AU6499780A - Diphenylmethane derivative and precursor - Google Patents
Diphenylmethane derivative and precursorInfo
- Publication number
- AU6499780A AU6499780A AU64997/80A AU6499780A AU6499780A AU 6499780 A AU6499780 A AU 6499780A AU 64997/80 A AU64997/80 A AU 64997/80A AU 6499780 A AU6499780 A AU 6499780A AU 6499780 A AU6499780 A AU 6499780A
- Authority
- AU
- Australia
- Prior art keywords
- acid
- cresol
- salts
- converted
- medium
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- CZZYITDELCSZES-UHFFFAOYSA-N diphenylmethane Chemical class C=1C=CC=CC=1CC1=CC=CC=C1 CZZYITDELCSZES-UHFFFAOYSA-N 0.000 title 1
- 239000002243 precursor Substances 0.000 title 1
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 abstract 18
- 150000003839 salts Chemical class 0.000 abstract 11
- 239000002253 acid Substances 0.000 abstract 7
- 229960004279 formaldehyde Drugs 0.000 abstract 6
- 235000019256 formaldehyde Nutrition 0.000 abstract 6
- GCFPFWRHYINTRX-UHFFFAOYSA-N 2-hydroxy-4-methylbenzenesulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C(O)=C1 GCFPFWRHYINTRX-UHFFFAOYSA-N 0.000 abstract 3
- AGAPQTXXLGLKFS-UHFFFAOYSA-N 5-hydroxy-2-[(4-hydroxy-5-methyl-2-sulfophenyl)methyl]-4-methylbenzenesulfonic acid Chemical compound C1=C(O)C(C)=CC(CC=2C(=CC(O)=C(C)C=2)S(O)(=O)=O)=C1S(O)(=O)=O AGAPQTXXLGLKFS-UHFFFAOYSA-N 0.000 abstract 2
- RLSSMJSEOOYNOY-UHFFFAOYSA-N m-cresol Chemical compound CC1=CC=CC(O)=C1 RLSSMJSEOOYNOY-UHFFFAOYSA-N 0.000 abstract 2
- FURVMUXSTJNEMY-UHFFFAOYSA-N 2-hydroxy-5-(hydroxymethyl)-4-methylbenzenesulfonic acid Chemical compound CC1=CC(O)=C(S(O)(=O)=O)C=C1CO FURVMUXSTJNEMY-UHFFFAOYSA-N 0.000 abstract 1
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 238000006482 condensation reaction Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- BDHFUVZGWQCTTF-UHFFFAOYSA-N sulfonic acid Chemical group OS(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-N 0.000 abstract 1
- 235000011149 sulphuric acid Nutrition 0.000 abstract 1
- 239000001117 sulphuric acid Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
- C07D295/027—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
- C07D295/027—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring
- C07D295/03—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring with the ring nitrogen atoms directly attached to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Phenolic Resins Or Amino Resins (AREA)
- Medicinal Preparation (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
For the Contracting States : DE, FR, IT, NL, BE, CH, GB, SE, LI, LU) 1. 2,2'-Dihydroxy-5,5'-methylenedi-(p-toluene-sulphonic acid) and its salts. For the Contracting State : AT 1. Process for the preparation of 2,2'-dihydroxy-5,5'- methylenedi-(p-toluenesulphonic acid) and its salts, characterized in that a) m-cresol-6-sulphonic acid and/or its salts are reacted in an acid medium with formaldehyde and/or formaldehyde donors and, if desired, a resulting salt is converted into the free acid or into another salt, b) m-cresol-6-sulphonic acid and/or its salts are converted, in a basic medium, by means of form-aldehyde and/or formaldehyde donors into 4-hydroxymethyl-m- cresol-6-sulphonic acid and the latter is subjected in an acid medium to a condensation reaction with m-cresol-6-sulphonic acid and/or its salts and, if desired, a resulting salt is converted into the free acid or into a another salt, or c) m-cresol which is substituent in the 6-position by a detachable substituent is reacted, in an acid medium, with formaldehyde and/or formaldehyde donors to give a 5,5'-disubstituted 4,4'-dihydroxy-2,2'-dimethyl diphenylmethane, the substituents in the 5-position and 5'-position are split off and the product is sulphonated in an acid medium with sulphuric acid and/or an agent which splits off sulphonic acid groups and, if appropriate, a resulting salt is converted into the free acid or into another salt.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH1076379 | 1979-12-04 | ||
| CH10763/79 | 1979-12-04 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU6499780A true AU6499780A (en) | 1981-06-11 |
| AU535714B2 AU535714B2 (en) | 1984-04-05 |
Family
ID=4366580
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU64997/80A Ceased AU535714B2 (en) | 1979-12-04 | 1980-12-02 | Diphenylmethane derivative and precursor |
Country Status (14)
| Country | Link |
|---|---|
| EP (1) | EP0029990B1 (en) |
| JP (1) | JPS56113754A (en) |
| AT (1) | ATE1523T1 (en) |
| AU (1) | AU535714B2 (en) |
| DE (1) | DE3060828D1 (en) |
| DK (1) | DK517580A (en) |
| ES (1) | ES8201545A1 (en) |
| GR (1) | GR71617B (en) |
| IE (1) | IE50610B1 (en) |
| IL (1) | IL61600A (en) |
| NZ (1) | NZ195716A (en) |
| PL (1) | PL228235A1 (en) |
| PT (1) | PT72160B (en) |
| ZA (1) | ZA807544B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4605726B2 (en) * | 1997-09-02 | 2011-01-05 | 日本曹達株式会社 | Molecular compounds containing phenol derivatives as component compounds |
| FR2964316B1 (en) * | 2010-09-03 | 2013-03-08 | Thierry Rouleau | DEVICE FOR ACHIEVING ASTRINGENT AND HEMOSTATIC-EFFICIENT GINGIVAL RETROACTION ASSOCIATED WITH A DISINFECTION AND AUTO-ELIMINATION EFFECT |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1518102C3 (en) * | 1964-03-09 | 1974-02-14 | Pabianickie Zaklady Farmaceutyczne Polfa Przedsiebiorstwo Panstwowe, Pabianice (Polen) | Process for the preparation of a pure water-soluble condensation product suitable for therapeutic purposes from m-cresol sulfonic acid and formaldehyde |
-
1980
- 1980-11-25 DE DE8080107328T patent/DE3060828D1/en not_active Expired
- 1980-11-25 EP EP80107328A patent/EP0029990B1/en not_active Expired
- 1980-11-25 AT AT80107328T patent/ATE1523T1/en not_active IP Right Cessation
- 1980-12-01 IL IL61600A patent/IL61600A/en unknown
- 1980-12-02 NZ NZ195716A patent/NZ195716A/en unknown
- 1980-12-02 GR GR63531A patent/GR71617B/el unknown
- 1980-12-02 AU AU64997/80A patent/AU535714B2/en not_active Ceased
- 1980-12-03 DK DK517580A patent/DK517580A/en not_active Application Discontinuation
- 1980-12-03 IE IE2519/80A patent/IE50610B1/en unknown
- 1980-12-03 ZA ZA00807544A patent/ZA807544B/en unknown
- 1980-12-03 ES ES497410A patent/ES8201545A1/en not_active Expired
- 1980-12-03 PL PL22823580A patent/PL228235A1/xx unknown
- 1980-12-04 PT PT72160A patent/PT72160B/en unknown
- 1980-12-04 JP JP17145380A patent/JPS56113754A/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| DE3060828D1 (en) | 1982-10-28 |
| IL61600A0 (en) | 1981-01-30 |
| JPS56113754A (en) | 1981-09-07 |
| AU535714B2 (en) | 1984-04-05 |
| IE50610B1 (en) | 1986-05-28 |
| ES497410A0 (en) | 1982-01-01 |
| ES8201545A1 (en) | 1982-01-01 |
| IL61600A (en) | 1984-06-29 |
| EP0029990B1 (en) | 1982-09-08 |
| GR71617B (en) | 1983-06-17 |
| IE802519L (en) | 1981-06-04 |
| ZA807544B (en) | 1981-11-25 |
| ATE1523T1 (en) | 1982-09-15 |
| PT72160A (en) | 1981-01-01 |
| NZ195716A (en) | 1983-06-14 |
| DK517580A (en) | 1981-06-05 |
| EP0029990A1 (en) | 1981-06-10 |
| PT72160B (en) | 1982-07-05 |
| PL228235A1 (en) | 1982-08-02 |
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