AU7637591A - Cis and trans stilbenes and their compositions for the treatment of hypertension - Google Patents

Cis and trans stilbenes and their compositions for the treatment of hypertension

Info

Publication number
AU7637591A
AU7637591A AU76375/91A AU7637591A AU7637591A AU 7637591 A AU7637591 A AU 7637591A AU 76375/91 A AU76375/91 A AU 76375/91A AU 7637591 A AU7637591 A AU 7637591A AU 7637591 A AU7637591 A AU 7637591A
Authority
AU
Australia
Prior art keywords
hypertension
compositions
cis
treatment
stilbenes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU76375/91A
Inventor
John Robert Carson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Janssen Pharmaceuticals Inc
Original Assignee
McNeilab Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by McNeilab Inc filed Critical McNeilab Inc
Publication of AU7637591A publication Critical patent/AU7637591A/en
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/20—Unsaturated compounds containing keto groups bound to acyclic carbon atoms
    • C07C49/213—Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing six-membered aromatic rings
    • C07C49/217—Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing six-membered aromatic rings having unsaturation outside the aromatic rings
    • C07C49/223—Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing six-membered aromatic rings having unsaturation outside the aromatic rings polycyclic

Abstract

Stilbenes of the formula (I): <CHEM> wherein Y, m, R<1>, R<2>, q, Alk, R<3>, n and R<4> are as defined herein and Ar<1> and Ar<2> are aromatic, including the salts and ammonium derivatives of formula (I), in treating angina, hypertension and cardiac arrhythmias. Pharmaceutical compositions, methods of use and synthesis and novel intermediates are also part of the invention.
AU76375/91A 1986-06-20 1991-05-03 Cis and trans stilbenes and their compositions for the treatment of hypertension Abandoned AU7637591A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US87662886A 1986-06-20 1986-06-20
US876628 1986-06-20

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
AU74534/87A Division AU7453487A (en) 1986-06-20 1987-06-19 Cis and trans stilbenes

Publications (1)

Publication Number Publication Date
AU7637591A true AU7637591A (en) 1991-08-08

Family

ID=25368200

Family Applications (2)

Application Number Title Priority Date Filing Date
AU74534/87A Abandoned AU7453487A (en) 1986-06-20 1987-06-19 Cis and trans stilbenes
AU76375/91A Abandoned AU7637591A (en) 1986-06-20 1991-05-03 Cis and trans stilbenes and their compositions for the treatment of hypertension

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AU74534/87A Abandoned AU7453487A (en) 1986-06-20 1987-06-19 Cis and trans stilbenes

Country Status (9)

Country Link
EP (1) EP0250254B1 (en)
JP (1) JPS6322547A (en)
AT (1) ATE64591T1 (en)
AU (2) AU7453487A (en)
DE (1) DE3770878D1 (en)
DK (1) DK315587A (en)
ES (1) ES2025164B3 (en)
GR (1) GR3002168T3 (en)
ZA (1) ZA874448B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4772755A (en) * 1987-03-19 1988-09-20 Mcneilab, Inc. 1,2-1,4 addition reaction sequence leading to disubstituted acelylenes

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3719712A (en) * 1969-09-29 1973-03-06 Merck & Co Inc 2-phenylethynyl-benzyl-amines
NO135027C (en) * 1971-01-15 1977-01-26 Merck & Co Inc
CA1292747C (en) * 1983-11-21 1991-12-03 John Robert Carson Aralykyl (arylethynyl) aralkyl amines and their use as vasodilators and antihypertensives

Also Published As

Publication number Publication date
ES2025164B3 (en) 1992-03-16
EP0250254B1 (en) 1991-06-19
ZA874448B (en) 1989-02-22
DK315587D0 (en) 1987-06-19
ATE64591T1 (en) 1991-07-15
DE3770878D1 (en) 1991-07-25
EP0250254A1 (en) 1987-12-23
AU7453487A (en) 1987-12-24
GR3002168T3 (en) 1992-12-30
JPS6322547A (en) 1988-01-30
DK315587A (en) 1987-12-21

Similar Documents

Publication Publication Date Title
AU1497692A (en) Sulfonamides and their medical use
CA2017066A1 (en) Azaindenes
AU4224993A (en) Substituted benzylamino nitrogen containing non-aromatic heterocycles
AU2843689A (en) 2-(2-hydroxy-3-phenoxypropylamino) ethylphenoxymethyl compounds
EP0807633A3 (en) Novel 2,3-disubstituted-(5,6)- heteroarylfused-pyrimidine-4-ones
ES2099206T3 (en) BENZENE DERIVATIVES THAT FAVOR THE PRODUCTION OF THE GROWTH FACTOR OF HUMAN NERVES.
ES2038668T3 (en) VASODILATORS OF BENZOTIAZEPINE WITH ARALQUILICA SUBSTITUTION.
HUT37912A (en) Process for preparing aralkyl-/aryl-ethynyl/-aralkyl-amines and for preparing pharmaceutical preparations containing them
AU7637591A (en) Cis and trans stilbenes and their compositions for the treatment of hypertension
ES533657A0 (en) A PROCEDURE FOR THE PREPARATION OF NEW DERIVATIVES OF PYRROLLO- (2,1-A) ISOQUILONINA.
GR3031908T3 (en) Novel 17-hydroxyiminoalkyl and 17-hydroxyiminomethylalkenyl cyclopentaneperhydrophenanthrene derivatives active on the cardiovascular system, a process for their preparation and pharmaceutical compositions containing same
DE3781044D1 (en) PROPHYLACTIC AND HEALING COMPOSITION CONTAINING AN 8-CHLORBENZOTHIAZEPINE COMPOUND AND ITS USE.