AU7829787A - Naphthalene and indan derivatives - Google Patents

Naphthalene and indan derivatives

Info

Publication number
AU7829787A
AU7829787A AU78297/87A AU7829787A AU7829787A AU 7829787 A AU7829787 A AU 7829787A AU 78297/87 A AU78297/87 A AU 78297/87A AU 7829787 A AU7829787 A AU 7829787A AU 7829787 A AU7829787 A AU 7829787A
Authority
AU
Australia
Prior art keywords
naphthalene
indan derivatives
derivatives
diastereomers
enantiomers
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
AU78297/87A
Other versions
AU597719B2 (en
Inventor
Andreas Bomhard
Jurgen Dammgen
Norbert Hauel
Joachim Heider
Walter Kobinger
Christian Lillie
Berthold Narr
Klaus Noll
Manfred Psiorz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Pharma GmbH and Co KG
Original Assignee
Dr Karl Thomae GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dr Karl Thomae GmbH filed Critical Dr Karl Thomae GmbH
Publication of AU7829787A publication Critical patent/AU7829787A/en
Application granted granted Critical
Publication of AU597719B2 publication Critical patent/AU597719B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/385—Saturated compounds containing a keto group being part of a ring
    • C07C49/417—Saturated compounds containing a keto group being part of a ring polycyclic
    • C07C49/423—Saturated compounds containing a keto group being part of a ring polycyclic a keto group being part of a condensed ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/50—Organo-phosphines
    • C07F9/53—Organo-phosphine oxides; Organo-phosphine thioxides
    • C07F9/5304—Acyclic saturated phosphine oxides or thioxides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Cardiology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Feedback Control In General (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)

Abstract

Naphthalene and indane derivatives of the formula <IMAGE> in which the substituents have the meaning given in the description, their enantiomers, their diastereomers and their acid addition salts with inorganic or organic acids which have useful pharmacological properties, in particular a heart rate-reducing action. The novel compounds can be prepared by processes known per se.
AU78297/87A 1986-09-11 1987-09-11 Naphthalene and indan derivatives Ceased AU597719B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3630903 1986-09-11
DE19863630903 DE3630903A1 (en) 1986-09-11 1986-09-11 NEW TETRAHYDRONAPHTHALINE AND INDANDERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND THE MEDICINAL PRODUCTS CONTAINING THEM

Publications (2)

Publication Number Publication Date
AU7829787A true AU7829787A (en) 1988-03-17
AU597719B2 AU597719B2 (en) 1990-06-07

Family

ID=6309344

Family Applications (1)

Application Number Title Priority Date Filing Date
AU78297/87A Ceased AU597719B2 (en) 1986-09-11 1987-09-11 Naphthalene and indan derivatives

Country Status (16)

Country Link
EP (1) EP0259782B1 (en)
JP (1) JPS6377842A (en)
KR (1) KR880003889A (en)
AT (1) ATE59378T1 (en)
AU (1) AU597719B2 (en)
DD (1) DD263525A5 (en)
DE (2) DE3630903A1 (en)
DK (1) DK472387A (en)
FI (1) FI873917A (en)
HU (1) HU206077B (en)
IL (1) IL83850A (en)
NO (1) NO166528C (en)
NZ (1) NZ221766A (en)
PH (1) PH25680A (en)
PT (1) PT85689B (en)
ZA (1) ZA876768B (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8809314D0 (en) * 1988-04-20 1988-05-25 Wellcome Found Anti-hypertensive sulfonanilides
EP0361577B1 (en) * 1988-09-19 1993-05-05 Akzo N.V. Tetrahydronaphthalene and indane derivatives
JP2931986B2 (en) * 1989-02-17 1999-08-09 武田薬品工業株式会社 Aralkylamine derivatives
US5166209A (en) * 1989-04-21 1992-11-24 Burroughs Wellcome Co. Pharmacologically active compounds
US5643784A (en) * 1990-12-04 1997-07-01 H, Lundbeck A/S Indan derivatives
NZ243065A (en) * 1991-06-13 1995-07-26 Lundbeck & Co As H Piperidine derivatives and pharmaceutical compositions
SE9103745D0 (en) * 1991-12-18 1991-12-18 Wikstroem Haakan ARYL-TRIFLATES AND RELATED COMPOUNDS
DK78692D0 (en) * 1992-06-12 1992-06-12 Lundbeck & Co As H DIMER PIPERIDINE AND PIPERAZINE DERIVATIVES
US5508306A (en) * 1992-11-13 1996-04-16 Synaptic Pharmaceutical Corporation Aromatic amine derivatives
JPH09502193A (en) * 1993-09-09 1997-03-04 スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー Phosphinic acid derivative having antihyperglycemic and / or antiobesity activity
US6048877A (en) * 1997-02-21 2000-04-11 Bristol-Myers Squibb Company Tetralone derivatives as antiarrhythmic agents
EP0971878B1 (en) 1997-02-27 2008-03-26 Takeda Pharmaceutical Company Limited Amine compounds, their production and use as amyloid-beta production inhibitors
CN101058543B (en) 2000-04-03 2010-05-26 武田药品工业株式会社 Process for producing amine derivatives

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CS159795B2 (en) * 1971-04-19 1975-01-31
CH654294A5 (en) * 1982-07-09 1986-02-14 Yason Srl CARDIAC AND CEREBRAL LEVEL CALCIUM BLOCKING COMPOUNDS, METHOD FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS.
NZ213651A (en) * 1984-10-11 1989-07-27 Hoffmann La Roche Tetrahydronapthalene derivatives and medicaments
DK691488A (en) * 1987-12-14 1989-06-15 Beecham Group Plc UNKNOWN RELATIONSHIPS

Also Published As

Publication number Publication date
HU206077B (en) 1992-08-28
NZ221766A (en) 1989-05-29
NO873784L (en) 1988-03-14
ATE59378T1 (en) 1991-01-15
NO873784D0 (en) 1987-09-10
EP0259782B1 (en) 1990-12-27
NO166528B (en) 1991-04-29
IL83850A0 (en) 1988-02-29
DE3767094D1 (en) 1991-02-07
DK472387A (en) 1988-03-12
NO166528C (en) 1991-08-07
FI873917A0 (en) 1987-09-10
ZA876768B (en) 1989-05-30
DD263525A5 (en) 1989-01-04
FI873917A (en) 1988-03-12
DE3630903A1 (en) 1988-03-24
PH25680A (en) 1991-09-04
IL83850A (en) 1991-09-16
HUT46885A (en) 1988-12-28
EP0259782A1 (en) 1988-03-16
KR880003889A (en) 1988-05-30
AU597719B2 (en) 1990-06-07
JPS6377842A (en) 1988-04-08
PT85689B (en) 1990-06-29
PT85689A (en) 1987-10-01
DK472387D0 (en) 1987-09-10

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