AU5078385A - Prolonged-action immunotoxins containing a glycopeptide constituent which inactivates ribosomes, modified on its polysaccharide units - Google Patents
Prolonged-action immunotoxins containing a glycopeptide constituent which inactivates ribosomes, modified on its polysaccharide unitsInfo
- Publication number
- AU5078385A AU5078385A AU50783/85A AU5078385A AU5078385A AU 5078385 A AU5078385 A AU 5078385A AU 50783/85 A AU50783/85 A AU 50783/85A AU 5078385 A AU5078385 A AU 5078385A AU 5078385 A AU5078385 A AU 5078385A
- Authority
- AU
- Australia
- Prior art keywords
- prolonged
- glycopeptide
- constituent
- modified
- polysaccharide units
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
- A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
- A61K47/6817—Toxins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6889—Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Inorganic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Molecular Biology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Abstract
Prolonged-acting immunotoxin consisting of a conjugate in which an antibody or antibody fragment is coupled, via a covalent structure containing a disulphide group or a thioether group, to a ribosome-inactivating glycoprotein having a prolonged action obtained by oxidation of its saccharide moieties with periodate ions.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR8502068A FR2577135B1 (en) | 1985-02-13 | 1985-02-13 | LONG-TERM ACTION IMMUNOTOXINS COMPRISING A GLYCOPEPTITIDE CONSTITUENT MODIFYING RIBOSOMES MODIFIED ON ITS POLYSACCHARIDE PATTERNS |
FR8502068 | 1985-02-13 |
Publications (2)
Publication Number | Publication Date |
---|---|
AU5078385A true AU5078385A (en) | 1986-08-14 |
AU591077B2 AU591077B2 (en) | 1989-11-30 |
Family
ID=9316241
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU50783/85A Ceased AU591077B2 (en) | 1985-02-13 | 1985-12-05 | Prolonged-action immunotoxins containing a glycopeptide constituent which inactivates ribosomes, modified on its polysaccharide units |
Country Status (14)
Country | Link |
---|---|
EP (1) | EP0192002B1 (en) |
JP (1) | JPH0725701B2 (en) |
KR (1) | KR930003333B1 (en) |
AT (1) | ATE75487T1 (en) |
AU (1) | AU591077B2 (en) |
CA (1) | CA1264667A (en) |
DE (1) | DE3585951D1 (en) |
DK (1) | DK563585A (en) |
FR (1) | FR2577135B1 (en) |
GR (1) | GR852914B (en) |
IE (1) | IE59909B1 (en) |
NZ (1) | NZ214482A (en) |
PT (1) | PT81623B (en) |
ZA (1) | ZA859299B (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU588008B2 (en) * | 1984-11-29 | 1989-09-07 | Sanofi Societe Anonyme | Drug comprising an association of at least one immunotoxin and at least one mannose containing polymer |
AU619740B2 (en) * | 1987-02-24 | 1992-02-06 | Xoma Corporation | Immunosuppression in immunotoxin based human therapy |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2566271B1 (en) * | 1984-06-20 | 1986-11-07 | Sanofi Sa | NOVEL CYTOTOXIC CONJUGATES FOR USE IN THERAPEUTICS AND PROCESS FOR OBTAINING SAME |
US4981979A (en) * | 1987-09-10 | 1991-01-01 | Neorx Corporation | Immunoconjugates joined by thioether bonds having reduced toxicity and improved selectivity |
IT1249051B (en) * | 1991-02-26 | 1995-02-11 | Italfarmaco Spa | IMMUNOTOXIN FROM ANTI-CD5 MONOCLONAL ANTIBODIES |
US5376546A (en) * | 1991-11-04 | 1994-12-27 | Xoma Corporation | Analogs of ribosome-inactivating proteins |
US5837491A (en) * | 1991-11-04 | 1998-11-17 | Xoma Corporation | Polynucleotides encoding gelonin sequences |
US5621083A (en) | 1991-11-04 | 1997-04-15 | Xoma Corporation | Immunotoxins comprising ribosome-inactivating proteins |
US6146850A (en) * | 1991-11-04 | 2000-11-14 | Xoma Corporation | Proteins encoding gelonin sequences |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL47372A (en) * | 1975-05-27 | 1979-10-31 | Yeda Res & Dev | Fab'dimers bound to daunomycin or adriamycin,their preparation and pharmaceutical compositions containing same |
FR2437213A1 (en) * | 1978-09-28 | 1980-04-25 | Cm Ind | CYTOTOXIC PRODUCTS FORMED BY COVALENT BINDING OF THE CHAIN TO RICIN WITH AN ANTIBODY AND THEIR PREPARATION METHOD |
JPS5616418A (en) * | 1979-07-20 | 1981-02-17 | Teijin Ltd | Antitumor protein complex and its preparation |
EP0044167A3 (en) * | 1980-07-14 | 1982-04-21 | The Regents Of The University Of California | Antibody targeted cytotoxic agent |
FR2504010B1 (en) * | 1981-04-15 | 1985-10-25 | Sanofi Sa | ANTI-CANCER MEDICINAL PRODUCTS CONTAINING THE RICIN-ASSOCIATED CHAIN ASSOCIATED WITH ANTIMELANOMA ANTIBODY AND PROCESS FOR THEIR PREPARATION |
JPS5843926A (en) * | 1981-09-08 | 1983-03-14 | Suntory Ltd | Selective carcinostatic agent |
FR2516794B1 (en) * | 1981-11-20 | 1985-10-25 | Sanofi Sa | NOVEL CANCER DRUGS FOR THE TREATMENT OF LEUKEMIA T CONTAINING RICIN AND A SPECIFIC MONOCLONAL ANTIBODY |
CA1203164A (en) * | 1982-03-09 | 1986-04-15 | Thomas J. Mckearn | Antibody conjugates |
PT80662B (en) * | 1984-06-20 | 1986-12-09 | Sanofi Sa | Process to obtain anti-tumoral glycoprotein modified on its glycidic portions |
-
1985
- 1985-02-13 FR FR8502068A patent/FR2577135B1/en not_active Expired
- 1985-12-04 EP EP85402403A patent/EP0192002B1/en not_active Expired - Lifetime
- 1985-12-04 AT AT85402403T patent/ATE75487T1/en active
- 1985-12-04 DE DE8585402403T patent/DE3585951D1/en not_active Expired - Fee Related
- 1985-12-04 ZA ZA859299A patent/ZA859299B/en unknown
- 1985-12-04 GR GR852914A patent/GR852914B/el unknown
- 1985-12-05 AU AU50783/85A patent/AU591077B2/en not_active Ceased
- 1985-12-05 PT PT81623A patent/PT81623B/en not_active IP Right Cessation
- 1985-12-05 KR KR1019850009153A patent/KR930003333B1/en not_active IP Right Cessation
- 1985-12-05 CA CA000497004A patent/CA1264667A/en not_active Expired - Fee Related
- 1985-12-05 IE IE307185A patent/IE59909B1/en not_active IP Right Cessation
- 1985-12-05 DK DK563585A patent/DK563585A/en not_active Application Discontinuation
- 1985-12-06 JP JP60274840A patent/JPH0725701B2/en not_active Expired - Lifetime
- 1985-12-09 NZ NZ214482A patent/NZ214482A/en unknown
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU588008B2 (en) * | 1984-11-29 | 1989-09-07 | Sanofi Societe Anonyme | Drug comprising an association of at least one immunotoxin and at least one mannose containing polymer |
AU619740B2 (en) * | 1987-02-24 | 1992-02-06 | Xoma Corporation | Immunosuppression in immunotoxin based human therapy |
Also Published As
Publication number | Publication date |
---|---|
JPS61200925A (en) | 1986-09-05 |
JPH0725701B2 (en) | 1995-03-22 |
ZA859299B (en) | 1986-08-27 |
NZ214482A (en) | 1989-08-29 |
CA1264667A (en) | 1990-01-23 |
DK563585D0 (en) | 1985-12-05 |
PT81623B (en) | 1988-04-21 |
KR930003333B1 (en) | 1993-04-26 |
FR2577135A1 (en) | 1986-08-14 |
GR852914B (en) | 1986-04-07 |
KR860006482A (en) | 1986-09-11 |
DE3585951D1 (en) | 1992-06-04 |
IE59909B1 (en) | 1994-04-20 |
DK563585A (en) | 1986-08-14 |
ATE75487T1 (en) | 1992-05-15 |
EP0192002A1 (en) | 1986-08-27 |
EP0192002B1 (en) | 1992-04-29 |
IE853071L (en) | 1986-08-13 |
PT81623A (en) | 1986-01-01 |
FR2577135B1 (en) | 1989-12-15 |
AU591077B2 (en) | 1989-11-30 |
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