AU8108998A - Aprotinin variants with improved properties and bikunins of aprotinin variants - Google Patents
Aprotinin variants with improved properties and bikunins of aprotinin variantsInfo
- Publication number
- AU8108998A AU8108998A AU81089/98A AU8108998A AU8108998A AU 8108998 A AU8108998 A AU 8108998A AU 81089/98 A AU81089/98 A AU 81089/98A AU 8108998 A AU8108998 A AU 8108998A AU 8108998 A AU8108998 A AU 8108998A
- Authority
- AU
- Australia
- Prior art keywords
- aprotinin variants
- bikunins
- improved properties
- aprotinin
- variants
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
- C07K14/8114—Kunitz type inhibitors
- C07K14/8117—Bovine/basic pancreatic trypsin inhibitor (BPTI, aprotinin)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Surgery (AREA)
- Gastroenterology & Hepatology (AREA)
- Hematology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Diabetes (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19725014 | 1997-06-13 | ||
DE19725014A DE19725014A1 (en) | 1997-06-13 | 1997-06-13 | Aprotinin variants with improved properties and bikunins of aprotinin variants |
PCT/EP1998/003259 WO1998056916A1 (en) | 1997-06-13 | 1998-06-02 | Aprotinin variants with improved properties and bikunins of aprotinin variants |
Publications (1)
Publication Number | Publication Date |
---|---|
AU8108998A true AU8108998A (en) | 1998-12-30 |
Family
ID=7832381
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU81089/98A Abandoned AU8108998A (en) | 1997-06-13 | 1998-06-02 | Aprotinin variants with improved properties and bikunins of aprotinin variants |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP1002083A1 (en) |
JP (1) | JP2002503958A (en) |
AU (1) | AU8108998A (en) |
DE (1) | DE19725014A1 (en) |
WO (1) | WO1998056916A1 (en) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP4565531B2 (en) * | 2000-09-01 | 2010-10-20 | 生化学工業株式会社 | DNA for targeting the bikunin gene |
GB0411145D0 (en) * | 2004-05-19 | 2004-06-23 | Imp College Innovations Ltd | Protease inhibitors and their therapeutic applications |
KR101277097B1 (en) * | 2004-12-23 | 2013-06-20 | 체에스엘 베링 게엠베하 | Prevention of thrombus formation and/or stabilization |
WO2008086858A1 (en) * | 2006-12-22 | 2008-07-24 | Bayer Schering Pharma Aktiengesellschaft | Production and use of non-native variants of domain 2 of human placental bikunin designed by directed molecular evolution |
WO2008110301A1 (en) * | 2007-03-13 | 2008-09-18 | Bayer Schering Pharma Aktiengesellschaft | Aprotinin variants with improved properties |
EP3110434B1 (en) | 2014-02-24 | 2018-09-19 | Takeda GmbH | Uti fusion proteins |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2208511A (en) * | 1987-08-07 | 1989-04-05 | Bayer Ag | Variants of bovine pancreatic trypsin inhibitor produced by recombinant dna technology |
US5591603A (en) * | 1987-08-28 | 1997-01-07 | Novo Nordisk A/S | Process for preparing aprotinin and aprotinin analogs in yeast cells |
DK225488D0 (en) * | 1988-04-26 | 1988-04-26 | Novo Industri As | POLYPEPTIDE |
DE3930522A1 (en) * | 1989-09-13 | 1991-03-21 | Bayer Ag | RECOMBINANT APROTININ VARIANTS - GENETIC METHOD FOR MICROBIAL PRODUCTION OF HOMOGENEOUS APROTININ VARIANTS, AND THE THERAPEUTIC APPLICATION THEREOF |
IL99585A0 (en) * | 1990-10-01 | 1992-08-18 | Novo Nordisk As | Aprotinin analogues,their production and pharmaceutical compositions containing them |
CA2139945A1 (en) * | 1992-07-13 | 1994-01-20 | Ignace Lasters | Bovine pancreatic trypsin inhibitor derived inhibitors of factor xa |
JPH08504568A (en) * | 1992-09-25 | 1996-05-21 | コルバス・インターナショナル、インコーポレイテッド | Inhibitor of factor VIIa-tissue factor complex derived from bovine pancreatic trypsin inhibitor |
ATE275583T1 (en) * | 1994-01-11 | 2004-09-15 | Dyax Corp | KALLIKREINHIBITING ßKUNITZ-DOMAINESS PROTEINS AND DERIVATIVES THEREOF |
US5589359A (en) * | 1994-08-05 | 1996-12-31 | Chiron Corporation | Chimeric proteins |
DE19629982A1 (en) * | 1996-07-25 | 1998-01-29 | Bayer Ag | Aprotinin variants with improved properties |
-
1997
- 1997-06-13 DE DE19725014A patent/DE19725014A1/en not_active Withdrawn
-
1998
- 1998-06-02 JP JP50147199A patent/JP2002503958A/en active Pending
- 1998-06-02 EP EP98930775A patent/EP1002083A1/en not_active Withdrawn
- 1998-06-02 WO PCT/EP1998/003259 patent/WO1998056916A1/en not_active Application Discontinuation
- 1998-06-02 AU AU81089/98A patent/AU8108998A/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
DE19725014A1 (en) | 1998-12-17 |
EP1002083A1 (en) | 2000-05-24 |
WO1998056916A1 (en) | 1998-12-17 |
JP2002503958A (en) | 2002-02-05 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
AU6307698A (en) | Useful properties of human lactoferrin and variants thereof | |
AU4208799A (en) | Interleukins-21 and 22 | |
AU6241698A (en) | Tace-like and matrilysin-like polypeptides | |
AU5752398A (en) | Novel ketobenzamides and their use | |
HUP0200444A2 (en) | Polymer conjugates of interferon betha-1a and uses | |
AU7718898A (en) | Txu-7-pap immunotoxin and use thereof | |
AU9781998A (en) | Huchordin and uses thereof | |
AU5040896A (en) | Benzonitriles and benzofluorides | |
AU2572797A (en) | Adam proteins and uses thereof | |
AU3227197A (en) | Lactoferrin variants and uses thereof | |
AU5685898A (en) | Encoder and decoder | |
AU1387399A (en) | Probucol esters and uses thereof | |
AU4899096A (en) | P-heteroatom-substituted phenols and uses thereof | |
AU7290898A (en) | Preparation of fagopyritols and uses therefor | |
AU1273899A (en) | Armor material and methods of making same | |
AU8108998A (en) | Aprotinin variants with improved properties and bikunins of aprotinin variants | |
AU2870197A (en) | Aprotinin variants having improved properties | |
HUP9800146A3 (en) | Thalidomide-derivatives and use of them | |
AU4219097A (en) | Manufacture of planar waveguide and planar waveguide | |
AU3479495A (en) | Alpha-1-antitrypsin and antithrombine-iii variants | |
AU2897500A (en) | "rzao" steering and variants | |
EP0998578A4 (en) | Sel-10 AND USES THEREOF | |
AU6084598A (en) | Antibiotic-ligand conjugates and methods of use thereof | |
PL341293A1 (en) | Beta-lypothropin and application thereof | |
EP0892354B8 (en) | Efficient representation and transmission of objects with variants |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
MK6 | Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase |