesterol
EP0581979B1 (fr)	1999-03-03	Dérivés de l'acide quinique et procédé de préparation de dérivés de l'acide quinique
FR2470762A1 (fr)	1981-06-12	Procede de traitement d'un residu de production d'acide adipique
EP0581980B1 (fr)	1999-03-03	Dérivés de l'acide quinique 3- et/ou 4-substitués et procédé de préparation de dérivés de l'acide quinique 3- et/ou 4-substitués
CN1038427C (zh)	1998-05-20	一步浸取饼粕提取油脂和茶皂素方法
US2837534A (en)	1958-06-03	Process for extracting pyrethrin synergists from sesame oil
CN112028876B (zh)	2021-04-20	一种回收吡蚜酮的方法
US1147767A (en)	1915-07-27	Manufacture of by-products from distillery-slop.
US20050103711A1 (en)	2005-05-19	Isolation of oleuropein aglycon from olive vegetation water
TWI653331B (zh)	2019-03-11	由生產芝麻油所產生的副產物中提取芝麻木酚素的方法
CH316155A (fr)	1956-09-30	Procédé de préparation d'un 5-prégnène-17a,21-diol-3,11,20-trione-3,20-dialcoylène-cétal
US4569767A (en)	1986-02-11	Reclamation process for sewage scum
US2734898A (en)	1956-02-14	Production of hecogenin from plant
WO2007143713A2 (en)	2007-12-13	A new method for obtainiing long chain aliphatic alcohols and fatty acids from sugar cane mud and related wax esters
JPH06200288A (ja)	1994-07-19	砂糖黍ワックスの製造方法
WO1988004650A1 (en)	1988-06-30	Process for the recovery of succinic acid from its mixtures with other carboxilic acids
FR2725447A1 (fr)	1996-04-12	Procede d'obtention d'oligomeres procyanidoliques
FR2503708A1 (fr)	1982-10-15	Procede pour isoler l'acide (+)-usnique de usnea barbata l.
CA1076145A (en)	1980-04-22	Process for recovering a dialkylarylketone