AU6734296A - Bicyclic lactam derivatives as thrombin inhibitors - Google Patents

Bicyclic lactam derivatives as thrombin inhibitors

Info

Publication number
AU6734296A
AU6734296A AU67342/96A AU6734296A AU6734296A AU 6734296 A AU6734296 A AU 6734296A AU 67342/96 A AU67342/96 A AU 67342/96A AU 6734296 A AU6734296 A AU 6734296A AU 6734296 A AU6734296 A AU 6734296A
Authority
AU
Australia
Prior art keywords
thrombin inhibitors
lactam derivatives
bicyclic lactam
bicyclic
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU67342/96A
Inventor
Marco Criscuoli
Fabio Paleari
Aldo Salimbeni
Carlo Scolastico
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Menarini Industrie Farmaceutiche Riunite SRL
Original Assignee
Menarini Industrie Farmaceutiche Riunite SRL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Menarini Industrie Farmaceutiche Riunite SRL filed Critical Menarini Industrie Farmaceutiche Riunite SRL
Publication of AU6734296A publication Critical patent/AU6734296A/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AU67342/96A 1995-08-01 1996-07-18 Bicyclic lactam derivatives as thrombin inhibitors Abandoned AU6734296A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IT95MI001688A IT1277405B1 (en) 1995-08-01 1995-08-01 BICYCLIC LACTAM DERIVATIVES AS THROMBIN INHIBITORS
ITMI95A1688 1995-08-01
PCT/EP1996/003167 WO1997005160A1 (en) 1995-08-01 1996-07-18 Bicyclic lactam derivatives as thrombin inhibitors

Publications (1)

Publication Number Publication Date
AU6734296A true AU6734296A (en) 1997-02-26

Family

ID=11372107

Family Applications (1)

Application Number Title Priority Date Filing Date
AU67342/96A Abandoned AU6734296A (en) 1995-08-01 1996-07-18 Bicyclic lactam derivatives as thrombin inhibitors

Country Status (3)

Country Link
AU (1) AU6734296A (en)
IT (1) IT1277405B1 (en)
WO (1) WO1997005160A1 (en)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20000029838A (en) * 1996-08-05 2000-05-25 몰레큐메틱스 리미티드 Use of beta-sheet mimetics as protease and kinase inhibitors and as inhibitors of transcription factors
EP1661566A3 (en) * 1996-08-05 2008-04-16 Myriad Genetics, Inc. Use of beta-sheet mimetics as protease and kinase inhibitors and as inhibitors of transcription factors
US6194435B1 (en) 1996-10-11 2001-02-27 Cor Therapeutics, Inc. Lactams as selective factor Xa inhibitors
US6063794A (en) 1996-10-11 2000-05-16 Cor Therapeutics Inc. Selective factor Xa inhibitors
US6369080B2 (en) 1996-10-11 2002-04-09 Cor Therapeutics, Inc. Selective factor Xa inhibitors
US6262047B1 (en) 1996-10-11 2001-07-17 Cor Therapeutics, Inc. Selective factor Xa inhibitors
WO1998046628A1 (en) * 1997-04-14 1998-10-22 Cor Therapeutics, Inc. SELECTIVE FACTOR Xa INHIBITORS
AU6896298A (en) 1997-04-14 1998-11-11 Cor Therapeutics, Inc. Selective factor xa inhibitors
WO1998046591A1 (en) 1997-04-14 1998-10-22 Cor Therapeutics, Inc. SELECTIVE FACTOR Xa INHIBITORS
WO1998046627A1 (en) 1997-04-14 1998-10-22 Cor Therapeutics, Inc. SELECTIVE FACTOR Xa INHIBITORS
US6228854B1 (en) 1997-08-11 2001-05-08 Cor Therapeutics, Inc. Selective factor Xa inhibitors
US6218382B1 (en) 1997-08-11 2001-04-17 Cor Therapeutics, Inc Selective factor Xa inhibitors
ATE211482T1 (en) * 1997-08-11 2002-01-15 Cor Therapeutics Inc SELECTIVE INHIBITORS OF FACTOR X CONTAINING AN AZEPINE STRUCTURE
US6333321B1 (en) 1997-08-11 2001-12-25 Cor Therapeutics, Inc. Selective factor Xa inhibitors
DE69810513T2 (en) * 1998-02-12 2004-03-18 Molecumetics, Ltd., Bellevue MIMETIC OF BETA LEAFLET AND METHOD FOR USE THEREOF
US6235877B1 (en) * 1999-08-04 2001-05-22 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Peptido-mimetic compounds containing RGD sequence useful as integrin inhibitors
AU3127900A (en) * 1998-12-23 2000-07-31 Du Pont Pharmaceuticals Company Thrombin or factor xa inhibitors
ITMI20031476A1 (en) * 2003-07-18 2005-01-19 Univ Degli Studi Milano PEPTIDO-MIMETIC COMPOUNDS WITH A AZABICICLOALCANIC STRUCTURE INCLUDING THE RGD SEQUENCE
KR100887045B1 (en) 2004-01-16 2009-03-04 더 리젠츠 오브 더 유니버시티 오브 미시간 Conformationally constrained smac mimetics and the uses thereof
US7932382B2 (en) 2004-01-16 2011-04-26 The Regents Of The University Of Michigan Conformationally constrained Smac mimetics and the uses thereof
GB0507577D0 (en) 2005-04-14 2005-05-18 Novartis Ag Organic compounds
AU2015362422B2 (en) * 2014-12-10 2019-11-14 Ono Pharmaceutical Co., Ltd. Dihydroindolizinone derivative

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4121947A1 (en) * 1991-07-03 1993-01-07 Basf Ag 2- (3- (4-AMIDINO-PHENYL)) - PROPIONIC ACID DERIVATIVES, THEIR PRODUCTION AND USE
CA2075154A1 (en) * 1991-08-06 1993-02-07 Neelakantan Balasubramanian Peptide aldehydes as antithrombotic agents
EE9700113A (en) * 1994-12-22 1997-12-15 Biochem Pharma Inc. Low molecular weight bicyclic thrombin inhibitors

Also Published As

Publication number Publication date
ITMI951688A0 (en) 1995-08-01
IT1277405B1 (en) 1997-11-10
WO1997005160A1 (en) 1997-02-13
ITMI951688A1 (en) 1997-02-01

Similar Documents

Publication Publication Date Title
AU4172397A (en) Lactam inhibitors of thrombin
AU6734296A (en) Bicyclic lactam derivatives as thrombin inhibitors
AU4875196A (en) Novel thrombin inhibitors
AU4787596A (en) Thrombin inhibitors
AU4062895A (en) Low molecular weight bicyclic thrombin inhibitors
AU1301697A (en) Tyrosin-derivate as alpha-v-integrin inhibitors
AU7497596A (en) Thrombin inhibitors
AU7145294A (en) Heterocyclic thrombin inhibitors
AU5208193A (en) Guanidinyl-substituted heterocyclic thrombin inhibitors
AU3832895A (en) Thrombin inhibitors
EP0820453A4 (en) Thrombin inhibitors
AU6419296A (en) Cyclic gmp-specific phosphodiesterase inhibitors
AU4791797A (en) 6-phenylpyridyl-2-amine derivatives useful as nos inhibitors
AU7631496A (en) Substituted 2-anilinopyrimidines useful as protein kinase inhibitors
AU6558096A (en) Cyclic adhesion inhibitors
AU7131196A (en) Pyrimidine derivatives as 5ht2c-receptor antagonists
AU8917098A (en) Azetidinone derivatives as beta-lactamase inhibitors
AU4153297A (en) Spirocyclic metalloprotease inhibitors
AU1507095A (en) Novel mono- and bicyclic DNA gyrase inhibitors
AU7570996A (en) Quinoline derivatives as type iv phosphodiesterase inhibitors
AU5887196A (en) Prothrombin derivatives
AU6183494A (en) Guanidinyl- or amidinyl-substituted heterocyclic thrombin inhibitors
AU3578695A (en) Acridone derivative
AU6741496A (en) Joining of polyolefin articles
AU3396697A (en) Thrombin inhibitor