AU6828500A - Method for detecting binding reactions through measurement of the relaxation of birefringence of magnetic nanoparticles - Google Patents

Method for detecting binding reactions through measurement of the relaxation of birefringence of magnetic nanoparticles

Info

Publication number
AU6828500A
AU6828500A AU68285/00A AU6828500A AU6828500A AU 6828500 A AU6828500 A AU 6828500A AU 68285/00 A AU68285/00 A AU 68285/00A AU 6828500 A AU6828500 A AU 6828500A AU 6828500 A AU6828500 A AU 6828500A
Authority
AU
Australia
Prior art keywords
birefringence
relaxation
measurement
magnetic nanoparticles
detecting binding
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU68285/00A
Inventor
Jean-Claude Bacri
Julien Browaeys
Roman Kotitz
Julia Lange
Regine Perzynski
Virginie Ponsinet
Thomas Rheinlander
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Institut fuer Diagnostikforschung GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19938384A external-priority patent/DE19938384A1/en
Application filed by Institut fuer Diagnostikforschung GmbH filed Critical Institut fuer Diagnostikforschung GmbH
Publication of AU6828500A publication Critical patent/AU6828500A/en
Abandoned legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/21—Polarisation-affecting properties
    • G01N21/23—Bi-refringence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54326—Magnetic particles
    • G01N33/54333—Modification of conditions of immunological binding reaction, e.g. use of more than one type of particle, use of chemical agents to improve binding, choice of incubation time or application of magnetic field during binding reaction

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • General Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Pathology (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analyzing Materials By The Use Of Magnetic Means (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
AU68285/00A 1999-08-06 2000-07-25 Method for detecting binding reactions through measurement of the relaxation of birefringence of magnetic nanoparticles Abandoned AU6828500A (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
DE19938384 1999-08-06
DE19938384A DE19938384A1 (en) 1999-08-06 1999-08-06 Detecting analytes or binding reactions, useful e.g. for diagnosis, based on measuring relaxation of birefringence of magnetic marker compounds
US14868699P 1999-08-16 1999-08-16
US60/148686 1999-08-16
PCT/EP2000/007150 WO2001011360A2 (en) 1999-08-06 2000-07-25 Relaxation of birefringence of magnetic nanoparticles during binding reactions

Publications (1)

Publication Number Publication Date
AU6828500A true AU6828500A (en) 2001-03-05

Family

ID=26054590

Family Applications (1)

Application Number Title Priority Date Filing Date
AU68285/00A Abandoned AU6828500A (en) 1999-08-06 2000-07-25 Method for detecting binding reactions through measurement of the relaxation of birefringence of magnetic nanoparticles

Country Status (4)

Country Link
EP (1) EP1200825B1 (en)
JP (1) JP2003528289A (en)
AU (1) AU6828500A (en)
WO (1) WO2001011360A2 (en)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7892817B2 (en) * 2004-05-18 2011-02-22 Koninklijke Philips Electronics, N.V. Magnetic rotation to improve signal-over-background in biosensing
US7781228B2 (en) 2005-04-07 2010-08-24 Menon & Associates, Inc. Magnetic resonance system and method to detect and confirm analytes
EP2385386B1 (en) 2005-05-09 2012-11-14 The General Hospital Corporation Magnetic resonance sensors for monitoring of an analyte concentration
CA2620861C (en) 2005-08-31 2016-07-05 T2 Biosystems, Inc. Nmr device for detection of analytes
US20070166730A1 (en) 2006-01-19 2007-07-19 Menon & Associates, Inc. Magnetic resonance system and method to detect and confirm analytes
SE529474C2 (en) * 2006-04-19 2007-08-21 Imego Ab Detecting magnetic response changes of a magnetic particle by measuring characteristic rotation time of magnetic particle, and measuring hydrodynamic volume of particle by detecting change of magnetization of the particle
CA2669045A1 (en) 2006-11-08 2008-05-15 T2 Biosystems, Inc. Nmr systems for in vivo detection of analytes
AT503845B1 (en) * 2007-04-11 2008-03-15 Arc Austrian Res Centers Gmbh Determining the relaxation behavior e.g. relaxation time of micro- or nano-particles, on which target molecules e.g. viruses are bound, comprises aligning the particles in dispersion and/or suspension by electrical and/or magnetic field
EP2217951A4 (en) 2007-11-06 2011-05-18 T2 Biosystems Inc Small magnet and rf coil for magnetic resonance relaxometry
CA2741550C (en) 2008-10-29 2018-12-04 T2 Biosystems, Inc. Nmr detection of coagulation time
US8409807B2 (en) 2010-10-22 2013-04-02 T2 Biosystems, Inc. NMR systems and methods for the rapid detection of analytes
US9714940B2 (en) 2010-10-22 2017-07-25 T2 Biosystems, Inc. NMR systems and methods for the rapid detection of analytes
WO2013010080A1 (en) 2011-07-13 2013-01-17 T2 Biosystems, Inc. Nmr methods for monitoring blood clot formation
WO2013043858A1 (en) 2011-09-21 2013-03-28 T2 Biosystems, Inc. Nmr methods for endotoxin analysis
WO2013158281A1 (en) 2012-04-20 2013-10-24 T2 Biosystems, Inc. Compositions and methods for detection of candida species
CA2893591A1 (en) 2012-12-07 2014-06-12 T2 Biosystems, Inc. Methods for monitoring tight clot formation
EP3405479A4 (en) 2016-01-21 2019-08-21 T2 Biosystems, Inc. Nmr methods and systems for the rapid detection of bacteria

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19503664C2 (en) * 1995-01-27 1998-04-02 Schering Ag Magnetorelaxometric detection of analytes

Also Published As

Publication number Publication date
JP2003528289A (en) 2003-09-24
EP1200825A2 (en) 2002-05-02
EP1200825B1 (en) 2005-08-24
WO2001011360A2 (en) 2001-02-15
WO2001011360A3 (en) 2001-07-05

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Legal Events

Date Code Title Description
MK6 Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase