AU6569386A - Eukaryotic fusion proteins, the preparation and use thereof and means for carrying out the process - Google Patents
Eukaryotic fusion proteins, the preparation and use thereof and means for carrying out the processInfo
- Publication number
- AU6569386A AU6569386A AU65693/86A AU6569386A AU6569386A AU 6569386 A AU6569386 A AU 6569386A AU 65693/86 A AU65693/86 A AU 65693/86A AU 6569386 A AU6569386 A AU 6569386A AU 6569386 A AU6569386 A AU 6569386A
- Authority
- AU
- Australia
- Prior art keywords
- fusion proteins
- new
- preparation
- carrying
- derivs
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/55—IL-2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/35—Fusion polypeptide containing a fusion for enhanced stability/folding during expression, e.g. fusions with chaperones or thioredoxin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
- C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Toxicology (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Endocrinology (AREA)
- Microbiology (AREA)
- Diabetes (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Materials For Medical Uses (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
Fusion proteins in which the C- or N-terminal essentially corresponds to the first 100 units of interleukin 2 are new. Also new are gene structures coding for the above fusion proteins, vectors containing these gene structures, and hot cells containing these vectors. Hirudin derivs. with an amino acide sequence begining N-terminally with Pro are new and claimed. Human interleukin 2 derivs. contg. Asp. C-terminally are new and claimed.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE3541856 | 1985-11-27 | ||
DE19853541856 DE3541856A1 (en) | 1985-11-27 | 1985-11-27 | EUKARYOTIC FUSION PROTEINS, THEIR PRODUCTION AND USE, AND MEANS FOR CARRYING OUT THE PROCESS |
Publications (2)
Publication Number | Publication Date |
---|---|
AU6569386A true AU6569386A (en) | 1987-06-04 |
AU595262B2 AU595262B2 (en) | 1990-03-29 |
Family
ID=6286938
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU65693/86A Ceased AU595262B2 (en) | 1985-11-27 | 1986-11-26 | Eukaryotic fusion proteins, the preparation and use thereof and means for carrying out the process |
Country Status (17)
Country | Link |
---|---|
EP (3) | EP0227938B1 (en) |
JP (1) | JP2566933B2 (en) |
KR (1) | KR950000300B1 (en) |
AT (2) | ATE122397T1 (en) |
AU (1) | AU595262B2 (en) |
CA (1) | CA1341203C (en) |
DE (4) | DE3541856A1 (en) |
DK (2) | DK172064B1 (en) |
ES (3) | ES2077747T3 (en) |
FI (1) | FI93471C (en) |
GR (1) | GR3005042T3 (en) |
HU (1) | HU203579B (en) |
IE (1) | IE59488B1 (en) |
IL (1) | IL80755A0 (en) |
NO (1) | NO176481C (en) |
PT (1) | PT83813B (en) |
ZA (1) | ZA868943B (en) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU591061B2 (en) * | 1984-06-14 | 1989-11-30 | Ucp Gen-Pharma Ag | Process for the manufacture of thrombin inhibitors |
US5286714A (en) * | 1991-12-07 | 1994-02-15 | Hoechst Aktiengesellschaft | Synthetic isohirudins with improved stability |
US5322926A (en) * | 1988-10-21 | 1994-06-21 | Hoechst Aktiengesellschaft | Isohirudins |
Families Citing this family (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3125021A (en) * | 1955-11-14 | 1964-03-17 | Smooth | |
DE3712985A1 (en) * | 1987-04-16 | 1988-11-03 | Hoechst Ag | BIFUNCTIONAL PROTEINS |
DE3545568A1 (en) * | 1985-12-21 | 1987-07-16 | Hoechst Ag | GM-CSF-PROTEIN, ITS DERIVATIVES, PRODUCTION OF SUCH PROTEINS AND THEIR USE |
DE3819079A1 (en) * | 1988-06-04 | 1989-12-07 | Hoechst Ag | HIRUDINE DERIVATIVES WITH DELAYED EFFECT |
DE3844211A1 (en) * | 1988-12-29 | 1990-07-05 | Hoechst Ag | NEW INSULINE DERIVATIVES, THE PROCESS FOR THEIR PRODUCTION, THEIR USE AND A PHARMACEUTICAL PREPARATION CONTAINING THEM |
US5179196A (en) * | 1989-05-04 | 1993-01-12 | Sri International | Purification of proteins employing ctap-iii fusions |
WO1991000912A1 (en) * | 1989-07-07 | 1991-01-24 | Massachusetts Institute Of Technology | Production and use of hybrid protease inhibitors |
CU22222A1 (en) * | 1989-08-03 | 1995-01-31 | Cigb | PROCEDURE FOR THE EXPRESSION OF HETEROLOGICAL PROTEINS PRODUCED IN A FUSION FORM IN ESCHERICHIA COLI, ITS USE, EXPRESSION VECTORS AND RECOMBINANT STRAINS |
GB8927722D0 (en) * | 1989-12-07 | 1990-02-07 | British Bio Technology | Proteins and nucleic acids |
DE3942580A1 (en) * | 1989-12-22 | 1991-06-27 | Basf Ag | METHOD FOR PRODUCING HIRUDINE |
US5270181A (en) * | 1991-02-06 | 1993-12-14 | Genetics Institute, Inc. | Peptide and protein fusions to thioredoxin and thioredoxin-like molecules |
DE4404168A1 (en) * | 1994-02-10 | 1995-08-17 | Hoechst Ag | Hirudin derivatives and process for their preparation |
PT821006E (en) | 1996-07-26 | 2004-09-30 | Aventis Pharma Gmbh | INSULIN DERIVATIVES WITH ENHANCED ZINC LINK |
DE19726167B4 (en) | 1997-06-20 | 2008-01-24 | Sanofi-Aventis Deutschland Gmbh | Insulin, process for its preparation and pharmaceutical preparation containing it |
DE19825447A1 (en) | 1998-06-06 | 1999-12-09 | Hoechst Marion Roussel De Gmbh | New insulin analogues with increased zinc formation |
DE10033195A1 (en) * | 2000-07-07 | 2002-03-21 | Aventis Pharma Gmbh | Bifunctional fusion proteins from hirudin and TAP |
US7638618B2 (en) | 2001-02-20 | 2009-12-29 | Sanofi-Aventis Deutschland Gmbh | Nucleic acids encoding a hirudin and pro-insulin as superscretable peptides and for parallel improvement of the exported forms of one or more polypeptides of interest |
US7202059B2 (en) | 2001-02-20 | 2007-04-10 | Sanofi-Aventis Deutschland Gmbh | Fusion proteins capable of being secreted into a fermentation medium |
DE10114178A1 (en) | 2001-03-23 | 2002-10-10 | Aventis Pharma Gmbh | Zinc-free and low-zinc insulin preparations with improved stability |
DE10227232A1 (en) | 2002-06-18 | 2004-01-15 | Aventis Pharma Deutschland Gmbh | Sour insulin preparations with improved stability |
CA2740685C (en) | 2008-10-17 | 2018-09-11 | Sanofi-Aventis Deutschland Gmbh | Combination of an insulin and a glp-1 agonist |
AU2010317995B2 (en) | 2009-11-13 | 2014-04-17 | Sanofi-Aventis Deutschland Gmbh | Pharmaceutical composition comprising a GLP-1 agonist, an insulin, and methionine |
JP5973918B2 (en) | 2009-11-13 | 2016-08-23 | サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | Pharmaceutical composition comprising a GLP-1 agonist and methionine |
JP6199186B2 (en) | 2010-08-30 | 2017-09-20 | サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | Use of AVE0010 for the manufacture of a medicament for the treatment of type 2 diabetes |
US9821032B2 (en) | 2011-05-13 | 2017-11-21 | Sanofi-Aventis Deutschland Gmbh | Pharmaceutical combination for improving glycemic control as add-on therapy to basal insulin |
RU2650616C2 (en) | 2011-08-29 | 2018-04-16 | Санофи-Авентис Дойчланд Гмбх | Pharmaceutical combination for use in glycemic control in patients with type 2 diabetes mellitus |
TWI559929B (en) | 2011-09-01 | 2016-12-01 | Sanofi Aventis Deutschland | Pharmaceutical composition for use in the treatment of a neurodegenerative disease |
HRP20230470T1 (en) | 2014-12-12 | 2023-07-21 | Sanofi-Aventis Deutschland Gmbh | Insulin glargine/lixisenatide fixed ratio formulation |
TWI748945B (en) | 2015-03-13 | 2021-12-11 | 德商賽諾菲阿凡提斯德意志有限公司 | Treatment type 2 diabetes mellitus patients |
TW201705975A (en) | 2015-03-18 | 2017-02-16 | 賽諾菲阿凡提斯德意志有限公司 | Treatment of type 2 diabetes mellitus patients |
KR20200080747A (en) | 2018-12-27 | 2020-07-07 | 주식회사 폴루스 | An Enzymatic Conversion Composition for Producing Insulin from Proinsulin and a Method for Producing Insulin from Proinsulin Using the Same |
KR20200080748A (en) | 2018-12-27 | 2020-07-07 | 주식회사 폴루스 | A Method for Purifying Proinsulin Using Anion Exchange Chromatography |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1985000817A1 (en) * | 1983-08-10 | 1985-02-28 | Amgen | Microbial expression of interleukin ii |
DK108685A (en) * | 1984-03-19 | 1985-09-20 | Fujisawa Pharmaceutical Co | GROWTH FACTOR I |
ATE78294T1 (en) * | 1984-03-27 | 1992-08-15 | Transgene Sa | EXPRESSION VECTORS FOR HIRUDIN, TRANSFORMED CELLS AND METHODS OF PRODUCTION OF HIRUDIN. |
EP0158198A1 (en) * | 1984-03-29 | 1985-10-16 | Takeda Chemical Industries, Ltd. | DNA and use thereof |
DE3429430A1 (en) * | 1984-08-10 | 1986-02-20 | Hoechst Ag, 6230 Frankfurt | GENE TECHNOLOGICAL METHOD FOR PRODUCING HIRUDINE AND MEANS FOR IMPLEMENTING THIS METHOD |
DE3526995A1 (en) * | 1985-07-27 | 1987-02-05 | Hoechst Ag | FUSION PROTEINS, METHOD FOR THEIR PRODUCTION AND THEIR USE |
CA1297003C (en) * | 1985-09-20 | 1992-03-10 | Jack H. Nunberg | Composition and method for treating animals |
US4865974A (en) * | 1985-09-20 | 1989-09-12 | Cetus Corporation | Bacterial methionine N-terminal peptidase |
-
1985
- 1985-11-27 DE DE19853541856 patent/DE3541856A1/en not_active Withdrawn
-
1986
- 1986-11-21 EP EP86116140A patent/EP0227938B1/en not_active Expired - Lifetime
- 1986-11-21 ES ES91114411T patent/ES2077747T3/en not_active Expired - Lifetime
- 1986-11-21 AT AT91114412T patent/ATE122397T1/en not_active IP Right Cessation
- 1986-11-21 DE DE8686116140T patent/DE3684892D1/en not_active Expired - Lifetime
- 1986-11-21 DE DE3650322T patent/DE3650322D1/en not_active Expired - Lifetime
- 1986-11-21 DE DE3650396T patent/DE3650396D1/en not_active Expired - Lifetime
- 1986-11-21 EP EP91114411A patent/EP0468539B1/en not_active Expired - Lifetime
- 1986-11-21 EP EP91114412A patent/EP0464867B1/en not_active Expired - Lifetime
- 1986-11-21 ES ES91114412T patent/ES2073081T3/en not_active Expired - Lifetime
- 1986-11-21 ES ES198686116140T patent/ES2032378T3/en not_active Expired - Lifetime
- 1986-11-21 AT AT91114411T patent/ATE127841T1/en not_active IP Right Cessation
- 1986-11-25 IL IL80755A patent/IL80755A0/en unknown
- 1986-11-25 HU HU864872A patent/HU203579B/en not_active IP Right Cessation
- 1986-11-25 FI FI864798A patent/FI93471C/en not_active IP Right Cessation
- 1986-11-26 NO NO864759A patent/NO176481C/en unknown
- 1986-11-26 CA CA000523857A patent/CA1341203C/en not_active Expired - Fee Related
- 1986-11-26 AU AU65693/86A patent/AU595262B2/en not_active Ceased
- 1986-11-26 PT PT83813A patent/PT83813B/en not_active IP Right Cessation
- 1986-11-26 JP JP61281621A patent/JP2566933B2/en not_active Expired - Lifetime
- 1986-11-26 IE IE311986A patent/IE59488B1/en not_active IP Right Cessation
- 1986-11-26 KR KR1019860009990A patent/KR950000300B1/en not_active IP Right Cessation
- 1986-11-26 DK DK568586A patent/DK172064B1/en not_active IP Right Cessation
- 1986-11-26 ZA ZA868943A patent/ZA868943B/en unknown
-
1992
- 1992-04-21 DK DK052292A patent/DK172210B1/en not_active IP Right Cessation
- 1992-06-26 GR GR920401111T patent/GR3005042T3/el unknown
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU591061B2 (en) * | 1984-06-14 | 1989-11-30 | Ucp Gen-Pharma Ag | Process for the manufacture of thrombin inhibitors |
US5322926A (en) * | 1988-10-21 | 1994-06-21 | Hoechst Aktiengesellschaft | Isohirudins |
US5286714A (en) * | 1991-12-07 | 1994-02-15 | Hoechst Aktiengesellschaft | Synthetic isohirudins with improved stability |
US5316947A (en) * | 1991-12-07 | 1994-05-31 | Hoechst Aktiengesellschaft | Synthetic isohirudins with improved stability |
US5616476A (en) * | 1991-12-07 | 1997-04-01 | Hoechst Aktiengesellschaft | Synthetic isohirudins with improved stability |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MK14 | Patent ceased section 143(a) (annual fees not paid) or expired |