AU7335796A - Novel peptide - Google Patents
Novel peptideInfo
- Publication number
- AU7335796A AU7335796A AU73357/96A AU7335796A AU7335796A AU 7335796 A AU7335796 A AU 7335796A AU 73357/96 A AU73357/96 A AU 73357/96A AU 7335796 A AU7335796 A AU 7335796A AU 7335796 A AU7335796 A AU 7335796A
- Authority
- AU
- Australia
- Prior art keywords
- peptide
- amino acid
- smooth muscle
- acid residues
- acid sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 8
- 125000000539 amino acid group Chemical group 0.000 abstract 3
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 2
- 210000000329 smooth muscle myocyte Anatomy 0.000 abstract 2
- 206010003210 Arteriosclerosis Diseases 0.000 abstract 1
- 208000031481 Pathologic Constriction Diseases 0.000 abstract 1
- 206010039491 Sarcoma Diseases 0.000 abstract 1
- 238000002399 angioplasty Methods 0.000 abstract 1
- 208000011775 arteriosclerosis disease Diseases 0.000 abstract 1
- 210000004204 blood vessel Anatomy 0.000 abstract 1
- 210000004899 c-terminal region Anatomy 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000002209 hydrophobic effect Effects 0.000 abstract 1
- 230000001575 pathological effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 208000037803 restenosis Diseases 0.000 abstract 1
- 210000002460 smooth muscle Anatomy 0.000 abstract 1
- 208000037804 stenosis Diseases 0.000 abstract 1
- 230000036262 stenosis Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/36—Blood coagulation or fibrinolysis factors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
- C07K14/8114—Kunitz type inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Cardiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
A peptide comprising a peptide (A) of an amino acid sequence being abundant in basic amino acid residues and a peptide (B) of an amino acid sequence comprising at least two consecutive, hydrophobic amino acid residues wherein the peptide (B) is linked to the C-terminal of the peptide (A) directly or via several amino acid residues. The novel peptide of the present invention has the activity to inhibit growth of smooth muscle cells and a pharmaceutical composition comprising said peptide is useful for preventing or treating pathological conditions associated with growth of smooth muscle cells such as arteriosclerosis, restenosis after angioplasty, luminal stenosis after grafting blood vessel and smooth muscle sarcoma.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP30079295 | 1995-10-24 | ||
JP7-300792 | 1995-10-24 | ||
PCT/JP1996/003080 WO1997015598A1 (en) | 1995-10-24 | 1996-10-23 | Novel peptide |
Publications (2)
Publication Number | Publication Date |
---|---|
AU7335796A true AU7335796A (en) | 1997-05-15 |
AU719366B2 AU719366B2 (en) | 2000-05-04 |
Family
ID=17889159
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU73357/96A Ceased AU719366B2 (en) | 1995-10-24 | 1996-10-23 | Novel peptide |
Country Status (9)
Country | Link |
---|---|
US (1) | US6191113B1 (en) |
EP (1) | EP0867450B1 (en) |
JP (1) | JP3930050B2 (en) |
KR (1) | KR100465222B1 (en) |
AT (1) | ATE273322T1 (en) |
AU (1) | AU719366B2 (en) |
CA (1) | CA2232240C (en) |
DE (1) | DE69633133T2 (en) |
WO (1) | WO1997015598A1 (en) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE371030T1 (en) * | 1996-02-23 | 2007-09-15 | Mochida Pharm Co Ltd | MELTRINE |
US5981471A (en) * | 1997-02-06 | 1999-11-09 | Entremed, Inc. | Compositions and methods for inhibiting cellular proliferation |
TWI257307B (en) * | 2000-07-12 | 2006-07-01 | Orthologic Corp | Pharmaceutical composition for cardiac tissue repair |
JP4213581B2 (en) | 2001-07-13 | 2009-01-21 | シーエムエス・ペプタイズ・パテント・ホールディング・カンパニー・リミテッド | Biologically active peptides |
WO2003060131A1 (en) * | 2002-01-09 | 2003-07-24 | Suntory Limited | SUGAR TRANSFERASE GnT-V HAVING ANGIOGENIC EFFECT |
AU2003256343B2 (en) * | 2002-07-02 | 2006-12-21 | Orthologic Corp. | Thrombin peptide derivatives |
TWI353252B (en) | 2004-04-28 | 2011-12-01 | Cms Peptides Patent Holding Company Ltd | Biologically active peptide vapeehptllteaplnpk der |
CN101501062B (en) | 2005-07-26 | 2012-07-18 | 康哲医药研究(深圳)有限公司 | Novel biologically active peptides and their new uses |
EP2063910A2 (en) * | 2006-09-22 | 2009-06-03 | Orthologic Corp. | Method of treating endothelial dysfunction |
US20110105400A1 (en) * | 2008-03-26 | 2011-05-05 | Orthologic Corp. | Methods for treating acute myocardial infarction |
US9228022B2 (en) | 2010-06-30 | 2016-01-05 | Novo Nordisk A/S | Antibodies that are capable of specifically binding tissue factor pathway inhibitor |
US9260518B2 (en) | 2010-06-30 | 2016-02-16 | Novo Nordisk A/S | Antibodies that are capable of specifically binding tissue factor pathway inhibitor |
PL236566B1 (en) | 2012-12-17 | 2021-01-25 | Univ Jagiellonski | Chemerin peptides, pharmaceutical compositions containing these peptides and use of these peptides for treating pathological of epithelia |
US20210054333A1 (en) * | 2018-03-15 | 2021-02-25 | Toray Industries, Inc. | Cell adhesive material |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5849536A (en) * | 1990-03-02 | 1998-12-15 | Bio-Technology General Corp. | Cloning and production of human von willebrand factor GPIb binding domain polypeptides and methods of using same |
US5254536A (en) * | 1992-01-10 | 1993-10-19 | The Du Pont Merck Pharmaceutical Company | Therapeutic utility of plasminogen activator inhibitor-1 to control bleeding |
WO1994013811A1 (en) * | 1992-12-04 | 1994-06-23 | N.V. Innogenetics S.A. | New polypeptides, nucleic acid sequences encoding them, and their use to prevent the adhesion of f107-fimbriated bacteria |
JP3428687B2 (en) | 1993-06-30 | 2003-07-22 | 財団法人化学及血清療法研究所 | Preparation of tissue factor coagulation inhibitor |
US5824644A (en) * | 1994-07-07 | 1998-10-20 | G. D. Searle & Co. | Method of attenuating arterial stenosis |
US5589359A (en) * | 1994-08-05 | 1996-12-31 | Chiron Corporation | Chimeric proteins |
JPH0859698A (en) * | 1994-08-15 | 1996-03-05 | Teijin Ltd | New peptide having blood coagulation regulating ability |
US5639726A (en) * | 1994-09-30 | 1997-06-17 | The Regents Of The University Of Michigan | Peptide mediated enhancement of thrombolysis methods and compositions |
JPH09124506A (en) * | 1995-08-29 | 1997-05-13 | Chemo Sero Therapeut Res Inst | Tissue factor pathway inhibitor-containing therapeutic agent for arteriosclerosis |
US5772629A (en) * | 1995-10-23 | 1998-06-30 | Localmed, Inc. | Localized intravascular delivery of TFPI for inhibition of restenosis in recanalized blood vessels |
US5981471A (en) * | 1997-02-06 | 1999-11-09 | Entremed, Inc. | Compositions and methods for inhibiting cellular proliferation |
-
1996
- 1996-10-23 AT AT96935411T patent/ATE273322T1/en not_active IP Right Cessation
- 1996-10-23 WO PCT/JP1996/003080 patent/WO1997015598A1/en active IP Right Grant
- 1996-10-23 AU AU73357/96A patent/AU719366B2/en not_active Ceased
- 1996-10-23 DE DE69633133T patent/DE69633133T2/en not_active Expired - Fee Related
- 1996-10-23 CA CA002232240A patent/CA2232240C/en not_active Expired - Fee Related
- 1996-10-23 EP EP96935411A patent/EP0867450B1/en not_active Expired - Lifetime
- 1996-10-23 KR KR10-1998-0702898A patent/KR100465222B1/en not_active IP Right Cessation
- 1996-10-23 JP JP51647497A patent/JP3930050B2/en not_active Expired - Fee Related
- 1996-10-23 US US09/051,986 patent/US6191113B1/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
DE69633133T2 (en) | 2005-07-28 |
ATE273322T1 (en) | 2004-08-15 |
WO1997015598A1 (en) | 1997-05-01 |
US6191113B1 (en) | 2001-02-20 |
AU719366B2 (en) | 2000-05-04 |
EP0867450A1 (en) | 1998-09-30 |
CA2232240A1 (en) | 1997-05-01 |
KR100465222B1 (en) | 2005-05-17 |
DE69633133D1 (en) | 2004-09-16 |
JP3930050B2 (en) | 2007-06-13 |
EP0867450B1 (en) | 2004-08-11 |
KR19990066965A (en) | 1999-08-16 |
EP0867450A4 (en) | 2000-01-19 |
CA2232240C (en) | 2007-01-16 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FGA | Letters patent sealed or granted (standard patent) |