AU6949098A - Improved methods of delivery using cationic lipids and helper lipids - Google Patents
Improved methods of delivery using cationic lipids and helper lipids Download PDFInfo
- Publication number
- AU6949098A AU6949098A AU69490/98A AU6949098A AU6949098A AU 6949098 A AU6949098 A AU 6949098A AU 69490/98 A AU69490/98 A AU 69490/98A AU 6949098 A AU6949098 A AU 6949098A AU 6949098 A AU6949098 A AU 6949098A
- Authority
- AU
- Australia
- Prior art keywords
- lipid
- dlpe
- cationic
- cationic lipid
- transfection complex
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/88—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using amphiphile liposome vesicle
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/543—Lipids, e.g. triglycerides; Polyamines, e.g. spermine or spermidine
- A61K47/544—Phospholipids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
- A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers with substantial amounts of non-phosphatidyl, i.e. non-acylglycerophosphate, surfactants as bilayer-forming substances, e.g. cationic lipids
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Zoology (AREA)
- Organic Chemistry (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Biochemistry (AREA)
- Dispersion Chemistry (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US83274997A | 1997-04-04 | 1997-04-04 | |
US08832749 | 1997-04-04 | ||
PCT/US1998/006606 WO1998044909A1 (fr) | 1997-04-04 | 1998-04-03 | Methodes ameliorees de transport utilisant des lipides cationiques et des lipides assistants |
Publications (1)
Publication Number | Publication Date |
---|---|
AU6949098A true AU6949098A (en) | 1998-10-30 |
Family
ID=25262531
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU69490/98A Abandoned AU6949098A (en) | 1997-04-04 | 1998-04-03 | Improved methods of delivery using cationic lipids and helper lipids |
Country Status (4)
Country | Link |
---|---|
EP (1) | EP0975332A1 (fr) |
AU (1) | AU6949098A (fr) |
CA (1) | CA2286739A1 (fr) |
WO (1) | WO1998044909A1 (fr) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AUPQ259399A0 (en) | 1999-09-01 | 1999-09-23 | Lustre Investments Pte Ltd | Therapeutic agents |
DE10213304A1 (de) * | 2001-05-10 | 2002-11-14 | Kuhs Kosmetik Gmbh & Co Kg | Pharmazeutische Zusammensetzung |
AU2005237764B2 (en) | 2004-05-05 | 2011-11-24 | Silence Therapeutics Gmbh | Lipids, lipid complexes and use thereof |
US8852472B2 (en) | 2004-12-27 | 2014-10-07 | Silence Therapeutics Gmbh | Coated lipid complexes and their use |
RU2553561C2 (ru) | 2006-07-21 | 2015-06-20 | Сайленс Терапьютикс Аг | Средства ингибирования экспрессии протеинкиназы 3 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5279833A (en) * | 1990-04-04 | 1994-01-18 | Yale University | Liposomal transfection of nucleic acids into animal cells |
JPH069365A (ja) * | 1992-06-25 | 1994-01-18 | Kanebo Ltd | 皮膚化粧料 |
US5650096A (en) * | 1994-12-09 | 1997-07-22 | Genzyme Corporation | Cationic amphiphiles for intracellular delivery of therapeutic molecules |
JPH09248182A (ja) * | 1996-03-15 | 1997-09-22 | Oyo Seikagaku Kenkyusho | プラスミド包埋多重膜リポソーム |
US5935936A (en) * | 1996-06-03 | 1999-08-10 | Genzyme Corporation | Compositions comprising cationic amphiphiles and co-lipids for intracellular delivery of therapeutic molecules |
-
1998
- 1998-04-03 AU AU69490/98A patent/AU6949098A/en not_active Abandoned
- 1998-04-03 EP EP98915263A patent/EP0975332A1/fr not_active Withdrawn
- 1998-04-03 WO PCT/US1998/006606 patent/WO1998044909A1/fr not_active Application Discontinuation
- 1998-04-03 CA CA002286739A patent/CA2286739A1/fr not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
EP0975332A1 (fr) | 2000-02-02 |
CA2286739A1 (fr) | 1998-10-15 |
WO1998044909A1 (fr) | 1998-10-15 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US6235310B1 (en) | Methods of delivery using cationic lipids and helper lipids | |
US6187760B1 (en) | Cationic phospholipids for transfection | |
US6008202A (en) | Stable lipid-comprising drug delivery complexes and methods for their production | |
US7993672B2 (en) | Stable lipid-comprising drug delivery complexes and methods for their production | |
Maurer et al. | Lipid-based systems for the intracellular delivery of genetic drugs | |
AU754563B2 (en) | Cationic lipid formulation delivering nucleic acid to peritoneal tumors | |
WO1997000965A2 (fr) | Vecteur lipidique servant a l'administration d'acides nucleiques | |
Singhal et al. | Gene transfer in mammalian cells using liposomes as carriers | |
Kim et al. | The effects of serum on the stability and the transfection activity of the cationic lipid emulsion with various oils | |
CA2348675A1 (fr) | Methodes de preparation de complexes de transfection polynucleotidiques | |
Rao et al. | Cell biological and biophysical aspects of lipid-mediated gene delivery | |
US5958894A (en) | Amphiphilic biguanide derivatives | |
JP2023538144A (ja) | 機能性のイオン化可能なリン脂質 | |
MacLachlan et al. | Diffusible‐PEG‐Lipid Stabilized Plasmid Lipid Particles | |
US6121457A (en) | Compositions and methods using novel substituted imidazolium lipids | |
AU6949098A (en) | Improved methods of delivery using cationic lipids and helper lipids | |
WO1998044909A9 (fr) | Methodes ameliorees de transport utilisant des lipides cationiques et des lipides assistants | |
WO1998033932A1 (fr) | Emulsions lipidiques utilisees comme agents de transfection genique et procede de preparation de telles emulsions | |
WO1999015206A1 (fr) | Procedes de preparation de complexes de transfection lipidiques/polynucleotidiques | |
Audrezet et al. | Novel cationic phosphonolipids agents for in vitro gene transfer to epithelial cell lines |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
MK5 | Application lapsed section 142(2)(e) - patent request and compl. specification not accepted |