AU7257391A - Recombinant thyrotropin receptor - Google Patents

Recombinant thyrotropin receptor

Info

Publication number
AU7257391A
AU7257391A AU72573/91A AU7257391A AU7257391A AU 7257391 A AU7257391 A AU 7257391A AU 72573/91 A AU72573/91 A AU 72573/91A AU 7257391 A AU7257391 A AU 7257391A AU 7257391 A AU7257391 A AU 7257391A
Authority
AU
Australia
Prior art keywords
thyrotropin receptor
recombinant
recombinant thyrotropin
receptor
thyrotropin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU72573/91A
Other languages
English (en)
Inventor
Basil Rapoport
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of AU7257391A publication Critical patent/AU7257391A/en
Abandoned legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72Receptors; Cell surface antigens; Cell surface determinants for hormones
    • C07K14/723G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH receptor
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/10Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
    • A61P5/12Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH for decreasing, blocking or antagonising the activity of the posterior pituitary hormones
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2869Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against hormone receptors
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/564Immunoassay; Biospecific binding assay; Materials therefor for pre-existing immune complex or autoimmune disease, i.e. systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, rheumatoid factors or complement components C1-C9
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • G01N33/76Human chorionic gonadotropin including luteinising hormone, follicle stimulating hormone, thyroid stimulating hormone or their receptors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/33Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Veterinary Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Rehabilitation Therapy (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Reproductive Health (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
AU72573/91A 1989-12-20 1990-12-19 Recombinant thyrotropin receptor Abandoned AU7257391A (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US45197389A 1989-12-20 1989-12-20
US451973 1989-12-20
US57501890A 1990-08-30 1990-08-30
US575018 1990-08-30

Publications (1)

Publication Number Publication Date
AU7257391A true AU7257391A (en) 1991-07-18

Family

ID=27036589

Family Applications (1)

Application Number Title Priority Date Filing Date
AU72573/91A Abandoned AU7257391A (en) 1989-12-20 1990-12-19 Recombinant thyrotropin receptor

Country Status (5)

Country Link
EP (1) EP0506890A4 (ja)
JP (1) JPH05504683A (ja)
AU (1) AU7257391A (ja)
IE (1) IE904641A1 (ja)
WO (1) WO1991009137A1 (ja)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU641209B2 (en) * 1989-12-14 1993-09-16 B.R.A.H.M.S. Diagnostica Gmbh Polypeptides having thyrotropin-receptor activity, nucleic acid sequences coding for such receptors and polypeptides, and applications of these polypeptides

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2180550T3 (es) * 1989-05-05 2003-02-16 Genentech Inc Moleculas receptoras de la hormona de glycoproteina.
US6261800B1 (en) 1989-05-05 2001-07-17 Genentech, Inc. Luteinizing hormone/choriogonadotropin (LH/CG) receptor
US5614363A (en) * 1990-01-25 1997-03-25 New England Medical Center Hospitals, Inc. TSH receptor
WO1991003483A1 (en) * 1989-09-08 1991-03-21 New England Medical Center Hospitals, Inc. Tsh receptor
EP0719858A3 (en) * 1994-12-27 1997-12-29 Tosoh Corporation Myeloma cell line expressing recombinant human thyroid stimulating hormone receptor
DE19645729C1 (de) * 1996-11-06 1998-06-04 Brahms Diagnostica Gmbh Rezeptorbindungsassay, für den Rezeptorbindungsassay geeigneter rekombinanter Fusionsrezeptor, Vektor zu dessen Herstellung sowie Reagenziensatz für die Durchführung des Rezeptorbindungsassays
DE19728991A1 (de) * 1996-11-06 1999-02-11 Brahms Diagnostica Gmbh Rezeptorbindungsassay, für den Rezeptorbindungsassay geeigneter rekombinanter Fusionsrezeptor, Vektor zu dessen Herstellung sowie Reagenziensatz für die Durchführung des Rezeptorbindungsassays
DE19651093C2 (de) * 1996-12-09 1999-06-10 Brahms Diagnostica Gmbh Rezeptorbindungsassay zum Nachweis von TSH-Rezeptor-Autoantikörpern sowie Reagenziensatz für die Durchführung eines solchen Rezeptorbindungsassays
US6686171B2 (en) * 1999-05-10 2004-02-03 Tropix, Inc. Competitive chemiluminescent assay for cyclic nucleotide monophosphates
ATE302415T1 (de) * 1999-10-12 2005-09-15 Ulrich Loos Verfahren zur bestimmung von autoantikörpern gegen den tsh-rezeptor
US6852546B1 (en) * 2000-03-30 2005-02-08 Diagnostic Hybrids, Inc. Diagnosis of autoimmune disease
US8293879B2 (en) 2000-03-30 2012-10-23 Diagnostic Hybrids, Inc. Methods of using chimeric receptors to identify autoimmune disease
EP2383290B1 (en) 2001-08-23 2019-05-08 Rsr Limited Epitope regions of a thyrotropin (tsh) receptor, uses thereof and antibodies thereto
JP5314234B2 (ja) 2002-11-29 2013-10-16 アールエスアール リミテッド チロトロピン受容体の結合対象及びその使用
CN102050875B (zh) * 2010-12-10 2013-05-29 天津市协和医药科技有限公司 一种促甲状腺素受体的提取及纯化方法
FR3126005A1 (fr) * 2021-08-04 2023-02-10 Upec Activateur pharmacologique et/ou génétique pour son utilisation pour préserver et régénérer la structure et la fonction musculaire en bloquant la sénescence
CN115925966A (zh) * 2021-09-22 2023-04-07 厦门英博迈生物科技有限公司 一种重组促甲状腺激素受体蛋白、制备方法及应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4472508A (en) * 1982-12-30 1984-09-18 The Beth Israel Hospital Association Test for detecting and measuring the graves' disease-specific immunoglobulins
US4818684A (en) * 1985-09-10 1989-04-04 The Trustees Of Columbia University In The City Of New York Auto-anti-idiotypic monoclonal antibodies to steroid receptors and uses thereof
ES2180550T3 (es) * 1989-05-05 2003-02-16 Genentech Inc Moleculas receptoras de la hormona de glycoproteina.
WO1991003483A1 (en) * 1989-09-08 1991-03-21 New England Medical Center Hospitals, Inc. Tsh receptor
ATE145240T1 (de) * 1989-12-14 1996-11-15 Brahms Diagnostica Gmbh Polypeptide mit thyrotropinrezeptor-aktivität, kodierende nukleinsäuresequenzen für solche rezeptoren und verwendung dieser polypeptide
WO1992008726A1 (en) * 1990-11-15 1992-05-29 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Rat thyrotropin receptor gene and uses thereof

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU641209B2 (en) * 1989-12-14 1993-09-16 B.R.A.H.M.S. Diagnostica Gmbh Polypeptides having thyrotropin-receptor activity, nucleic acid sequences coding for such receptors and polypeptides, and applications of these polypeptides

Also Published As

Publication number Publication date
IE904641A1 (en) 1991-07-17
EP0506890A1 (en) 1992-10-07
EP0506890A4 (en) 1993-06-30
JPH05504683A (ja) 1993-07-22
WO1991009137A1 (en) 1991-06-27

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