AU6113694A - Inhalation device - Google Patents

Inhalation device

Info

Publication number
AU6113694A
AU6113694A AU61136/94A AU6113694A AU6113694A AU 6113694 A AU6113694 A AU 6113694A AU 61136/94 A AU61136/94 A AU 61136/94A AU 6113694 A AU6113694 A AU 6113694A AU 6113694 A AU6113694 A AU 6113694A
Authority
AU
Australia
Prior art keywords
swirl chamber
capsule
mouthpiece
cover
medicament
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
AU61136/94A
Other versions
AU680874B2 (en
Inventor
Brindra Paul Singh Chawla
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fisons Ltd
Original Assignee
Fisons Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB939304011A external-priority patent/GB9304011D0/en
Priority claimed from GB939311646A external-priority patent/GB9311646D0/en
Application filed by Fisons Ltd filed Critical Fisons Ltd
Publication of AU6113694A publication Critical patent/AU6113694A/en
Application granted granted Critical
Publication of AU680874B2 publication Critical patent/AU680874B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/003—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up
    • A61M15/0031—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up by bursting or breaking the package, i.e. without cutting or piercing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/06—Solids
    • A61M2202/064—Powder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2206/00—Characteristics of a physical parameter; associated device therefor
    • A61M2206/10—Flow characteristics
    • A61M2206/16—Rotating swirling helical flow, e.g. by tangential inflows

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Manipulator (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Weting (AREA)
  • Catching Or Destruction (AREA)
  • Dental Tools And Instruments Or Auxiliary Dental Instruments (AREA)

Abstract

A device for the administration of powdered inhalation medicament contained initially in a capsule having at least one aperture formed therein, comprising a swirl chamber (1) adapted to receive the medicament capsule; a mouthpiece (2) communicating with the swirl chamber (1) and separated therefrom by a grid (4); at least one air inlet (5) in tangential communication with the swirl chamber (1) whereby air can be drawn through the device via the mouthpiece (2) to cause a swirling air flow through the swirl chamber (1); and a cover member (7), having a continuous substantially planar inner surface, provided on the base of the swirl chamber (1) remote from the mouthpiece (2); said cover (7) being moveable between a first position in which the capsule can be inserted into the swirl chamber (1) and a second position in which the capsule is retained in the swirl chamber (1) and rotates upon air being drawn through the device, thereby dispensing the medicament contained therein.

Description

INHALATION DEVICE
This invention relates to an inhalation device, in particular to an inhalation device for use with pre-pierced capsules of dry powder medicament.
The administration of inhalation medicaments in dry powder form is well known. Powdered medicament is often supplied in capsules which are loaded into a dispensing device wherein the medicament is released from the capsule then inhaled by the patient.
Powdered medicament contained in a capsule may be dispensed using the device known as the SPINHALER™. This device comprises a housing which retains an individual capsule of medicament which is pierced in situ thus releasing the medicament for inhalation. This device has the disadvantage that small fragments of the capsule may be produced during the opening process which could be inhaled by the patient.
Furthermore, the design of piercing mechanism may limit the device to use with medicament capsules of only one size.
European Patent Application 0333334 discloses a device for the administration of medicament from capsules in which the capsule is pierced prior to it's insertion in a dispensing chamber by pushing it onto a pin located in a recess in the base of the dispensing chamber. This device suffers from the disadvantage that it is only possible to pierce one end of the capsule at a time. Thus if it is desired to pierce the capsule at both ends to assist the release of medicament, the piercing procedure must be repeated with the possibility of losing medicament from the first aperture whilst the second is being formed. Furthermore, the recess provided in the base of the dispensing chamber provides an area in which medicament can become trapped possibly reducing the dose administered to the patient and/or making cleaning the device more difficult.
Pre-pierced medicament capsules, i.e. capsules the walls of which are provided with one or more apertures during manufacture, are known. European Patent
Application 0385156 discloses a disposable inhaler containing a single pre-pierced capsule. However, this device suffers from the drawback that it may be necessary to carry several separate devices in order to provide a day's supply of medicament. It is also wasteful since the device cannot be refilled and is thus discarded after only one use. We have now devised an improved inhalation device which overcomes or substantially mitigates the disadvantages of the prior art devices described above.
According to the invention there is provided a device for the administration o powdered inhalation medicament contained initially in a capsule having at least one aperture formed therein, said device comprising a swirl chamber adapted to receive the medicament capsule; a mouthpiece communicating with the swirl chamber and separated therefrom by a grid; at least one air inlet in tangential communication with the swirl chamber whereby air can be drawn through the device via the mouthpiece to cause a swirling air flow through the swirl chamber; and a cover member, having a continuous substantially planar inner surface, provided on the base of the swirl chamber remote from the mouthpiece; said cover being moveable between a first position in which the capsule can be inserted into the swirl chamber and a second position in which the capsule is retained in the swirl chamber and rotates upon air being drawn through the device, thereby dispensing the medicament contained therein.
The cover member may be removably attached to the base of the swirl chamber remote from the mouthpiece, e.g. by a snap-fit or screw-threaded engagement. Alternatively, the cover member may be slidably attached to the base of the swirl chamber to provide access thereto. However, we prefer the cover member to be in hinged engagement with the base of the swirl chamber, pivotal movement about the hinge allowing the cover to move between the first and second positions. When the cover member is in hinged engagement with the swirl chamber the cover member is preferably adapted to resiliently engage a flange on the swirl chamber at a position remote from the hinge. This resilient engagement ensuring that, when in the second position, the cover member remains closed.
The cover member may be made of a transparent material, thus allowing the patient to readily determine if all the medicament contained in the capsule has been inhaled.
When the cover member is in the second position the continuous substantially planar inner surface of the cover member defines the base of the swirl chamber. The continuous substantially planar surface of the cover member provides an effective seal at the base of the swirl chamber thus preventing the escape of medicament. It also facilitates rotation of the capsule within the swirl chamber.
The device according to the invention may have any practicable number of air inlets in tangential communication with the swirl chamber. We prefer the device to have two air inlets in tangential communication with the swirl chamber. The air inlets are preferably spaced at regular intervals around the swirl chamber.
The mouthpiece of the device may also be provided with a removable cover to help prevent the ingress of dirt and moisture between uses. When the device is provided with a mouthpiece cover it is preferably adapted to cover the both the mouthpiece and the air inlet(s) communicating with the swirl chamber. The mouthpiece cover is preferably provided with protruding element(s) adapted to cover the air inlet(s). 5 The device according to the invention can be used in a manner which depends only upon the inspiration of the patient to achieve dispersion of the medicament contained in the capsule. It can also be used in a positive gas assisted manner in which an external source of gas, e.g. air, is used to assist rotation of the capsule in the swirl chamber. The external source of gas may be provided manually or electrically, using, o for example, a compressed gas cylinder or air compressor. The use of the device in a gas assisted manner may be particularly useful for patients who have low inspiration rates, e.g. infants, the elderly or patients at a critical stage of an asthma attack.
The capsules for use in the device according to the invention may be made from any material in which apertures may be formed, suitable materials include hard or soft s gelatin, polystyrene, nylons, polyalkylenes such as polyethylene, cellulose, alkyl cellulose and acetate polymers.
The capsules may be of any shape but are preferably cylindrical. The capsules may contain one or more apertures, e.g. 1 to 6, and especially 2 apertures. The apertures may be situated in any portion of the capsule body. However, when the 0 capsules are cylindrical we prefer them to have an aperture situated at the end of the capsule and more preferably at both ends of the capsule.
The capsule apertures may be of any shape, e.g. square, rectangular, oval, or preferably circular. When the apertures are circular they may have a diameter of between 0.50 and 1.20 mm, preferably from 0.50 to 1.01 mm, more preferably from 0.76 5 to 1.01 mm and especially 0.81 mm. When the capsule contains more then one aperture then the apertures may have the same or different dimensions.
The method used for forming the capsule apertures will be dependent upon the size, shape and position of the apertures, any conventional techniques known perse may be employed. When a circular or oval aperture is required a cutting tool may be used; o alternatively laser light may be employed or a hot needle. When a square or rectangular aperture is required a cutting tool with an inclined terminal face may be employed.
The capsules for use in the device according to the invention may be provided in a blister-pack adapted to seal the capsule aperture(s) until they are removed from the pack, as described in International Patent Application PCT/GB93/01909.
Although the device according to the invention has thus far been described for use in oral inhalation of medicaments, it is also suitable for the administration of nasal medicaments by inhalation. The necessary adaptation for this mode of administration will be readily apparent to those skilled in the art and may take the form of an elongate air passage adapted for insertion into the nostril rather than a mouthpiece.
The device may be used for dispensing any medicament which is conventionally administered by inhalation to the lung or the nose. Such medicaments include drugs for use in the prophylactic or remedial treatment of reversible obstructive airways disease. Specific active ingredients which may be mentioned include salts of cromoglycic acid, e.g. sodium cromoglycate; salts of nedocromil, e.g. nedocromil sodium; inhaled steroids such as beclomethasone dipropionate, tipredane, budesonide and fluticasone; anticholinergic agents such as ipratropium bromide; bronchodilators, e.g. salmeterol, salbutamol, reproterol, terbutaline, isoprenaline and fenoterol, and salts thereof. If desired a mixture of active ingredients, for example, a mixture of sodium cromoglycate and a bronchodilator, such as salbutamol, reproterol, isoprenaline, terbutaline, fenoterol or a salt of any one thereof, may be used.
Other active ingredients that may be mentioned include antihistamines, e.g. clemastine, pentamidine and salts thereof, acetyl-ø-methylcholine bromide; peptide hormones, e.g. insulin and amylin; bradykinin antagonists; PLA2 inhibitors; PAF antagonists; lipoxygenase inhibitors; leukotriene antagonists; CNS active drugs, e.g. NMDA antagonists, glutamate antagonists, CCK agonists and antagonists; macrolide compounds, e.g. FK 506, rapamycin, cyclosporin and structurally related compounds; vitamins; vaccines, e.g. MMR vaccine and polio vaccine; and vectors for gene therapy, e.g. plasmids containing genes intended to correct genetic disorders such as cystic fibrosis.
The powdered medicament will generally be administered as a composition including one or more additional pharmaceutically acceptable additives, e.g. a solid carrier of larger particle size. The solid pharmaceutically acceptable carrier will generally be a non-toxic material chemically inert to the inhalation medicament but may, if so desired, also comprise larger particles of the inhalation medicament. Examples of carriers which may be used in the composition include a dextran, mannitol and, preferably, lactose. A particularly preferred carrier is crystalline lactose.
The powdered medicament may also be formulated as a so-called "pelletised" composition, i.e. as soft pellets of diameter greater than 30 μm, each pellet comprising a plurality of individual particles loosely held together such that upon inhalation the pellets disintegrate to the constituent particles. Pelletised compositions may be prepared according to the method described in GB 1520247.
The particular formulation of powdered medicament contained in the capsule will, of course, depend upon the nature of the active ingredient.
The amount of powdered medicament contained in the capsule will depend on the desired dosage and the potency of the active ingredient, but will generally be from about 10 μg to 50 mg, e.g. 20 mg.
According to a further aspect of the invention there is provided a method for administering powdered inhalation medicament contained initially in a capsule having at least one aperture formed therein, which comprises inserting the capsule in a device consisting of a swirl chamber adapted to receive the medicament capsule; a mouthpiece communicating with the swirl chamber and separated therefrom by a grid; at least one air inlet in tangential communication with the swirl chamber whereby air can be drawn through the device via the mouthpiece to cause a swirling air flow through the chamber; and a cover member provided on the base of the swirl chamber remote from the mouthpiece, said cover being moveable between a first position in which a capsule can be inserted into the swirl chamber and a second position in which the capsule is retained in the swirl chamber, and drawing air through the device, such that the capsule rotates in the swirl chamber thereby dispensing the medicament contained therein.
The device according to the invention has advantages over known inhalation devices in that the medicament capsules do not need to be individually pierced by hand; the risk of capsule fragments being inhaled by the patient is substantially reduced; it is safe since there is no sharp piercing mechanism which could cause accidental injury to the patient, it is suitable for the administration of a wide variety of inhalation medicaments which may be contained in capsules of varying sizes; it gives improved capsule emptying; it is of a more compact design; manufacture of the device is considerably simplified since no capsule opening mechanism is required; it is easy to clean; and, since the device contains no internal moving parts, it is less prone to malfunction and therefore may have an extended lifetime. A preferred embodiment of the invention will now be described, by way of illustration only, with reference to the accompanying drawings, in which:
Figure 1 is a perspective view of a device according to the invention with the mouthpiece cover in place, Figure 2 is a perspective view of a device according to Figure 1 with the mouthpiece cover removed,
Figure 3 is a side view of the device of Figure 2,
Figure 4 is a longitudinal section of the device of Figure 3 with cover open, and without the mouthpiece cover, Figure 5 is the same longitudinal section of the device as in Figure 4 but with cover closed, and
Figure 6 is a section along the line X-X of Figure 5.
An inhalation device according to the invention comprises a generally cylindrical swirl chamber (1) adapted to receive a capsule (not shown) of powdered inhalation medicament having an aperture formed at each end. A mouthpiece (2), having a removable mouthpiece cover (3), extends from swirl chamber (1) and is separated therefrom by a grid (4). Two tangential air inlets (5, 5a) open into swirl chamber (1). When the mouthpiece cover (3) is in place on the device air inlets (5, 5a) are covered by extensions of the mouthpiece cover (6, 6a). The base of swirl chamber (1) remote from mouthpiece (2) is provided with a cover (7) having a continuous substantially planar inner surface, the cover (7) being attached to the base of the swirl chamber (1) via hinge (8), thus allowing access to the swirl chamber (1) for insertion and removal of a capsule. The end of the cover (7) remote from the hinge (8) is adapted to resiliently engage the base of the swirl chamber (1). In use, cover (7) is opened and a capsule (not shown) of inhalation medicament having an aperture at each end is inserted into swirl chamber (1). Cover (7) is then closed and the mouthpiece cover (3) removed thus exposing air inlets (5, 5a). The patient inhales through mouthpiece (2), thereby drawing air through tangential air inlets (5, 5a) into swirl chamber (1). The air flowing into swirl chamber (1) causes the capsule to rotate thereby dispensing the medicament contained therein which is entrained into air flow (A) and inhaled by the patient. Once the medicament has been inhaled the mouthpiece cover (3) is replaced and cover (7) is opened to allow removal of the empty capsule.

Claims (6)

1. A device for the administration of powdered inhalation medicament contained initially in a capsule having at least one aperture formed therein, said device comprising a swirl chamber (1) adapted to receive the medicament capsule; a mouthpiece (2) s communicating with the swirl chamber (1) and separated therefrom by a grid (4); at least one air inlet (5) in tangential communication with the swirl chamber (1) whereby air can be drawn through the device via the mouthpiece (2) to cause a swirling air flow through the swirl chamber (1); and a cover member (7), having a continuous substantially planar inner surface, provided on the base of the swirl chamber (1) remote o from the mouthpiece (2); said cover (7) being moveable between a first position in which the capsule can be inserted into the swirl chamber (1) and a second position in which the capsule is retained in the swirl chamber (1) and rotates upon air being drawn through the device, thereby dispensing the medicament contained therein.
2. A device according to Claim 1 wherein the cover member (7) is in hinged s engagement with the base of the swirl chamber (1).
3. A device according to Claim 1 or 2 which has two air inlets (5, 5a) in tangential communication with the swirl chamber (1).
4. A device according to any one of the preceding claims which is provided with a mouthpiece cover (3). o
5. A device according to Claim 4, wherein the mouthpiece cover (3) is adapted to cover the mouthpiece (2) and the air inlet(s) (5) communicating with the swirl chamber
6. A device according to Claim 5, wherein the mouthpiece cover (3) is provided with a protruding element(s) (6) adapted to cover the air inlet(s) (5). 5
AU61136/94A 1993-02-27 1994-02-28 Inhalation device Ceased AU680874B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB9304011 1993-02-27
GB939304011A GB9304011D0 (en) 1993-02-27 1993-02-27 Inhalation device
GB9311646 1993-06-05
GB939311646A GB9311646D0 (en) 1993-06-05 1993-06-05 Inhalation device
PCT/GB1994/000388 WO1994019041A1 (en) 1993-02-27 1994-02-28 Inhalation device

Publications (2)

Publication Number Publication Date
AU6113694A true AU6113694A (en) 1994-09-14
AU680874B2 AU680874B2 (en) 1997-08-14

Family

ID=26302515

Family Applications (1)

Application Number Title Priority Date Filing Date
AU61136/94A Ceased AU680874B2 (en) 1993-02-27 1994-02-28 Inhalation device

Country Status (19)

Country Link
US (1) US5787881A (en)
EP (1) EP0773807B1 (en)
JP (1) JPH08507704A (en)
KR (1) KR100297344B1 (en)
AT (1) ATE185977T1 (en)
AU (1) AU680874B2 (en)
BR (1) BR9406253A (en)
CA (1) CA2157043A1 (en)
DE (1) DE69421415T2 (en)
DK (1) DK0773807T3 (en)
ES (1) ES2139733T3 (en)
FI (1) FI953983A (en)
GR (1) GR3031814T3 (en)
HU (1) HU217896B (en)
IL (1) IL108780A (en)
NO (1) NO311497B1 (en)
NZ (1) NZ261892A (en)
PL (1) PL173041B1 (en)
WO (1) WO1994019041A1 (en)

Families Citing this family (79)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9302550D0 (en) * 1993-07-30 1993-07-30 Ernst Hoerlin POWDER INHALES
JP3317823B2 (en) * 1995-08-11 2002-08-26 株式会社ユニシアジェックス Dosing device
JP3328132B2 (en) * 1996-03-21 2002-09-24 株式会社ユニシアジェックス Inhaler type dispenser
GB9626233D0 (en) * 1996-12-18 1997-02-05 Chawla Brinda P S Medicament packaging and deliveery device
US6062213A (en) * 1998-06-16 2000-05-16 Fuisz Technologies Ltd. Single unit dose inhalation therapy device
GB2353222B (en) 1999-06-23 2001-09-19 Cambridge Consultants Inhalers
US9006175B2 (en) 1999-06-29 2015-04-14 Mannkind Corporation Potentiation of glucose elimination
US7305986B1 (en) 1999-07-23 2007-12-11 Mannkind Corporation Unit dose capsules for use in a dry powder inhaler
US7464706B2 (en) 1999-07-23 2008-12-16 Mannkind Corporation Unit dose cartridge and dry powder inhaler
WO2002013897A2 (en) 2000-08-14 2002-02-21 Advanced Inhalation Research, Inc. Inhalation device and method
US6357490B1 (en) 2000-08-22 2002-03-19 Advanced Inhalation Research, Inc. System, method and apparatus for filling containers
SE0100034D0 (en) * 2001-01-04 2001-01-04 Astrazeneca Ab A delivery device
US6443152B1 (en) * 2001-01-12 2002-09-03 Becton Dickinson And Company Medicament respiratory delivery device
US6722364B2 (en) * 2001-01-12 2004-04-20 Becton, Dickinson And Company Medicament inhalation delivery devices and methods for using the same
EP1238680B1 (en) * 2001-03-05 2003-12-10 Ivo Pera Inhaling device for dispersing powdered medicaments contained in a capsule through the respiratory tract
US6766799B2 (en) * 2001-04-16 2004-07-27 Advanced Inhalation Research, Inc. Inhalation device
GB2375308A (en) * 2001-05-10 2002-11-13 Cambridge Consultants Inhalers
EP1392382B1 (en) * 2001-05-10 2008-08-06 Vectura Delivery Devices Limited Inhaler
US20030070679A1 (en) * 2001-06-01 2003-04-17 Boehringer Ingelheim Pharma Kg Capsules containing inhalable tiotropium
GB0130055D0 (en) 2001-12-14 2002-02-06 Technology Innovation Ltd Medicament packaging
DE60318938T2 (en) 2002-03-20 2009-01-22 Mannkind Corp., Valencia INHALER
ATE477193T1 (en) * 2003-03-15 2010-08-15 Brin Tech Internat Ltd PACKAGING FOR MEDICINAL PRODUCTS
GB0317374D0 (en) 2003-07-24 2003-08-27 Glaxo Group Ltd Medicament dispenser
GB0410712D0 (en) 2004-05-13 2004-06-16 Novartis Ag Organic compounds
GB0418278D0 (en) * 2004-08-16 2004-09-15 Glaxo Group Ltd Medicament dispenser
DK1786784T3 (en) 2004-08-20 2011-02-14 Mannkind Corp Catalysis of diketopiperazine synthesis
JP4990142B2 (en) 2004-08-23 2012-08-01 マンカインド コーポレイション Diketopiperazine salt, diketomorpholine salt, or diketodioxane salt for drug delivery
US7694676B2 (en) * 2005-04-22 2010-04-13 Boehringer Ingelheim Gmbh Dry powder inhaler
GB0515584D0 (en) * 2005-07-28 2005-09-07 Glaxo Group Ltd Medicament dispenser
HUE028691T2 (en) 2005-09-14 2016-12-28 Mannkind Corp Method of drug formulation based on increasing the affinity of crystalline microparticle surfaces for active agents
AU2007210177C1 (en) 2006-01-31 2012-11-01 Oriel Therapeutics, Inc. Dry powder inhalers having spiral travel paths, unit dose microcartridges with dry powder, related devices and methods
AU2007216966C1 (en) 2006-02-22 2014-03-20 Mannkind Corporation A method for improving the pharmaceutic properties of microparticles comprising diketopiperazine and an active agent
DE102006010089A1 (en) * 2006-02-24 2007-10-18 Aha-Kunststofftechnik Gmbh The dry powder inhaler
GB0611656D0 (en) * 2006-06-13 2006-07-19 Cambridge Consultants Dry powder inhalers
GB0616299D0 (en) * 2006-08-16 2006-09-27 Cambridge Consultants Drug Capsules for dry power inhalers
GB0622827D0 (en) * 2006-11-15 2006-12-27 Glaxo Group Ltd Sheet driver for use in a drug dispenser
WO2008091355A2 (en) * 2007-01-24 2008-07-31 Breathe Pharmaceuticals, Inc. Drug transfer device
WO2008156586A2 (en) * 2007-06-12 2008-12-24 Alkermes, Inc. Inhalation device for powdered substances
PT2230934E (en) 2007-12-14 2012-11-20 Aerodesigns Inc Delivering aerosolizable food products
US8485180B2 (en) 2008-06-13 2013-07-16 Mannkind Corporation Dry powder drug delivery system
ES2655921T3 (en) 2008-06-13 2018-02-22 Mannkind Corporation A dry powder inhaler and drug delivery system
ES2904623T3 (en) 2008-06-20 2022-04-05 Mannkind Corp Interactive device to establish a real-time profile of inhalation efforts
WO2010011329A2 (en) * 2008-07-23 2010-01-28 Map Pharmaceuticals, Inc. The delivery of powdered drug via inhalation
TWI532497B (en) 2008-08-11 2016-05-11 曼凱公司 Use of ultrarapid acting insulin
BRPI0920673A2 (en) * 2008-10-08 2015-12-29 Astrazeneca Ab indexing inhaler linked to the cover movement
US8314106B2 (en) 2008-12-29 2012-11-20 Mannkind Corporation Substituted diketopiperazine analogs for use as drug delivery agents
EP2405963B1 (en) 2009-03-11 2013-11-06 MannKind Corporation Apparatus, system and method for measuring resistance of an inhaler
WO2010144789A2 (en) 2009-06-12 2010-12-16 Mannkind Corporation Diketopiperazine microparticles with defined specific surface areas
WO2011056889A1 (en) 2009-11-03 2011-05-12 Mannkind Corporation An apparatus and method for simulating inhalation efforts
AU2010319328A1 (en) 2009-11-12 2012-05-31 Stc.Unm Dry powder inhaler with flutter dispersion member
KR20130117755A (en) 2010-06-21 2013-10-28 맨카인드 코포레이션 Dry powder drug delivery system and methods
FR2962342B1 (en) * 2010-07-07 2013-02-15 Valois Sas DRY POWDER INHALER.
FR2962341B1 (en) * 2010-07-07 2013-02-15 Valois Sas DRY POWDER INHALER.
US8561609B2 (en) 2010-12-07 2013-10-22 Respira Therapeutics, Inc. Dry powder inhaler
CN105667994B (en) 2011-04-01 2018-04-06 曼金德公司 Blister package for pharmaceutical kit
WO2012174472A1 (en) 2011-06-17 2012-12-20 Mannkind Corporation High capacity diketopiperazine microparticles
WO2013008040A1 (en) * 2011-07-13 2013-01-17 Pharmaxis Ltd Improvements relating to delivery devices
EP2731572B1 (en) * 2011-07-13 2021-04-07 Pharmaxis Ltd. Improvements relating to delivery devices
DK2731571T3 (en) 2011-07-13 2020-02-17 Pharmaxis Ltd IMPROVEMENTS ON DELIVERY DEVICES
BR112014004921B1 (en) 2011-09-07 2020-12-08 Concentrx Pharmaceuticals, Inc. dry powder inhalation device
WO2013063160A1 (en) 2011-10-24 2013-05-02 Mannkind Corporation Methods and compositions for treating pain
US10463815B2 (en) 2012-02-21 2019-11-05 Respira Therapeutics, Inc. Inhaler to deliver substances for prophylaxis or prevention of disease or injury caused by the inhalation of biological or chemical agents
CN108057154B (en) 2012-07-12 2021-04-16 曼金德公司 Dry powder drug delivery system and method
US9764103B2 (en) * 2012-10-05 2017-09-19 Lily A. Neff Salt puffer
US10159644B2 (en) 2012-10-26 2018-12-25 Mannkind Corporation Inhalable vaccine compositions and methods
JP6523247B2 (en) 2013-03-15 2019-05-29 マンカインド コーポレイション Method of making microcrystalline diketopiperazine particles and method of making dry powder composition
EP3021834A1 (en) 2013-07-18 2016-05-25 MannKind Corporation Heat-stable dry powder pharmaceutical compositions and methods
EP3030294B1 (en) 2013-08-05 2020-10-07 MannKind Corporation Insufflation apparatus
US10307464B2 (en) 2014-03-28 2019-06-04 Mannkind Corporation Use of ultrarapid acting insulin
US10561806B2 (en) 2014-10-02 2020-02-18 Mannkind Corporation Mouthpiece cover for an inhaler
WO2016075749A1 (en) 2014-11-10 2016-05-19 日本たばこ産業株式会社 Cartridge and non-combusting flavor inhaler
MX2017009112A (en) 2015-01-14 2018-06-15 Respira Therapeutics Inc Powder dispersion methods and devices.
PT108426B (en) * 2015-04-30 2017-07-24 Hovione Farmaciência S A POWDER INHALER FOR ADMINISTRATION OF HIGH DOSES OF DRUGS
ES2760943T3 (en) * 2016-05-23 2020-05-18 Presspart Mfg Ltd Dry powder inhaler
EP3600504B1 (en) 2017-03-28 2023-07-12 Concentrx Pharmaceuticals, Inc. Device for delivering dry powder medicaments
KR101992171B1 (en) * 2017-06-27 2019-06-25 한국유나이티드제약 주식회사 Inhaler for dry powder
CN110201281B (en) * 2018-02-28 2021-08-06 张江 Inhalation administration device and inhalation administration combination structure
CA193818S (en) * 2020-03-11 2022-04-20 Breathesuite Inc Monitoring device for inhalers
KR102662529B1 (en) * 2021-09-02 2024-04-30 중앙대학교 산학협력단 Portable drug inhaler

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4069819A (en) * 1973-04-13 1978-01-24 Societa Farmaceutici S.P.A. Inhalation device
IT1016489B (en) * 1974-03-18 1977-05-30 Isf Spa INHALER
AT384552B (en) * 1985-08-01 1987-12-10 Hurka Wilhelm INHALATION DEVICE FOR DOSING AND DISTRIBUTING SOLID BODIES INTO THE BREATHING AIR
GB8804069D0 (en) * 1988-02-22 1988-03-23 Britains Petite Ltd Dispensers for powdered medication
IT1228460B (en) * 1989-02-23 1991-06-19 Phidea S R L DISPOSABLE INHALER WITH PRE-PERFORATED CAPSULE
IT1237118B (en) * 1989-10-27 1993-05-18 Miat Spa MULTI-DOSE INHALER FOR POWDER DRUGS.
IL98441A (en) * 1990-06-14 1995-12-31 Rhone Poulenc Rorer Ltd Powder inhalers
US5429122A (en) * 1990-09-26 1995-07-04 Zanen; Pieter Inhaler devices provided with a reservoir for several doses of medium for inhaling, transporting device, whirl chamber
DE59107894D1 (en) * 1991-03-21 1996-07-11 Ritzau Pari Werk Gmbh Paul Nebulizers, in particular for use in devices for inhalation therapy
GB9106648D0 (en) * 1991-03-28 1991-05-15 Rhone Poulenc Rorer Ltd New inhaler
US5476093A (en) * 1992-02-14 1995-12-19 Huhtamaki Oy Device for more effective pulverization of a powdered inhalation medicament
US5560490A (en) * 1992-09-09 1996-10-01 Fisons Plc Pharmaceutical packaging with capsule sealing means
US5349947A (en) * 1993-07-15 1994-09-27 Newhouse Michael T Dry powder inhaler and process that explosively discharges a dose of powder and gas from a soft plastic pillow
EP0682955B1 (en) * 1994-05-19 2001-09-05 PARI GmbH Spezialisten für effektive Inhalation Device for drying and buffering aerosols

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NO953327L (en) 1995-08-24
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DE69421415T2 (en) 2000-02-10
HUT73520A (en) 1996-08-28
CA2157043A1 (en) 1994-09-01
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IL108780A (en) 1999-06-20
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US5787881A (en) 1998-08-04
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AU680874B2 (en) 1997-08-14
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PL173041B1 (en) 1998-01-30
DK0773807T3 (en) 2000-04-17

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