AU6338999A - Combination of norpregnane derivatives and cyclodextrin - Google Patents
Combination of norpregnane derivatives and cyclodextrinInfo
- Publication number
- AU6338999A AU6338999A AU63389/99A AU6338999A AU6338999A AU 6338999 A AU6338999 A AU 6338999A AU 63389/99 A AU63389/99 A AU 63389/99A AU 6338999 A AU6338999 A AU 6338999A AU 6338999 A AU6338999 A AU 6338999A
- Authority
- AU
- Australia
- Prior art keywords
- cyclodextrin
- combination
- gestagen
- derivatives
- beta
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Steroid Compounds (AREA)
Abstract
The invention relates to a combination of at least one gestagen and a beta -cyclodextrin or an gamma -cyclodextrin or the derivatives of said cyclodextrins obtained by etherification or esterification of the free alcohol functions of cyclodextrin, wherein the gestagen is a bridged 4,17-C>2<-steroid. The gestagen is preferably (21S)-21-hydroxy-21-methyl-14,17-ethano-19-norpregna-4,9,15-triene-3,2 0-dion). The cyclodextrin is preferably beta -cyclodextrin. Said combination is used as medicament in the treatment of climateric complaints and fertility control.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19848303A DE19848303A1 (en) | 1998-10-14 | 1998-10-14 | Stable combination of 14,17-over-bridged steroid gestagen and cyclodextrin compound, useful for treating climacteric disorders or for contraception |
DE19848303 | 1998-10-14 | ||
PCT/EP1999/007711 WO2000021570A1 (en) | 1998-10-14 | 1999-10-13 | Combination of norpregnane derivatives and cyclodextrin |
Publications (1)
Publication Number | Publication Date |
---|---|
AU6338999A true AU6338999A (en) | 2000-05-01 |
Family
ID=7885041
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU63389/99A Abandoned AU6338999A (en) | 1998-10-14 | 1999-10-13 | Combination of norpregnane derivatives and cyclodextrin |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP1121152B1 (en) |
AT (1) | ATE264115T1 (en) |
AU (1) | AU6338999A (en) |
DE (2) | DE19848303A1 (en) |
WO (1) | WO2000021570A1 (en) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
UY27088A1 (en) * | 2000-12-20 | 2002-07-31 | Schering Ag | ESTROGEN-CYCLODEXTRINE COMPLEX COMPOSITIONS |
EP1216713A1 (en) | 2000-12-20 | 2002-06-26 | Schering Aktiengesellschaft | Compositions of estrogen-cyclodextrin complexes |
EP1216699A1 (en) * | 2000-12-21 | 2002-06-26 | Schering Aktiengesellschaft | Transdermal system comprising a highly potent progestin |
DE10234525A1 (en) * | 2002-07-25 | 2004-02-05 | Schering Ag | New compositions, useful as male contraceptives, comprise synergistic active agent combination of androgenic 11beta-halo-steroid and gestagenic 14 alpha, 17alpha-ethylene-estratrienone derivative |
WO2004011008A1 (en) * | 2002-07-25 | 2004-02-05 | Schering Aktiengesellschaft | COMPOSITION CONTAINING AN ANDROGENOUS 11β-HALOGEN STEROID AND A PROGESTATIONAL HORMONE, AND MALE CONTRACEPTIVE BASED ON SAID COMPOSITION |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4383992A (en) * | 1982-02-08 | 1983-05-17 | Lipari John M | Water-soluble steroid compounds |
DE3346123A1 (en) * | 1983-12-21 | 1985-06-27 | Janssen Pharmaceutica, N.V., Beerse | PHARMACEUTICAL PREPARATIONS OF SUBSTANCES MEDICAL OR UNSTABLE IN WATER AND METHOD FOR THE PRODUCTION THEREOF |
NL8801670A (en) * | 1988-07-01 | 1990-02-01 | Walter Adrianus Josephus Johan | PHARMACEUTICAL PREPARATION. |
WO1990001320A1 (en) * | 1988-08-15 | 1990-02-22 | American Maize-Products Company | Water soluble branched beta cyclodextrin steroid complex |
FR2667070A1 (en) * | 1990-09-21 | 1992-03-27 | Besins Iscovesco Labo | STEROIDS INCLUDED IN CYCLODEXTRINS PROCESS FOR THEIR PREPARATION COMPLEXES AND CORRESPONDING GOLENIC FORMS AND THEIR THERAPEUTIC APPLICATIONS. |
DE4426709A1 (en) * | 1994-07-20 | 1996-01-25 | Schering Ag | Solid dosage forms containing steroidal sex hormones |
DE4428654A1 (en) * | 1994-08-12 | 1996-02-15 | Consortium Elektrochem Ind | Water soluble cyclodextrin derivatives with lipophilic substituents and process for their preparation |
DE4447401A1 (en) * | 1994-12-23 | 1996-07-04 | Schering Ag | 14.17-C¶2¶-bridged steroids |
-
1998
- 1998-10-14 DE DE19848303A patent/DE19848303A1/en not_active Ceased
-
1999
- 1999-10-13 AU AU63389/99A patent/AU6338999A/en not_active Abandoned
- 1999-10-13 AT AT99950719T patent/ATE264115T1/en not_active IP Right Cessation
- 1999-10-13 EP EP99950719A patent/EP1121152B1/en not_active Expired - Lifetime
- 1999-10-13 WO PCT/EP1999/007711 patent/WO2000021570A1/en active IP Right Grant
- 1999-10-13 DE DE59909196T patent/DE59909196D1/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
EP1121152B1 (en) | 2004-04-14 |
DE59909196D1 (en) | 2004-05-19 |
WO2000021570A1 (en) | 2000-04-20 |
EP1121152A1 (en) | 2001-08-08 |
ATE264115T1 (en) | 2004-04-15 |
DE19848303A1 (en) | 2000-04-20 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MK6 | Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase |