AU5454801A - Methods of enhancing splp-mediated transfection using endosomal membrane destabilizers - Google Patents

Methods of enhancing splp-mediated transfection using endosomal membrane destabilizers

Info

Publication number
AU5454801A
AU5454801A AU5454801A AU5454801A AU5454801A AU 5454801 A AU5454801 A AU 5454801A AU 5454801 A AU5454801 A AU 5454801A AU 5454801 A AU5454801 A AU 5454801A AU 5454801 A AU5454801 A AU 5454801A
Authority
AU
Australia
Prior art keywords
splp
enhancing
methods
mediated transfection
endosomal membrane
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
AU5454801A
Inventor
Angela M I Lam
Lorne R Palmer
Pieter R Cullis
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of British Columbia
Original Assignee
University of British Columbia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/553,639 external-priority patent/US6852334B1/en
Priority claimed from PCT/CA2000/000451 external-priority patent/WO2000062813A2/en
Application filed by University of British Columbia filed Critical University of British Columbia
Publication of AU5454801A publication Critical patent/AU5454801A/en
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/88—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using amphiphile liposome vesicle
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
    • A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers with substantial amounts of non-phosphatidyl, i.e. non-acylglycerophosphate, surfactants as bilayer-forming substances, e.g. cationic lipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
AU5454801A 2000-04-20 2001-04-20 Methods of enhancing splp-mediated transfection using endosomal membrane destabilizers Pending AU5454801A (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US09/553,639 US6852334B1 (en) 1999-04-20 2000-04-20 Cationic peg-lipids and methods of use
PCT/CA2000/000451 WO2000062813A2 (en) 1999-04-20 2000-04-20 Cationic peg-lipids and methods of use
US22794900P 2000-08-25 2000-08-25
PCT/CA2001/000555 WO2001080900A2 (en) 2000-04-20 2001-04-20 Enhanced stabilised plasmid-lipid particle-mediated transfection using endosomal membrane

Publications (1)

Publication Number Publication Date
AU5454801A true AU5454801A (en) 2001-11-07

Family

ID=27168648

Family Applications (2)

Application Number Title Priority Date Filing Date
AU5454801A Pending AU5454801A (en) 2000-04-20 2001-04-20 Methods of enhancing splp-mediated transfection using endosomal membrane destabilizers
AU2001254548A Ceased AU2001254548B2 (en) 2000-04-20 2001-04-20 Enhanced stabilised plasmid-lipid particle-mediated transfection using endosomal membrane

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU2001254548A Ceased AU2001254548B2 (en) 2000-04-20 2001-04-20 Enhanced stabilised plasmid-lipid particle-mediated transfection using endosomal membrane

Country Status (4)

Country Link
EP (1) EP1355670A2 (en)
JP (1) JP2004508012A (en)
AU (2) AU5454801A (en)
WO (1) WO2001080900A2 (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040048260A1 (en) * 2002-09-10 2004-03-11 Fu-Hsiung Chang Transfection of nucleic acid
WO2005032593A1 (en) * 2003-10-01 2005-04-14 Japan Science And Technology Agency Polyarginine-modified liposome capable of transferring into nucleus
MXPA06012722A (en) 2004-05-05 2007-02-14 Atugen Ag Lipids, lipid complexes and use thereof.
KR101366482B1 (en) * 2004-12-27 2014-02-21 사일런스 테라퓨틱스 아게 Coated lipid complexes and their use
JP2007063194A (en) * 2005-08-31 2007-03-15 Tokyo Institute Of Technology Material-introducing carrier, method for introducing material and kit for introducing material
AU2013257401B2 (en) * 2006-04-20 2016-03-17 Silence Therapeutics Gmbh Lipoplex formulations for specific delivery to vascular endothelium
CA2649630C (en) * 2006-04-20 2016-04-05 Silence Therapeutics Ag Lipoplex formulations for specific delivery to vascular endothelium
WO2008009477A2 (en) 2006-07-21 2008-01-24 Silence Therapeutics Ag Means for inhibiting the expression of protein kinase 3
US8877206B2 (en) 2007-03-22 2014-11-04 Pds Biotechnology Corporation Stimulation of an immune response by cationic lipids
RU2530555C2 (en) 2008-04-17 2014-10-10 ПиДиЭс БАЙОТЕКНОЛОДЖИ КОРПОРЭЙШН Stimulation of immune response by enantiomers of cationic lipids
US20130022649A1 (en) 2009-12-01 2013-01-24 Protiva Biotherapeutics, Inc. Snalp formulations containing antioxidants
CN105101991A (en) 2012-09-21 2015-11-25 Pds生物科技公司 Improved vaccine compositions and methods of use
EP3308789A4 (en) * 2015-06-10 2019-04-24 Keio University Nucleic acid delivery carrier, nucleic acid delivery kit, and nucleic acid delivery method
WO2017083820A1 (en) 2015-11-13 2017-05-18 Pds Biotechnology Corporation Lipids as synthetic vectors to enhance antigen processing and presentation ex-vivo in dendritic cell therapy
CN111979190A (en) * 2019-05-23 2020-11-24 南京依莫诺飞生物科技有限公司 Culture medium for transfecting T cells and application thereof

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5885613A (en) * 1994-09-30 1999-03-23 The University Of British Columbia Bilayer stabilizing components and their use in forming programmable fusogenic liposomes
IL122290A0 (en) * 1995-06-07 1998-04-05 Inex Pharmaceuticals Corp Lipid-nucleic acid complex its preparation and use
WO1997038010A2 (en) * 1996-04-11 1997-10-16 The University Of British Columbia Fusogenic liposomes
TW520297B (en) * 1996-10-11 2003-02-11 Sequus Pharm Inc Fusogenic liposome composition and method
WO1998046208A1 (en) * 1997-04-17 1998-10-22 The Regents Of The University Of Michigan Hair follicle dna delivery system
AU7490098A (en) * 1997-05-15 1998-12-08 Genzyme Corporation Cationic amphiphile formulations
CN100567493C (en) * 1997-06-27 2009-12-09 加利福尼亚大学董事会 Spermatophyte with characteristic of delayed seed distribution
US6395713B1 (en) * 1997-07-23 2002-05-28 Ribozyme Pharmaceuticals, Inc. Compositions for the delivery of negatively charged molecules
AU8428998A (en) * 1997-07-24 1999-02-16 Inex Pharmaceuticals Corporation Preparation of lipid-nucleic acid particles using a solvent extraction and direct hydration method
CA2271582A1 (en) * 1998-05-14 1999-11-14 Sean C. Semple Method for administration of therapeutic agents, including antisense, with repeat dosing
JP2002518313A (en) * 1998-06-19 2002-06-25 ジエンザイム コーポレイション Cationic amphiphilic micelle complex
EP1100464A1 (en) * 1998-07-31 2001-05-23 Korea Institute Of Science And Technology Lipid emulsion and solid lipid nanoparticle as a gene or drug carrier
EP1144012A1 (en) * 1999-01-21 2001-10-17 Georgetown University Ligand-peg post-coating stabilized lipoplex and polyplex for targeted gene delivery
WO2000062813A2 (en) * 1999-04-20 2000-10-26 The University Of British Columbia Cationic peg-lipids and methods of use
WO2001005374A1 (en) * 1999-07-15 2001-01-25 Inex Pharmaceuticals Corp. Methods for preparation of lipid-encapsulated therapeutic agents

Also Published As

Publication number Publication date
WO2001080900A3 (en) 2003-04-24
EP1355670A2 (en) 2003-10-29
WO2001080900A2 (en) 2001-11-01
AU2001254548B2 (en) 2006-09-28
JP2004508012A (en) 2004-03-18

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