AU7519500A - Pharmaceutical gel containing active substances - Google Patents

Pharmaceutical gel containing active substances

Info

Publication number
AU7519500A
AU7519500A AU75195/00A AU7519500A AU7519500A AU 7519500 A AU7519500 A AU 7519500A AU 75195/00 A AU75195/00 A AU 75195/00A AU 7519500 A AU7519500 A AU 7519500A AU 7519500 A AU7519500 A AU 7519500A
Authority
AU
Australia
Prior art keywords
alpha
tocopherol
gel
skin
active substances
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU75195/00A
Inventor
Cornelia Beier
Karin Klokkers
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hexal AG
Original Assignee
Hexal AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hexal AG filed Critical Hexal AG
Publication of AU7519500A publication Critical patent/AU7519500A/en
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A61K31/355—Tocopherols, e.g. vitamin E
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dermatology (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

The invention relates to a topically applied pharmaceutical gel which contains active substances and which has topical or systemic action, whereby the use of an otherwise common short-chain monovalent alcohol is forgone. In addition to having a very good activity, a formulation of this type can prevent skin irritations, skin damages or skin sensitivities. A particular embodiment of the invention depicts an emulsion gel for treating inflammatory skin diseases. This embodiment contains phospholipids and/or natural vitamin E and/or alpha -tocopherol and/or alpha -tocopherol derivatives, preferably alpha -tocopherol acetate as well as at least one corticosteroid, preferably prednicarbate. The gel is used to treat inflammatory skin diseases such as atopic dermatitis or neurodermatitis, psoriasis, acute and chronic eczema, burns and contact eczema. Another embodiment of the invention depicts an emulsion gel for systemically administering hormones containing phospholipids and/or alpha -tocopherol and/or alpha -tocopherol derivatives and at least one estrogen, preferably estradiol.
AU75195/00A 1999-09-23 2000-09-16 Pharmaceutical gel containing active substances Abandoned AU7519500A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19945522A DE19945522A1 (en) 1999-09-23 1999-09-23 Pharmaceutical gel containing active ingredients
DE19945522 1999-09-23
PCT/EP2000/009059 WO2001021153A2 (en) 1999-09-23 2000-09-16 Pharmaceutical gel containing active substances

Publications (1)

Publication Number Publication Date
AU7519500A true AU7519500A (en) 2001-04-24

Family

ID=7922969

Family Applications (1)

Application Number Title Priority Date Filing Date
AU75195/00A Abandoned AU7519500A (en) 1999-09-23 2000-09-16 Pharmaceutical gel containing active substances

Country Status (5)

Country Link
EP (1) EP1214055B1 (en)
AT (1) ATE294570T1 (en)
AU (1) AU7519500A (en)
DE (2) DE19945522A1 (en)
WO (1) WO2001021153A2 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7025966B2 (en) 2003-12-05 2006-04-11 Mary Kay Inc. Compositions of marine botanicals to provide nutrition to aging and environmentally damaged skin
WO2006105805A1 (en) * 2005-04-07 2006-10-12 Miso Sabovic Delaying skin ageing and disorders caused by skin ageing by suppression of angiotensin ii production or activity
CN101232869B (en) * 2005-06-16 2016-03-02 沃纳奇尔科特有限责任公司 The gel combination of topical
US10016442B2 (en) 2005-06-16 2018-07-10 Allergan Pharmaceuticals International Limited Estrogen compositions for vaginal administration
FR2901704A1 (en) * 2006-05-31 2007-12-07 Galderma Res & Dev S N C Snc USE OF AZASETRON FOR THE TREATMENT OF ROSACEA AND PHARMACEUTICAL COMPOSITIONS
CA2784827C (en) 2009-12-16 2018-10-23 Shasun Pharmaceuticals Limited Composition of dexibuprofen transdermal hydrogel
DE102010013081A1 (en) * 2010-03-26 2011-09-29 B. Braun Melsungen Ag Antimicrobial oil in water emulsion
DE102012007212A1 (en) 2012-04-11 2013-10-17 Merz Pharma Gmbh & Co. Kgaa Preparation for topical application to mucous membranes with polyhexanide as active ingredient
DE202014100305U1 (en) * 2013-12-23 2015-04-20 Nawa-Heilmittel Gmbh Transparent gel

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU203476B (en) * 1988-06-16 1991-08-28 Chinoin Gyogyszer Es Vegyeszet Process for producing stabile, aquous suspoemulsion containing primicin and suspoemulsionic pharmaceutical composition containing them as active component
MY105521A (en) * 1989-04-17 1994-10-31 Healthpoint Ltd Moisturizing vehicle for topical application of vitamin a acid.
DE4313402A1 (en) * 1993-04-23 1994-10-27 Hexal Pharma Gmbh Transdermal preparation of active compound
US5654337A (en) * 1995-03-24 1997-08-05 II William Scott Snyder Topical formulation for local delivery of a pharmaceutically active agent
JP2002540080A (en) * 1999-03-19 2002-11-26 パーカー ヒューズ インスティテュート Gel microemulsion formulation

Also Published As

Publication number Publication date
ATE294570T1 (en) 2005-05-15
EP1214055B1 (en) 2005-05-04
DE50010243D1 (en) 2005-06-09
EP1214055A2 (en) 2002-06-19
WO2001021153A3 (en) 2001-10-11
DE19945522A1 (en) 2001-04-05
WO2001021153A2 (en) 2001-03-29

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Legal Events

Date Code Title Description
MK6 Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase