AU699199B2 - The use of dimeticone for the local antibacterial therapy and/or the prevention and therapy of helicobacter pylori (HP) associated syndromes and infectious diseases - Google Patents
The use of dimeticone for the local antibacterial therapy and/or the prevention and therapy of helicobacter pylori (HP) associated syndromes and infectious diseasesInfo
- Publication number
- AU699199B2 AU699199B2 AU20713/95A AU2071395A AU699199B2 AU 699199 B2 AU699199 B2 AU 699199B2 AU 20713/95 A AU20713/95 A AU 20713/95A AU 2071395 A AU2071395 A AU 2071395A AU 699199 B2 AU699199 B2 AU 699199B2
- Authority
- AU
- Australia
- Prior art keywords
- therapy
- dimeticone
- helicobacter pylori
- prevention
- infectious diseases
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/80—Polymers containing hetero atoms not provided for in groups A61K31/755 - A61K31/795
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Inorganic Chemistry (AREA)
- Communicable Diseases (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Description
The Use of Di eticone for the Local Antibacterial Therapy and/or the Prevention and Therapy of Helicobacter Pylori
(Hp) Associated Syndromes and Infectious Diseases
TECHNICAL FIELD OF THE INVENTION
The invention relates to the use of dimethylpolysiloxane (dimeticone) for the local antibacterial therapy and the prevention and treatment of syndromes and infections associated with Helicobacter pylori (Hp) .
BACKGROUND OF THE INVENTION
Commercial dimeticone-containing products such as for instance sab simplex **R* and LefaxftΛ (see the Rote Liste 1993) are used to treat flatulence and to prepare patients for sonography.
WO 90/07930 discloses the use of dimethylpolysiloxane, in particular in conjunction with silica gel in the treatment of diseases of the esophagus, the stomach and the duodenum, such as esophagitis, ulcera (ventriculi and duodeni) and gaεtrites. Said document describes the capability of dimeticone to form and maintain a protective film in the
esophagus, the stomach and the duodenum after oral administration.
In recent years, it has become known that in some forms of chronic gastritis and in the development of ulcera (ulcus ventriculi and duodeni) , the infection of the gastro¬ intestinal (GI) tract with the gram negative pathogen Hp is a pathogenetic factor, and its relationship to the genesis of gastric carcinoma is being increasingly discussed.
Although it has been known among pathologists since the close of the 19th century that spiral bacteria are present in the stomach mucosa, it was not until 1983 that Hp was cultured from bioptic material of the antrum mucosa of patients afflicted with peptic ulcera and gastritis. (Marshall, B.J.: Unidentified curved bacilli on gastric epithelium in active chronic gastritis. Lancet I (1983), 1273-1275) .
Hp is acid-instable and sensitive to competition from other bacteria. Hence, the pathogen can only grow in a particular ecological niche. It finds this niche directly underneath the protective mucosa layer on the epithelium of the antrum and the body mucosa, but also on gastric metaplasies of the duodenal mucosa.
The route of Hp infection has not, so far, been elucidated. The infection was thought likely to be passed on orally from man to man, especially since it has not yet been possible to establish a pathogen reservoir of animal origin. The rate of infection depends on sanitation standards. In Western industrialized countries, the infection rate is about 1% per year. Hence, Hp infections are found in 60% of the persons aged 60.
The association of the Hp pathogen with different symptoms of the upper GI tract was systematically investigated in the past few years. The high prevalence of Hp infection in a population not afflicted with ulcus initially led to the assumption that Hp is a harmless saprophyte. Nowadays it is considered an established fact that the pathogen causes the B-type gastritis in the mucosa of the stomach. (Dixon, M.F.: Helicobacter pylori and peptic ulceration: Histopathological aspects. J. Gastroenterol. Hepatol. 6 (1991), 125-130).
The B-type gastritis is closely related to Hp infection which is detected in almost 100% of these patients.
The B-type gastritis is almost always present in patients suffering from ulcus duodeni, although the pathogenetic relationship is still unclear.
Experiences made in many years with acid blockers not possessing an antibacterial effect against Hp, have shown that ulcera can be cured even in cases of persistent Hp growth. About 10% of the patients cured from Hp by an antibacterial therapy, show an ulcus relapse within a year. Admittedly, these patients, as a rule, also suffer from an Hp re-infection. It must remain an open question why the relapse of the Hp infection in these patients is sufficient to cause an ulcus relapse within a year, when 40% of the population not afflicted with ulcera are Hp positive.
Ulcus ventriculi is also considered to be associated with Hp. In this case, the correlation with the Hp infection is not as close, as only 70-80% of the patients with gastric ulcera are Hp positive (Marshall, B.J. , loc. cit.).
SUMMARY OF THE INVENTION
Surprisingly, dimeticone has been found to be effective in the local antibacterial therapy of Hp infections and the prevention and treatment of Hp associated diseases, as it reduces Hp growth.
Therefore, the invention relates to the use of dimeticone for the local antibacterial therapy and the prevention and treatment of Hp associated diseases, in particular the prevention and treatment of gastritis, ulcus ventriculi, ulcus duodeni and gastric carcinoma.
In a randomized clinical comparative test, dimeticone was found to significantly reduce the growth of Hp in test persons with diagnosed ulcus ventriculi, when it was administered in a dose of 80 mg four times a day over 4 weeks. A similar result was not achieved with ranitidine administered in a dose of 300 mg for 4 weeks in the evening.
In a gastroscopic investigation of the stomach, the Hp growth was examined by an additional biopsy of the antrum mucosa. The results of this study are summarized in the following table.
T A B L E
Helicobacter Dimeticone (N = 27) Ranitidine (N = 30) pylori τo Tl τo Tl not present 2/ 9.5% 11/52.4% 2/13.6% 4/18.2% little 9/42.9% 5/23.8% 9/40.9% 13/59.1% medium 8/38.1% 5/23.8% 6/27.3% 4/18.2% much 2/ 9.5% 0/ 0.0% 4/18.2% 1/ 4.5%
T0 = without treatment
Tη_ = after a 4-week treatment
The foregoing data clearly show that the administration of dimeticone leads to a significant reduction of the Hp growth. In 52.4% of the patients treated with dimeticone, the pathogen could no longer be detected after a 4 week treatment.
According to the invention, dimeticone may be used either alone or in combination with other active ingredients, such as antibiotics, e.g. a oxicillin, tetracycline, clathromycin or metronidazole and/or proton-pump-inhibitors, H2-blockers, antacids or antitumor agents.
While we have described an embodiment of this invention, it is apparent that our embodiment may be altered to provide other embodiments which utilize the method of this invention. Therefore, it will be appreciated that the scope of this invention is to be defined by the appended claims, rather than by the specific embodiment which has been presented by way of example.
Claims (6)
1. The use of dimeticone for preparing a pharmaceutical composition for the local antibacterial therapy of Helicobacter pylori infections.
2. The use according to claim 1 for preventing and treating diseases associated with Helicobacter pylori.
3. The use according to claim 1 for preventing and treating chronic gastritis.
4. The use according to claim 1 for preventing and treating ulcus ventriculi.
5. The use according to claim 1 for preventing and treating ulcus duodeni.
6. The use according to claim 1 for preventing gastric carcinoma.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DEP4409357 | 1994-03-18 | ||
DE4409357A DE4409357C2 (en) | 1994-03-18 | 1994-03-18 | Use of Dimeticon to eradicate Heliobacter pylori |
PCT/EP1995/000972 WO1995025525A1 (en) | 1994-03-18 | 1995-03-15 | The use of dimeticone for the local antibacterial therapy and/or the prevention and therapy of helicobacter pylori (hp) associated syndromes and infectious diseases |
Publications (2)
Publication Number | Publication Date |
---|---|
AU2071395A AU2071395A (en) | 1995-10-09 |
AU699199B2 true AU699199B2 (en) | 1998-11-26 |
Family
ID=6513210
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU20713/95A Ceased AU699199B2 (en) | 1994-03-18 | 1995-03-15 | The use of dimeticone for the local antibacterial therapy and/or the prevention and therapy of helicobacter pylori (HP) associated syndromes and infectious diseases |
Country Status (14)
Country | Link |
---|---|
EP (1) | EP0804242A1 (en) |
JP (1) | JPH09510466A (en) |
CN (1) | CN1244129A (en) |
AU (1) | AU699199B2 (en) |
CA (1) | CA2185882A1 (en) |
CZ (1) | CZ300796A3 (en) |
DE (1) | DE4409357C2 (en) |
FI (1) | FI963682A (en) |
HU (1) | HU215595B (en) |
NO (1) | NO963893L (en) |
NZ (1) | NZ282805A (en) |
PL (1) | PL316307A1 (en) |
SK (1) | SK132496A3 (en) |
WO (1) | WO1995025545A1 (en) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6100245A (en) * | 1999-09-07 | 2000-08-08 | Mcneil-Ppc, Inc. | Use of simethicone to treat ulcerative colitis |
BR0318319A (en) * | 2003-05-25 | 2006-07-18 | Yuwan Wang | preparation methods and formulations / compositions sustained by the use of dimethicone as a vehicle |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5120533A (en) * | 1989-01-19 | 1992-06-09 | Steigerwald Arzneimittelwerk Gmbh | Treatment of ulcers of the gastrointestinal tract using dimethylpolysiloxane |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR3848M (en) * | 1964-05-04 | 1966-01-17 | Robert Schapiro | Therapeutic associations for the treatment of numerous organic or functional digestive disorders. |
GB1357737A (en) * | 1970-10-09 | 1974-06-26 | Arpic Sa | Sustained release pharmaceutical compositions |
NZ217844A (en) * | 1985-10-11 | 1989-10-27 | Sumitomo Pharma | A sustained release pharmaceutical composition containing silicone elastomer and an albumin |
US4837029A (en) * | 1987-04-06 | 1989-06-06 | Carolina Medical Products, Inc. | Low foaming, aqueously homogenizable rifampin composition |
US5446070A (en) * | 1991-02-27 | 1995-08-29 | Nover Pharmaceuticals, Inc. | Compositions and methods for topical administration of pharmaceutically active agents |
IE903302A1 (en) * | 1989-09-15 | 1991-04-10 | Pehrom Pharmaceutical Corp | Topical preparation for treatment of aphthous ulcers and¹other lesions |
NZ235876A (en) * | 1989-11-01 | 1992-06-25 | Mcneil Ppc Inc | Pharmaceutical compositions containing effective amount of antidiarrheal composition and antiflatulent effective amount of simethicone |
US5229137A (en) * | 1992-05-06 | 1993-07-20 | Brigham And Women's Hospital, Inc. | Methods and pharmaceutical compositions for treating episodic heartburn |
WO1994003209A1 (en) * | 1992-07-29 | 1994-02-17 | Merck & Co., Inc. | Dexibuprofen/antacid/simethicone combinations |
-
1994
- 1994-03-18 DE DE4409357A patent/DE4409357C2/en not_active Expired - Fee Related
-
1995
- 1995-03-15 CN CN95192553A patent/CN1244129A/en active Pending
- 1995-03-15 HU HU9602839A patent/HU215595B/en not_active IP Right Cessation
- 1995-03-15 JP JP7524363A patent/JPH09510466A/en not_active Withdrawn
- 1995-03-15 CZ CZ963007A patent/CZ300796A3/en unknown
- 1995-03-15 PL PL95316307A patent/PL316307A1/en unknown
- 1995-03-15 CA CA002185882A patent/CA2185882A1/en not_active Abandoned
- 1995-03-15 EP EP95913130A patent/EP0804242A1/en not_active Withdrawn
- 1995-03-15 NZ NZ282805A patent/NZ282805A/en not_active IP Right Cessation
- 1995-03-15 WO PCT/EP1995/000973 patent/WO1995025545A1/en not_active Application Discontinuation
- 1995-03-15 AU AU20713/95A patent/AU699199B2/en not_active Ceased
- 1995-03-15 SK SK1324-96A patent/SK132496A3/en unknown
-
1996
- 1996-09-17 NO NO963893A patent/NO963893L/en not_active Application Discontinuation
- 1996-09-17 FI FI963682A patent/FI963682A/en unknown
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5120533A (en) * | 1989-01-19 | 1992-06-09 | Steigerwald Arzneimittelwerk Gmbh | Treatment of ulcers of the gastrointestinal tract using dimethylpolysiloxane |
Also Published As
Publication number | Publication date |
---|---|
PL316307A1 (en) | 1997-01-06 |
HUT75711A (en) | 1997-05-28 |
NZ282805A (en) | 1998-02-26 |
CN1244129A (en) | 2000-02-09 |
EP0804242A1 (en) | 1997-11-05 |
NO963893D0 (en) | 1996-09-17 |
AU2071395A (en) | 1995-10-09 |
SK132496A3 (en) | 1997-06-04 |
NO963893L (en) | 1996-11-04 |
HU9602839D0 (en) | 1996-12-30 |
CZ300796A3 (en) | 1997-09-17 |
DE4409357C2 (en) | 1996-10-17 |
JPH09510466A (en) | 1997-10-21 |
HU215595B (en) | 1999-01-28 |
FI963682A0 (en) | 1996-09-17 |
CA2185882A1 (en) | 1995-09-28 |
DE4409357A1 (en) | 1995-09-21 |
WO1995025545A1 (en) | 1995-09-28 |
FI963682A (en) | 1996-11-13 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MK14 | Patent ceased section 143(a) (annual fees not paid) or expired |