AU551898B2 - 2-amino-1,2,3,4-tetrahydronaphthalene derivatives - Google Patents

2-amino-1,2,3,4-tetrahydronaphthalene derivatives

Info

Publication number
AU551898B2
AU551898B2 AU88430/82A AU8843082A AU551898B2 AU 551898 B2 AU551898 B2 AU 551898B2 AU 88430/82 A AU88430/82 A AU 88430/82A AU 8843082 A AU8843082 A AU 8843082A AU 551898 B2 AU551898 B2 AU 551898B2
Authority
AU
Australia
Prior art keywords
amino
hydrogen atom
tetrahydronaphthalene derivatives
parkinson
therapy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU88430/82A
Other versions
AU8843082A (en
Inventor
Nigel Beeley
Gerard Cremer
Michael Dimsdale
Philippe Manoury
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Synthelabo SA
Original Assignee
Synthelabo SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synthelabo SA filed Critical Synthelabo SA
Publication of AU8843082A publication Critical patent/AU8843082A/en
Application granted granted Critical
Publication of AU551898B2 publication Critical patent/AU551898B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)

Abstract

New compounds of the formula: <IMAGE> wherein R1 represents a hydrogen atom or an alkanoyl group containing from 1 to 4 carbon atoms, R2 and R3 each represent a hydrogen atom or a C1-C4 alkyl group, and R4 represents a hydroxy or methoxy group in the 6-position or 7-position, have been found to be useful in therapy, and more particularly in the treatment of cardiovascular diseases and Parkinson's disease.
AU88430/82A 1981-09-16 1982-09-15 2-amino-1,2,3,4-tetrahydronaphthalene derivatives Ceased AU551898B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR8117454A FR2512814A1 (en) 1981-09-16 1981-09-16 AMINO-2-TETRAHYDRO-1,2,3,4-NAPHTHALENE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC USE
FR8117454 1981-09-16

Publications (2)

Publication Number Publication Date
AU8843082A AU8843082A (en) 1983-03-24
AU551898B2 true AU551898B2 (en) 1986-05-15

Family

ID=9262178

Family Applications (1)

Application Number Title Priority Date Filing Date
AU88430/82A Ceased AU551898B2 (en) 1981-09-16 1982-09-15 2-amino-1,2,3,4-tetrahydronaphthalene derivatives

Country Status (20)

Country Link
US (1) US4442126A (en)
EP (1) EP0074903B1 (en)
JP (3) JPS5862141A (en)
AT (1) ATE23328T1 (en)
AU (1) AU551898B2 (en)
CA (1) CA1224491A (en)
DE (1) DE3274105D1 (en)
DK (1) DK163055C (en)
ES (2) ES8400396A1 (en)
FI (1) FI77650C (en)
FR (1) FR2512814A1 (en)
GR (1) GR77000B (en)
HU (1) HU187789B (en)
IE (1) IE53756B1 (en)
IL (1) IL66804A (en)
MX (1) MX158073A (en)
NO (1) NO154391C (en)
NZ (1) NZ201919A (en)
PT (1) PT75567B (en)
ZA (1) ZA826770B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU572497B2 (en) * 1981-05-08 1988-05-12 Per Arvid Emil Carlsson 1,2,3,4-tetrahydro-2-naphthylamines

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5970653A (en) * 1982-10-15 1984-04-21 Takeda Chem Ind Ltd Naphthalenecaroxamide compound and intraocular pressure reducing agent containing the same
US4588747A (en) * 1984-08-27 1986-05-13 Synthelabo 1,2,3,4-tetrahydronaphthalene derivatives used as antiglaucoma agents
DE3832571A1 (en) * 1988-09-24 1990-05-31 Boehringer Ingelheim Kg USE OF 2,7-DIAMINO-1,2,3,4-TETRAHYDRONAPHTHALINES AS DRUGS, NEW 2,7-DIAMINO-1,2,3,4-TETRAHYDRONAPHTHALINES AND METHOD FOR THE PRODUCTION THEREOF
CA1335106C (en) * 1989-02-27 1995-04-04 John Mehnert Schaus Ring-substituted 2-amino-1,2,3,4-tetra-hydronaphthalenes
DE3919624A1 (en) * 1989-06-15 1990-12-20 Boehringer Ingelheim Kg NEW 2,5-DIAMINOTETRALINE, METHOD FOR THE PRODUCTION THEREOF, AND ITS USE AS A MEDICAMENT
US5071875A (en) * 1989-09-25 1991-12-10 Northwestern University Substituted 2-amidotetralins as melatonin agonists and antagonists
JPH03113240U (en) * 1990-03-08 1991-11-19
CZ370198A3 (en) * 1996-05-31 1999-05-12 Pharmacia & Upjohn Company Aryl substituted cyclic amines as selective dopamine d3 ligands

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3991207A (en) * 1971-03-18 1976-11-09 Pfizer Inc. Combination therapy for Parkinson's disease
DK254975A (en) * 1974-06-12 1975-12-13 Takeda Chemical Industries Ltd METHOD OF PREPARATION OF AMINOTETRALOL COMPOUNDS
JPS5346947A (en) * 1976-10-07 1978-04-27 Takeda Chem Ind Ltd Tetraol compounds and their preparation
JPS545959A (en) * 1977-06-14 1979-01-17 Funai Yaihin Kogyo Production of novel cyclic aminoalcohol and salt thereof
DE2803582A1 (en) * 1978-01-27 1979-08-02 Sandoz Ag 2-Amino-tetra:hydro-naphthol derivs. - used as adrenergic and dopamine receptor stimulants useful for treating heart failure, cardiac infarct, hypertension and Parkinsonism
US4320148A (en) * 1980-11-24 1982-03-16 Smithkline Corporation 2-Aminotetralin compounds, pharmaceutical compositions and method of producing central alpha1 agonist activity

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU572497B2 (en) * 1981-05-08 1988-05-12 Per Arvid Emil Carlsson 1,2,3,4-tetrahydro-2-naphthylamines

Also Published As

Publication number Publication date
DK412082A (en) 1983-03-17
ZA826770B (en) 1983-07-27
IE822249L (en) 1983-03-16
IL66804A0 (en) 1982-12-31
DK163055B (en) 1992-01-13
DK163055C (en) 1992-06-15
MX158073A (en) 1989-01-04
NZ201919A (en) 1985-10-11
JPS61165324A (en) 1986-07-26
EP0074903A2 (en) 1983-03-23
JPS6121621B2 (en) 1986-05-28
JPS61165323A (en) 1986-07-26
NO154391C (en) 1986-09-10
EP0074903B1 (en) 1986-11-05
ES8403857A1 (en) 1984-04-01
IL66804A (en) 1986-03-31
CA1224491A (en) 1987-07-21
NO823125L (en) 1983-03-17
EP0074903A3 (en) 1983-07-27
ES515744A0 (en) 1983-10-16
FI823194A0 (en) 1982-09-15
ES8400396A1 (en) 1983-10-16
FI77650C (en) 1989-04-10
GR77000B (en) 1984-09-04
FR2512814A1 (en) 1983-03-18
ATE23328T1 (en) 1986-11-15
IE53756B1 (en) 1989-02-01
NO154391B (en) 1986-06-02
JPS5862141A (en) 1983-04-13
FI77650B (en) 1988-12-30
US4442126A (en) 1984-04-10
AU8843082A (en) 1983-03-24
PT75567B (en) 1985-12-09
FR2512814B1 (en) 1984-02-24
DE3274105D1 (en) 1986-12-11
ES523775A0 (en) 1984-04-01
PT75567A (en) 1982-10-01
FI823194L (en) 1983-03-17
HU187789B (en) 1986-02-28

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