AU574064B2 - Growth hormone releasing factor analogues - Google Patents
Growth hormone releasing factor analoguesInfo
- Publication number
- AU574064B2 AU574064B2 AU25268/84A AU2526884A AU574064B2 AU 574064 B2 AU574064 B2 AU 574064B2 AU 25268/84 A AU25268/84 A AU 25268/84A AU 2526884 A AU2526884 A AU 2526884A AU 574064 B2 AU574064 B2 AU 574064B2
- Authority
- AU
- Australia
- Prior art keywords
- grf
- growth hormone
- hormone releasing
- releasing factor
- leu
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 101710142969 Somatoliberin Proteins 0.000 title abstract 3
- 102000038461 Growth Hormone-Releasing Hormone Human genes 0.000 title 1
- 239000000095 Growth Hormone-Releasing Hormone Substances 0.000 title 1
- 229920001184 polypeptide Polymers 0.000 abstract 4
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 4
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 4
- 101000825742 Homo sapiens Somatoliberin Proteins 0.000 abstract 2
- 102100022831 Somatoliberin Human genes 0.000 abstract 2
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 2
- 150000001408 amides Chemical class 0.000 abstract 2
- 150000001413 amino acids Chemical class 0.000 abstract 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 239000007788 liquid Substances 0.000 abstract 1
- 239000007791 liquid phase Substances 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 125000006239 protecting group Chemical group 0.000 abstract 1
- 239000011347 resin Substances 0.000 abstract 1
- 229920005989 resin Polymers 0.000 abstract 1
- 238000010532 solid phase synthesis reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/60—Growth hormone-releasing factor [GH-RF], i.e. somatoliberin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Endocrinology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
1. Claims for the Contracting States : BE CH DE FR GB IT LI LU NL SE Polypeptides of the general formula (Leu**27 )-GRF wherein GRF represents at least the first 28 amino acids of the full sequence of natural human growth hormone releasing factor and wherein the carboxyl terminus of the molecule is present in free form or as the amide. 1. Claims for the Contracting State : AT A method for the preparation of polypeptides of the general formula (Leu**27 )-GRF wherein GRF represents at least the first 28 amino acids of the full sequence of natural human growth hormone releasing factor and wherein the carboxyl terminus of the molecule is present in free form or as the amide, characterized in that (a) the protecting groups of a protected polypeptide of corresponding amino acid sequence, which has been synthetized according to the liquid phase method, are cleaved off in a manner known per se, or (b) a carrier resin-bound protected polypeptide of corresponding amino acid sequence, which has been synthetized according to the solid phase method, is treated with anhydrous liquid HF.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US47270083A | 1983-03-07 | 1983-03-07 | |
US472700 | 1983-03-07 |
Publications (2)
Publication Number | Publication Date |
---|---|
AU2526884A AU2526884A (en) | 1984-09-13 |
AU574064B2 true AU574064B2 (en) | 1988-06-30 |
Family
ID=23876594
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU25268/84A Ceased AU574064B2 (en) | 1983-03-07 | 1984-03-05 | Growth hormone releasing factor analogues |
Country Status (11)
Country | Link |
---|---|
EP (1) | EP0121764B1 (en) |
JP (1) | JPH0786120B2 (en) |
AT (1) | ATE53220T1 (en) |
AU (1) | AU574064B2 (en) |
CA (1) | CA1254000A (en) |
DE (1) | DE3482387D1 (en) |
DK (1) | DK162130C (en) |
IE (1) | IE57097B1 (en) |
IL (1) | IL71150A (en) |
NZ (1) | NZ207378A (en) |
ZA (1) | ZA841638B (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU575843B2 (en) * | 1983-08-10 | 1988-08-11 | The Administrators Of The Tulane Eductional Fund | Growth hormone releasing peptides |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4518586A (en) * | 1983-01-13 | 1985-05-21 | The Salk Institute For Biological Studies | GRF Analogs III |
IL70530A (en) * | 1983-01-13 | 1986-09-30 | Salk Inst For Biological Studi | Synthetic peptides having growth hormone releasing factor activity and compositions containing them |
BG49718A3 (en) * | 1983-07-15 | 1992-01-15 | Bio Technology General Corp | Method for preparing of polypeptid with superoxiddismutasne activitty |
DE3327007A1 (en) * | 1983-07-27 | 1985-02-07 | Hoechst Ag, 6230 Frankfurt | PRODUCTION OF POLYPEPTIDES WITH AN ACID-CARBOXYTERMINUS |
US4617149A (en) * | 1983-09-21 | 1986-10-14 | Eli Lilly And Company | Growth hormone release factor analogs |
CA1340265C (en) * | 1985-01-18 | 1998-12-15 | Kirston E. Koths | Oxidation resistant muteins |
US4734399A (en) * | 1985-08-06 | 1988-03-29 | Hoffmann-La Roche Inc. | Growth hormone releasing factor analogs |
ES2001203A6 (en) * | 1985-08-12 | 1988-05-01 | Syntex Inc | Bovine growth hormone releasing factor derivative. |
EP0448513A3 (en) * | 1990-03-21 | 1991-12-27 | Japat Ltd | Process for production of peptidylglycine alpha-hydroxylating monooxygenase and use thereof |
EP0544706A4 (en) * | 1990-06-29 | 1993-10-13 | Hoffmann-La Roche Inc. | Histidine substituted growth hormone releasing factor analogs |
ATE119916T1 (en) * | 1990-12-10 | 1995-04-15 | Hoffmann La Roche | METHOD FOR THE ENZYMATIC PRODUCTION OF GRF(1-44)NH2. |
CA2084061A1 (en) * | 1991-04-09 | 1992-10-10 | Arthur M. Felix | Growth hormone releasing factor analogs |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU3333084A (en) * | 1983-09-21 | 1985-03-28 | Eli Lilly And Company | (hse)27, (met(0)27 & (met(s-me))27 growth hormone release factor analogues |
AU557046B2 (en) * | 1983-01-13 | 1986-12-04 | Salk Institute For Biological Studies, The | Grf analogs |
-
1984
- 1984-03-05 DE DE8484102383T patent/DE3482387D1/en not_active Expired - Fee Related
- 1984-03-05 EP EP84102383A patent/EP0121764B1/en not_active Expired - Lifetime
- 1984-03-05 AT AT84102383T patent/ATE53220T1/en not_active IP Right Cessation
- 1984-03-05 DK DK151884A patent/DK162130C/en not_active IP Right Cessation
- 1984-03-05 CA CA000448864A patent/CA1254000A/en not_active Expired
- 1984-03-05 ZA ZA841638A patent/ZA841638B/en unknown
- 1984-03-05 IL IL71150A patent/IL71150A/en not_active IP Right Cessation
- 1984-03-05 AU AU25268/84A patent/AU574064B2/en not_active Ceased
- 1984-03-05 NZ NZ207378A patent/NZ207378A/en unknown
- 1984-03-06 IE IE537/84A patent/IE57097B1/en not_active IP Right Cessation
- 1984-03-06 JP JP59041481A patent/JPH0786120B2/en not_active Expired - Lifetime
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU557046B2 (en) * | 1983-01-13 | 1986-12-04 | Salk Institute For Biological Studies, The | Grf analogs |
AU3333084A (en) * | 1983-09-21 | 1985-03-28 | Eli Lilly And Company | (hse)27, (met(0)27 & (met(s-me))27 growth hormone release factor analogues |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU575843B2 (en) * | 1983-08-10 | 1988-08-11 | The Administrators Of The Tulane Eductional Fund | Growth hormone releasing peptides |
Also Published As
Publication number | Publication date |
---|---|
ATE53220T1 (en) | 1990-06-15 |
NZ207378A (en) | 1989-05-29 |
IL71150A0 (en) | 1984-06-29 |
EP0121764B1 (en) | 1990-05-30 |
DK151884A (en) | 1984-09-08 |
EP0121764A3 (en) | 1985-12-04 |
IE840537L (en) | 1984-09-07 |
AU2526884A (en) | 1984-09-13 |
IE57097B1 (en) | 1992-04-22 |
ZA841638B (en) | 1984-10-31 |
DK151884D0 (en) | 1984-03-05 |
DK162130B (en) | 1991-09-23 |
IL71150A (en) | 1987-02-27 |
EP0121764A2 (en) | 1984-10-17 |
DK162130C (en) | 1992-03-02 |
JPH0786120B2 (en) | 1995-09-20 |
JPS59176238A (en) | 1984-10-05 |
DE3482387D1 (en) | 1990-07-05 |
CA1254000A (en) | 1989-05-09 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
AU574064B2 (en) | Growth hormone releasing factor analogues | |
DE3469535D1 (en) | Crystal suspensions of insulin derivatives, process for their preparation and their use | |
HU902697D0 (en) | Process for the enzymatic removal of the n-terminal sequence of proteins | |
EP0218712A4 (en) | Novel procoagulant proteins. | |
EP0235205A4 (en) | Peptide analogues of mammalian insulin-like growth factor-1. | |
ES8604111A1 (en) | Enzyme inhibitors. | |
EP0456152A3 (en) | Peptidamides, their process of preparation and the agents containing these peptides as fibrin-thrombin clotting inhibitors | |
IL85020A0 (en) | Pancreatic secretory trypsin inhibitor and variants thereof,process expression vector and recombinant host therefor and pharmaceutical compositions containing it | |
GR860399B (en) | Process for obtaining peptidic derivatives pepstatine analogs renines inhibitors and proteases acids | |
DE69029377D1 (en) | SUBSTITUTION ANALOGS OF MAGAIN PEPTIDES | |
DE3364838D1 (en) | Process for the conversion of preproinsulin analogues into insulins | |
EP0330700A4 (en) | Human prourokinase-like polypeptide. | |
SE8703855D0 (en) | VASOACTIVE PEPTIDES | |
CA1267086C (en) | Method of administering diuretic atrial peptides | |
JPS6466199A (en) | Novel insulin-like growth factor-i derivative and its production |