AU599312B2 - Method for treating muscle tension, muscle spasticity and anxiety with 3-aryloxy-azetidinecarboxamides - Google Patents

Description

The Commissioner of Patents ARTHUR S. CAVE CO.

Sicinature of Declarant John Calmers Gordon Assistant Secretary PATENT AND TRADE MARK ATTORNEYS SYbITEY CO0W AILTF. OF AUJSTr.PL5 F orm102 Reulation PATENTS ACT, 1952 13 2) COMPLETE SPECIFICATION

(ORIGINAL)

FOR OFFICE USE Short Title-.

Int. C14 Applic-ation Numberi Lodged: 5 0%1g.

Complete Specification-Lo'ged, Accepted: Lapsed: Published: Priority: Related Art: flwa. twsj "nd iG rr~*f gj tlt

IC

t C X C TO BE COMPLETED BY APPLICPNTT Nam~e of Applicant: 4 1 -4Address of Applicant., Actual Inventor: -~Address for Service: A.H. ROBINS COMPANY, INCORPORATED Richmond, Virginia, U.S.A.

Chandler Roy TAYLOR, Jr, Albert Duncan and Harold Fisher STAUFFER, Jr CALE, Jr ARTHUR S. CAVr, CO., Patent and. Trade Mark Attorneys, 1 Alfred Street, Sydney, New South Wales, Australia, 2000.

Complete Specification for the invention entitled: "Method _for eaiti ng muscle tens ion,' muscle spastic it-and anxiety with 3-aryloxy-azetidinecarboxamides".

The followingc statement is a full description of this invention, 1 nludingthe best method of performing it knovm to me3- -1- ASC -4 9 la BACKGROUND OF THE INVENTION 1. Field of Invention.

This invention relates to a method of treating muscle tension, muscle spasticity and anxiety in living animals,including humans, with 3-aryloxyazetidinecarboxamides, certain of which are novel.

2. Information Disclosure Statement.

Certain of the compounds useful in the method of the present invention are disclosed in U. S. Patent No.

4,226,861 as having anticonvulsant activity and use in C tr I treating epilepsy having the formula: t T R1 R-NHC-N 1.5 wherein R is loweralkyl and R 1 is hydrogen, aminocarbonyl or trifluoromethyl.

Certain other of the compounds useful in the present invention are disclosed in U. S. patent application Serial No. 664,036 filed on October 22, 1984, as having antip0 convulsant activity and having the formula: (R )n

NH

2 -C-N 0 wherein R' H, F, loweralkyl, loweralkoxy, trifluoromethyl, acetyl, or aminocarbonyl. That U. S. application is a continuation-in-part application of U application Serial No. 409,476 filed August 19, 198/, which states that the compounds of U. S. Patent 4,226,86), mentioned above, have muscle relaxant property and based on another less reliable test states that the compounds in U. S. application No.

409,476 do not have muscle relaxant activity at an effective anticonvulsant dosage. The subject matter of U. S. application No. 409,476 subsequently was published in European patent application 102-194-A on March 7, 1984.

S application. -Sef~misa 53 11S Ede A-hit~we-it- discloses a group of novel compounds within the generic formula of the present invention and others wherein R' and R 2 encompass aminoloweralkyl radicals as having anticonvulsant activity and methods and compositions for treating epilepsy.

9 4.

I IS cI t SUMMARY OF THE INVENTION The 3-aryloxyazetidinecarboxamides useful in the method of treating muscle tension, muscle spasticity and/or anxiety in animals of this invention have the formula: R Z II O-Ar

N-C-N

R

2

R

3 Formula I wherein Ar is selected from pyridyl in any of its positions including pyridyl or halo substituted pyridyl, from phenyl or phenyl substituted by 1 or 2 radicals selected from chloro, bromo, iodo, fluoro, loweralkyl, loweralkoxy, nitro, aminocarbonyl,. trifluoromethyl, or acetyl; Z is oxygen or sulfur;

R

1 and R 2 are selected from hydrogen, loweralkyl, aryl, allyl, substituted allyl, propargyl, cycloalkyl, loweralkylcycloalkyl, cycloalkylloweralkyl, arylloweralkyl and dialkylaminoalkyl, and R 1 and R 2 when tbken together with the adjacent nitrogen atom may form a heterocyclic amine radical including azetidinyl, pyrrolidinyl, piperidinyl, -3homopiperidinyl, imidazolyl, piperazinyl, 4-substituted piperazinyl and morpholinyl;

R

3 is selected from hydrogen, loweralkyl, aryl or arylloweralkyl; the geometrical isomers including cis, trans, (E) and isomers thereof, and the pharmaceutically acceptable salts thereof when R 1 and/or R 2 have a salt-forming basic amino component or when Ar is pyridyl.

The compounds of Formula I are novel except wherein Ar is phenyl or phenyl substituted by trifluoromethyl or aminocarbonyl at the same time Z is oxygen, R 3 is hydrogen, and R 1 and R 2 are a combination of hydrogen and loweralkyl and wherein Ar is phenyl or phenyl substituted by fluoro, loweralkyl, loweralkoxy, trifluoromethyl, acetyl or aminocarbonyl at the same time Z is oxygen and R 1

R

2 and R 3 are hydrogen.

In the further definition of symbols and in the St formulas hereof and where they appear elsewhere throughout this specification and in the claims, the terms have the following significance.

The term "loweralkyl" as used herein, unless otherwise specified, includes straight and branched chain radicals of up to eight carbons inclusive and is exemplified by such groups as methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, 25 tert-butyl, amyl, isoamyl, hexyl, heptyl, and octyl radicals and the like. The term "loweralkoxy" has the formula -0-loweralkyl.

SThe term "cycloalkyl" as used herein includes primarily cyclic alkyl radicals containing 3-9 carbon atoms inclusive and includes such groups as cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl and the like.

The term "loweralkylcycloalkyl" refers to cycloalkyl substituted by alkyl radicals of 1-8 carbon length.

The term "cycloalkylloweralkyi" refers to a cycloalkyl radical linked via 1-8 carbon alkyl chains, including branched chains, to the amide nitrogen.

The term "substituted allyl" means allyl substituted by alkyl radicals in any one of its 3 positions.

452 -4- The term "aryl" under the definition of R 1

R

2 and R 3 refers to phenyl r phenyl substituted by non-interfering 4 elc\ ro< radicals/shaS halo, loweralkyl, loweralkoxy, nitro, cyano, trifluoromethyl, carbomethoxy, carboethoxy, and the like.

The term "arylloweralkyl" under the definition of R 1

R

2 and R 3 refers to an aryl group as defined above linked via 1-8 carbon alkyl chains, including branched chains, to the amide nitrogen.

The term "4-substituted-piperazinyl" under the definition of R 1 and R 2 refers to a piperazine radical.

substituted by usual radicals common in the art, 4 +l Saryl as defined above and loweralkyl as defined above.

As defined above under Formula I, pharmaceutically acceptable salts are included when R 1 and/or R 2 have a saltforming amino component or when Ar is pyridyl. Salt-forming amino components are present, for example, when R 1 and/or Ra are diloweralkylaminoloweralkyl, or when together they 0 form piperazinyl or imidazololyl radicals. Pharmaceutically acceptable acid addition salts are those salts which are *o 20 physiologically compatible in warm-blooded animals. The acid addition salts may be formed by either strong or weak acids. Representative of strong acids are hydrochloric, hydrobromic, sulfuric, and phosphoric acids. Representative of useful weak acids are fumaric, maleic, succinic, oxalic, 25 citric, tartaric, hexamic and the like.

As stated above, the method of this invention employs the compounds of Formula I to relieve muscle tension and spasticity to relax muscles) and/or anxiety in animals, including humans. The procedure for testing 30 compounds for muscle relaxant activity is the Morphine- Induced Straub-Tail-In-Mice Test and the procedure for indicating antianxiety response is the Vogel Conflict Test based on shock suppressed drinking behavior. Both tests are given in detail hereinbelow under "Pharmacological Test Procedures." The method utilizing one or more of the compounds of Formula I is adaptable for treating tensed and spastic T -I Lu 5 muscles and for treating anxiety in the same individual or for treating tensed and spastic muscles when anxiety is not present or for treating anxiety when there are no muscle problems. Examples of effective muscle treatment would be for muscular conditions arising from tetanus, whiplash, stroke, multiple schlerosis, cerebral palsy and the like.

Compounds of Formula I wherein R 1 and R 2 have an allyl, substituted allyl, propargyl or cycloalkyl value are preferred for their potency as muscle relaxants.

DETAILED DESCRIPTION OF THE INVENTION The methods used to prepare the muscle relaxants and antianxiety agents of Formula I which are used in the method of'this invention-are classified as follows by equation under Method Classes A, B, and C.

t o C c C LI t It t I t t

-L

7~7 ~f

I

I

I

6 Method Class A From Phenoxyazetidine H-N

R

3 X) n z Ooj+ R2N=C=Z R2 -Ni

R

2

-NHC-

x n H- X)n202 0 n R' R N-CIICl RR N-.IN R3R 3 0- 001 H-N

H

2 N-C-NHU40 2

HEN-C-

R 3 R 3 R NH 2 CH2)n N-(CH2) x-NH2 x =0-8 -C=z O2 H-N 0 2

(CH

2

N-(CH

2 <-2I ()n n 0

'C

-7 Method Class B Via Aryloxy-l-chlorocarbonylazetidine a) (Ar=Phenyl, Substituted-phenyl, Pyridyl) z z Cl-C-N 0-Ar R 2

NH,

2 R R 2 HN-C 0-Ar b) Z Cl-C-N -0-Ar HN (CHa)jF

R

3 0-Ar C) z z Cl-C-N 0-Ar +R6 R-N N N 0Ar

R

3 d) Z Cl-C-N -Ar

H-~

S

S

I If d S I 4 5 *s St 9 5 4 *4 I I *61 I- 45 4 ''It t~

S

t~ ft

S

I~

14

S

IL S I S -t ~c fj-N- -N 0-Ar

N

7 z Method Class C Via Methane (or Phenyl) sulfonyl azetidine H-N -OSO 2

W

R2 -N=C=Z z

R

2 NH-C-N -0S0 2 x iftrNaH

DF

W CH3, phenyl, i 4

-CH

3 -phenyl -8- Method Class A reactions comprise a pro~cess for preparing phenoxy compounds of Formula I by reacting a compound of the formula: (Xn H-N 0 Q R 3 with one a) b) c) d) of the following classes of compounds: R 2 N C Z

R

1

R

2 N-C-Cl

II

0 0 1k N-C -NHNO 2 N c= C Dr 0 4, Or 0 o ii o 0~ 0 80 0O 00 00 0 o 0 00 00 0 000 0 o 0o 00 0 0000 o o.

00 0 00 *8 0 0 00 0 00 0 8.4400 0 00 0 00 00 or, e) and f) the product of and R NH2 or (CH2)n N-(CH)x-NH2 =0o-8 Method Class B reactions comprise a process for preparing certain aryloxy compounds of Formula I by reacting a compound of the formula: 25 z Cl-C-N 0A with one of the following clai;ses of compounds: a) R 2 NH2 or, b) a heterocyclic amino compound.

Method Class C reactions comprise a process for preparing m-fluorophenoxy compounds of Formula I by reacting a compound of the formula: OS0 2

W

R

3 W=CHS, CeHI. 4-CH -A-C Hw 452 2 9 with an isocyanate of the formula

R

2

-N=C=Z

to give a compound of the formula

R

2 NH-C-N

SO

2

W

and thereafter reacting with sodium hydride and a metafluorophenol of the formula

X

to give a compound of the formula to give a compound of the formula @0* 0 0 00< o a, 0 0 z R2NH-C-

S..

00 0 @00 0

SI

00 0 t i Methods of preparing the starting phenoxyazetidines used in Method Class A are outlined by equation in Chart I.

Methods of preparing the starting aryloxy-l-carbonylazetidines used in Method Class B are outlined by equation in Chart II.

The starting l-(diphenylmethyl)-3-hydroxyazetidines used in Method Class C route (See Chart III) may be prepared by the method of Anderson Lok., J. ORG. CHEM.

(1972) 37: 3953 from benzhydrylamine and an appropriate 30 epihalohydrin. Cis and trans isomers of the l-(diphenylmethyl)-3-hydroxyazetidines when they exist may be separated by chromatography. Starting 0-methylbenzyl-3-azetidinol is prepared by the method of Tetsuya Okutani, et al., CHEM.

PHARM. BULL., Vol 22 (1974) p. 1490. Preparations 1-6 illustrate the methods.

1~ 452

I

.i 10 Chart I Preparation of Starting 1-Unsubstituted phenoxyazetidines R4*

*CH-

C 6

H

5 (see Preparations 2 and 1) CH 3

SO

2 Cl/'NEt 3 2) NaOH, with or without phase catalyst 3) HOQ x)n See also U.S. Patent 4,379,151 (see Preparations 3 and 6) (xn Pd/c or H, 2 Pd(OH) 2

/C

(See Preparation 4) H-N 3~ t 1' It 44 4,4 f~ 14 44 4 44 44 .4 4 4 4 44 44 4 444 4 -R CH 3 phenyl or Subst. phenyl.

is restricted to substituents that are electron withdrawing; fluoro, chloro, bromo, iodo or CF 3 ***When X 4 -cl, 4-Br, 4-1, 4-F or iI-CF 3 yields are very low.

""*Except X cannot be chloro, brorno, or iodo in the product as hydrogenolysis removes these radicals.

44 44 4 4444 4 44 4 4 1 4 44 44 4 O It 4 14 46 44I~ I 44 I 4 4 substituted by 1 or 2 radicals selected from chloro, bromo, iodo, fluoro, loweralkyl, loweralkoxy, nitro, aminocarbonyl, trifluoromethyl, or acetyl; /2 -1 452 11 chart Ii Preparation of Starting l-Carbonyl-3 -aryloxy azetidines CH-N O0H

CSH

5 (see Preparation 1 for

R

3

=CH

3 hal haloal I~Nhal

C

6

HS

kt t halo (z=O or S) (see Preparation in Chart I) Rand R 2are selected from hydrogen, loweralkyl, aryl, allyl, substituted allyl, propargyl, cycloalkyl, loweralkyicycloalkyl, cycloalkyllowe'ralkyl, arylloweralkyl, /3 452 12 Chart III Preparation of Starting lMethane-(or phenyl) sulfonylazetidine R 4-HN O I

C

6

H

5 R= CH 3

C

8

H

5 wso 2 C1 NEt 3 toluene W CH 3

C

6

H

-CSH

4 -4CH 3

R

4 -CHN -S2 IH2, Pd/c H-N >OS02W R 3 it t fir .4 9 S 94 at 4 4 9 99 99 4.

a 4 a 9 94 i~ t *94 at 9 t

I

a ri a, a a S a ~9 64 IS S I 'I S a I A It I i 1 Sii 13 0 0 $0 'og 09 4 Z 4 qaO 0 O B i' B rr 4 ar a L (-c 4 C Preparation 1 trans-l-(Diphenylmethyl)-2-methyl--azetidinol oxalate Ir:1].

A mixture of 126.4 g (0.72 mole) of diphenylmethylamine and 100 g (0.66 mole) of 3-bromo-l,2-epoxybutane in 300 ml of methanol was stirred while being protected from light for 96 hr, then heated at reflux for 30 hr as the color changed from pale yellow to deep amber. A sample was assayed by 1 H-nmr and showed 3 methyl doublets. A fine beige precipitate was removed by filtration (diphenylmethylamine hydrobromide) and the filtrate concentrated on a rotary evaporator to yield 174.6 g of crude oil. A 1.5 sample was neutralized and placed on a 4 mm thick plate of a Chromatotron® and eluted with 10% ethyl acetate-toluene.

A total of sixteen fractions were collected which consisted of 6 distinct spots by TLC. The major component separated was 700 mg and appeared to be the trans isomer. This sample was converted to the oxalate salt. The main concentrate was converted to the free base with ammonium hydroxide and extracted into toluene which was dried over magnesium sulfate and concentrated. The reaction residue was dissolved in methanol and treated with 58 g of oxalic acid, heated to give a homogenous solution and allowed to cool after seeding with a sample of the trans oxalate salt. Filtration yielded 62 g of white granular product, m.p. 147-148.5 0 C. A second crop of 26 g was also obtained.

The 'H-nmr spectrum showed only a single CHs doublet with j (CH-H) of 6.1 Hz which is consistent with the trans compound.* Total yield of title compound was 88 g *Robert H. Higgins and Norman H. Cromwell, J. Hetero. Chem.

30 8 1059-62 (1971).

Analysis: Calculated for Cr 7 HieNO.C 2

H

2 0 4 C,66.46; H,6.16; N,4.08 Found c,66.38; H,6.16; N,4.07 L~C~ LI I- "Method for treating muscle tension, muscle spasticity and anxiety with 3-aryloxy-azetidinecarboxamides".

The following statement is a full description of this invention, A.L/ including the best method of performing it known to me-

AI

-1 ASC-49 him•.,n- ,n 1 52 14 Preparation 2 1-(Diphenylmethyl)-3-azetidinol methanesulfonate (ester) hydrochloride [1:11.

A mixture of 60.02 g (0.22 mole) of 1-diphenylmethyl- 3-azetidinol hydrochloride and 48.94 g (0.484 mole) of triethylamine in 800 ml of toluene was stirred for 24 hr, then cooled to 5°C. in an ice bath and treated with 27.7 g (0.24 mole) of methanesulfonyl chloride added at a rate which maintained the temperature below 15 0 C. The reaction mixture was stirred for 3 hr and filtered to remove the triethylamine hydrochloride. The filtrate was treated with g (0.242 mole) of 4-trifluoromethylphenol followed by 19.35 g (0.484 mole) of sodium hydroxide and 1.6 g (0.005 mole) of tetrabutylammonium bromide in 60 ml of water.

The reaction mixture was stirred rapidly at reflux for 18 hrs, then stirred for 72 hr while it cooled to ambient temperature.

The reaction mixture was transferred to a separatory funnel and washed with 4 x 200 ml of water (emulsion). The toluene phase was dried over magnesium sulfate and concen- I Cc trated in vacuo to 82 g of oil. This residue was dissolved S 20 in 200 ml of isopropyl alcohol and treated with 20 ml of concentrated hydrochloric acid. Upon cooling, a solid separated and was removed by filtration (5.1 The filtrate was treated with isopropyl ether to give an oil S"C' which was worked up later. The solid was identified by spectral analysis as the methylsulfonate of the starting azetidinol. Recrystallization from isopropyl alcohol gave 3.3 g of fine white crystalline material, m.p. 172-173 C., S(shrinks 167 0 Analysis: Calculated for C 17 HlsNO s S-HCl: C,57.70; H,5.70; N,3.96 Found C,57.80; H,5.86; N,3.92 te J acetyl, or aminocarbonyl. That U. S. application is a I K 15 Preparation 3 trans-l-(Diphenylmethyl)-2-methyl-3-3-(trifluoromethyl) phenoxylazetidine oxalate r1:11.

A stirred slurry of 1.2 g (0.03 mole) of sodium hydride dispersion in mineral oil) in 50 ml of dry DMF was treated with 3.45 g (0.01 mole) of trans-l-diphenylmethyl-2methylazetidin-3-ol oxalate added in small portions. When the addition was complete and the evolution of hydrogen ceased, the reaction was heated to 80°C. for 2 hr then 1.64 g (0.01 mole) of 3-fluoro-trifluoromethylbenzene was added dropwise. The reaction mixture was stirred at 80 C. for an additional 18 hr. The reaction mixture was diluted with ice water and extracted with 3 x 25 ml of toluene. The extracts were combined, dried over magnesium sulfate, filtered, and the filtrate treated with 1 g of oxalic acid. The resulting solid was collected by filtration. Recrystallization from acetone-isopropyl ether yielded 2.2 g of fine white crystals, m.p. 146-147°C. Proton NMR shows it to be the trans compound.

t Analysis: Calculated for Ca 4 HaaFsNO.C2Ha04: C,64.06; H,4.96, tt N,2.87 S 20 Found ,64.26; H,4.99; N,2.89 c Preparation 4 t r f trans-2-Methyl-3-r3-(trifluoromethyl)phenoxy]azetidine oxalate ri:l].

A methanol-warm water solution of 33 g (0.068 mole) of Scc trans-l-diphenylmethyl-2-methyl-3-[3-(trifluoromethyl) tt i phenoxy]azetidine oxalate was treated with ammonium hydroxide ,S until basic, then extracted with 4 x 150 ml of methylene k chloride. The combined methylene chloride extracts were washed with water, dried over magnesium sulfate, and concentrated in vacuo to a pale yellow oil. This oil was dissolved in 200 ml of 190 ethanol plus 5 ml of triethylamine and hydrogenated on a Parr apparatus with 3.3 g of 5% palladium-on-charcoal catalyst with a 40 psi atmosphere of hydrogen at 70°C. for 12 hr. After the calculated amount of hydrogen had been absorbed, the catalyst was removed by I j.i- L o -iL-LI.u,.yu c am ine radical including azetidinyl, pyrrolidinyl, piperidinyl, j

S

TS

26.73 g of crude product. An 8 g portion was converted to the oxalate salt in isopropyl alcohol yielding 6.1 g of fine white powder; m.p. 155-156 0 C. Total yield extrapolated from the aliquot converted to the oxalate salt was 84% of theory.

Analysis: Calculated for C 1 iH 1 2

F

3

NO-C

2 Ha0 4 C,48.61; H,4.39; N,4.36 Found C,48.67; H,4.38; N,4.34 Preparation trans-l-(Diphenylmethyl)-2-methyl-3-azetidinol methanesulfonate (ester) hydrochloride [1:11.

A solution of 6 g (0.025 mole) of trans-l-diphenylmethyl-2-methylazetidin-3-ol (obtained from the hydrochloride salt by partitioning in organic solvent and aqueous base, separating and evaporating the organic phase) in 40 ml of dry benzene was treated with 10 ml of triethylamine and cooled to 5 C. While stirring, the reaction mixture was treated with 3.54 g (0.03 mole) of methanesulfonyl chloride 20 at a rate to control the temperature below 100C. After stirring for 3 hr, TLC (20% ethyl acetate/methylene chloride on silica gel) showed the reaction to be incomplete. An additional 1.14 g (0.01 mole) of methanesulfonyl chloride was added and stirring continued for 1 hr. The reaction S* 25 mixture was diluted with 100 ml of water and the benzene layer separated, washed with 300 ml of water, dried over magnesium sulfate and concentrated to an oil. The oil was *o dissolved in isopropyl ether and treated with ethereal.

hydrogen chloride. The solid salt was removed and recrystal- S. 30 lized from 190 ethanol to give 3.4 g of fluffy white crystals, m.p. 152-153°C.

Analysis: Calculated for CisHeaNOsS'HCl: C,58.77; H,6.03; N,3.81 Found C,58.68; H,6.o8; N,3.80 452 17 Preparation 6 S-(Diphenylmethyl)-3-r3-(trifluoromethvl)phenoxyl azetidine.

N-Diphenylmethyl-3-hydroxyazetidine hydrochloride (I) was prepared from benzhydrylamine and epichlorohydrin according to Anderson and Lok, J. Org. Chem., 2:3953 (1972).

I (41.33 g, 0.15 mole) and triethylamine (42 ml, 0.30 mole) were stirred in toluene (250 ml) while methane sulfonylchloride (12 ml, 0.15 i) was added dropwise over 10 minutes with stirring and the temperature was maintained between 4° and 12°C. TLC (silica gel, 10% ethyl acetate in methylene chloride) at one hour showed all starting materials had reacted. The mixture was filtered to remove the triethylamine hydrochloride which was rinsed twice with toluene.

The filtrate and washings combined to about 450 ml of solution. To this solution was added m-trifluoromethylphenol (27.5 g, 0.17 mole), tetrabutyl ammonium bromide (2.4 50% sodium hydroxide (24 g, 0.3 mole) and water je (24 ml) and the mixture was stirred vigorously and heated to reflux under nitrogen for 2.5 hr. The toluene layer of the mixture was separated and washed once with water, dried over sodium sulfate and evaporated to an oil. This oil was seeded and pumped on an oil pump overnight. A solid cake weighing 49.7 was obtained. Some of this solid was dissolved in isopropanol with brief heating. Water was then added to cause slight cloudiness. The mixture was seeded and cooled to cause crystallization. The white solid was collected by filtration, washed with 50% aquous isopropanol, and dried under vacuum overnight. Proton NMR showed slight contamination by silicone oil, m.p. 82.5-84 0

C.

Analysis: Calculated for Ca2HaoFsNO:C,72.05; H,5.26; N,3.65 Found :c,71.62; H,5.29; N,3.61 4 49 452 18 The following examples illustrate preparation of compounds encompassed by Formula I and useful in the method of treatment of the invention. The scope of the invention is not limited by the examples, however.

Example 1 N-Methyl-3-[34trifluoromethyl)phenoxy]-l-azetidinecarbothioamide.

Crude 3-[3-(trifluoromethyl)phenoxy]azetidine from catalytic debenzylation of 26.0 g (0.078 mole) -5 1-benzhydryl- 3-(trifluoromethyl)phenoxy]azetidine was dissolved in 100 ml of methylene chloride and treated dropwise under a nitrogen atmosphere with a solution of 5.0 g (0.0678 mole) of methylisothiocyanate in 15 ml of methylene chloride: The reaction mixture was stirred for 16 hr at ambient temperature and let stand over the weekend. The solution was filtered through a celite filter pad to remove a fine crystalline prec-^itate and the filtrate was evaporated under reduced pressure. The residual oil was crystallized from isopropyl C ether to give 12.6 g of product, m.p. 79-86 0 A 5.0 g St 20 sample was recrystallized from isopropyl ether (charcoal) to 0 give 3.2 g, m.p. 89-93 which was shown by TLC on silica gel (10% methanol-toluene) to be contaminated by a lower Rf material. -The filtrate was evaporated under reduced pressure,combined with the 3.2 g of solid and dissolved in 100 ml of methylene chloride. The solution was stirred with 25 g of silica gel for 0.5 hr and filtered through a sintered glass filter. The silica gel was washed with a Ssmall volume of methylene chloride and the filtrate evaporated under reduced pressure. The residual solid was recrystallized from isopropyl ether to give 1.3 g of pure product, m.p. 96-98 0 c.

Analysis: Calculated for Cs 2 HisFaNaOS: C,49.65; H,4.51; S"N,9.65 Found C,49.58; H,4.48; N,9.58 4 52 19 Example 2 N-(2,6-Dimethylphenyl) 3-(trifluoromethyl)phenoxy]-1azetidinecarbothioamide.

Crude 3-(3-(trifluoromethyl)phenoxy]azetidine from catalytic debenzylation of 30.0 g (0.078 mole) of 1benzhydryl-3-[3-(trifluoromethyl)phenoxy]azetidine was dissolved in 100 ml of methylene chloride and treated dropwise under a nitrogen atmosphere with a solution of 12.7 g (0.078 mole) of 2,6-dimethylphenylisothiocyanate in 25 ml of methylene chloride. The product began to precipitate during the addition and an additional 50 ml of methylene chloride was added to facilitate stirring. After stirring overnight at ambient temperature, the product was collected by filtration (13.5 g, m.p. 196-199 0 A 6.0 g sample was recrystallized from isopropanol to give 5.3 g of product, m.p. 197-199 0

C.

Analysis: Calculated for C 1 sH 9 sFN 2 OS: C,59.99; H,5.03: N,7.36 Found C,60.04; H,5.04; N,7.35 Example 3 N-(Phenylmethyl)-3-F3-(trifluoromethyl)phenoxy]-lazetidinecarboxamide.

STo a stirred and chilled (10-200C.) solution of 0.04 mole of 3-[3-(trifluoromethyl)phenoxy]azetidine in 100 ml of methylene chloride was added dropwise 6.12 g (0.0 4 6 mole) of benzyl isocyanate. The reaction mixture was stirred at room temperature for 2 hr and was filtered. The filter cake was washed with petroleum ether (2 x 50 ml), dilute aqueous sodium bicarbonate (2 x 50 ml), and water (2 x 50 ml), yielding 12 g Recrystallization twice from ethyl acetate gave 9.0 g of clear white flakes, m.p. 173.5-1750C.

Analysis: Calculated for C1sHIFsNaOa C,61.71; H,4.89; N,8.00 Found C,61.57; H,4.87; N,7.99 r 452 20 Example 4 N-(2.6-Dichlorophenyl)-3-r3-(trifluoromethyl)phenoxy]l-azetidinecarbothioamide.

A solution of 0.04 mole of 3-[3-(trifluoromethyl) phenoxy]azetidine in 100 ml of absolute ethanol was stirred in a tap water bath while 8.16 g (0.04 mole) of 2,6-dichlorophenyl isothiocyanate was added all at once. The reaction was slightly exothermic and as the isothiocyanate began to dissolve, product began to precipitate. After stirring for 45 minutes the reaction mixture was heated on a steam bath to assure that all the isothiocyanate dissolved, and upon cooling, filtration yielded 15.2 g of white crystalline product. A portion of this material (7.9 g) was recrystallized from absolute ethanol to give 4.3 g of pure crystalline powder, m.p. 196-197c.

Analysis: Calculated for C17H1isFCl 2 NaOS: C,48.47; H,3.11; N,6.65 Found C,48.40; H,3.07; N,6.54 Example N-r[-(Diethylamino)propyll-3-[3-(trifluoromethyl) phenoxyl-l-azetidinecarbothioamide, oxalate [1:11.

t t A solution of (0.0584 mole) of phenoxy]azetidine was stirred at 10 C. while 10.66 g (0.0584 Smole) of 3-(diethylamino)propyl isothiocyanate was added all at once. After stirring overnight at ambient temperature, the reaction mixture was concentrated at 50°C. on a rotary evaporator to a thick syrup residue. The residue was dissolved in isopropanol and treated with 5.3 g of oxalic acid, warmed on a steam bath to dissolve the acid, and upon cooling, a solid salt precipitated. An equal volume of isopropyl ether was added to ensure complete precipitation. Filtration gave 26 g of crude product.

A portion (13 g) was recrystallized from isopropanol/ methanol/isopropyl ether (100/50/50) (cooled in a refrigerator) to yield upon filtration 7.5 g of white product, m.p. 155-157°C. Proton NMR confirmed that this was the expected product.

452 21- Analysis: Calculated for CisHa e

F

3

N

3

O'C

2

H

2 0 4 C,50.10; H,5.89 N,8.76 Found C,50.02; H,5.97; N,8.89 Example 6 N-r -(Dimethylamino)propyll-3-r3-(trifluoromethyl)phenoxyl-1-azetidinecarbothioamide.

A stirred solution of 0.0584 mole of 3-[3-(trifluoromethyl)phenoxy]azetidine at 10 0 C. was treated with 8.42 g (0.0584 mole) of 3-(dimethylamino)propyl isothiocyanate all at once and allowed to stir at ambient temperature overnight. The reaction mixture was treated with 5.3 g (0.0584 mole) of oxalic acid and diluted with 200 ml of isopropyl ether which yielded only 3.8 g of product. The volume was reduced to 100 ml at 50°C. in vacuo and diluted with 500 ml of isopropyl ether to yield an additional 15.3 g of product. The combined solid material was dissolved in isopropyl alcohol and upon cooling, a fine precipitate formed (N,N-dimethyl-l,3-propanediamine oxalate) which was removed by filtration. The product failed to crystallize; addition of isopropyl ether gave only an amorphous gel.

After trying to obtain a more satisfactory product for 3 weeks, the reaction material was converted to the free base and taken up in isopropyl ether. The ether solution was stirred with 300 ml of water overnight to remove the diamine. The product crystallized as the free base from the heterogenous mixture and was filtered to give 11.3 g of fine beige crystals. Rework of the filtrate gave an additional 2.3 g of product. A portion (8 g) was recrystallized from benzene/ligroin to yield 5.8 g of very fine beige crystals which were dried at 82OC. under vacuum, m.p. 107-108 0

C.

Analysis: Calculated for CseH 2 2 FsNs0S: C,53.17; H,6.14; N,11.63 5 Found C,53.29; H,6.15; SN,11.60 ~i u, 1 452 22 Example 7 N-(2-Propenyl)-3-[3-(trif uoromethyl)phenoxy3-lazetidinecarboxamide.

A solution of 18.9 g (0.05' mole)-of crude 3-[3- (trifluoromethyl)phenoxy]azetidine (contains an equal molar amount of diphenylmethane) in 100 ml of isopropyl ether was stirred under nitrogen while 4.16 g (0.05 mole) of 2-propenyl isocyanate was slowly added. The reaction mixture which was somewhat turbid, cleared and after 1 hr a fine crystalline precipitate began to form. After stirring for 18 hrs, the product was removed by filtration, washed with fresh isopropyl ether and air dried to yield g of white crystals, m.p. 75-76 0 c.

Analysis: Calculated for C 14 Hg 1

F

3

N

2 0 2 C,56.00; H,5.04; N,9.33 Found c,55.98; H,5.05; N,9.31 Example 8 N-Cyclopropyl-3-r3-(trifluoromethyl)phenoxy]-lazetidinecarboxamide.

A mixture of 1.9 g (0.033 mole) of cyclopropylamine and 4.9 g of 1,1'-carbonyldiimidazole in 60 ml of tetrait hydrofuran was stirred at ambient temperature for 1 hr.

SThe clear solution which formed was treated with a solution of (0.03 mole) of 3-[3-(trifluoromethyl)phenoxy]azetidine in 20 ml of tetrahydrofuran. After stirring overnight, the S 25 solid precipitate was removed by filtration to give 4.4 g of gray-white-powder. The CI mass spectrum showed a p+l at 381 m/e which was consistent with the expected product.

Recrystallization from benzene/ligroin gave 2.3 g of a S" light gray powder, m.p. 152-153 0

C.

Analysis: Calculated for C 14

H

15

F

3

N

2 0: C,56.00 H,5.0 4 N,9.33 Found C,55-97; H,5.07; N,9.28 452 23 Example 9 N-[3-(Diethvlamino)propyl l-3- 3-(trifluoromethyl) phenoxyl-l-azetidinecarboxamide bxalate A mixture of 4.3 g (0.033 mole) of 3-diethylaminopropylamine and 4.9 g (0.033 mole) of l,l'-carbonyldiimidazole in 60 ml of methylene chloride was stirred at ambient temperature for 1 hr. The resulting solution was treated with 3-[3-(trifluoromethyl)phenoxy]azetidine (obtained from 9.21 g (0.03 mole) of the oxalate salt) in 30 ml of methylene chloride. After stirring for 18 h3:, the reaction mixture was transferred to a separatory funnel and washed with 3 x 20 ml of water, dried over magnesium sulfate and concentrated in vacuo to a dark oil. The residue (8 g) was chromatogarphed on a '150 g neutral alumina column by eluting with chloroform. Concentration of the initial fraction gave the product as an amber oil which was dissolved in methylisobutyl ketone and treated with 2 g of oxalic acid.

Dilution with isopropyl ether gave an oil which solidified and was recrystallized from acetone/isopropyl ether to give 6.25 g of beige crystals, m.p. 91-93 0 c.

20 Analysis: Calculated for C 8

H

2 eeFsN 3 Oe-1.5 Cs 2

H

2 0 c,49.61; H,5.75; N,8.26 Found C,49.56; H,5.73; N,8.24 SExample N-2-(Propenyl)-3-r 4-(trifluoromethyl)phenoy -1azetidinecarboxamide.

I t A solution of 8.7 g (0.04 mole) of crude 3-[4-(tritfluoromethyl)phenoxy]azetidine ii: 75 ml of isopropyl ether was stirred under a blanket of nitrogen while 4.2 g (0.05 mole) of 2-propenyl isocyanate was added dropwise. After stirring for 3 days, no crystalline product precipitated.

The reaction mixture was concentrated to a dark reddish oil. TLC (20% ethyl acetate/methylene chloride on silica t gel) showed at least 6 spots, all well separated. The residue was dissolved in chloroform, chromatographed on a 350 g silica gel column and eluted with chloroform until the reddish forerun was removed. The column was then eluted 4 24 with an ethyl acetate/chloroform gradient to 4% ethyl acetate. All the fractions were combined and concen.. ited to give 4.8 of orange oil, which crystallized on star ing.

Recrystallization from acetone/cyclohexane gave 3.3 of beige crystals, m.p. 91-92.5°C.

Analysis: Calculated for C1 4 HsF 3 s 2 NOa: C,56,00 H,5.04; N,9.33 Found C,55.98; H,5.17; N,9.36 Example 11 N-(Cyclopropylmethyl)-3-[3-(trifluoromethyl)phenoxy 1-azetidinecarboxamide.

A solution of 2.6 g (0.024 mole) of (aminomethyl) cyclopropane hydrochloride in 50 ml of pyridine was stirred under a blanket of nitrogen while 3.9 g (0.024 mole) of f 15 1,1'-carbonyldiimidazole was added. After stirring for minutes, the TLC methanol/methylene chloride on silica gel) showed no reaction; therefore, 2 ml of triethylamine was added. The reaction mixture after minutes became cloudy and the TLC showed a new product.

The 'eaction was treated with 6.2 g (0.02 mole) of 3-(3- (trifluoromethyl)phenoxy]azetidine oxalate. After stirring for 1 hr, a sample was removed, and upon dilution with water, a solid precipitated. The CI mass spectrum indicated it was product. After 2 days, the reaction was diluted with 5 volumes of water and the resulting precipitate collected by filtration to yield 6.5 g of pale yellow crystalline product. Recrystallization from ethanol/water produced white plate-like crystals which were dried at 82 0 C. for 3 hr in a drying pistol under vacuum; weight of the product was 5.8 g m.p. 132-1330C.

Analysis: Calculated for CisHj 7 FsN 2 0 2 C,57.32; H,5.45; N,8.91 Found C,57.22; H, 5 .44 N,8.86 4 -o S452 25 Example 12 N,N-Diethyl-3-r3-( trifluoromethyl)phenoxyl-l-azetidinecarboxamide.

A stirred slurry of 5 g (0.0163 mole) of 3-[3-(trifluoromethyl)phenoxy azetidine oxalate in'50 ml of tetrahydrofuran was treated with 5 ml of triethylamine and after 1 hr, 2.5 g (0.018 mole) of diethylcarbamoyl chloride was-added. After stirring an additional 15 hr, the reaction was treated with ml of water and saturated with calcium chloride. The tetrahydrofuran was decanted from the solid residue and concentrated in vacuo to an oil. The crude oil was chromatographed on a Water's Prep-LC using 50% ethyl acetate/ toluene as the eluent. After concentration of the main fractions 3.1 g of pale yellow oil was obtained.

Analysis: Calculated for C 15 Hs 1

F

s Na 2 0: C,56.96; H,6.05; N,8.86 SFound C,56.69; H,6.01; N,8.77 Example 13 N,N-Dimethyl-3-F3-(trifluoromethyl)phenoxy-lazetidinecarboxamide.

A stirred slurry of 5 g (0.0163 mole) of 3-[3-(trifluoromethyl)phenoxy]azetidine oxalate in 50 ml of tetrahydrofuran was treated with 5 ml of triethylamine and after 1 hr, 1.95 g (0.018 mole) of dimethylcarbamoyl chloride was added. After stirring an additional 15 hr, the reaction mixture was treated with 20 ml of water and 10 g of calcium chloride.

The tetrahydrofuran layer was decanted and the residue triturated with 20 ml of ethyl acetate,then decanted. The Scombined teLrahydrofuran and ethyl acetate solution was concentrated in The crude residue was chromatographed on a Waters Prep-LC using 50% ethyl acetate/toluene as the eluent. After concentration of the main fractions, 3.6 g of pale yellow oil was obtained.

1 Analysis: Calculated for CisH 1 sFsN 2 0 2 C,54.17; H,5.25; N,9.72 Found C,53.73; H,5.20 N,9.60 N-(2 -Propynyl trifluoromethyl )phenoxy -1azetidinecarboxamide.

azetidinecarboxamide.

mixture of 3.9 g (0.024 mole) of 1,1'-carbonyldiimidazole and 1.32 g (0.024 mole) of 2-propynylamine in 50 ml of tetrahydrofuran was stirred at ambient temperature for 1 hr, then treated with 6.2 g of 3-[3-(trifluoromethyl) phenoxy]azetidine. The reaction mixture was treated with 3 ml of triethylamine and stirred for 18 hr. The reaction mixture was diluted with an equal volume of water and filtered to yield 8 g of wet product. Recrystallization from isopropyl ether gave 3.8 g of gray solid, a mixture of product and the symmetrical urea of starting 2-propynylamine.

A second recrystallization from ethanol-water yielded 2.6 g of pure product, m.p. 105-106 0

C.

Analysis: Calculated for C 14

H

1 sFsN 2 0 2 C,56.38; H,4.39; N,9.39 Found C,56.32; H,4.34; N,9.44 Example I N-Cyclohexyl-3-[3-( trifluoromethyl)phenoxy3-l- St 20 azetidinecarboxamide.

vr 20 14, 4 A stirred mixture of 5 g (0.0163 mole) of 3-[3-(trifluoromethyl)phenoxy]azetidine oxalate and 2.04 g (0.018 mole) of cyclohexyl isocyanate in 50 ml of tetrahydrofuran was treated with 2 ml of triethylamine then stirred for t 9 t 5 18 hr. Dilution of the mixture with water gave a solid precipitate which was collected by filtration to yield 12 g of crude product. Recrystallization from acetone/water gave 5 g of fine white crystals, m.p. 148-150 C. TLC (ethyl acetate on silica gel) showed a trace of symmetrical cyclohexyl urea as well as the product. A second recrystallization from isopropanol yielded 1.65 g of white powder; dried under 0.5 mm/Hg vacuum, m.p. 153-154 0

C.

Analysis: Calculated for C 1 Ha 21 FsN 2 0 2 C,59.64; H,6.18; N,8.18 Found C,59.52; H,6.20; N,8.17 452 27 Example 16 N-Cyclopropyl-3-[4-(trifluoromethyl)phenoxy-lazetidinecarboxamide.

A stirred slurry of 4.4 g (0.027 mole) of l,1'-carbonyldiimidazole in 50 ml of methylene chloride under nitrogen was treated with 1.54 g (0.027 mole) of cyclopropylamine.

After a short (2 min) induction period, the clear solution became suddenly exothermic, bringing the reaction to a gentle reflux. After 1 hr when the reaction mixture had cooled to ambient temperature, 9.6 g (0.025 mole) of 3-[4-(trifluoromethyl)phenoxy]azetidine, 56.66% purity (contains diphenylmethane) was added all at once and stirring continued for 18 hr. The reaction mixture was concentrated on a rotary evaporator to give a partially crystalline residue. The residue was partitioned between 30/60 petroleum' ether and water and the resulting waxy solid removed by filtration. Recrystallization from isopropyl ether yielded 5-7 9 of silver plate-like crystals, m.p. 14 5 -147 0

C.

After drying at 80 0 C. under 0.5 mm/Hg vacuum, the weight was not diminished, m.p. 152-153 C.

Analysis: Calculated for C 1 4 HsFsNaOa 2 C,56.00; H,5.04; N,9.33 Found C,55.77; H,4.98 Sf N,9.44 Example 17 N-(Cvclopropvlmethl)-3-r4-(trifluoromethyl)phenoxy1- 1-azetidinecarboxamide.

A stirred mixture of 4.4 g (0.027 mole) of 1,1'carbonyldiimidazole and 2.9 g (0.027 mole) of (aminoethyl) cyclopropane hydrochloride in 50 ml of methylene chloride was treated with the dropwise addition of 2.73 g (0.027 mole) of triethylamine. The reaction was exothermic. The mixture was cooled while stirring for 1 hr, then 9.6 g (0.025 mole) 4: of 3-[4-(trifluoromethyl)phenoxy]azetidine 56.66% (contains 4. diphenylmethane) was added all at once and stirring continued for 18 hr. The reaction mixture was concentrated on a rotary evaporator to give an amber residue. Trituration of this residue with 30/60 petroleum ether gave only an 1452 -28 insoluble oil. The trituration step was repeated with 2 x 20 ml of 30/60 petroleum ether and the residue treated with water to yield a white solid. The solid was recrystallized from isopropyl ether to yield 4.8 g of white platelike crystals; after during at 8 0 0C. under 0 .5 nun hq vacuum, Mn.P. 132-133 0

C.

Analysi Is: Calculated for C1.

5

H

17

F

3

N

2 0 2 C,57-32; N,8.91 Found C,57.26, H,5.46; N,8.93 Example 18 N-3(ityaiopoyl3r-tilooehl phenoxy1-l-azetidinecarbothioamide.

A stirred solution of 1.92 g (0.005 mole) of 3-E'4- (triflourornethyl)phenoxyjazetidine, 56.66% (contains diphenylmethane) in 20 ml of isopropyl ether was treated with 0.88 g (D0.005 mole) of 3-(diethylamino)propyl isothiocyanate and stirred for 3.5 hr. The reaction mixture was treated with 0.5 g of oxalic acid dissolved in 2 ml of methanol. After stirring for 18 hr, the solid was collected by filtration, yielding 1.9 g of fine tan powder, m.p.

147-150 0 C. The solid was dissolved in water and treated with dilute sodium hydroxide. An oil separated which solidified and was collected by filtration. Recrystallization from cyclohexane yielded 1.1 g of fine tan crystals, M.P. 109-ll0"C.

Analysis: Calculated for CIBH2F 3 N4 3 0S: C,55-51; H,6,,73; N 10O.79 Found :C,55.68; H'6.67 Nsl0.73 Example 19 N-r3-(Diethylamino)propyll-3-r4-(trifluoromethyl) phenoxyl-l-azetidinecarboxami*de oxalate r 1:2.1.

A stirred solution of 4.4 g (0.027 mole) of 1,11carbonyldiimidazole in 50 ml of miethylene chloride under £nitrogen was treated with the dropwise addition of 3.52 9 (0.027 mole) of 3-(diethylamino)propylamine. The reaction mixture was stirred for 1 hr as the somewhat exothermic reaction cooled to ambient temperature then treated with un, a rarr apparatus with 3.3 g of palladium-on-charcoal catalyst with a 40 psi atmosphere of hydrogen at 70°C. for 12 hr. After the calculated amount of hydrogen had been absorbed, the catalyst was removed by S- 452 29 9.6 g (0.025 mole) of 3-[4-(trifluoromethyl)phenoxy]azetidine, 56.66% (contains diphenylmethane) all at once. After stirring for 18 hr, the reaction mixture was concentrated on a rotary evaporator and the residue dissolved in toluene.

The toluene solution was washed with 3 x 20 ml of water, then treated with 2.5 g of'oxalic acid in 10 ml of isopropanol The resulting solid was collected by filtration and triturated with boiling acetone. After filtration, 1.8 g of unidentified fine white precipitate formed which was separated by filtration. The acetone solution was concentrated to a solid which was recrystallized from isopropyl alcohol/isopropyl ether to yield 9.2 g of cru'e product (4 spots on TLC; 10% methanol/methylene chloride on silica gel). Recrystallization from methyl ethyl ketone yielded 6.8 g of fine white powder, m.p. 129-130 0

C.

Analysis: Calculated for CleHpsF 3 NsO2*2C 2 Ha0 4 c,47.74; H,5.46; N,7.59 Found C,47.82; H,5.68; N,7.76 c Example S 20 N-(2-Propynyl)-3- 4-(trifluoromethyl )phenoxy-lazetidinecarboxamide.

t A solution of 4.4 g (0.027 mole) l,l'-carbonyldiimidazole in 50 ml of tetrahydrofuran was stirred under nitrogen while 1.49 g (0.027 mole) of 2-propynylamine was added with a syringe and needle through a septum installed in one neck of the reaction flask. After stirring for 2 hr, 9.6 g (0.025 mole) of 3-[4-(trifluoromethyl)phenoxy]azetidine (56.66% purity; contains diphenylmethane) was added all at S6 once and stirring continued for an additional 18 hr. The reaction mixture was diluted with ice-water and extracted with 30/60 petroleum ether to remove the diphenylmethane.

The oily aqueous portion was extracted with 4 x 50 ml of Smethylene chloride. These extracts were combined, dried over sodium sulfate and concentrated to an amber oil on a rotary evaporator. The oil solidified when triturated with a small amount of isopropyl ether (50 ml). Filtration N,3.80 30 yielded 6.1 g of rose-tinted solid product. TLC methanol/methylene chloride on silica gel) showed a mixture of 3 products and some starting material. Recrystallization from ethanol/water gave the product in several small fractions. These were combined and recrystallized from isopropyl ether to yield 4.1 g of pale beige powder, m.p.

135-137 0 C. TLC still showed some symmetrical 2-propynyl urea. The solid was recrystallized again from ethanol/ water to yield 3.5 g of pale yellow crystalline product, m.p. 140-141c.

Analysis: Calculated for C 1 4

H

13 sFN 2 0 2 C,56.38; H,4.39; N,9.39 Found C,56.34; i,4.36; N,9.32 Example 21 N-(2-Methyl-2-propenyl)-3--(trifluoromethy)phenoxyl- 1-azetidinecarboxamide.

A stirred solution of 3.6 g (0.022 mole) of 1,1'carbonyldiimidazole in 75 ml of methylene chloride under nitrogen was treated with 1.6 g (0.022 mole) of 2-methyl- 20 2-propenylamine (added via a syringe and needle through a septum placed in one neck of the reaction flask). After stirring for 1 hr, 6.2 g (0.02 mole) of 3-[4-(trifluoromethyl)phenoxy]azetidine oxalate was added all at once followed in 30 min with 5 ml of triethylamine and stirring was continued for 3 hr. The reaction mixture was washed with water (2 x 25 ml), dried over magnesium sulfate and concentrated in vacuo. The oily residue solidified on standing and was recrystallized from isopropyl ether to yield 3.7 g of fine white crystals, m.p. 101-102 0

C.

Analysis: Calculated for CisH 1 7

F

3

N

2 0 2 C,57.32 H,5.45; N,8.91 Found C,57.45; H,5.517 N,9.23 S 4 C I i 8 4 il I il-ii~_ 111~ 452 31 C t e t cc e c II i4 t

II

It t t 4'FF a. t r e t llt t Example 22 N-(2-Methyl-2-propenyl)-3-pr-(trifluoromethyl)phenoxyll-azetidinecarboxamide.

A solution of 3.6 g (0.022 mole) of l,l'-carbonyldiimidazole in 75 ml of methylene chloride was stirred under nitrogen while 1.6 g (0.022 mole) of methallylamine was added with a syringe and needle through a septum installed in one neck of the reaction flask. The reaction was slightly exothermic. The reaction mixture was stirred for 1 hr, then treated with 6.2 g (0.02 mole) of 3-[3-(trifluoromethyl)phenoxy]azetidine oxalate followed in 0.5 hr with 5 ml of triethylamine and stirring continued for 16 hr.

The reaction mixture was washed with 2 x 30 mi of water, dried over magnesium sulfate, and concentrated on a rotary evaporator to yield 6.7 g of oily residue which solidified.

The residue was recrystallized from isopropyl ether to yield 5.4 g of fine white crystals, m.p. 90-910C.

Analysis: Calculated for Ci5sH 7

F

3

N

2 0 2 C,57.32; H,5.

4 N,8.91 Found C,57.20; H,5.50; N,8.95 20 Example 23 N-(3-Methyl-2-butenyl)--r4-(trifluoromethyl)phenoxy7- 1-azetidinecarboxamide.

A solution of 3.6 g. (0.022 mole) of 1,1'-carbonyldiimidazole in 100 ml of methylene chloride was cooled in a 25 tap water bath and while stirring under nitrogen, 1.87 g (0.022 mole) of 3-methyl-2-butenylamine was added dropwise.

After stirring for 1 hr, 6.2 g (0.02 mole) of 3-[4-(trifluoromethyl)phenoxy]azetidine oxalate was added all at once followed in 0.5 hr with 5 ml of triethylamine and 30 stirring continued for an additional 16 hr. The reaction mixture was washed with 2 x 50 ml of water, dried over magnesium sulfate and concentrated on a rotary evaporator to yield a semi-solid residue. Trituration with isopropyl ether and filtration yielded 7 g of crude product which was recrystallized from ethanol-water to give 5.5 g (83.8%) of white crystals, m.p. 156.5-1580c.

14 0 I I Ii Found N, 9.65 N,9.58 4 9.

I

1452 32 Analysis: Calculated for Found Cj8 6

H

1 9

F

3

N

2 0 2 C,58.53; H,5.83; N 8.53 C,58.81; H:5.89; N,8.58 *4 #4 C ~,4 II I lb

I,

II

I.

I. I I I

I

I It

SI--

lit I I- Ii It I- I-Itt I- (I- Example 214 N-(3-methyl-2-butenyl)-3-r3-(trifluoromethylr)_phenox' 1-a zet idinecarboxanide.

A solution of 3.6 g (0.022 mole) of l,l'-carbonyldiimidazole in 100 ml of tetrahydrofuran was cooled with a tap water bath and stirred under~ nitrogen while 1.6 g (0.022 mole) of 3-methyl-2-butenylamine was added with a syringe and needle. The reaction mixture was stirred for 1 hr, then treated with 6.2 g (0.02 mole) of 3-[3-(trifluoromethyl)phenoxyjazetidine oxalate followed in 0.5 hr with ml of triethylamine and stirring continued for 72 hr.

The reaction mixture was diluted with 500 ml of ice water and extracted with 6 X 50 ml of methylene chloride. The combined extracts,were washed with water, dried over magnesium sulfate and concentrated to a solid residue on a rotary evaporator. Recrystallization from ethanol-water 20 yielded 6 g of white crystals, m.p. 1143-11440c.

Analysis: Calculated for C~I.Ha 6

F

3

N

2 0 2 C,58-53; H,5.83; Found .C,58.146; H,586; N,8.69 Example 2~ (E)-N-(2-Butenyl)-3-14-(trifluoromethyl)phenoxylazetidinecarboxamide.

A mixture of 3.6 g (0.022 mole) 6f l,1'-carbonyldiimidazole and 1.6 g (0.022 mole) of trans-crotylamine was stirred for 1 hr, then treated with 6.2 g (0.02 mole) of 3-[4-(trifluoromethy1)phenoxy~azetidine oxalate and followed in 0.5 1? with 5 ml of triethylamine with stirring continued for 16 hr. The partially crystalline mixture was washed with 2 x 50 Ml of water, dried over magnesium sulfate and concentrated on a rotary evaporator to a solid residue, 114.2 g. Recrystallization from methanol-water yi~nllded 5.35 g of fine white crystals, m.p.

157-158%.- 4 *~4ttt

I

VI I I4 I-b u C,61.57; H,4.87; N,7.99 452 33 Analysis: Calculated for CisH 7

F

3 aNO: C,57.32; H,5.45; N,8.91 Found C,57.47; H,5N9; N,9.00 Example 26 (E)-N-(2-Butenyl)-3-r3-(trifluoromethyl)phenoxy -lazetidinecarboxamide.

A solution of 3.6 g (0.022 mole) of 1,1'-carbonyldiimidazole in 60 ml of methylene chloride was cooled in an ice bath while stirring under nitrogen while 1.6 g (0.022 mole) of trans-crotylamine was added dropwise.

After warming to ambient temperature, 6.2 g (0.02 mole) of 3-[3-(trifluoromethyl)phenoxy]azetidine oxalate was added all at once followed in 0.25 hr by 5 ml of triethylamine with stirring continued for 72 hr. The reaction solution was washed with 2 x 50 ml of water, dried over magnesium sulfate and concentrated on a rotary evaporator to a solid residue, 7 g. Recrystallization from methanolwater gave 5.5 g of slightly yellow product. A second It recrystallization with charcoal treatment from isopropyl 20 ether yielded 3.75 g of fine white crystals, C m.p. 127-128 0

C.

Analysis: Calculated for C 15 H17FsNa 2 0: C,57.32; H, 5 .4 5 SN, 8.91 c t' Found C,57.35; H,5.47; N,8.94 Example 27

S

t 25 N-Phenyl-3-[3-(trifluoromethyl)phenoxyl-l-azetidine- 4 carboxamide.

SA stirred slurry of 6.2 g (0.02 mole) of 3-[3-(trifluoromethyl)phenoxy*]azetidine oxalate in 60 ml of tetrahydrofuran was treated with 5 ml of triethylamine followed 30 by 2.62 g (0.022 mole) of phenyl isocyanate and stirring continued for 16 hr. The reaction mixture was diluted S" with water until an oil separated which quickly solidified.

The aqueous tetvahydrofuran was decanted and the solid residue recrystallized from ethanol-water to yield 5.3 g of white crystals, m.p. 137-138 0

C.

464.14 4 ml I S S

S.

A portion (13 g) was recrystallized from isopropanol/ methanol/isopropyl ether (100/50/50) (cooled in a refrigerator) to yield upon filtration 7.5 g of white product, m.p. 155-157 0C. Proton NMR confirmed that this was- the expected product.

4-M 452 314 Analysis: Calculated for C 17

HISF

3

N

2 0 2 C,60-71; H, 1 4.50 N, 8.33 Found .C,60.81; H,4.147; N, 8.35 Example 28 N-Phenyl-3-r14-( trifluoroinethyl)phenoxy1-l-azetidinecarboxamide.

A stirred slurry of 6.2 g (0.02 mole) of 3-E 1 4-(trifluoromethyl)phenoxy~azetidine oxalate and 2.62 g (0.022 mole) of phenyl isocyanate in 60 ml of tetrahydrofuran was treated with 5 ml of triethylamine and stirring continued fo'r 16 hr. The reaction mixture was diluted with water until an oil separated. The tetrahydrofuran-water portion was decanted and the residue solidified on standing.

Recrystallization from ethanol-water yielded 3.5 g (53.4en') of fine white crystals, m.p. l7 4.5-176 0 c.

Analysis: Calculated for Cj 7 Hj 5

F

3

N

2 0 2 :C,60.7l; H,14-50; N,8.33 Found :c,60.91; H,14.53; N, 8.35 Example 29 trans-N.2-Dimethvl-3-r3-(trifluoromethvl phenoxv -1azetidi4necarboxamide.

A stirred solution of 6 g (0.015 mole) of crude trans- 2-methyl-3-[3-(trifluoromethyl)phenoxy~azetidine in 50 ml of tetrahydrofuran was treated with 0.94 g (0.0165 mole) of methyl isocyanate added dropwise and stirred for 16 hr under a blanket of nitrogen. Dilution of the reaction mixture with water produced an oil which solidified. After A decanting the aqueous tetrahydrofuran phase, the solid residue was recrystallized from ethanol-water to yield 3.95 g of fine whit6 crystals, m.p. 104-5-106 0 c.

P 30 Analysis: Calculated for C 13

H

15

F

3

N

2 0 2 C,5J4.17; H,5-25; N*9.72 lFound :C,5 1 4-50; H,5.29; N09.71 F7 452 Exai-,,ple trans-2-Methvl-3-r3-(trifluoromethyl)phefloxV1-l-azetidinecarboxamide.

A mixture of 6 g (0.015 mole) of crude trans-2-methyl- 3 -[3-(trifluoromethyl)phenoxy~azetidine (Purity 56.6% contains diphenylmethane) and 2.4 g (0.0225 mole) of nitrourea in 40 ml of acetone was treated with 4 ml of water, then heated until a clear homogenous solution was obtained. The reaction mixture was stirred overnight as it cooled to ambient temperature and diluted with water Y, until an oil separated. The oil solidified and was recrystallized from ethanol/water, yielding 4.3 g of white plate-like crystals; m.p. 117-118 0 C. The product was recrystallized from benzene, yielding 3.35 g of crystals, m.p. 118-119 0 c.

Analysis: Calculated for C- 1 2

H

1 3

F

3

N

2 0 2 C,52-56; 11,4-78; N,10.22 Found :C,52-54; 11,4.74,.

N,10-17 Example 31 trn 2-e~lN(-rpny) phenoxyl -l-azetidinecarboxanide.

A solution of 6 g (0.015 mole) of crude trans-2-methyl- 3-[3-(trifluoromethyl)phenoxy~azetidinc in 50 ml of tetrahydrofuran was treated with 1. g (0.0165 mole) of 2-propenyl isocyanate all at once and stirred under a blanket of nitrogen for 16 hr. The reaction mixture was diluted with water until an oil separated. The oil failed to crystallize and after 7 weeks it was triturated with isopropyl ether (3 x 25 ml). The combined tri~turates gave 400 mg of white granular crystals m, p. 55-57 0

C.

Analysis: calculated for CISH 17

F

3

N

2 0 2 C,57.321 H,5.45;* N,8.91 Found C,716 11 H5.50; NO8.97 452 -36 Example 32 3-(3-Chlorophenoxy)-N-meth 1-1-azetidinecarboxkamide.

A solution of l-chlorocarbonyl-3-(3-chlorophenoxy) azetidiie (0.01275 mole) in 20 ml of tetrahydrofuran was treated with 4 ml (0.05 mole) of 40% aqueous methylamine and stirred for 16 hr. The reaction mixture was diluted with water until an oil began to separate, then extracted with 3 x 50 ml of benzene. The combined extracts were dried over magnesium sulfate and concentrated to a solid which was recrystallized from benzene/ligoin to yield 1.2 g of fine white crystals, m.p. 140-1410c.

Analysis: Calculated for CllHl 3 C1N 2 0 2 :C,54.89;. H,5.44,.

N,11.64 Found :c,55.05; H,5.58, N, 11 .52 Example 33 3-(3-Chlorophenoxy) (2-propenyi) -l-azetidinecarboxamide.

A solution of 5.4 g (0.017 mole) of l-chlorocarbonyl- 3-(3-chlorophenoxy)azetidine in 20 ml of tetrahydrofuran was treated with 2.3 g (0.04 mole) of 2-propenylamine and stirred for 2 hr. The reaction solution was concentrated in vacuo to a rose beige solid. Trituration of the solid with water gave, after filtering, 4.4 g of crude product.

After drying, the solid was recrystallized with charcoal treatment from 2% acetone/isopropyl ether to yield 1.7 g of pale beige crystals, M.P. 87-890C.

Analysis: Calculated for C 13

HISCIN

2 0 2 C,58-54; H,5.67; N, 10-.50 Found .C,58.

1 48; H65.72; Nto4 452 37 Example 34 N-Methyl-3-(2-pyridinyloxy)-l-azetidinecarboxamide.

A 2M benzene solution of phosgene (40 ml, 0.08 mole) was added to a suspension of 10 g of finely ground potassium carbonate in 40 ml of methylene chloride. The mixture was stirred for 15 min. at room temperature and 10 g (0.056 mole of 1-(l-phenylethyl)-3-(2-pyridyloxy)azetidine in 50 ml of methylene chloride was added with mild cooling. The mixture was stirred at room temperature for 1 hr and concentrated on a rotary evaporator (25°C./30 min). The residue was treated with 100 ml of tetrahydrofuran and cooled with an ice bath. To the cooled, stirred mixture was added 20 ml of 40% aqueous methylamine. The mixture was stirred for' min and partitioned between methylene chloride and water. The mothylene chloride was dried over sodium sulfate and concentrated. The residue was crystallized from benzene-ethanol and recrystallized from ethyl acetateisopropyl alcohol. Yield of title compound was 2.3 g m.p. 165-168 0 c.

^Analysis: Calculated for CloHisN 3 a0: C,57.96; H,6.32; N,20.28 20 Found C,57.93; H,6.34; N,20.12 Example N-(2-Propenyl)-3-(2-pyridinyloxy)-l-azetidinecarboxamide.

To a stirred suspension of 10 g (0.072 mole) of finely 25 ground potassium carbonate in 90 ml of methylene chloride was added 32 ml (0.062 mole) of 2M phosgene in benzene.

The mixture was stirred for 15 min and 8 g (0.031 mole) of l 1-(l-phenylethyl)-3-(2-pyridyloxy)azetidine in 50 ml of methylene chloride was added. The mixture was stirred at 25°C. for 2 hr and concentrated on a rotary evaporator at 25°C./30 min and the residue was treated with 100 ml of S tetrahydrofuran. The stirred mixture was cooled with an ice "bath and treated dropwise with 4 g (0.07 mole) cf llyl amine. After stirring 30 min at 25°C., the mN yrial was partitioned between water and methylene chloride. The methylene chloride was dried and concentrated. The residue .4 1 38 was chromatographed on a Waters® PREP-500 HPLC using a silica column and eluting with 50% ethylacetate-hexane. The product was crystallized twice from isopropyl ether. Yield of title compound was 1.5 g m.p. 72-76°0.

Analysis: Calculated for C 1 HaHsNs02: C,61.79; H,6.48; N,18.01 Found C,61.53; H,6.50; N,17.96 Example 36 3-(2-Pyridinyloxy)-l-azetidinecarboxamide.

A 2M benzene solution of phosgene (32 ml, 0.062 mole) was added to a stirred suspension of 10 g of finely ground potassium carbonate in 80 ml of methylene chloride. The mixture was stirred for 15 min and 8 g (0.031 mole) of l-(l-phenylethyl)-3-(2-pyridyloxy)azetidine in 50 ml of methylene chloride added. The mixture was stirred for min and concentrated on a rotary evaporator (25 0 C./30 min).

The residue was treated with 100 ml of tetrahydrofuran, cooled with an ice bath and 20 ml of concentrated ammonium hydroxide added slowly while stirring vigorously. The mixture was stirred 1 hr at room temperature and partitioned 41 20 between methylene chloride and water. The water layer was V st 9 extracted 2 times with methylene chloride and the combined organic layers were concentrated. The residue was S. crystallized from benzene and recrystallized from isopropyl ether. Yield of title compound was 1.4 g, m.p. 133-137 0

C.

Analysis: Calculated for C 9

H

11

N

3 0 2 C,55.95; H,5.74; N,21.75 Found C,55.73; H,5.71; N,21.10 Example 37 2-rl-(l-Phenylethyl)-3-azetidinyloxylpyridine.

The maleate salt of l-(l-phenylethyl)-3-a 1dinol g,.22 mole) was partitioned between o-uene and dilute sodium hydroxide and was extracted ce with toluene. The organic layer was dried (sod iumsulfate) and concentrated.

The residue was dissolv ein 125 ml of dimethylformamide and added dropwise tfa stirred suspensi s of 9.6 g (.24 mole) of sodium y6ride (washed three tim;l' with isooctane) in 0 of dimethylformamide at 25-35° The solution was ia. a~lf. ^-filai^taa^ i. 'T~T vi~.-W -11i i n nu iin ri~iniij- .n iilii ij-imilin LL L I i F~~rdC,53.73; H,5.20; N,9.60

UM

-39heated to C. and 35 g (.22 mole) of 2-bromopyridine was added dropwise while heating to 75 0 C. The solution stirred and heated at 90 for 1 hr followed b eating at 120 C. for 2.75 hr. The mixture was stir at room temperature overnight and concentra .The residue was partitioned between water and Iopropyl ether. The organic layer was washed twice water, dried (sol~ium sulfate), V filtered and conce rated. Crude yield was 30 The kesidue was distille o give 8 g, bp 128-13I4 0 c./.0l mrn of product.

410 Analys' Calculated for CjGH 1 8

N

2 0: C,75-57; H,7.13; N,11.01 Found :C,75.20; H,7.18; N,10.90 Example 38 1-[3-F4-(Trifluoromethyl)phenoxy]-l-azet'idinylcarbonyl]- 1H-imidazole.

A mixture of 1.7 g (0.01 mole) l,l'-carbonyldiimidazole V in 50 ml of tetrahydrofuran and 3 g (0.015 mrolea) of V 3-[4-(trifluoromethyl)phenoxy]azetidine was stirred for 6 hr. The reaction mixture was diluted with water and extracted iith 3 x 50 ml of methy,,lene chloride. The extracts upon concentrating in vacuo gave an amber residue which was dissolved in 20 ml of benzene and washed with dilute hydro- I chloric acid, then washed with water. The benzene portion was concentrated to give a semi-solid residue which when triturated with isopropyl ether gave 1.14 g of gray material.

Recrystallization from acetonitrile gave 1.3 g of p fine gray crystals, m.p. 139-140 0

C.

Analysis: Calculated for C 1 4

H

12

F

3

N

3 0 2 C,54.02; H,3.89; Found :C,5 1 4.33; H, 3.96 Example 39 N-Methyl-3-phenoxy-l-azetidinecarboxamide.

The compound was prepared from the methane sulfonate of 3-phenoxyazetidine and methylisocyanate as described in Example 1 of U. S. Patent 4,226,861, m.p. 139-1~41 0 c.

e 452 40 Example 4o N-Methyl-3- r4-(trifluoromethyl)phenoxy 1 -1-azet idinecarboxamide.

The compound was prepared from 3-[ 4 -(trifluoromethylphenoxy)azetidine ard methylisocyanate as described in Example 3 of U. S. Patent 4,226,861, m.p. 154-1570C.

Example 41 N-Methyl-3-73-(trifluDrometh yl henoxy)-l-azetidinecarboxamide.

The compound was prepared from 3-t3-(trifluoromethylYphenoxy)azetidine and rethylisocyanate as described in Example 4 of U. S. Patent 4,226,861, m.p. 1457147C.

Example 42 N-Methyl-3-_r2-&t rifluorometlyl)phenoxyl-l--zetidinecarboxamide.

The compound was prepared from 3-[2-(trifluoromethyl)phenoxy)azetidine and methylisocyanate as described in Example 5 of U. S. Patent 4,226,861, m~p. 134-1360C.

Example 43 N-Methyl-3-t2-(aminocarbonyl)phenoxyl-l-azetidinecarboxamide.

The compound was prepared from 2-(3-azetidinyloxy) benzamide and-methylisocyanate as described in Example 2 of U. S. Patent 4,226,861, m.p. 236-240 0 c.

Example 44 N-Methvl-3-r3-(aminocarbonyl)phenoxyl-l-azetidinecarboxamide.

The compound was prepared from 3-(3-azetidinyloxy) benzamide and methylisocyanat- as described in Example 6 of U. S. Patent 4,226,861, rnp. 238-240C.

Example N-Methyl-3-r4-(aminocarbonyl)phenoxy1-l-azetidinecarboxamide.

The compound was prepared from 14 -(3-azetidinyloxy) benzamide and methylisocyanate as described in Example 7 of U. S. Patent 4,226,861, m.p. 208-210 C.

for 18 hr. The reaction mixture was concentrated on a rotary evaporator to give an amber residue. Trituration of this residue with 30/60 petroleum ether gave only an 1452 41 Example 46 3-r3-(Trifluoromethy )phenoxyl-l-azetidinecarboxamide.

A mixture of 30.6 g (0.141 mole) of 3-[3-(trifluoromethyl)phenoxy]azetidine and 42 g (0.321 mole) of nitrourea in 500 ml of acetone was stirred for 5 days (5 days not required, but convenient) at room temperature. The mixture was filtered and the filtrate concentrated in vacuo.

The residue was partitioned between 150 ml of water and 100 ml of ethyl acetate and the layers separated. The aqueous layer was washed with 100 ml of ethyl acetate. The ethyl acetate layers were washed with 75 ml of 5% aqueous sodium hydroxide solution followed by 75 ml of water, dried over sodium sulfate and concentrated in vacuo. The residual oil was crystallized from ethyl alcohol-ethyl acetate to give 22 g substantially the title compound.

Recrystallization twice from ethyl alcohol gave 9.9 g of white crystalline solid, m.p. 151-152.5 C.

Analysis: Calculated for C 11 HaIF 3 N20a: C,50.77; H,4.26; N,10.76 Found C,50.90; H,4.29; N,10.71 Example 47 N-Ethyl-3-r 3-(trifluoromethyl)phenoxyl -l-azetidinecarboxamide.

To a stirred and chilled (15-20°C.) solution of 0.024 mole of 3-[3-(trifluoromethyl)phenoxy]azetidine in 50 ml of dry benzene was added dropwise 1.99 g (0.028 mole) of 4| ethyl isocyanate. The reaction mixture was stirred at room temperature overnight and was diluted with 50 ml of Smethylene chloride. The solution was washed with 5% sodium hydroxide (2 x 50 ml), water (50 ml), saturated sodium chloride (25 ml), dried over sodium hydroxide, and concentrated in vacuo. The residue (9.6 g) was twice recrystallized from ethyl acetate-isopropyl ether to give 5.4 g of a white solid, m.p. 125-126 0

C.

Analysis: Calculated for C1sHs 1

F

s

N

2 0 2 C,5 4 .16; H,5.24; N,9.72 Found c, 5 4.24; H,5.23; N,9.74 V. w treated with the dropwise addition of 3.52 g S 35 (0.027 mole) of 3-(diethylamino)propylamine. The reaction mixture was stirred for 1 hr as the somewhat exothermic reaction cooled to ambient temperature then treated with i m im n I in l i A452

I

42 Example 48 N-(l-Methylethyl)-3-r[-(trifluoromethyl)phenoxy]-lazetidinecarboxamide.

To a stirred and chilled (10-20 0 solution of 9.0 g (0.042 mole) of 3-[3-(trifluoromethyl)phenoxy]azetidine in 100 ml of dry methylene chloride was added dropwise 4.1 g (0.048 mole) of isopropyl isocyanate. The reaction mixture was stirred at room temperature for 2 hr and was diluted with 100 ml of methylene chloride. The solution was washed with 5% sodium hydroxide (2 x 40 ml), water (50 ml), saturated sodium chloride (50 ml), dried(sodium sulfate) and concentrated in vacuo. The residue was crystallized from ethyl acetate, affording 7.6 g 'Recrystallization from ethyl acetate gave 5.0 g of clear white needles, m.p. 150-151.5 0

C.

Analysis: Calculated for C1 4 HiyFsN 2 0 2 C,55.62; H,5.68; N,9.27 Found C,55.77; H,5.68; N,9.22 Example 49 N-Propyl-3-[3-(trifluoromethyl)phenoxy -l-azetidinecarboxamide.

To a stirred and chilled (10-15 0 solution of 0.027 mole of 3-[3-(trifluoromethyl)phenoxy]azetidine in 100 ml of dry benzene was added dropwise 4.0 g (0.047 mole) of n-propy! isocyanate. The reaction mixture was stirred at room temperature for 30 minutes. The benzene was washed til with dilute sodium bicarbonate (50 ml), water (25 ml), saturated sodium chloride (25 ml), anC dried(sodium sulfate). The solution volume was reduced to 50 ml, and

S

l t 30 ml of petroleum ether was added, yielding 6.5 g (81%) of product. Recrystallization from isopropyl etherisopropyl alcohol gave 6.0 g of small white needles, m.p.

S115-117 0.

SAnalysis: Calculated for C 14

H

17

F

3

N

2 0 2 C,55.63; H,5.67; N,9.27 Found c,55.65; H,5.68; N,9.25 IvvL Buu.uIII bu±Liae ana concentratea to an amfler oil on a rotary evaporator. The oil solidified when triturated with a small amount of isopropyl ether (50 ml). Filtration 452 -43 Example N-Butyl-3-[3-(trifluoro-methyl)phenoxy -1-azetidinecarboxamide.

A solution of 18.9 (0.05 mole) of crude 3-[3-(trifluoromethyl)-phenoxy~azetidine (contains an equal molar amount of diphenylmethane') in 100 ml of isopropyl ether was stirred under nitrogen while 4.96 g (0.05 mole) of N-butyl isocyanate was slowly added. The clear reaction solution became warm to the touch, and after a white crystalline solid began to precipitate. After stirring for 16 hr, the solid was removed by filtration, washed with fresh isopropyl ether and air dried to yield 8 g of pale beige crystals, m.p. 108-109 0 c.

Analysis: Calculated for C 15 HjqF 3

N

2 0 2 C,56.96, H,6.05; N,8.86 Found :C,56.78; H,6.06; N,8.83 Example 51 N-Ethyl-3-E 4 -(trifluoromethyl)phenoxy]lazetidinecarboxamide.

A solution of 6.5 g (0.03 mole) of crude 3-[ 1 4-(trifluoromethyl)phenoxyjazetidi4ne in 50 ml of isopropyl ether was stirred under a blanket of nitrogen while 2.85 g (0.04 mole) of ethyl isocyanate was added dropwise. After stirring for 2 hr at ambient temperature, a solid began to precipitate, and after 14 hr, the solid was collected 4 by filtration to yield 3.7 g of beige product, m.p. 914-96 0 c.

CC 25 Rework of the filtrate gave only a trace of additional L4.4.product. The product was recrystallized from isopropyl ether/hexane (treated with charcoal) to yield 2.61 g of product, m.p. 109-110'C.

~Analysis: Calculated for C 1 3

H

1 5

SF

3

N

2 0 2 C5.1;H5.25; t 30 c~44*N,9.72 Found ,5.o 1H5.33; N,9.89 1 452 44 Example 52 N-Butyl-3-r4-(trifluoromethyl)phenoxy-l-azetidinecarboxamide.

A solution of 6.5 g (0.03 mole) of crude 3-[4-(trifluoromethyl)phenoxylazetidine in 50 ml of isopropyl ether was stirred under a blanket of nitrogen while 4 g (0.04 mole) of n-butyl isocyanate was added dropwise. The reaction was slightly exothermic and after 30 min, a solid separated. The solid was collected by filtration after 3 hr to give 3.85 g of crystalline product, m.p. 135-136 0

C.

After 24 hr, a second batch of crystals was obtained; g; m.p. 132-134°C. The two fractions were combined and recrystallized from cyclohexane to yield 3.6 g of product m.p. 136-137 0

C.

Analysis: Calculated for C 15 HIsF 3

N

2 0 2 C,56.96; H,6.05; N,8.86 Found C,57.12; H,6.13; N,8.93 Example 53 N-Propyl-3-r4-(trifluoromethyl)phenoxy -l-azetidinecarboxamide.

A solution of 8.7 g (0.04 mole) of crude 3-[4-(trifluoromethyl)phenoxy]azetidine in 75 ml of isopropyl ether was stirred under a blanket of nitrogen while 4.3 g (0.05 mole) of n-propyl isocyanate was added dropwise. After stirring for 2 hr, only a trace of crystalline precipitate 25 formed in the reaction mixture, and after stirring for 18 hr, filtration yielded only 1.1 g of product, m.p.

112-114°C. The filtrate was concentrated in vacuo to give a dark amber residue. After 3 days, only 1.3 g of additional crude product could be obtained from isopropyl 30 ether/hexane. All of the reaction products were dissolved in chloroform and chromatographed on a 200 g silica gel column. Elution with chloroform gave a reddish forerun, which was discarded. The elution was changed to 2% ethyl acetate/chloroform, then to 4% ethyl acetate, and finally to 2% methanol/chloroform. All the fractions were combined 452 and concentrated to yield 4.1 g of white solid.. Recrystallization from cyclohexane yielded 2.86 of fine white crystalline product, m.p. 119-120 0

C.

Analysis: Calculated for C1 4

H

17

F

3 N2O 2 C,55.63; H,5.67; N,9-27 Found :c,55.50; H,5-77; N,9.19 ,Example- 514 3-r14-(Trifluororethyl)phenoxyl-l-azetidinecarboxamide.

A solution of 9.6 g (0.025 mole) of 3-E14-(trifluoromethyl)phenoxyjazetidine 56.66% (contains d iphenylmethane) in 50 ml of acetone was treated with 4.22 g (0.0145 mole) of nitrourea and 5 ml of water. The mixture was heated on a hot plate until a clear solution was obtained then allowed to cool to ambient temperature during the next 14 hr. The reaction mixture was diluted with 200 ml of ice water and an oil separated (diphenylmethane) which was dissolved in 30/60 petroleum ether and separated. Upon standing, a fine white precipitate formed in the aqueous solution. Filtration S 4: yielded 3.6 g of fine white crystals, m.p. 176-1780C.

After drying under 0.5 mm Hg vacuum at 80 0 the product S weight was reduced to 3.1 g M.P. 178-179 0

C.

S Analysis: Calculated for CjjHj 1

F

3

N

2 CtC,5074; H,14.26; t"I N 10.77 Found C, 50.72 H, 1 4.214; N, 10 .72 Exhmple N-(l-Methlethl)-3-r4-(trifluoromethvl)phenoxv1-lazetidinecarboxamide.

A stirred slurry of 6.2 g (0.02 mole) of 3-E14-(trifluoromethyl)phenoxy~azetidine oxalate in 60 ml of tetrahydrofuran was treated with 1.8 g (0.022 mole) of 1-methylethyl isocyanate and after 0.5 hr, 5 ml of triethylamine was added. A clear yellow solution was obtained and was 44 stirred for 18 hr, then treated with 10 ml of water, yielding 5.3 g of pale yellow crl !stalz, m.p.

151-152 0 c.

Analysis: Calculated for C1.

4

H

17

F

3

N

2

O

2 :C,55.63; Ho,67; N,9.27 Found :C,55-80; H,5.71: N,9.24 sulfate and concentrated on a rotary evaporator to a solid residue, 14.2 g. Recrystallization from methanol-water yielded 5.35 g of fine white crystals, m.p.

157-158 0 c.

452 46 Example 56 N-(1,1-Dimethylethyl)-3-r[-(trifluoromethyl)phenoxyl- 1-azetidinecarboxamide.

A stirred slurry of 6.2 g (0.02 mole) of 3-[E-(trifluoromethyl)phenoxy]azetidine oxalate, in 60 ml of tetrahydrofuran was treated with 2 g (0.022 mole) of 1,1dimethylethyl isocyanate and* after 0.5 hr 5 ml of triethylamine was added. The reaction slurry quickly turned to a pale yellow solution which was stirred for 18 hr, then treated with 10 ml of water. After 20 min, the tetra-, hydrofuran portion was separated, dried over magnesium sulfate and concentrated on a rotary evaporator. The solid residue was recrystallized from isopropyl ether to yield 9 of fine white crystals, m.p. 145-1460C.

Analysis: Calculated for C 1 sH1eF 3

N

2 0 2 C,56.96; H,6.05; N,8.86 Found C,56.97; H,6.15; N,8.86 Example 57 N-(2-Methylpropyl)-3-r3-(trifluoromethyl)phenoxyl-lazetidinecarboxamide.

A stirred solution of 3.6 g (0.022 mole) of 1,1'carbonyldiimidazole in 100 ml of methylene chloride under nitrogen was treated with 1.6 g (0.022 mole) of 2-methylpropylamine (added via a syringe and needle through a septum placed in one neck of the reaction flask). After stirring for 1 hr, 6.2 g (0.02 mole)of 3-[3-(trifluoromethyl)phenoxy] t azetidine oxalate was added all at once followed in 30 min with 5 ml of triethylamine and stirring continued for 18 hr.

The reaction mixture was washed with water (2 x 25 ml), dried over magnesium sulfate and concentrated in vacuo, yielding 13 g of crude solid residue. Recrystallization from ethanol/water yielded 5.9 g of product having a pink 4iC tv cast. A second recrystallization from cyclohexane yielded 4.8 g of fine white crystals, m.p. 124-125 0 C. Rework of the filtrates yielded 1.2 g additional beige crystals.

Total yield of product was 75.6% of theory.

Analysis: Calculated for CisHigFsN 2 a0: C,56.96; H,6.05; N,8.86 Found C,57.01 H,6.11t N,8.88 with water until an oil separated which quickly solidified.

The aqueous tet:ahydrofuran was decanted and the solid residue recrystallized from ethanol-water to yield 5.3 g of white crystals, m.p. 137-138 0

C.

v S- i 452 47 Example 58 N-(l,1-Dimethylethyl)-3-[3-(trifluoromethyl)phenoxy 1-azetidinecarboxamide.

A stirred slurry of 6.2 g (0.02 mole) of 3-[3-(trifluoromethyl)phenoxylazetidine oxalate in 60 ml of tetrahydrofuran was treated with 2 g (0.02 mole) of 1,1-dimethylethyl isocyanate followed in 30 min with 5 ml of triethylamine. The clear solution which developed was stirred for 18 hr. The reaction mixture was treated with 10 ml of water and after 20 min, the tetrahydrofuran portion was separated, dried over magnesium sulfate, and concentrated on a rotary evaporator. The solid residue was recrystallized from ethanol/water, yielding 5.8 g of fine white crystals, m.p. 105-107 0

C.

Analysis: Calculated for CisHisF 3

N

2 Oa: c,56.96; H,6.05; N,8.86 Found C,56.95; H,6.14; N,8.92 Example 59 N-(2-Methylpropyl)-3-r4-(trifluoromethyl)phenoxy]-1 azetidinecarboxamide.

I"r 20 A stirred solution of 3.6 g (0.022 mole) of 1,1- I t 4 a 4 carbonyldiimidazole in 100 ml of methylene chloride under 'i nitrogen was treated with 1.6 g (0.022 mole) of 2-methylpropylamine (added via a syringe and needle through a septum placed in one neck of the reaction flask). After 25 stirring for 1 hr, 6.2 g (0.02 mole) of 3-[4-(trifluoromethyl)phenoxy]azetidine oxalate was added all at once followed in 30 min with 5 ml of triethylamine and stirring 9 S.was continued for 18 hr. The reaction mixture was washed with water (2 x 25 ml), dried over magnesium sulfate, and concentrated in vacuo. The solid residue was recrystallized from ethanol/water, yielding 5.4 g of pale yellow crystals.

Analysis: Calculated for C 15 Hi 9

F

3

N

2 0 2 C,56.96; H,6.05; N,8.86 Found C,57.02; H,6.08; N,8.82 452 48 Example 3-(3-Chlorophenoxy)-1-azetidinecarboxamide.

A solution of 5.4 g (0.017 mole) of l-chlorocarbonyl- 3-(3-chlorophenoxy)azetidine in 20 ml of tetrahydrofuran was treated with 3 ml of ammonium hydroxide and stirred for 1 hr. The reaction mixture was concentrated in vacuo to a wet solid, 4 g, which was recrystallized after drying, from benzene to yield 1.5 g of white crystalline powder, m.p. 163-164.5°C. Yield calculated from the l-(2-phenylethyl)azetidine compound was 38.9%.

Analysis: Calculated for C 1 oH 1 lC1N 2 0 2 C,52.99; H,4.897 N,12.36 Found C,52.99; H,4.91 N,12.32 Example 61 3-(3-Fluorophenoxy)-N-methyl-l-azetidinecarboxamide.

A stirred mixture of 5.4 g (0.02 mole) of 3-(3-fluorophenoxy)-azetidine oxalate and 1.7 g (0.022 mole) of methyl isocyanate in 20 ml of tetrahydrofuran was treated with ml of triethylamine then stirring was continued for 3 hr.

The reaction was diluted with water and the fine crystalline precipitate obtained was collected by filtration and dried at 60°c. under vacuum to yield 3 g of product, m.p. 155-156 0

C.

Analysis: Calculated for CI 1

H

1 sFN 2 0 2 C,58.92; H,5.84; N,12.49 Found C,58.93; H,5.91; N,12.26 Example 62 S, -(3-Fluorophenoxy)-N-methyl-l-azetidinecarboxamide.

A stirred slurry of 0.38 g (0.02 mole) of 60% sodium hydride as a mineral oil suspension in 10 ml of dry dimethylformamide was treated under nitrogen with the dropwise addition of 1.12 g (0.01 mole) of 3-fluorophenol in 20 ml of dimethylformamide. After 1 hr, the mixture was heated at 90 C. for 20 min then 2.1 g (0.01 mole) of N-methyl-3-[(methanesulfonyl)oxy]-l-azetidinecarboxamide was added as a solid. The reaction mixture was then stirred at 90°C. for 8 hr. The reaction mixture was cooled by adding ice water then further diluted to 200 ml 49 with water and extracted with 3 x 50 ml of methylene chloride. Less than 1 g of oil 'was obtained upon concentrations of the extracts. Extraction with 4 x 50 ml of benzene gave only a trace of product. The mass spectr un (CI) showed the expected p+i at 225 m/e. The product solidified on standing and was recrystallized from methanol/ water to yield 650 mg of flake-like silver crystals, i.p. 156-158 0 c.

Analysis: Cacltdfor C 11

H

1 gFN 2

O

2 C,5.92 Hi,5.84; N.12.J49 Found C,58.93; H,5.91; N1,12.42 452 50 Pharmacological Test Procedures Muscle Relaxant Test The test procedure relied on to indicate positive muscle relaxant activity is the morphine-Induced Straub Tail in Mice Test described by G. D. Novak in DRUG DEVELOPMENT RESEARCH (1982) 2: 383-386, except 8 animals per group were used per test rather than 10. The test is summarized as follows: The test drug, reference drug, and control articles to be administered are prepared in saline, aqueous methylcellulose suspension or other, depending on solubility, in such concentration that the volume administered is 10 mlAg. The initial screening dose of the test drug is usually 100 mgkg. Groups of 8 mice are given an IP dose of a compound or vehicle prepared as described above. After 15 min, mice are administered morphine sulfate, 60 mg/g, subcutaneously. Fifteen minutes after administration of morphine 30 min after test compound administration), mice were scored for presence of Straub Tail defined as an elevation of the tail at least 90 degrees from the horizontal. An EDso value may be determined from at least three logarithmically spaced doses by the method 00 of Litchfield and Wilcoxon (1949), j. PHARMACOL. EXP. THER.

H26: 99-113. Compared to a reference compound, methocarbamol, which exhibited an EDso of 75-110 in the above Straub Tail Test, the more active compounds of Formula I were 5-10 times more active.

'S 5 Antianxiety Test The test screening procedure relied on to indicate positive antianxiety response is a modification of the Vogel Conflict Test which is based on shock-suppressed drinking behavior in rats outlined by J. R. Vogel, et al in PSYCHOPHARMACOLOGY 21: 1-7 (1971). Th.- procedure wxed is i as follows: The test reference and control articles to be administered intraperitoneally in physiological salinet aqueous methylcellulose or other depending on a solubility in such concentration that the volume administered is 5 mlAg. The initial screening dose of the test article 452 51 is usually 100.0 mg/kg initially, and the reference drug (diazepam) is 5 mg/kg.

Prior to dosing, rats are housed 2 per cage and deprived of water for 48 hr and thereafter randomized into treatment groups of five. Feed is available ad libitum. Thirty minutes after dosing, each rat Is placed individually in a plexiglass cage measuring iS cm in width, 13 cm in height and 29.5 cm in length and equipped with a stainless steel grid floor. The cage is covered with a plastic lid containing holes to facilitate introduction of a water bottle (30 ml plastic centrifuge tube) with a rubber stopper and metal drinking tube. A Drinkometer circuit (Omniteck Electronics, Inc., 3000 Cortona Road, Columbus, Ohio 432 0 4 is connected between the drinking tube and the grid floor of the apparatus so that the rat completes the circuit whenever it licks the tube. The procedure is to allow the rat to find the drinking tube and complete 20 licks (as displayed on the Drinkometer digital readout) prior to the start of the experimental session. Rats not reaching this criterion are discarded.

A three minute experimental session is initiated by a 0.25 t t, mA shock at the 20th lick. Rats that continue drinking t 4 will experience a shock at each successive 20th lick. The 4 4t total number of shocks during the experimental session are recorded as follows: total licks 1 total shocks statistical analysis is performed by the Dunn's Multiple Comparison Test described by 0. J. Dunn (1964) TECHNOMETRICS 6(3):241-52. The mean number of shocks experienced by the control group is compared with those of each drug-treated group. significance is considered at P-0.1. The higher the total shocks compared to control, the more active is the compound. Active compounds may then be similarly tested t at reduced dosages. Illustratively, one preferred compound, the compound of Example 16, namely, N-cyclopropyl-3-[4-(trifluoromethyl)jhenoxy3-l-azetidinecarboxamide was active at as low a dosage as 10 mg per kg, where total number of shocks taken as calculated above over control was 14//4.6 (P=0.03) compared to about 12-15/4 for diazepam.

-xl-F-- 52 Pharmaceutical Compositions The methods of treating anxiety, muscle tension, and spasticity in mammals is best carried out by administering as active ingredients in a pharmaceutical composition at least one of the compounds of Formula I in association with a pharmaceutical carrier or excipient. The compounds are thus presented in a therapeutic composition suitable for oral, rectal, parenteral, subcutaneous, intramuscular, intraperitoneal, or intravenous administration. Thus, for example, the composition for oral administration can take the form of elixirs, capsules, tablets, or coated tablets containing carriers conveniently used in the pharmaceutical art. Suitable tableting excipients include lactose, potato, and maize starches, talc, gelatin, stearic and silicic acids, magnesium stearate and polyvinyl pyrrolidone.

For parenteral administration, the carrier can be comprised of a sterile parenterally acceptable liquid; water or arachis oil conta .ned in ampoules.

In compositions for rectal administration, the carrier can be comprised of a suppository base, cocoa butter or glyceride.

Advantageously, the compositions are formulated as dosage units, each unit being adapted to supply a fixed dose of activeingredients. Tablets, coated tablets, capsules, ampoules and suppositories are examples of preferred dosage forms according to the invention. It is only necessary that the active ingredient constitute an f 't effective amount; such that a suitable effective dosage will be consistent with the dosage form employed.

t' t The exact individual dosages as well as daily dosages will, of course, be determined according to standard medical principles under the direction of a physician or veterinarian.

t*(m Testing suggests that compounds of Formula I will be I effective in man for muscle relaxant effects at about 4-40 mg/kg body weight per day. Illustratively, one compound, namely, N-methyl-3-3- (trifluoromethyl)phenoxy3-l-azetidine carboxamide (Example 41), was found to be about 5 times as i; L1. il 452 53 potent as Methocarbamol as a muscle relaxant.

The suggested regimen, for example, for the compound of Example41 as a muscle relaxant appears to be about 10 mg/kg/ day or for a 75 kg individual about a unit dosage of 250 mg, t.i.d.

Effective daily dosages of compounds of Formula I as antianxiety agents are projected to be about 1-10 mg/kg/day body weight based on animal data.

Formulations may be prepared and administered in the manner described in our co-pending/application 53s87 (b.

-imu54 ied concurrently 1 ith

I

1"

Claims (6)

1. A method of treating muscle tension, muscle spasticity and anxiety in an animal, including a human, by administering to said animal an effective amount of a compound selected from the group having the formula: R z II N-C-N O-Ar wherein; R Ar is selected from pyridyl in any of its positions, including pyridyl substituted by halo, from phenyl or phenyl substituted by 1 or 2 radicals selected from chloro, bromo, iodo, fluoro, loweralkyl, loweralkoxy, nitro, aminocarbonyl, trifluoromethyl, or acetyl; Z is oxygen or sulfur, 1 2 R and R are selected from hydrogen, loweralkyl, aryl, allyl, substituted allyl, propargyl, cycloalkyl, loweralkylcycloalkyl, cycloalkylloweralkyl, arylloweralkyl, cycloalkylamino, loweralkyl, and diloweralkylaminoloweralkyl, 1 2 and R and R when taken together with the adjacent nitrogen atom may form a heterocyclic amine radical selected from azetidinyl, pyrrolidinyl, piperidinyl, homopiperidinyl, imidazolyl, piperazinyl, 4-substituted piperazinyl and morpholinyl, R is selected from hydrogen, loweralkyl, aryl or arylloweralkyl; the geometrical isomers including cis, trans, and isomers thereof, and the pharmaceutically acceptable acid addition salts thereof when R 1 and/or R 2 0202e/AC i i- have a salt-forming basic amino component or when Ar is pyridyl.

2. The method of claim 1 wherein the compound used is N-methyl-3- (trif luoromethyl )phenoxy I-1--zetidine- carbothioamide; on

6-dimethylphenyl) -3-[3-(trifluoromethyl)phenoxy]-l- azetidinecarbothioamide; or 0202e/AC 56 N-(Phenylmethyl) trifluoromethyl)phenoxy]-l-azetidine- carboxamide; or N-(2,6-dichnlorophenyl)-3-[3-(trifluoromethyl)phenoxyj-l- azetidinecarbothioarnide; or N-[3-(diethylamino)prooyl-3-[3-(trifluoromethy.l)phenoxy]- l-azetidinecarbothioamide or a pharmaceutically acceptable acid addition salt thereof; or N-[3-(dixnethylamino)propyl]-3-[3-(trifluoromethyl)phenoxyJ- 1-azetidinecarbothioamide or a pharmaceutically acceptable 4 acid addition' salt thereof; or N-(2-propenyl)-3-[3-(trifluoromethyl)phenoxyJ-l-azetidine- carboxamide; or N-cyclopropyl-3-[3-(trifluoromethyl)phenoxy-l-azetidine- carboxamide; or N-[3-(diethylami'io)propyl]-3-[3-(trifluorometlhyl)phenoxyj- 1-azetidinecarboxamide or a pharmaceutically acceptable acid addition salt thereof; or N-2-(propenyl)-3-.C4-(trifluoromethyl)phenoxy-l-azetidine carboxamide; or N-(cyclopropylmethyl)-3-[3-(trifluoromethyl)phenoxy]-l- azetidinecarboxamide; or N,N-diethyl-3-[3-(trifluoromethyl)phenoxyJ-l-azetidine- carboxarnide; or A 4 N,N-dimethyl-33(trifluoroethyl)phenoxy-l-azetidine- carboxamide; or which was discarded. The elution was changed to 2% ethyl acetate/chloroform, then to 4% ethyl acetate, and finally to 2% methanol/chloroform. All the fractions were combined -57 N-(2-propynyl) 3-(tr if luoromethyl)phenoxy]-l-azetidine- carboxamide; or N-cyclohexyl-3-[3-( trifluoromethyl)phenoxy)-l-azetidine- carboxamide; or N-cyclopropyl--[4-( trifluoromethyl )phenoxy)-l-azetidine- carboxamide; or N-(cyclopropylmethyl)-3-[4-(trifluoronethyl)phenoxyJ-l- azetidinecarboxamide; or N-[3-(diethylamino)propylJ--[4-(trifluoromethyl)phenoxy]- l-azetidinecarbothioamide or a pharmaceutically acceptable acid addition salt thereof; or N-(3-(diethylamino)propylJ-3-[4k(trifluorornethyl)phenoxy>- 1-azetidinecarboxamide or a pharmaceutically acceptable acid addition salt thereof; or N-(2-propynyl)-3-[ 1 4-(trifluoromethyl)phenoxy)-l-azetidine carboxamide or N-(2-methyl-2-propenyl)-3-[lt-(trifluoromethyl)phenoxyj-1- azetidinecarboxamide or N-(2-methyl-2-propenyl)-3-[3-(trifluoromethyl)phenoxy)-l- azetidinecarboxaiide; or N-3mty--uey)3[-(rfurmty~hnx]l azetidinpcarboxamide; or azetidinecarboxamide; or -N-(C2.-but enyl) C4.(tr if luoromethyl)phenoxy..-1.-a zet idine- carboxamide; or (E)-N-(?-butenyl)-3-[j3-(trifluoroniethyl)phenoxy]-l-azetidine- carboxamide or N -phenyl-3-[3-( trifluoromethyl)phenoxy]-l-azetidine- carboxamide; or N -phenyl-3-[4-(trifluoromethyl)phenoxy]-l-azetidine- carboxamide; or trans-N,2-dimethyl1-3-[3-( trifluorornethyl)phenoxyj-l- azetidiriecarboxamide; or trans-2-methyl-3-[3-(trifluoromethyl)phenoxyj-l-azetidine- carboxamide; or trans j-2-methyl-N-(2-propenyl)-3-f3-(trifluoromethyl)phienoxy]- 1-azetidinecarboxamide; or 3-3clrpenx)Nmtyilaeiiecroaie o 3-(3-chlorophenoxy) -N-(2-ethy1-)l-tidinecrboaidenid oro N-methyl-3-(2-pyridinyloxy) -1-azetidinecarboxamide or a phar'maceutically acceptable acid addition salt thereof; or N-(2-propenyl)-3-(2-pyridinyloxy)-l-azetidinecarboxamide or a pharmaceutically acceptable acid addition salt thereof; or 3-(2-pyridinyloxy)-l-azetidinecarboxanide or a pharmaceutically acceptable acid addition salt thereof; or 4 ~r 0~ m scofl recrystaiiization trom cycionexane yielded 48g of fine white crystals, zn.p. l24-125 0 c. Rework of the filtrates yielded 1.2 g additional beige crystals. Total yield of product was 75.6% of theory. Analysis: Calculated for C 15 H 1 qF 3 N 2 0 2 C,56.56; H,6.05; N,8.86 Found :C,57.01; H,6.11; N,8.88 -59- 2-l(-hnlty)3aeiiyoyprdn or a 4 pharmaceutically acceptable acid addition salt thereof; or l-r3-rL4-( trifluoromethyl)phenoxy3--azetidilylcarbonl3-lH- imidazole or a pharmaceutically acceptable acid addition Salt thereof or N-methvl-3-phenoxy-l-azetidiecarboxamide; or N-methyl-3-[4-(trifluoromethyl)phenoxy]-l-azetidile- carboxamide or N-methyl-3-[3-( trifluoromethyl)phenoxy]-l-azetidine- V carboxamide; or N-methyl-3-C2-(trifluoromfethyl)pheloxY3-1-azetidilc- carboxamide or carboxamide or N-methyl-3-[3-( aminocarbonyl )phenoxyj -1-azetidine- carboxamide; or carboxamide or 3-E3-(trifluoromethyl)phefoxy-l-azetidinecarboxamide; or N-ethyl-3-E 3-C trifluoromethyl)phenoxyj-l-azetidine- carboxarnide or N-(l-methylethyl)-3-[3-(trifluoromethyl)phenoxy-l-azetidile /(V.PL 4 v carboxamide or crystals. Analysis: calculated for C 15 H 19 F 3 N 2 O 2 C,56.96; H,6.05; Found 2; N, 8.86 Found :C,57-02 H,6.08; N,8.82 N-propyl-3--[3-(trifluoromethyl)phenoxy-l-azetidine- carboxamide; or N-butyl-3-[3-(trifluoromethyl)phenoxy]-1-azetidine- 4. carboxamide; or N-ethYl-3-[I4-.trifluoromethyl)phenoxy]-1-azetidinecarboxanide; or j N-butY1-3--[ 4 -,(trifluoromethyl )phenoxy]-l-azetidinecarboxanide', or N-propyl-3-['4-(trifluoromethy1)phenoxy]-l-azetidine- carboxamide; or N-lmtyehl--4(rfurmty~hnxD1aeiie carboxamide; or N-(1,1-dimethylethyl)-3-fp4-(trifluoromethyl)phenoxy]-1- azetidinecarboxamide; or N-2-methylpropy1)-3-[3-(trifluorornethiyl)ph-enoxy]-l-azetidine- carboxamide; or N-(1,1-dimethylethyl)-3-[3-(trifluoronethyl)phenoxy-l- azetidinecarboxamide; or N-(2-methylpropyl)-3-[4-(trifluoromethyl)phenoxy]-l- azetidinecarboxamide; or 3-(3-chlorophenoxy)-1-azetidinecarboxamide; or 3-flubrophenoxy) -N-methyl-l-azetidinecar~boxamide r 2 61 3. The method of claim 1 or claim 2 which is for treating muscle tension and muscle spacticity in animals, including humans. 4. The method of claim 3 wherein the compound used has an 1 2 R and R radical selected from the group consisting of allyl, substituted allyl, propargyl or cycloalkyl. The method of claim 1 or claim 2 which is for treating anxiety in animals, including humans. 6. A 3-aryloxyazetidinecarboxamide compound selected from the group having the formula: R Z IN-C-N-Ar R2 wherein; R Ar is selected from pyridyl in any of its positions, including pyridyl substituted by halo, from phenyl or phenyl substituted by 1 or 2 radicals selected from chloro, bromo, iodo, fluoro, loweralkyl, loweralkoxy, nitro, aminocarbonyl, trifluoromethyl, or acetyl; Z is oxygen or sulfur, R1 and R 2 are selected from hydrogen, loweralkyl, aryl, allyl, substituted allyl, propargyl, cycloalkyl, loweralkylcycloalkyl, cycloalkylloweralkyl, arylloweralkyl, cycloalkylamino, loweralkyl, and diloweralkylaminoloweralkyl, 1 2 and R and R when taken together with the adjacent nitrogen atom may form a heterocyclic amine radical selected from azetidinyl, pyrrolidinyl, piperidinyl, homopiperidinyl, imidazolyl, piperazinyl, 4-substituted piperazinyl and Y- 0202e/AC ks. 0 ^CY J 62 morpholinyl, R 3 is selected from hydrogen, loweralkyl, aryl or arylloweralkyl; the geometrical isomers including cis, trans, and isomers thereof, and the pharmaceutically acceptable acid addition salts thereof when R 1 and/or R2 have a salt-forming basic amino component or when Ar is pyridyl, with the proviso that when R 3 is hydrogen, Z is oxygen and Ar is phenyl or phenyl substituted by trifluoro- 1 2 methyl, aminocarbonyl, then R and R cannot be a combination of hydrogen and loweralkyl, and the further proviso than when R is hydrogen, Z is oxygen and Ar is phenyl or phenyl substituted by fluoro, loweralkyl, loweralkoxy, 1 2 trifluoromethyl, acetyl or aminocarbonyl, R and R cannot both be hydrogen.

7. The compound of claim 6 which is N-methyl-3-[3- (trifluoromethyl)phenoxy]-l-azetidinecarbothioamide; or N-(2,6-dimethylphenyl)-3-[3-(trifluoromethyl)phenoxy]-l- azetidinecarbothioamide; or N-(phenylmethyl)-3-[3-(trifluoromethyl)phenoxy]-l- azetidinecarboxamide; or N-2,6-dichlorophenyl)-3[3-(trifluoromethyl)phenoxy] -1-azetidinecarbothioamide; or N-[3-(diethylamino)propyl]-3-[3-(trifluoromethyl)phenoxy]-1- azetidinecarbothioamide or a pharmaceutically acceptable acid addition salt thereof; or 202e/AC IVT~ 63 dime thyl- amino)propyl>-3-[3-(trifluoromethyl)phenoxy]-l-azetidine- carbothioarnide or a pharmaceutically acceptable acid addition salt thereof; or N- (2-propenyl) 3-E3-( trifluoromethyl)phenoxy)-l-azetidinecarboxamide; or N-cyclopropyl- trifluoromethyl)phenoxy]-1-azetidinecarboxamide; or amino)propyl]-3-[3-(trifluoromethyl)phenoxy3-1-azetidine- carboxamide or a pharmaceutically acceptable acid addition salt thereof; or N-2-(propenyl) 3-[4-(trifluoromethyl)phenoxy]-l-azetidinecarboxamide or cyclopropyl- methyl)-3-[3-( trifluoromethyl)phenoxyJ-l-azetidine- carboxamide; or N, N-diethyl-3- trifluorornethyl)phenoxy)-l-azetidinecarboxamide; or N, N-dimethyl-3- [3-(trifluoromethyl)phenoxyj-1-azetidinecarboxamide; or N- (2 -propynyl) 3-E3-(trifluorornethyl)phenoxy3-l-azetidinecarboxamide; or N -c ycl oh exy 1- 3-[3-(trifluoromethyl)phenoxy3-1-azetidinecarboxamide; or N-cyclopropyl- 3-C4-(trifluoromethyl)pheroxy)-l-azetidinecarboxamide; or N-C cyclopropyl- methyl) trifluoromethyl)pherioxyj-l-azetidine- carboxamide; or N-E 3-C diethyl- amino )propylj trifluoromethyl )phenoXY)-.I-azetidine carbothiuamide or a pharmaceutically acceptable acid addition salt thereof; or N-(3-diethyl- amino)propylj-3-[4-( trifluoromethy1)phenoxy]-l-azetidine- carboxamide or a pharmaceutically acceptable acid addition Bait thereof or N- (2 -propynyl) 3-[4-(trifluoromethyl)phenoxy)-l-azetidinecarboxamide; or N-(2 -rethyl-2 propenyl)-3-.l4-(trifluoromethyl)phenoxy-l-azetidine- carboxamide; or N-(2-methyl-2- propenyl)-3-[3-(trifuoromethyl)plienoxy--azetidine- carboxamide; or butenyl)-3-[-(trifluoromethyl)phenoxy-lazetidine-. carboxamide; or 2-butenyl) trifluoromethyl)phenoxyj-l-azetidine- carboxamide; or (2 butenyl)-3-[-(trifluoromethyl)phenoxy...azetidine- carboxamide; or butenyl)-3-[3-(trifluoromethyl)phenoxy.Nazetidine- E3(rfurrehlpeoy--ztdncarboxamide; or N -ph enl.-3- £'3-(trifluoromethy1)phenoxy)-l-azetidinecarboxanide; o trans-N,2- dimethyl-3-[ trifluoromethyl)phenoxyj-1-azetidine- carboxamide; Or trans-2-methyl- 3-13,'-(trifluorornethyl)phenoxy)-l-azetidinecarboxamide; or 65 trans-2-methyl- -(2-propny)-3-[3-(trifluoromethyl)phe carboxamid or 3-(3-chioro- phenoxy)-N-rethyl-l-azetidinecarboxamide; or 3-(3-chloro- phenoxy)-N-(2-propenyl)-l-azetidinecarboxamide; or N-methyl-3- (2-pyridinyloxy)-l-azetidinecarboxamide or a pharmaceutically acceptable acid addition salt thereof; or N-(2-propenyl)- 3-(2-pyridinyloxy)-l-azetidinecarboxamide or a pharma- ceutically acceptable acid addition salt thereof; or 3-(2- pyridinyloxy)-l-azetidinecarboxamide or a pharmaceutically acceptable acid addition salt thereof; or ethyl)-.3-azetidinyloxypyridine or a pharmaceutically acceptable acid addition salt thereof; or fluoromethyl)phenoxyJ-l-azetidinylcaronyl]-lH-imidazole or a pharmaceutically acceptable acid addition salt thereof; or 3-fluoro- phenoxy)-N-methyl-1-azetidinecarboxamide; 1 2

8. A caqlond of claim 6 wherein the compnd has an R or R radical selected fron the group consisting of allyl, substituted allyl, propargyl or cycloalkyl.

9. A pharmaceutical canposition ccmprising, a 3-aryloxyazetidinecarboxamide conpound as defined in any one of claims 6, 7 or 8, and of L2 f,4 L ;-II r 66 a pharmaceutically acceptable excipient or carrier therefor. A compound of the formula shown in claim 6, said compound substantially as herein described with reference to any one of the Examples. DATED this 19th day of April, 1990. A.H. ROBINS COMPANY, INC. By Its Patent Attorneys ARTHUR S. CAVE CO.