AU5411099A - Improved process for the preparation of salts and esters of clavulanic acid - Google Patents

Improved process for the preparation of salts and esters of clavulanic acid

Info

Publication number
AU5411099A
AU5411099A AU54110/99A AU5411099A AU5411099A AU 5411099 A AU5411099 A AU 5411099A AU 54110/99 A AU54110/99 A AU 54110/99A AU 5411099 A AU5411099 A AU 5411099A AU 5411099 A AU5411099 A AU 5411099A
Authority
AU
Australia
Prior art keywords
esters
salts
preparation
improved process
clavulanic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU54110/99A
Inventor
Pieter Theodorus Kerkhof
Ageeth Geertruida Lefferts
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Koninklijke DSM NV
Original Assignee
DSM NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by DSM NV filed Critical DSM NV
Publication of AU5411099A publication Critical patent/AU5411099A/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/188—Heterocyclic compound containing in the condensed system at least one hetero ring having nitrogen atoms and oxygen atoms as the only ring heteroatoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D503/00—Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
AU54110/99A 1998-07-16 1999-07-13 Improved process for the preparation of salts and esters of clavulanic acid Abandoned AU5411099A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP98202390 1998-07-16
EP98202390 1998-07-16
PCT/EP1999/005026 WO2000004028A1 (en) 1998-07-16 1999-07-13 Improved process for the preparation of salts and esters of clavulanic acid

Publications (1)

Publication Number Publication Date
AU5411099A true AU5411099A (en) 2000-02-07

Family

ID=8233939

Family Applications (1)

Application Number Title Priority Date Filing Date
AU54110/99A Abandoned AU5411099A (en) 1998-07-16 1999-07-13 Improved process for the preparation of salts and esters of clavulanic acid

Country Status (6)

Country Link
EP (1) EP1095046A1 (en)
CN (1) CN1312814A (en)
AU (1) AU5411099A (en)
CA (1) CA2337072A1 (en)
TR (1) TR200100082T2 (en)
WO (1) WO2000004028A1 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1222528C (en) * 2000-05-13 2005-10-12 史密斯克莱·比奇曼公司 Process for purification of salt of clavulanic acid
KR20090094261A (en) * 2006-12-01 2009-09-04 디에스엠 아이피 어셋츠 비.브이. Process for the production of clavulanic acid
CN103304583B (en) * 2013-07-09 2016-01-20 山东新时代药业有限公司 A kind of method reclaiming clavulanic acid from clavulanic acid amine salt crystalline mother solution
CN104450813B (en) * 2014-11-22 2017-04-12 太原理工大学 Synthesis method for benzhydrylamine
CN109305978A (en) * 2017-07-26 2019-02-05 山东睿鹰先锋制药有限公司 A kind of new method preparing Clavulanate
CN109535184B (en) * 2017-09-21 2020-11-20 联邦制药(内蒙古)有限公司 Method for preparing potassium clavulanate from clavulanic acid tert-octylamine

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1578739A (en) * 1976-07-23 1980-11-05 Beecham Group Ltd Amine salts of clavulanic acid methods for their preparation and compositions containing them
ES2010143A6 (en) * 1989-03-01 1989-10-16 Pharma Mar S A Pharmar A new process for obtainment of Z(2R,5R)-3-(2-hydroxyethyliden)-7-oxo-4-oxa-1-azabicyclo(3,2,0)-heptane-2-carboxylic acid and pharmaceutically acceptable salts and esters thereof, from fermentation broths of Streptomyces sp.
AT400033B (en) * 1992-03-10 1995-09-25 Biochemie Gmbh NEW METHOD FOR ISOLATING AND PURIFYING CLAVULANIC ACID AND FOR PRODUCING PHARMACOLOGICALLY COMPATIBLE SALTS THEREOF
AT399155B (en) * 1992-03-26 1995-03-27 Lek Tovarna Farmacevtskih NEW ALKYLENE DIAMMONIUM DICLAVULANATE DERIVATIVES, METHOD FOR THE PRODUCTION AND USE THEREOF
SI9300296B (en) * 1992-06-11 1998-06-30 Smithkline Beecham P.L.C. Process and intermediates for the preparation of clavulanic acid
KR100200239B1 (en) * 1992-10-21 1999-06-15 김충환 Process for preparing salts of clavulanic acid
GB9305565D0 (en) * 1993-03-18 1993-05-05 Smithkline Beecham Plc Novel compounds and processes
AU682030B2 (en) * 1993-03-26 1997-09-18 Dsm N.V. Diamine salts of clavulanic acid
US5741903A (en) * 1993-03-26 1998-04-21 Gist-Brocades N.V. Diamine salts for purification of clavulanic acid
EP0937084A1 (en) * 1996-11-11 1999-08-25 Gist-Brocades B.V. Process for the preparation of salts and esters of clavulanic acid
WO1999024441A1 (en) * 1997-11-10 1999-05-20 Dsm N.V. Crystallization of beta-lactam compounds

Also Published As

Publication number Publication date
CA2337072A1 (en) 2000-01-27
EP1095046A1 (en) 2001-05-02
WO2000004028A1 (en) 2000-01-27
CN1312814A (en) 2001-09-12
TR200100082T2 (en) 2001-06-21

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Legal Events

Date Code Title Description
MK6 Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase