AU7384291A - Preparation of optically active norbornane amine derivatives - Google Patents
Preparation of optically active norbornane amine derivativesInfo
- Publication number
- AU7384291A AU7384291A AU73842/91A AU7384291A AU7384291A AU 7384291 A AU7384291 A AU 7384291A AU 73842/91 A AU73842/91 A AU 73842/91A AU 7384291 A AU7384291 A AU 7384291A AU 7384291 A AU7384291 A AU 7384291A
- Authority
- AU
- Australia
- Prior art keywords
- preparation
- optically active
- norbornane
- lower alkyl
- amine derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/33—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings
- C07C211/39—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of an unsaturated carbon skeleton
- C07C211/41—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of an unsaturated carbon skeleton containing condensed ring systems
- C07C211/42—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of an unsaturated carbon skeleton containing condensed ring systems with six-membered aromatic rings being part of the condensed ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
- C07C209/82—Purification; Separation; Stabilisation; Use of additives
- C07C209/86—Separation
- C07C209/88—Separation of optical isomers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/33—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings
- C07C211/39—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of an unsaturated carbon skeleton
- C07C211/41—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of an unsaturated carbon skeleton containing condensed ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
- C07C311/20—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/36—Systems containing two condensed rings the rings having more than two atoms in common
- C07C2602/42—Systems containing two condensed rings the rings having more than two atoms in common the bicyclo ring system containing seven carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
A process for preparing an optically active compound useful as an intermediate for the preparation of clinically important thromboxane A2 (TXA2) receptor antagonist by resolving a racemic mixture of norbornyl amine of formula (I): <CHEM> wherein R<1> is hydrogen, lower alkyl or lower alkyl substituted with -COOR<3> at the terminal methyl residue; R<3> is lower alkyl; Y is oxygen or methylene; m and n are independently 0 or 1 with a chiral acid.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2085443A JP2891740B2 (en) | 1990-03-30 | 1990-03-30 | Method for producing optically active norbornane-based amine derivative |
JP2-85443 | 1990-03-30 |
Publications (2)
Publication Number | Publication Date |
---|---|
AU7384291A true AU7384291A (en) | 1991-10-03 |
AU632676B2 AU632676B2 (en) | 1993-01-07 |
Family
ID=13859017
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU73842/91A Ceased AU632676B2 (en) | 1990-03-30 | 1991-03-27 | Preparation of optically active norbornane amine derivatives |
Country Status (12)
Country | Link |
---|---|
EP (1) | EP0452000B1 (en) |
JP (1) | JP2891740B2 (en) |
KR (1) | KR0183988B1 (en) |
AT (1) | ATE129231T1 (en) |
AU (1) | AU632676B2 (en) |
CA (1) | CA2039401C (en) |
DE (1) | DE69113851T2 (en) |
DK (1) | DK0452000T3 (en) |
ES (1) | ES2080891T3 (en) |
GR (1) | GR3017815T3 (en) |
HU (1) | HU215926B (en) |
TW (1) | TW197412B (en) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2055572A1 (en) * | 1990-12-18 | 1992-06-19 | David Kronenthal | Processes and intermediates for thromboxane receptor antagonists |
US5684159A (en) * | 1995-05-30 | 1997-11-04 | Rhone-Poulenc Rorer S.A. | L-tartaric acid salt of a (1R) diastereomer of a 2-azadihydroxybicyclo 2.2.1!heptane compound and the preparation of 2-azabicyclo 2.2.1!heptane compounds |
KR101299720B1 (en) * | 2006-08-16 | 2013-08-28 | 주식회사 엘지생명과학 | A novel process for preparing 3-amino-5-fluoro-4-dialkoxypetanoic acid ester |
CN110467539B (en) * | 2019-08-30 | 2023-01-06 | 浙江普洛家园药业有限公司 | Resolution method of 2,6-dimethyl tyrosine ester and application thereof |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CH547771A (en) * | 1970-07-17 | 1974-04-11 | Hoffmann La Roche | PROCESS FOR THE MANUFACTURING OF BORNANAMINE DERIVATIVES. |
CA1278577C (en) * | 1985-11-18 | 1991-01-02 | Tatsuo Tsuri | Bicyclic sulfonamide derivatives |
JP2561466B2 (en) * | 1987-05-18 | 1996-12-11 | 塩野義製薬株式会社 | Phenylsulfonylaminoalkylbicycloheptyl heptenoic acid derivative |
-
1990
- 1990-03-30 JP JP2085443A patent/JP2891740B2/en not_active Expired - Fee Related
-
1991
- 1991-03-23 TW TW080102289A patent/TW197412B/zh active
- 1991-03-27 AU AU73842/91A patent/AU632676B2/en not_active Ceased
- 1991-03-28 AT AT91302753T patent/ATE129231T1/en not_active IP Right Cessation
- 1991-03-28 EP EP91302753A patent/EP0452000B1/en not_active Expired - Lifetime
- 1991-03-28 DK DK91302753.8T patent/DK0452000T3/en active
- 1991-03-28 CA CA002039401A patent/CA2039401C/en not_active Expired - Fee Related
- 1991-03-28 DE DE69113851T patent/DE69113851T2/en not_active Expired - Fee Related
- 1991-03-28 ES ES91302753T patent/ES2080891T3/en not_active Expired - Lifetime
- 1991-03-29 HU HU911056A patent/HU215926B/en not_active IP Right Cessation
- 1991-03-30 KR KR1019910005146A patent/KR0183988B1/en not_active IP Right Cessation
-
1995
- 1995-10-19 GR GR950402662T patent/GR3017815T3/en unknown
Also Published As
Publication number | Publication date |
---|---|
AU632676B2 (en) | 1993-01-07 |
CA2039401C (en) | 2003-02-25 |
HUT60992A (en) | 1992-11-30 |
EP0452000B1 (en) | 1995-10-18 |
CA2039401A1 (en) | 1991-10-01 |
DK0452000T3 (en) | 1995-11-27 |
ES2080891T3 (en) | 1996-02-16 |
GR3017815T3 (en) | 1996-01-31 |
JP2891740B2 (en) | 1999-05-17 |
JPH03284657A (en) | 1991-12-16 |
DE69113851T2 (en) | 1996-05-15 |
HU911056D0 (en) | 1991-10-28 |
EP0452000A3 (en) | 1992-08-26 |
HU215926B (en) | 1999-03-29 |
ATE129231T1 (en) | 1995-11-15 |
EP0452000A2 (en) | 1991-10-16 |
KR0183988B1 (en) | 1999-05-15 |
KR910016685A (en) | 1991-11-05 |
DE69113851D1 (en) | 1995-11-23 |
TW197412B (en) | 1993-01-01 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MK14 | Patent ceased section 143(a) (annual fees not paid) or expired |