AU681919B2 - N-alkyl peptide chelate formers, their metal complexes with radionuclides, processes for producing them and radio-pharmaceutical compositions containing these compounds - Google Patents

N-alkyl peptide chelate formers, their metal complexes with radionuclides, processes for producing them and radio-pharmaceutical compositions containing these compounds

Info

Publication number: AU681919B2
Authority: AU; Australia
Prior art keywords: radionuclides; radio; compounds; processes; producing
Prior art date: 1993-11-01
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Ceased

Application number

AU81038/94A

Other versions

AU8103894A (en

Inventor

Ludger Dinkelborg

Bernd Noll

Steffi Noll

Paul-Eberhard Schulze

Hartmut Spies

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Bayer Pharma AG

Original Assignee

Institut fuer Diagnostikforschung GmbH

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-11-01

Filing date

1994-10-27

Publication date

1997-09-11

1994-10-27 Application filed by Institut fuer Diagnostikforschung GmbH filed Critical Institut fuer Diagnostikforschung GmbH

1995-05-23 Publication of AU8103894A publication Critical patent/AU8103894A/en

1997-09-11 Application granted granted Critical

1997-09-11 Publication of AU681919B2 publication Critical patent/AU681919B2/en

2014-10-27 Anticipated expiration legal-status Critical

Status Ceased legal-status Critical Current

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
- C07D457/04—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 8
- C07D457/06—Lysergic acid amides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C327/00—Thiocarboxylic acids
- C07C327/20—Esters of monothiocarboxylic acids
- C07C327/26—Esters of monothiocarboxylic acids having carbon atoms of esterified thiocarboxyl groups bound to carbon atoms of six-membered aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
- C07D457/10—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hetero atoms directly attached in position 8
- C07D457/12—Nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0072—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the A ring of the steroid being aromatic
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/57536—Endothelin, vasoactive intestinal contractor [VIC]
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
- C07K5/0806—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0827—Tripeptides containing heteroatoms different from O, S, or N

AU81038/94A 1993-11-01 1994-10-27 N-alkyl peptide chelate formers, their metal complexes with radionuclides, processes for producing them and radio-pharmaceutical compositions containing these compounds Ceased AU681919B2 (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
DE4337600A DE4337600A1 (en)	1993-11-01	1993-11-01	N-alkyl peptide chelating agents, their metal complexes with radionuclides, processes for their preparation and radiopharmaceutical compositions containing these compounds
DE4337600		1993-11-01
PCT/DE1994/001295 WO1995012610A1 (en)	1993-11-01	1994-10-27	N-alkyl peptide chelate formers, their metal complexes with radionuclides, processes for producing them and radio-pharmaceutical compositions containing these compounds

Publications (2)

Publication Number	Publication Date
AU8103894A AU8103894A (en)	1995-05-23
AU681919B2 true AU681919B2 (en)	1997-09-11

Family

ID=6501750

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AU81038/94A Ceased AU681919B2 (en)	1993-11-01	1994-10-27	N-alkyl peptide chelate formers, their metal complexes with radionuclides, processes for producing them and radio-pharmaceutical compositions containing these compounds

Country Status (11)

Country	Link
EP (1)	EP0726909A1 (en)
JP (1)	JPH09508351A (en)
KR (1)	KR960705842A (en)
CN (1)	CN1134158A (en)
AU (1)	AU681919B2 (en)
CA (1)	CA2173844A1 (en)
DE (1)	DE4337600A1 (en)
HU (1)	HUT74881A (en)
NO (1)	NO961743L (en)
WO (1)	WO1995012610A1 (en)
ZA (1)	ZA948411B (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6241963B1 (en) *	1995-10-19	2001-06-05	The Trustees Of The University Of Pennsylvania	Dopamine and serotonin transporter ligands and imaging agents
US6162378A (en) *	1999-02-25	2000-12-19	3D Systems, Inc.	Method and apparatus for variably controlling the temperature in a selective deposition modeling environment
US6171578B1 (en)	1999-04-14	2001-01-09	Diatide, Inc.	Benzodiazepine derivatives for imaging thrombi
CA2408408C (en)	2000-05-12	2013-07-09	Genzyme Corporation	Modulators of tnf- alpha signaling

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ZA811340B (en) *	1980-06-09	1982-03-31	Morton Norwich Products Inc	N-(cycloalkyl)amino acid compounds
AU1995392A (en) *	1991-05-08	1992-12-21	Mallinckrodt Medical, Inc.	Technetium chelates to be used for determining the renal function
JPH0570484A (en) *	1991-09-12	1993-03-23	Hitachi Chem Co Ltd	Peptide and its salt
CA2129036A1 (en) *	1992-02-06	1993-08-19	Mallinckrodt Inc.	Ligands for improving metal chelate formation kinetics
ATE196094T1 (en) *	1992-05-21	2000-09-15	Diatide Inc	TECHNETIUM-99M LABELED PEPTIDES FOR IMAGING THROMBUS
DE4311021A1 (en) *	1993-03-31	1994-10-27	Diagnostikforschung Inst	Bifunctional chelating agents, their technetium and rhenium complexes, processes for their preparation and radiopharmaceutical compositions containing these compounds

1993
- 1993-11-01 DE DE4337600A patent/DE4337600A1/en not_active Withdrawn
1994
- 1994-10-26 ZA ZA948411A patent/ZA948411B/en unknown
- 1994-10-27 HU HU9601140A patent/HUT74881A/en unknown
- 1994-10-27 EP EP95900059A patent/EP0726909A1/en not_active Withdrawn
- 1994-10-27 CN CN94193990A patent/CN1134158A/en active Pending
- 1994-10-27 JP JP7512959A patent/JPH09508351A/en active Pending
- 1994-10-27 WO PCT/DE1994/001295 patent/WO1995012610A1/en not_active Application Discontinuation
- 1994-10-27 CA CA002173844A patent/CA2173844A1/en not_active Abandoned
- 1994-10-27 AU AU81038/94A patent/AU681919B2/en not_active Ceased
1996
- 1996-04-30 KR KR1019960702247A patent/KR960705842A/en not_active Application Discontinuation
- 1996-04-30 NO NO961743A patent/NO961743L/en unknown

Also Published As

Publication number	Publication date
ZA948411B (en)	1995-06-30
WO1995012610A1 (en)	1995-05-11
CA2173844A1 (en)	1995-05-11
DE4337600A1 (en)	1995-05-04
HUT74881A (en)	1997-02-28
AU8103894A (en)	1995-05-23
EP0726909A1 (en)	1996-08-21
KR960705842A (en)	1996-11-08
NO961743D0 (en)	1996-04-30
CN1134158A (en)	1996-10-23
NO961743L (en)	1996-04-30
JPH09508351A (en)	1997-08-26
HU9601140D0 (en)	1996-07-29

Legal Events

Date	Code	Title	Description
2000-06-01	MK14	Patent ceased section 143(a) (annual fees not paid) or expired

Publication	Publication Date	Title
EP0666238A4 (en)	1996-02-21	Metal oxide powder and process for producing the same.
AU2569292A (en)	1994-03-29	Powder metal alloy process
AU586831B2 (en)	1989-07-27	Metal complexes
HUP9801949A3 (en)	2000-09-28	Ternary radiopharmaceutical complexes
EP0666239A4 (en)	1996-02-07	Composite metal oxide powder and process for producing the same.
AU3778989A (en)	1989-11-29	Diaminedithiol chelating agents for radiopharmaceuticals
AU3132193A (en)	1993-06-28	Uva-absorbing sunscreen metal complexes
AU3072292A (en)	1993-06-28	Uva-absorbing sunscreen metal complexes
AU7384394A (en)	1995-01-24	Chelating compounds
GB8802788D0 (en)	1988-03-09	Composition & process for treating metal surfaces
GB9006522D0 (en)	1990-05-23	Metal complexes
AU681919B2 (en)	1997-09-11	N-alkyl peptide chelate formers, their metal complexes with radionuclides, processes for producing them and radio-pharmaceutical compositions containing these compounds
GB2218711B (en)	1992-02-26	Process for producing powdered inorganic compounds and metal compositions.
IL111817A0 (en)	1995-01-24	Halogen-containing metal complexes, diagnostic agents containing the same and processes for the preparation thereof
GB9323521D0 (en)	1994-01-05	A process for the preparation of aluminium-heavy metal mixed complexes
AU3072192A (en)	1993-06-28	Process for preparing uva-absorbing sunscreen metal complexes
AU6417296A (en)	1998-01-14	Compounds which can form complexes with metals
IL63928A0 (en)	1981-12-31	Beta-diketone metal complexes,processes for the preparation thereof and pharmaceutical compositions containing the same
AU8218582A (en)	1982-10-07	Addition agent for iron-base alloys
AU573216B2 (en)	1988-06-02	Metal amine complexes
EP0792170A4 (en)	2000-03-15	Radionuclide metal chelates for the radiolabeling of ligands, anti-ligands or other proteins
AU4237493A (en)	1994-12-12	Bicyclopolyazamacrocyclocarboxylic acid complexes, their conjugates, processes for their preparation, and use as radiopharmaceuticals
AU4239893A (en)	1994-12-12	Bicyclopolyazamacrocyclophosphonic acid complexes, a process for their preparation, and their conjugates, for use as radiopharmaceuticals
EP0427048A3 (en)	1991-12-27	Metal complex compounds
GB9317762D0 (en)	1993-10-13	Novel group iv metal complexes