AU770818B2 - Substituted thiazolidinedione derivative, process for its preparation and its pharmaceutical use - Google Patents
Substituted thiazolidinedione derivative, process for its preparation and its pharmaceutical use Download PDFInfo
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- AU770818B2 AU770818B2 AU27538/02A AU2753802A AU770818B2 AU 770818 B2 AU770818 B2 AU 770818B2 AU 27538/02 A AU27538/02 A AU 27538/02A AU 2753802 A AU2753802 A AU 2753802A AU 770818 B2 AU770818 B2 AU 770818B2
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
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- Health & Medical Sciences (AREA)
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- Organic Chemistry (AREA)
- Diabetes (AREA)
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- Emergency Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Description
AUSTRALIA
PATENTS ACT 1990 DIVISIONAL APPLICATION NAME OF APPLICANT: SmithKline Beecham plc ADDRESS FOR SERVICE: DAVIES COLLISON CAVE Patent Attorneys 1 Little Collins Street Melbourne, 3000.
INVENTION TITLE: "Substituted thiazolidinedione derivative, process for its preparation and its pharmaceutical use" The following statement is a full description of this invention, including the best method of performing it known to us: SUBSTITUTED THIAZOLIDINEDIONE DERIVATIVE, PROCESS FOR ITS PREPARATION AND ITS PHARMACEUTICAL USE This application is a divisional of Australian Patent Application No.
22722/99, the entire contents of which are incorporated herein by reference.
This invention relates to a novel pharmaceutical, to a process for the preparation of the pharmaceutical and to the use of the pharmaceutical in medicine.
International Patent Application, Publication Number W094/05659 discloses certain thiazolidinedione derivatives having hypoglycaemic and hypolipidaemic activity including 5-[4-[2-(N-methyl-N-(2-pyridyl)amino)ethoxy]benzyl]thiazolidine- 2.4-dione, maleic acid salt (hereinafter also referred to as "Compound Compound is disclosed solely as an anhydrous form. It has now been discovered that Compound exists in a novel hydrated form which is particularly suitable for bulk preparation and handling. This can be prepared by an efficient, economic and reproducible process particularly suited to large scale preparation.
The novel hydrate also has useful pharmaceutical properties and in particular it is indicated to be useful for the treatment and/or prophylaxis of diabetes mellitus, conditions associated with diabetes mellitus and certain complications thereof.
Accordingly, the present invention provides a hydrate of 5-[4-[2-(N-methyl-N- (2-pyridyl)amino)ethoxy]benzyl]thiazolidine-2,4-dione, maleic acid salt (the "Hydrate") characterised in that the Hydrate: comprises water in the range of from 0.3 to 0.6 molar equivalents; and (ii) provides an infrared spectrum containing peaks at 1757, 1331, 1290, 1211 and 767 cm-1; and/or (iii) provides a Raman spectrum containing peaks at 1758, 1610, 1394, 1316 and 1289 cm-l; and/or g 25 (iv) provides a solid state nuclear magnetic resonance spectrum containing chemical shifts substantially as set out in Table I; and/or S. provides an X-ray powder diffraction (XRPD) pattern substantially as set out in Figure 4.
Suitably, the water content of the Hydrate is in the range of from 0.3 to molar equivalents, for example 0.4 molar equivalents.
In one favoured aspect, the Hydrate provides an infra red spectrum substantially in accordance with Figure 1.
In one favoured aspect, the Hydrate provides a Raman spectrum 35 substantially in accordance with Figure 2.
In one favoured aspect, the Hydrate provides a solid state nuclear magnetic resonance spectrum substantially in accordance with Figure 3.
.:000 resonance spectrum substantially in accordance with Figure 3.
The Hydrate can exist in certain dehydrated forms which reversibly convert to the Hydrate when contacted with water, either in liquid or vapour form. The present invention encompasses all such reversibly rehydratable forms of the Hydrate.
The present invention encompasses the Hydrate isolated in pure form or when admixed with other materials, for example the known anhydrous form of Compound I.
the above mentioned reversibly rehydratable forms or any other material.
Thus in one aspect there is provided the Hydrate in isolated form.
In a further aspect there is provided the Hydrate in pure form.
In yet a further aspect there is provided the Hydrate in crystalline form.
The invention also provides a process for preparing the Hydrate. characterised in that 5-[ 4 2 -(N-methyl-N-(2-pyridyl)amino)ethoxy]benzyl]thiazolidine-2.4-dione.
maleic acid salt is crystallised from aqueous ethanol, conveniently aqueous denatured ethanol.
Suitably, the aqueous ethanol contains from 2% to 15% of water by volume.
15 such as 5% to 15% of water by volume, favourably 7% to 12% of water by volume.
preferably 10 to 12%, for example Other aqueous solvents may also be used to prepare the Hydrate, for example isopropanol. acetonitrile. tetrahydrofuran, methyl ethyl ketone, ethyl acetate or acetic acid, or mixtures thereof. The precise amount of water used in each of the alternative 2 C solvents will depend upon the particular solvent chosen but typically it is in the range of from 2 to 15% of water by volume of water, for example For certain solvents.
such as in ethyl acetate, water levels as low as 1% by volume can provide the Hydrate .(thus providing a suitable range of 1 to 15% of water by volume in the appropriate solvent). Alternatively, the Hydrate can be obtained by crystallization from water 25 containing a small amount (for example 2 to 5% by volume) of an organic acid such as acetic acid.
Crystallisation and any recrystallization is generally carried out at low to ambient temperature, such as in the range of between 0 to 30°C for example 25 0
C.
alternatively crystallisation may be initiated at an elevated temperature, such as in the range of between 30°C and 60 0 C for example 50°C, and then completed by allowing the temperature of the solvent to cool to ambient or low temperature, such as in the range of between 0 to 30°C for example 20 0
C.
The crystallisation can be initiated by seeding with crystals of the Hydrate but this is not essential.
Compound I is prepared according to known procedures, such as those disclosed in W094/05659. The disclosures of W094/05659 are incorporated herein by reference.
When used herein the term 'prophylaxis of conditions associated with diabetes mellitus' includes the treatment of conditions such as insulin resistance. impaired glucose tolerance, hyperinsulinaemia and gestational diabetes.
Diabetes mellitus preferably means Type II diabetes mellitus.
Conditions associated with diabetes include hyperglycaemia and insulin resistance, especially acquired insulin resistance and obesity. Further conditions associated with diabetes include hypertension. cardiovascular disease. especially atherosclerosis, certain eating disorders, in particular the regulation of appetite and food intake in subjects suffering from disorders associated with under-eating .such as anorexia nervosa. and disorders associated with over-eating, such as obesity and anorexia bulimia. Additional conditions associated with diabetes include polycystic ovarian syndrome and steroid induced insulin resistance.
The complications of conditions associated with diabetes mellitus encompassed herein includes renal disease, especially renal disease associated with the development of Type II diabetes including diabetic nephropathy.
glomerulonephritis, glomerular sclerosis, nephrotic syndrome, hypertensive nephrosclerosis and end stage renal disease.
As used herein 'aqueous' with reference to a given solvent or solvent mixture refers to a solvent which contains sufficient water to provide Hydrate i.e having from 20 0.3 to 0.6 molar equivalents of water.
As mentioned above the compound of the invention has useful therapeutic properties: The present invention accordingly the Hydrate for use as an active therapeutic substance.
More particularly, the present invention provides the Hydrate for use in the 25 treatment and/or prophylaxis of diabetes mellitus, conditions associated with diabetes mellitus and certain complications thereof.
The Hydrate may be administered per se or, preferably, as a pharmaceutical composition also comprising a pharmaceutically acceptable carrier. The formulation of the Hydrate and dosages thereof are generally as disclosed for Compound in International Patent Application. Publication Number W094/05659.
Accordingly, the present invention also provides a pharmaceutical composition comprising the Hydrate and a pharmaceutically acceptable carrier therefor.
The Hydrate is normally administered in unit dosage form.
The active compound may be administered by any suitable route but usually by the oral or parenteral routes. For such use. the compound will normally be employed in the form of a pharmaceutical composition in association with a pharmaceutical carrier, diluent and/or excipient. although the exact form of the composition will naturally depend on the mode of administration.
Compositions are prepared by admixture and are suitably adapted for oral, parenteral or topical administration, and as such may be in the form of tablets.
capsules. oral liquid preparations, powders, granules, lozenges, pastilles.
reconstitutable powders, injectable and infusable solutions or suspensions.
suppositories and transdermal devices. Orally administrable compositions are preferred, in particular shaped oral compositions, since they are more convenient for general use.
Tablets and capsules for oral administration are usually presented in a unit dose, and contain conventional excipients such as binding agents, fillers. diluents.
tabletting agents, lubricants, disintegrants, colourants, flavourings, and wetting agents.
The tablets may be coated according to well known methods in the art.
Suitable fillers for use include cellulose, mannitol. lactose and other similar 15 agents. Suitable disintegrants include starch, polyvinylpyrrolidone and starch derivatives such as sodium starch glycollate. Suitable lubricants include, for example.
magnesium stearate. Suitable pharmaceutically acceptable wetting agents include sodium lauryl sulphate.
Solid oral compositions may be prepared by conventional methods of 20 ble.icing, filling, tabletting or the like. Repeated blending operaticns may be used to distribute the active agent throughout those compositions employing large quantities of fillers. Such operations are, of course, conventional in the art.
Oral liquid preparations may be in the form of, for example, aqueous or oily suspensions, solutions, emulsions, syrups, or elixirs, or may be presented as a dry 25 product for reconstitution with water or other suitable vehicle before use. Such liquid preparations may contain conventional additives such as suspending agents, for example sorbitol, syrup, methyl cellulose, gelatin, hydroxyethylcellulose, carboxymethyl cellulose, aluminium stearate gel or hydrogenated edible fats, emulsifying agents, for example lecithin, sorbitan monooleate, or acacia; non-aqueous vehicles (which may include edible oils), for example, almond oil, fractionated coconut oil, oily esters such as esters of glycerine, propylene glycol, or ethyl alcohol: preservatives, for example methyl or propyl p-hydroxybenzoate or sorbic acid. and if desired conventional flavouring or colouring agents.
For parenteral administration, fluid unit dose forms are prepared containing a compound of the present invention and a sterile vehicle. The compound, depending on the vehicle and the concentration, can be either suspended or dissolved. Parenteral solutions are normally prepared by dissolving the active compound in a vehicle and filter sterilising before filling into a suitable vial or ampoule and sealing.
-4- Advantageously. adjuvants such as a local anaesthetic, preservatives and buffering agents are also dissolved in the vehicle. To enhance the stability, the composition can be frozen after filling into the vial and the water removed under vacuum.
Parenteral suspensions are prepared in substantially the same manner except that the active compound is suspended in the vehicle instead of being dissolved and sterilised by exposure to ethylene oxide before suspending in the sterile vehicle.
Advantageously. a surfactant or wetting agent is included in the composition to facilitate uniform distribution of the active compound.
In addition such compositions may contain further active agents such as anti-hypertensive agents and diuretics.
As is common practice, the compositions will usually be accompanied by written or printed directions for use in the medical treatment concerned.
As used herein the term 'pharmaceutically acceptable' embraces compounds, compositions and ingredients for both human and veterinary use: for example the term 'pharmaceutically acceptable salt' embraces a veterinarily acceptable salt.
The present invention further provides a method for the treatment and/or prophylaxis of diabetes mellitus. conditions associated with diabetes mellitus and certain complications thereof, in a human or non-human mammal which comprises administering an effective, non-toxic, amount of Hydrate to a human or non-human mammal in need thereof.
Conveniently, the active ingredient may be administered as a pharmaceutical composition hereinbefore defined, and this forms a particular aspect of the present invention.
In the treatment and/or prophylaxis of diabetes mellitus, conditions associated with diabetes mellitus and certain complications thereof Hydrate may be taken in doses, such as those described above.
Similar dosage regimens are suitable for the treatment and/or prophylaxis of non-human mammals.
In a further aspect the present invention provides the use of Hydrate for the manufacture of a medicament for the treatment and/or prophylaxis of diabetes mellitus, conditions associated with diabetes mellitus and certain complications thereof.
No adverse toxicological effects are indicated in the above mentioned treatments for the compounds of the invention.
The following examples illustrate the invention but do not limit it in any way.
Example 1: Preparation of Hydrate of 5-[4-j2-(N-methyl-N-(2pyridyl)amino)ethoxvybenzyljthiazolidine-2.4-dione, maleic acid salt.
5-[4-[2-(N-methyl-N-(2-pyridyl)amino)ethoxy]benz-vl]thiazolidine-2.4-dione free base (6.0 g) and maleic acid (2.1 g) were heated to 60°C in denatured ethanol (60 ml) containing additional water (6.1 ml. i.e. a total water content of approximately and stirred at this temperature for 30 minutes during which a solution was obtained. The solution was filtered. re-heated to 55°C. and then cooled to 20-25°C and stirred for eighteen hours. The product was filtered and dried at 50 0 C in vacuo to give the title compound (4.62 g, 58%).
CHARACTERISING DATA: The following characterising data were generated for the Hydrate: A Water content This was determined as 1.55% w/w (0.41 molar equivalents) using a Karl Fischer apparatus.
B Infrared The infrared absorption spectrum of a mineral oil dispersion of the Hydrate was obtained using a Nicolet 710 FT-IR spectrometer at 2 cm'I resolution. Data were digitised at 1 cm t intervals. The spectrum obtained is shown in Figure 1. Peak positions are as follows: 3574, 3458, 3377, 3129, 2776, 1757, 1743, 1708, 1691,1640,1620, 1585, 1542, 1512, 1414, 1350, 1331, 1306. 1290, 1249, 1238, 1211.
1183, 1163,1143. 1107, 1078, 1063, 1031. 1002, 974, 954. 927, 902, 865, 836. 830, 817, 809, 767, 735, 717, 663, 616, 585, 558. 520 and 508 cm- 1 30 C Raman A Raman spectrum of the Hydrate was recorded through glass vials using a Perkin Elmer 2000R spectrometer at 4 cm 1 resolution and is shown in Figure 2 (1800 200 cm- 1 Excitation was achieved using a Nd:YAG laser (1064 nm) with a power output of 500 mW. Data were digitised at I cm 1 intervals. Peak positions are as follows: 1758. 1743. 1703. 1610. 1586. 1544, 1468. 1435, 1394. 1330. 1316, 1289. 1265, 1238. 1206, 1185. 1148. 1095. 1032. 1003. 976. 923. 903. 843. 825. 780, 741, 722, 664,637. 606. 526.471. 403. 331 and 293 cm- 1 40 D NMR *oo• -6- The 90.55MHz 13C CP-MAS NMR spectrum for the Hydrate is shown below in Figure 3. Chemical shifts are tabulated in Table I. Data were recorded at ambient temperature and 10 kHz spinning frequency, without prior grinding of the sample. on a Bruker AMX360WB spectrometer, with 1.6ms cross polarization, and a repetition rate of 20 s. Chemical shifts were referenced to the high-field resonance of solid adamantane (38.4 ppm relative to tetramethylsilane). and are judged accurate to within 0.5ppm. Peaks were not assigned.
Table I.
13C Chemical Shifts of the Hydrate Chemical Shift (ppm) 32.4 59.3 117.6 152.8 177.5 38.8 65.6 119.8 154.9 179.2 42.1 67.0 133.1 159.4 42.9 68.4 135.2 160.2 43.8 111.5 138.5 168.1 53.0 113.8 139.9 171.3 54.7 115.3 148.5 174.4 57.2 116.4 149.0 175.0 E X-Ray Powder Diffraction (XRPD) The XRPD pattern of the Hydrate is shown below in Figure 4 and a summary of the XRPD angles and calculated lattice spacing characteristic of the Hydrate is given in Table II.
A PW1710 X-ray powder diffractometer (Cu X-ray source) was used to generate the spectrum using the following acquisition conditions: Tube anode: Cu Generator tension: 40 kV Generator current: 30 mA Start angle: 3.5 25 End angle: 35.0 020 Step size: 0.020 Time per step: 4.550 s *oooo •••go Table II.
X-Ray Powder Diffraction Angles and Calculated Lattice Spacing Characteristic of the Hydrate.
Example 2 The maleate salt of 5-[ 4 2 -(N-methyl-N-(2-pyridyl)amino)ethoxy]benzyl] thiazolidine-2,4,-dione anhydrate (3.0 g) was stirred and heated at 55-60°C in acetonitrile (30 ml) containing water (I ml) until complete dissolution was achieved.
The resultant solution was stirred and cooled to 20-25 0 C and the product was filtered, washed with acetonitrile (5 ml) and dried at 50C in vacuo to give the title compound (1.8 g, The water content of the product was 1.77%.
Example 3 The procedure of Example 2 was repeated using tetrahydrofuran (15 ml) containing water (0.5 ml) as solvent. Yield 1.8 g water content 1.60%.
Example 4 The procedure of Example 2 was repeated using methyl ethyl ketone (30 ml) containing water (1 ml) as solvent. Yield 2.05 g water content 1.58%.
-8- Example The procedure of Example 2 was followed using 2.0 g maleate salt, heating to 65 0 C in ethyl acetate (150 ml) containing water (1.5 ml) as solvent. Yield 1.34 g water content 1.61%.
Example 6 The procedure of Example 2 was followed, heating to 65-70°C in isopropanol (33 ml) containing water (1 ml) as solvent. Yield 2.4 g water content 1.58%.
Example 7 The procedure of Example 2 was repeated using a mixture of water (20 ml) and acetic acid (1.0 g) as solvent. Yield 0.76 g water content 1.78%.
Throughout this specification and the claims which follow, unless the context requires S otherwise, the word "comprise", and variations such as "comprises" and "comprising", will be understood to imply the inclusion of a stated integer or step or group of integers or steps but not the exclusion of any other integer or step or group of integers or steps.
The reference to any prior art in this specification is not, and should not be taken as, an acknowledgment or any form of suggestion that that prior art forms part of the common general knowledge in Australia.
*i -9-
Claims (16)
1. A hydrate of 5-[4-[2-(N-methyl-N-(2-pyridyl)amino)ethoxy]benzyl] thiazolidine-2,4-dione, maleic acid salt, characterised in that it: comprises water in the range of from 0.3 to 0.6 molar equivalents; and (ii) provides an infra red spectrum containing peaks at 1757, 1331, 1290, 1211 and 767 and/or (iii) provides a Raman spectrum containing peaks at 1758, 1610, 1394, 1316 and 1289 and/or (iv) provides a solid state nuclear magnetic resonance spectrum containing chemical shifts substantially as set out in Table I; and/or provides na X-ray powder diffraction (XRPD) pattern substantially as set out in Figure 4.
2. A hydrate according to claim 1, wherein the water content is in the range of from 0.3 to 0.5 molar equivalents.
3. A hydrate according to claim 1 or claim 2, which provides an infra red spectrum substantially in accordance with Figure 1. o
4. A hydrate according to any one of claims 1 to 3, which provides a Raman spectrum substantially in accordance with Figure 2.
5. A hydrate according to any one of claims 1 to 4, which provides a solid state nuclear magnetic resonance spectrum substantially in accordance with Figure 3.
6. A hydrate according to any one of claims 1 to 5, which provides an X-ray powder diffraction (XRPD) pattern substantially as set out in Figure 4.
7. A hydrate according to any one of claims 1 to 6, when isolated in pure form, or when admixed with other materials. P:\OpcrlMalr2003\2514982 350doc-18/12)3 11
8. A hydrate according to claim 7, in which the other material is the anhydrous form of the maleic salt of 5-[4-[2-(N-methyl-N-(2-pyridyl)amino)ethoxy]benzyl] thiazolidine-2,4-dione.
9. A hydrate according to any one of claims 1 to 8, in crystalline form.
A process for preparing a hydrate according to claim 1, characterised in that 5-[4-[2-(N-methyl-N-(2-pyridyl)amino)ethoxy]benzyl]thiazolidine-2,4-dione, maleic acid salt is crystallised from aqueous ethanol.
11. A process according to claim 10 wherein the aqueous ethanol is aqueous denatured ethanol.
12. A process according to claim 10, wherein the aqueous ethanol contains from 2% to 15% of water by volume.
13. A pharmaceutical composition comprising an effective, non-toxic amount of a hydrate according to claim 1 and a pharmaceutically acceptable carrier therefor.
14. A hydrate according to claim 1, for use in the treatment and/or prophylaxis of o* diabetes mellitus, conditions associated with diabetes mellitus and certain complications thereof.
15. The use of a Hydrate according to any one of claims 1 to 9 for the manufacture of a medicament for the treatment and/or prophylaxis of diabetes mellitus, conditions associated with diabetes mellitus and certain complications thereof. 30
16. A method for the treatment and/or prophylaxis of diabetes mellitus, conditions associated with diabetes mellitus and certain complications thereof, in PA~Opak01k2003U251 4 982 350 dmc.18112J03 12 human or non-human mammal which comprises administering an effective, non- toxic, amount of a Hydrate according to any one of claims 1 to 9 to a human or non- human in need thereof. DATED this 16 1h day of December, 2003 SmithKline Beecham plc By DAVIES COLLISON CAVE Patent Attorneys for the Applicants
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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GB9726563 | 1997-12-16 | ||
GBGB9726563.1A GB9726563D0 (en) | 1997-12-16 | 1997-12-16 | Novel pharmaceutical |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
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AU22722/99A Division AU2272299A (en) | 1997-12-16 | 1998-12-14 | Substituted thiazolidinedione derivative, process for its preparation and its pharmaceutical use |
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AU2753802A AU2753802A (en) | 2002-05-16 |
AU770818B2 true AU770818B2 (en) | 2004-03-04 |
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Application Number | Title | Priority Date | Filing Date |
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AU22722/99A Abandoned AU2272299A (en) | 1997-12-16 | 1998-12-14 | Substituted thiazolidinedione derivative, process for its preparation and its pharmaceutical use |
AU27538/02A Ceased AU770818B2 (en) | 1997-12-16 | 2002-03-20 | Substituted thiazolidinedione derivative, process for its preparation and its pharmaceutical use |
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AU22722/99A Abandoned AU2272299A (en) | 1997-12-16 | 1998-12-14 | Substituted thiazolidinedione derivative, process for its preparation and its pharmaceutical use |
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US (4) | US20020133016A1 (en) |
EP (1) | EP1042321A1 (en) |
JP (1) | JP2002508371A (en) |
KR (1) | KR100549141B1 (en) |
CN (3) | CN101318957A (en) |
AP (1) | AP1363A (en) |
AR (2) | AR017211A1 (en) |
AU (2) | AU2272299A (en) |
BG (1) | BG64850B1 (en) |
BR (1) | BR9813598A (en) |
CA (1) | CA2314967A1 (en) |
CO (1) | CO4990943A1 (en) |
CZ (1) | CZ300081B6 (en) |
DZ (1) | DZ2679A1 (en) |
EA (1) | EA002833B1 (en) |
EG (1) | EG22250A (en) |
GB (1) | GB9726563D0 (en) |
HR (1) | HRP20000404A2 (en) |
HU (1) | HUP0102292A3 (en) |
ID (1) | ID24714A (en) |
IL (2) | IL160847A0 (en) |
MA (1) | MA26581A1 (en) |
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NO (1) | NO317255B1 (en) |
NZ (1) | NZ504703A (en) |
OA (1) | OA11900A (en) |
PE (1) | PE20000125A1 (en) |
PL (1) | PL341213A1 (en) |
RS (1) | RS50080B (en) |
SA (1) | SA99200200B1 (en) |
SK (1) | SK286422B6 (en) |
TR (2) | TR200001793T2 (en) |
TW (1) | TW487709B (en) |
UA (1) | UA66821C2 (en) |
UY (2) | UY25309A1 (en) |
WO (1) | WO1999031093A1 (en) |
ZA (1) | ZA9811504B (en) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
USRE39384E1 (en) | 1993-09-01 | 2006-11-07 | Smithkline Beecham P.L.C. | Substituted thiazolidinedione derivatives |
US6664278B2 (en) | 1997-12-16 | 2003-12-16 | Smithkline Beecham P.L.C. | Hydrate of 5-[4-[2-(N-methyl-N-(2-pyridil)amino)ethoxy]benzyl]thiazolidine-2,4-dione maleic acid salt |
GB9726568D0 (en) | 1997-12-16 | 1998-02-11 | Smithkline Beecham Plc | Novel pharmaceutical |
US20020137940A1 (en) | 1997-12-16 | 2002-09-26 | Smithkline Beecham P.L.C. | 5-[4-[2-(N-methyl-N-(2-pyridyl)amino)ethoxy]benzyl]thiazolidine-2, 4-dione, maleic acid salt, hydrate as pharmaceutical |
GB9909041D0 (en) * | 1999-04-20 | 1999-06-16 | Smithkline Beecham Plc | Novel pharmaceutical |
KR100744359B1 (en) * | 1999-04-23 | 2007-07-30 | 스미스클라인비이참피이엘시이 | Thiazolidinedione Derivative and its Use as Antidiabetic |
TR200103060T2 (en) * | 1999-04-23 | 2002-05-21 | Smithkline Beecham P. L. C. | New pharmaceutical ingredients |
US20040248945A1 (en) | 1999-04-23 | 2004-12-09 | Smithkline Beecham P.L.C. | Thiazolidinedione derivative and its use as antidiabetic |
ATE246191T1 (en) | 1999-04-23 | 2003-08-15 | Smithkline Beecham Plc | POLYMORPHOUS OF 5-(4-(2-(N-METHYL-N-(2-PYRDYL)AMINO)ETHOXY)BENZYL)THIAZOLIDINE-2,4-DIONE MALEIC ACID SALT |
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WO1994005659A1 (en) * | 1992-09-05 | 1994-03-17 | Smithkline Beecham Plc | Substituted thiazolidinedione derivatives |
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DE3856378T2 (en) | 1987-09-04 | 2000-05-11 | Beecham Group Plc | Substituted thiazolidinedione derivatives |
US6288095B1 (en) | 1987-09-04 | 2001-09-11 | Beecham Group P.L.C. | Compounds |
GB8820389D0 (en) * | 1988-08-26 | 1988-09-28 | Beecham Group Plc | Novel compounds |
GB9124513D0 (en) * | 1991-11-19 | 1992-01-08 | Smithkline Beecham Plc | Novel process |
US5741803A (en) | 1992-09-05 | 1998-04-21 | Smithkline Beecham Plc | Substituted thiazolidinedionle derivatives |
SG47100A1 (en) * | 1994-02-10 | 1998-03-20 | Smithkline Beecham Plc | Use of insulin sensitisers for treating renal diseases |
DE4404198A1 (en) | 1994-02-10 | 1995-08-17 | Henkel Kgaa | 2-fluoro-6-nitroaniline |
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CA2426117A1 (en) | 2000-09-26 | 2002-04-04 | Dr. Reddy's Research Foundation | Novel polymorphic forms of 5-[4-[2-[n-methyl-n-(2-pyridyl)amino]ethoxy]benzyl] thiazolidine-2,4-dione maleate and process for their preparation |
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