AU7169696A - 3-spirolactam, 3-spiroamino, 3-spirolactone and 3-spirobenzopyran piperidines and pyrrolidines promote release of growth hormone - Google Patents

3-spirolactam, 3-spiroamino, 3-spirolactone and 3-spirobenzopyran piperidines and pyrrolidines promote release of growth hormone

Info

Publication number
AU7169696A
AU7169696A AU71696/96A AU7169696A AU7169696A AU 7169696 A AU7169696 A AU 7169696A AU 71696/96 A AU71696/96 A AU 71696/96A AU 7169696 A AU7169696 A AU 7169696A AU 7169696 A AU7169696 A AU 7169696A
Authority
AU
Australia
Prior art keywords
spiroamino
spirolactam
spirobenzopyran
spirolactone
pyrrolidines
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU71696/96A
Inventor
Robert W. Marquis Jr.
John T. Olson
Arthur A. Patchett
Lihu Yang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9603485.5A external-priority patent/GB9603485D0/en
Priority claimed from GBGB9603919.3A external-priority patent/GB9603919D0/en
Priority claimed from GBGB9603918.5A external-priority patent/GB9603918D0/en
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of AU7169696A publication Critical patent/AU7169696A/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06104—Dipeptides with the first amino acid being acidic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C07K5/06165—Dipeptides with the first amino acid being heterocyclic and Pro-amino acid; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0806—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
AU71696/96A 1995-09-26 1996-09-23 3-spirolactam, 3-spiroamino, 3-spirolactone and 3-spirobenzopyran piperidines and pyrrolidines promote release of growth hormone Abandoned AU7169696A (en)

Applications Claiming Priority (13)

Application Number Priority Date Filing Date Title
US433195P 1995-09-26 1995-09-26
US433395P 1995-09-26 1995-09-26
US433095P 1995-09-26 1995-09-26
US004330 1995-09-26
US004331 1995-09-26
US004333 1995-09-26
GBGB9603485.5A GB9603485D0 (en) 1996-02-20 1996-02-20 3-spirolactone piperidines and pyrrolidines promote release of growth hormone
GB9603485 1996-02-20
GBGB9603919.3A GB9603919D0 (en) 1996-02-23 1996-02-23 3-Spirobenzopyran piperidines and pyrrolidines promote release of growth hormone
GB9603919 1996-02-23
GBGB9603918.5A GB9603918D0 (en) 1996-02-23 1996-02-23 3-Spirolactam and 3-spiroamino piperidines and pyrrolidines promote release of growth hormone
GB9603918 1996-02-23
PCT/US1996/015518 WO1997011697A1 (en) 1995-09-26 1996-09-23 3-spirolactam, 3-spiroamino, 3-spirolactone and 3-spirobenzopyran piperidines and pyrrolidines promote release of growth hormone

Publications (1)

Publication Number Publication Date
AU7169696A true AU7169696A (en) 1997-04-17

Family

ID=27547257

Family Applications (1)

Application Number Title Priority Date Filing Date
AU71696/96A Abandoned AU7169696A (en) 1995-09-26 1996-09-23 3-spirolactam, 3-spiroamino, 3-spirolactone and 3-spirobenzopyran piperidines and pyrrolidines promote release of growth hormone

Country Status (2)

Country Link
AU (1) AU7169696A (en)
WO (1) WO1997011697A1 (en)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998016527A1 (en) * 1996-10-15 1998-04-23 Fujisawa Pharmaceutical Co., Ltd. Benzoxepine derivatives which promote release of growth hormone
JP2000514838A (en) * 1997-05-14 2000-11-07 藤沢薬品工業株式会社 Piperidino derivatives that stimulate growth hormone release.
ATE470671T1 (en) 1998-01-16 2010-06-15 Helsinn Therapeutics Us Inc COMPOUNDS HAVING GROWTH HORMONE RELEASING PROPERTIES
WO2000009537A2 (en) 1998-08-14 2000-02-24 Administrators Of The Tulane Educational Fund Compounds having growth hormone releasing activity
EP1930021A3 (en) 1999-02-18 2008-06-18 Kaken Pharmaceutical Co., Ltd. Novel amide derivatives as growth hormone secretagogues
RU2002104496A (en) 1999-07-21 2003-09-27 Астразенека Аб (Se) NEW COMPOUNDS
WO2001070337A1 (en) * 2000-03-23 2001-09-27 Merck & Co., Inc. Spiropiperidine derivatives as melanocortin receptor agonists
ES2333097T3 (en) 2000-05-31 2010-02-17 Raqualia Pharma Inc USE OF SECRETAGOGS OF GROWTH HORMONE TO STIMULATE GASTROINTESTINAL MOTILITY.
US7476653B2 (en) 2003-06-18 2009-01-13 Tranzyme Pharma, Inc. Macrocyclic modulators of the ghrelin receptor
CU23558A1 (en) 2006-02-28 2010-07-20 Ct Ingenieria Genetica Biotech COMPOUNDS ANALOG TO THE PEPTIDIC SECRETAGOGS OF THE GROWTH HORMONE
EP2644618B1 (en) 2007-02-09 2016-08-17 Ocera Therapeutics, Inc. tether intermediates for the synthesis of macrocyclic ghrelin receptor modulators
EP2020414A1 (en) * 2007-06-20 2009-02-04 Laboratorios del Dr. Esteve S.A. spiro[piperidine-4,4'-thieno[3,2-c]pyran] derivatives and related compounds as inhibitors of the sigma receptor for the treatment of psychosis
UY34094A (en) * 2011-05-27 2013-01-03 Novartis Ag DERIVATIVES OF PIPERIDINE 3-ESPIROCYCLIC AS AGRONISTS OF GHRELINE RECEPTORS
PE20142443A1 (en) 2012-05-03 2015-01-28 Novartis Ag SALT OF L-MALATE OF DERIVATIVES OF 2,7-DIAZA-SPIRO [4,5] DEC-7-ILO AND CRYSTALLINE FORMS OF THE SAME AS AGONISTS OF THE GRELIN RECEPTOR
US9119832B2 (en) 2014-02-05 2015-09-01 The Regents Of The University Of California Methods of treating mild brain injury
WO2017075535A1 (en) 2015-10-28 2017-05-04 Oxeia Biopharmaceuticals, Inc. Methods of treating neurodegenerative conditions

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3125580A (en) * 1964-03-17 x d diphenyl -
US5536716A (en) * 1992-12-11 1996-07-16 Merck & Co., Inc. Spiro piperidines and homologs which promote release of growth hormone

Also Published As

Publication number Publication date
WO1997011697A1 (en) 1997-04-03

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