AU7131698A - Polyamine transport inhibitors - Google Patents

Polyamine transport inhibitors

Info

Publication number
AU7131698A
AU7131698A AU71316/98A AU7131698A AU7131698A AU 7131698 A AU7131698 A AU 7131698A AU 71316/98 A AU71316/98 A AU 71316/98A AU 7131698 A AU7131698 A AU 7131698A AU 7131698 A AU7131698 A AU 7131698A
Authority
AU
Australia
Prior art keywords
transport inhibitors
polyamine transport
polyamine
inhibitors
transport
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU71316/98A
Inventor
Marie Audette
Rene Charest-Gaudrealt
Richard Poulin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Universite Laval
Ilex Oncology Inc
Original Assignee
Universite Laval
Ilex Oncology Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Universite Laval, Ilex Oncology Inc filed Critical Universite Laval
Publication of AU7131698A publication Critical patent/AU7131698A/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/02—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C211/14—Amines containing amino groups bound to at least two aminoalkyl groups, e.g. diethylenetriamines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
    • C07C211/27—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring having amino groups linked to the six-membered aromatic ring by saturated carbon chains
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C237/10—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by nitrogen atoms not being part of nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/39—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
    • C07C323/40—Y being a hydrogen or a carbon atom
    • C07C323/41—Y being a hydrogen or an acyclic carbon atom
AU71316/98A 1998-04-21 1998-04-21 Polyamine transport inhibitors Abandoned AU7131698A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US1998/007806 WO1999054283A1 (en) 1998-04-21 1998-04-21 Polyamine transport inhibitors

Publications (1)

Publication Number Publication Date
AU7131698A true AU7131698A (en) 1999-11-08

Family

ID=22266863

Family Applications (1)

Application Number Title Priority Date Filing Date
AU71316/98A Abandoned AU7131698A (en) 1998-04-21 1998-04-21 Polyamine transport inhibitors

Country Status (4)

Country Link
EP (1) EP1003715A1 (en)
AU (1) AU7131698A (en)
CA (1) CA2304557C (en)
WO (1) WO1999054283A1 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6646149B1 (en) 1997-07-15 2003-11-11 Nicolaas M. J. Vermeulin Polyamine analogues as therapeutic and diagnostic agents
US6794545B1 (en) 1999-04-30 2004-09-21 Slil Biomedical Corporation Conformationally restricted polyamine analogs as disease therapies
USRE43327E1 (en) 2001-01-08 2012-04-24 Aminex Therapeutics, Inc. Hydrophobic polyamine analogs and methods for their use
MXPA04005509A (en) 2001-12-07 2004-12-06 Slil Biomedical Corp Cycloalkyl substituted polyamines for cancer therapy and methods of synthesis therefor.
CN102659605B (en) * 2012-05-08 2013-11-13 天津市普莱克医药科技有限公司 Synthesizing method of spermidine
KR102454783B1 (en) 2016-03-25 2022-10-13 아미넥스 테라퓨틱스, 인크. bioavailable polyamines
TW202110431A (en) 2019-05-17 2021-03-16 美商癌症預防製藥股份有限公司 Methods for treating familial adenomatous polyposis
EP4221698A1 (en) 2020-09-30 2023-08-09 Aminex Therapeutics, Inc. Combination drug substance of polyamine transport inhibitor and dfmo

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5242947A (en) * 1988-02-10 1993-09-07 New York University Use of polyamines as ionic-channel regulating agents
US5456908A (en) * 1994-03-01 1995-10-10 The University Of Kentucky Research Foundation Polyamine-polyamine and polyamine-protein transport inhibitor conjugates and their use as pharmaceuticals and in research relating to polyamine transport
US6083496A (en) * 1996-10-22 2000-07-04 Universite Laval Polyamine transport inhibitors

Also Published As

Publication number Publication date
WO1999054283A1 (en) 1999-10-28
EP1003715A1 (en) 2000-05-31
CA2304557A1 (en) 1999-10-28
CA2304557C (en) 2008-12-30

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Legal Events

Date Code Title Description
MK6 Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase