AU664227B2 - High viscosity pump system for a dispenser pouch - Google Patents

High viscosity pump system for a dispenser pouch Download PDF

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Publication number
AU664227B2
AU664227B2 AU32520/93A AU3252093A AU664227B2 AU 664227 B2 AU664227 B2 AU 664227B2 AU 32520/93 A AU32520/93 A AU 32520/93A AU 3252093 A AU3252093 A AU 3252093A AU 664227 B2 AU664227 B2 AU 664227B2
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Australia
Prior art keywords
panels
pouch
combination
insert
liquid
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AU32520/93A
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AU3252093A (en
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Peter N. Thomsen
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Classifications

    • AHUMAN NECESSITIES
    • A47FURNITURE; DOMESTIC ARTICLES OR APPLIANCES; COFFEE MILLS; SPICE MILLS; SUCTION CLEANERS IN GENERAL
    • A47KSANITARY EQUIPMENT NOT OTHERWISE PROVIDED FOR; TOILET ACCESSORIES
    • A47K5/00Holders or dispensers for soap, toothpaste, or the like
    • A47K5/06Dispensers for soap
    • A47K5/12Dispensers for soap for liquid or pasty soap
    • A47K5/1211Dispensers for soap for liquid or pasty soap using pressure on soap, e.g. with piston
    • A47K5/1215Dispensers for soap for liquid or pasty soap using pressure on soap, e.g. with piston applied by a peristaltic action

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  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)
  • Reciprocating Pumps (AREA)
  • Nozzles (AREA)
  • Closures For Containers (AREA)

Description

li_ _I1IILIIIIIII_ AU9332520 OPI DATE 28/07/93 APPLN. ID 32520/93 AOJP DATE 30/09/93 PCT NUMBER PCT/AU92/00687 INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (51) International Patent Classification 5 (11) International Publication Number: WO 93/12981 35/40, 33/38, A47K 5/00 A47K 5/12 B65D 35/28 Al (43) International Publication Date: 8 July 1993 (08.07.93) 35/56 (21) International Application Number: PCT/AU92/00687 Published With international search report.
(22) International Filing Date: 30 December 1992 (30.12.92) Priority data:64 2 2 814,763 30 December 1991 (30.12.91) US 4 (71X72) Applicant and Inventor: THOMSEN, Peter, N. [DK/ AU]; 11B Short Street, Hunters Hill, NSW 2110 (AU).
(74) Agent: MAXWELL, Peter, Francis; Peter Maxwell Associates, Blaxland House, 5 Ross Street, North Parramatta, NSW 2151 (AU).
(81) Designated States: AU, JP, KR, European patent (AT, BE, CH, DE, DK, ES, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE).
(54)Title: HIGH VISCOSITY PUMP SYSTEM FOR A DISPENSER POUCH 17 17 (57) Abstract A dispensing pouch (10) comprises a pair of superimposed panels (11, 12) sealed together to define a reservoir adapted to contain a high viscosity liquid therein. A spout (23) is formed on a lower end of the pouch and has a pump (16) disposed therein that defines a charging chamber communicating with the reservoir to retain a pre-measured charge of the liquid therein. The liquid is discharged from the charging chamber (20) in re- 12 sponse to the external application of pumping pressure onto an outer side of the spout The pouch (10) is adapted for mounting in a dispensing unit having a dual action pressure plate for periodically pumping and dispensing the pre-measured charge of liquid from the charging chamber of the pump The pump (16) is preferably defined by a separate in, sert sandwiched between the panels (11, 12) of the pouch A method for making the pouch is also disclosed.
21 19 20 9 7 9 23 /1 1 24 I 1 II lall C~ -I ~4 ill 141~-~ 1~ ~i WO 93/12981 PCT/AU92/00687 i HIGH VISCOSITY PUMP SYSTEM FOR A DISPENSER POUCH TECHNICAL FIELD This invention relates generally to a dispenser pouch adapted to contain a high viscosity liquid therein and more particularly to a sealed pouch having a pump adapted to dispense a pre-measured charge of liquid therefrom when an external pumping pressure is applied to the pouch.
BACKGROUND ART Conventional dispensers for liquids having relatively high viscosities, such as heavy duty soaps, shampoos, tomato ketchup, mayonnaise, tooth paste, high viscosity oils or the like, oftentimes take the form of a semirigid plastic container having an openable closure cap or a reciprocal dispensing valve mounted thereon. Conventional dispensers of this type are relatively expensive to manufacture, are prone to malfunction and leakage and normally do not insure that a pre-measured charge of the liquid will be efficiently dispensed therefrom.
Other types of conventional dispensers include thinwalled plastic pouches that are heat sealed to retain a liquid product therein. A corner of the pouch is either ripped open to dispense the product or a closure plug is used for this purpose. Further, U.S. Patent Nos. 3,009,498; 3,184,121; 3,815,794 and 4,252,257 and Canadian Patent No.
735,289 disclose pouches or bags which provide various types of closures to seal the bags after product has been dispensed therefrom. Bags of this type are incapable of efficiently dispensing relatively high viscosity liquids 3,000 to irll' qrl I I r r -7 WO 93/12981 PCT/AU92/00687 -2- 14,000 centipoises) and require mechanical manipulation or other extraneous forces to open and close the valves thereof.
The dispenser pouches disclosed in applicant's U.S.
Patent Nos. 5,000,350 and 5,067,635 have solved the above prior art problems by providing systems that function efficiently to dispense liquids having a wide variety of viscosities. However, when liquids having relatively high viscosities in excess of 3,000 centipoises) were used in the so called deep-drawn pouch of the type shown in Figs.
4 and 5 of U.S. Patent No. 5,000,350, the dispensing efficiency of the pouch was found to lessen when the contents of the pouch approached empty.
DISCLOSURE OF THE I ENTION According to one aspect of the invention there is provided a pump system in combination with a dispenser pouch comprising a pair of overlying panels defining a reservoir F pted to contain a liquid therein and a spout on a lower ,d of said pouch, said pump system comprising pump means disposed in said spout for dispensing said liquid from said pouch in response to the application of pumping pressure thereto, charging chamber means for retaining a pre-measured charge of said liquid therein, inlet passage means for communicating liquid from said reservoir to automatically recharge said charging chamber means with said pre-measured charge of liquid in response to release of pumping pressure from aid pump means and outlet means for dispensing said premeasured charge of liquid from said charging means chamber in response to said application of pumping pressure to said pump TI r I.
pr WO 93/12981 PCT/AU92/00687 -3means.
According to another aspect of the invention there is provided a method for making a dispenser pouch with a pump system comprising the steps of positioning an insert, defining a bulbous portion, between a pair or outer panels, and sealing said panels together to from a reservoir between said panels and to define a charging chamber in the bulbous portion of said insert communicating with said reservoir.
BRIEF DESCRIPTION OF THE DRAWINGS In order that the inventS -n may be more readily understood and put into practical effect reference will now be made to the accompanying drawings in which: Fig. 1 is a side elevational view of a dispenser pouch according to an embodiment of the invention; Fig. 2 is a front elevational view of the dispenser pouch showing Fig. 1 with a portion of a flat panel 12 thereof being broken-away to expose a reservoir and pump system therein; Fig. 3 is an enlarged sectional view through the pouch, taken in the direction of arrows III-Ill in Fig. 2; Fig. 4 is an enlarged sectional view, taken in the direction of arrows; IV-IV in Fig. 2; *1 NLI -r
L-
_.LIIII LYIIC--LI~ WO 93/12981 PCf/AU92/00687 Fig. 5 Fig. 6 Figs. 7 to is an isometric view of an insert adapted for assembly with the pouch to form the pump system thereof; is an exploded isometric view of the dispensing unit, more fully described in applicant's U.S. Patent No. 5,000,350.
9 are partial sectional views illustrating the sequential application of pumping pressure to the pump system of the dispenser pouch, mounted in a dispensing unit; illustrates a modification to the dispensing unit; and is a partial view, similar to Fig. 1, illustrating a modified pouch.
OUT THE INVENTION Fig. 10 Fig. 11 MODE FOR CARRYING Figs. 1 to 4 illustrate a dispensing pouch comprising a pair or superimposed panels 11 and 12. Common numerals depict components and constructions corresponding to like-numbered ones disclosed in my U.S. Patent Nos. 5,000,350 and 5,067,635. The pouch defines a reservoir 13 (Fig. 2) adapted to contain a high-viscosity liquid product therein, such as soap, shampoo, tomato ketchup, mayonnaise, heavy duty oil, or other suitable product in liquid form.
In the preferred embodiment of this invention, panels 11 and 12 constitute a pair of separate composite plastic sheets nylon/polyethylene laminate, 6 to 8 mils thick) superimposed over each other during manufacture and heatii 1 pr i SWO 93/12981 PCT/AU92/00687 sealed together substantially about their peripheries, as depicted at side seams 14 and 14'. An upper end 15 of the dispenser pouch may be left open during initial stages of the packaginig process to initially fill the pouch with a liquid product whereafter the end is heat-sealed. Alternatively, flat panel 12 could be heat-sealed to deep-drawn panel 11 after the reservoir is filled with product. As described hereinafter, a pump system 16 is combined with the type of dispenser pouch described in my above-referenced patents to insure efficient dispensing of the high viscosity product packaged therein.
One or more holes 17 can be formed through the upper seam of the pouch to adapt it for mounting purposes, as also described in my above-referenced patents. A lower end of the pouch is preferably closed during manufacture by sealed panel portions forming a removable closure portion (not shown).
The closure portion can be snipped-off by scissors, for example, when the dispenser pouch is placed in use by s consumer.
Each panel 11 and 12 is preferably composed of coextruded composite plastic materials of the types described in my aforementioned patents, the disclosures of which are incorporated by reference herein. Individual thicknesses and cowipositions of the panels will vary, depending on the particularly consumer product application under consideration. The composite thickness of each panel is r preferably selected from the approximate range of from 3.0 to 4 10.0 mils for most home and industrial pouch applications and jl r P -111~~~ WO 93/12981 PCT/AU92/00687 -6the pouches are adapted to contain from 50 ml to 5,000 ml of a liquid product in reservoir 13. Further, it is contemplated that most of the dispenser pouches would have a total length in the approximate range of from 10.0 cm to 36.0 cm and an internal maximum width of reservoir 13 (between seams 14 and 14' in Fig. 2) of from 5.0 cm to 12.0 cm.
Pump systems 16 comprises a separate one-piece and button-like insert 18 (Fig. 5) that is sandwiched between panels 11 and 12. If so desired, diametrically opposed peripheral portions 19 of the preformed insert (Fig. 2) can be heat-sealed to at least one of the panels and preferably between the panels, after the insert has been dropped into the like-shaped recess formed in panel 12, when flat panel 12 is heat-sealed to panel 11. The pump system is adapted to dispense relatively high viscous liquids from the pouch in response to application of pumping pressure thereto, as described hereinafter with reference to Figs. 7 to 9.
The insert may be composed of polyethylene, rubber or other suitable material having sufficient thickness and other dimensional, physical and mechanical durometer hardness of from 60 to 80) properties to effect the desired pumping action. The preformed insert, shown in this normally relaxed condition in Figs. 1 to 5 defines a charging chamber A 20 communicating with a plurality of passages or slots 21, formed circumferentially through an underside of an annular mounting flange 22 of the insert. The charging chamber is adapted to retain a pre-measured charge of liquid therein with the chamber being defined by the centrally disposed ~CL_1 WO 93/12981 P(7r/AU92/00687 -7bulbous portion of the insert and the opposing inner surface portions of panel 12.
When the bulbous portion of the insert is compressed externally "hrough overlying panel 11, the resulting pumping action is sufficient to dispense the liquid from the charging chamber, through the lower-most slots 21 (Fig. Release of the pumping pressure will permit the bulbous portion of the insert to reassume its normally expanded condition, illustrated in Figs. 1 to 5, to ready the dispenser pouch for the next-following dispensing function. Simultaneously with automatic expansion of the insert, the relative decrease in pressure (partial vacuum) in chamber 20, aided by gravity feed (the dispenser pouch is normally mounted vertically), will function to recharge chamber 20 with a pre-measured charge of liquid from reservoir 13.
In the preferred embodiment of this invention, the bulbous portion of the insert is at least generally semispherical (Figs. 3 and Further, although the pump system of invention is adapted for use with the type of pouch disclosed in U.S. Patent No. 5,067,635, it is preferably utilized with the type of pouch disclosed in U.S.
Patent No. 5,000,350 wherein panel 11 is deep-drawn to assume its illustrated expanded condition on one side of the pouch and panel 12 is at least substantially flat. The cavity defined in panel 11, conforming to the outer shape of insert 18, is also preformed during a deep-drawing step in the method for making the pouch.
c I r t- -a "M r WO 93/12981 PCT/AU92/00687 -8- Referring to Figs. 1 to 4, pump system 16 is disposed in a downwardly tapered neck or spout 23 of the dispenser pouch. As described in applicant's above-referenced patents, the spout terminates at its lower end at a valve 24, including a normally closed passage 25 (Fig. 2) that forms an outlet from the pouch communicating with the lowermost outlet passages 21 from pump system 16. Passage 25 is preferably rectangular and straight and is defined by overlying portions of panels 11 and 12 that are normally flattened and compressed together to close the valve.
Spout 23 defines a plurality of waffle-like parallel passages 26 preformed in panel 11 for communicating with reservoir 13 to aid in the periodical communication of the pre-measured charge of liquid to charging chamber 20 of pump system 16. The composite cross-sectional area of passages 26, defining an inlet to chamber 20, is substantially larger four times) than the cross-sectional area of outlet passage 25. When the dispenser pouch is mounted vertically or use, as described in detail hereinafter, the high viscosity product retained in reservoir 13 and charging chamber 20 will not leak since valve 24 is normally closed.
Compression of the bulbous portion of insert 18 (Fig. 9) will function to open valve 24 to dispense the contents form charging chamber Upon release, the insert will exhibit sufficient spring-back characteristics and "memory" to enable the insert to reassume its normally expanded condition illustrated in Figs, 1 to 5, as will be appreciated by those skilled in the ~I I L I r WO 93/12981 PCT/AU92/00687 -9packaging arts. Simultaneously therewith, a negative pressure (partial vacuum) will be created in charging chamber (valve 24 closing automatically to prevent exposure of the chamber to ambient air pressure). Thus, another predetermined charge of liquid will be communicated from reservoir 13 and into chamber 20, via passages 26 and any clearance existing between panels and flange 22 (Fig. 3).
The efficient operation of the pump system will insure that at least substantially all of the packaged product can be used by a consumer.
Fig. 6 illustrates a combined and dispensing unit 29 of the type disclosed in U.S. Patent No. 5,000,350. The unit comprises a mounting bracket 30 adapted to be secured on a wall or the like by a standard adhesive or by other suitable fastening means inserted through holes 31 formed through the back panel of the bracket. A first cover portion 32a of a two-part cover is pivotally mounted on a lower end of the mounting bracket by a pair of transversely disposed pins 33, mounted in slots 34. A flange 32b is formed centrally on an upper end of cover portion 32a to normally hold it in a fixed position on the mounting bracket, along with a cantilevered leaf spring 30a (one shown) that normally overlies each pin 33.
Finger holes (not shown) are formed through a bottom wall of the mounting bracket to facilitate release of springs from pins 33 in the manner described in U.S. Patent No, 5,000,350. In particular, cover portion 32a can be lifted, moved forwardly and upwardly into a slot portion 34a, and yn~-CU(V-Y~- 19IWCTI IrX1UiFi I L l I- WO 93/12981 PCI/AU92/00687 then pivoted outwardly and downwardly on pins 33 to expose phantom-lined pouch 10. A mounting pin 35 is secured on the frontal side of mounting bracket 30 to removably mount pouch thereon. If so desired a pair of laterally spaced pins and accommodating holes 17 (Fig. 1) can be used for this purpose.
The cover further comprises a second cover portion or press plate 32c, pivotally mounted by pins 32d (one shown) on bracket 30. When press plate 32c is pushed down, toward mounting brackets 20 for dispensing purposes as sequentially shown in Figs. 7 to 9, a compression means 37 will function to compress and apply a descending pumping pressure onto a pump system 16 to open valve 24 (Fig. 9) and dispense the pre-measured charge of liquid product from charging chamber 20. The compression means comprises a cam member or pressure plate 38 pivotally mounted by a pair of pins 39 on inner sides of press plate 32c.
An upper end of the pressure plate is normally springbiased into relatively "light" and non-dispensing contact with the pouch by a compression coil spring 40. As sequentially shown in Figs. 7 to 9, application of hand or finger pressure to press plate 32c will pivot the press plate on pins 32d. An upper edge 3Ba of pressure plate 38 will initially move into line contact with the upper end of spout 23, across passages 26, to block further entry of liquid into the charging chamber. The motion of the cam member generally mimics the application of descending finger pressure onto .1 WO 93/12981 PCT/AU9/00687 -11spout 23 for dispensing purposes, a milking type action.
As shown in Fig. 9, continued application of pressure to press plate 32c will function to pivot pressure plate 38 about edge 38a to completely exhaust charging chamber Upon release of the press plate, spring 40 will return the press and pressure plates to their Fig. 7 normal positions.
Charging chamber 209 will then fill automatically, via passages 26, slots 21 and any clearance existing between the panels and flange 22 (Fig. 3) to ready the unit for a subsequent dispensing function. A sight window 41 (Fig.
can be mounted centrally in cover portion 32a to visually indicate the diminished quantity of liquid remaining in transparent pouch As more clearly shown in Figs. 7 to 9, mounting bracket has a stationary back-up plate 42 formed integrally thereon. If so desired and as shown in Fig. 10, pinch-off means in the form of a stop member 42 can be secured on the back-up plate, for more closely controlling the precise closing of the inlet to chamber 20 from reservoir 13 in response to downward pivoting of pressure plate 38. The stop member may have a wedge-shaped cross-section terminating at its apex at a straight edge 44 to define a line contact and closure across the full widths of spout 23 and stop member 43 when the dispensing function is commenced. The panel material forming the corrugated portion of the pouch defining passages 26 will exhibit sufficient "memory" characteristics Sto permit the passages to reassume their normal fully open L. iau w WO 93/12981 PCT/A LJ92/00687 -12condition when pumping pressure is removed from the pouch.
Normally closed valve 24 is preferably similar to that described in applicant's U.S. Patent Nos. F,000,350 and 5,067,635 but can be sized and constructed to normally remain "slightly" open. In the latter case, the size (crosssectional area and length) of outlet passage 25 would be matched against the viscosity of the particular liquid that is packaged in the dispenser to prevent any leakage. In particular, the viscosity of such liquid would be sufficiently high to prevent leakage thereof through the outlet passage when the dispenser assumes its normal predispensing condition (Fig. prior to activation of pump system 16.
Fig. 11 discloses a modified dispenser pouch wherein the cavity for accommodating insert 18 is preformed in panel 12, rather than panel 11. Pump system 16 is thus exposed for contact and compression on the opposite side of the modified pouch. Waffle-like passages can be formed in either panel 12 (Fig. 11) or panel 11 (Figs. 1 to The modified pouch can be mounted in dispensing unit 29 (Fig. 6) to function in the same manner as above described pouch INDUSTRIAL APPLICABILITY The dispenser pouch and pump system of the invention may be used to dispense liquid soap.

Claims (19)

1. A pump system in combination with a dispenser pouch comprising a pair of overlying panels defining a reservoir adapted to contain a liquid therein and a spout on a lower end of said pouch, said pump system comprising pump means entirely disposed in said spout, including a separate button- like insert having a bulbous portion disposed in a like- shaped recess defined in one of said panels of said spout, for dispensing said liquid from said pouch in response to the application of pumping pressure thereto, charging chamber means, defined within said insert, for retaining a pre- measured charge of aid liquid therein, inlet passage means within said spout for communicating liquid form said reservoir to automatically recharge said charging chamber means with said pre-measured charge of liquid in response to release of pumping pressure from said pump means, outlet means for dispensing said pre-measured charge of liquid from 4 said charging chamber means in response to said application 0 o of pumping pressure to said pump means, and normally closed o'o valve means, defined by and between said panels at said 0 0 outlet means, for opening automatically in response to said 00 oo0 application of said pumping pressure to said pump means. 0
2. The combination of claim 1 wherein said panels are sealed together about peripheral portions thereof and wherein said pump means is defined by said separate insert which is sandwiched between said panels. .r I- C.I -14-
3. The combination of claim 2 wherein peripheral portions of said insert are heat sealed to at least one of said panels.
4. The combination of claim 2 wherein said bulbous portion is centrally disposed on said insert.
The combination of claim 4 wherein said bulbous portion is at least generally semispherical.
6. The combination of claim 1 wherein said inlet passage means has a cross-sectional area substantially larger than a cross-sectional area of said outlet means.
7. The combination of claim 1 wherein only one of said panels is expanded on only one side of said pouch to define said reservoir and the other one of said panels is at least i: substantially flat. 4 6 4 A 448 o el
8. The combination of claim 1 further comprising a dispensing unit including a mounting bracket having said dispenser pouch mounted thereon, a cover mounted on said mounting bracket to at least substantially cover said dispenser pouch, and dispensing means for engaging and applying said pumping pressure to said pump means to selectively dispense said pre-meauured charge of liquid from said charging chamber means. ii mb Ii
9. The combination of claim 9 wherein said dispensing means comprises a pivotally mounted press plate forming a bottom portion of said cover covering said charging chamber and pressure plate means pivotally mounted on said press plate for engaging and compressing said pump means in response to pivoting of said press plate.
The combination of claim 9 further comprising a stationary back-up plate and wherein said pump means is disposed between said pressure plate means and said back-up plate.
11. The combination of claim 9 further comprising pinch-off means for closing said inlet passage means in response to pivoting of said press plate.
12. The combination of claim 11 wherein said pinch-off I I means comprises stop means mounted on said back-up plate for A defining a line contact and closure between said pouch and 0, ~said stop means in response to pivoting of said press plate. a
13. A method for making a dispenser pouch having a pump system which comprises pump means including an insert having a bulbous portion, said method comprising the steps of positioning the insert between a pair of outer panels, and IL, 1 -16- sealing said panels together to form a reservoir between said panels and to define a charging chamber in the bulbous portion of said insert communicating with said reservoir.
14. The method of claim 13 wherein said sealing step further comprises forming inlet passage means for communicating said reservoir with said charging chamber and outlet passage means for dispensing said pre-measured charge of liquid from said charging means chamber in response to external application of pumping pressure over said charging chamber.
The method of claim 14 wherein said sealing step comprises sealing said panels together about peripheral portions thereof. 66
16. The method of claim 15 wherein peripheral portions of a o said insert are heat sealed to at least one of said panels. 0 00
17. Th- method of claim 14 further comprising preforming 00 the bulbous portion of said insert to be at least generally semispherical.
18. The method of claim 14 further comprising forming said inlet passage means to have a cross-.ectional area substantially larger than a cross-sectional area of said Q outlet passage means. 'T9 i~ i i -17-
19. The method of claim 13 further comprising pre-expanding only one of said panels on only one side of said pouch and preforming the other one of said panels to be at least substantially flat. -I A pump system in combination with a dispenser pouch substantially as hereinbefore described with reference to the accompanying drawings. Dated this 6th day of September 1995. PETER NIELS THOMSEN, Patent Attorneys for the Applicant: PETER MAXWELL ASSOCIATES 4t 4 4 0 4 04 6 44 J Q 1 g r
AU32520/93A 1991-12-30 1992-12-30 High viscosity pump system for a dispenser pouch Ceased AU664227B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US07/814,763 US5207355A (en) 1991-12-30 1991-12-30 High viscosity pump system for dispenser pouch
US814763 1991-12-30
PCT/AU1992/000687 WO1993012981A1 (en) 1991-12-30 1992-12-30 High viscosity pump system for a dispenser pouch

Publications (2)

Publication Number Publication Date
AU3252093A AU3252093A (en) 1993-07-28
AU664227B2 true AU664227B2 (en) 1995-11-09

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AU32520/93A Ceased AU664227B2 (en) 1991-12-30 1992-12-30 High viscosity pump system for a dispenser pouch

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US (1) US5207355A (en)
EP (1) EP0618871B1 (en)
AU (1) AU664227B2 (en)
DE (1) DE69227701T2 (en)
SG (1) SG47514A1 (en)
WO (1) WO1993012981A1 (en)

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Also Published As

Publication number Publication date
SG47514A1 (en) 1998-04-17
EP0618871A4 (en) 1997-03-12
DE69227701D1 (en) 1999-01-07
DE69227701T2 (en) 1999-06-10
EP0618871A1 (en) 1994-10-12
EP0618871B1 (en) 1998-11-25
AU3252093A (en) 1993-07-28
WO1993012981A1 (en) 1993-07-08
US5207355A (en) 1993-05-04

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