AU5077100A - Non-human transgenic animals deficient in gas6 function and their use - Google Patents

Non-human transgenic animals deficient in gas6 function and their use

Info

Publication number
AU5077100A
AU5077100A AU50771/00A AU5077100A AU5077100A AU 5077100 A AU5077100 A AU 5077100A AU 50771/00 A AU50771/00 A AU 50771/00A AU 5077100 A AU5077100 A AU 5077100A AU 5077100 A AU5077100 A AU 5077100A
Authority
AU
Australia
Prior art keywords
transgenic animals
human transgenic
animals deficient
gas6
function
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU50771/00A
Other languages
English (en)
Inventor
Cristina Aparicio
Peter Carmeliet
Desire Collen
Bjorn Dahlback
Pablo Garcia De Frutos
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Vlaams Instituut voor Biotechnologie VIB
Original Assignee
Vlaams Instituut voor Biotechnologie VIB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vlaams Instituut voor Biotechnologie VIB filed Critical Vlaams Instituut voor Biotechnologie VIB
Publication of AU5077100A publication Critical patent/AU5077100A/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New breeds of animals
    • A01K67/027—New breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0276—Knockout animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/035—Animal model for multifactorial diseases
    • A01K2267/0375—Animal model for cardiovascular diseases
AU50771/00A 1999-06-10 2000-06-08 Non-human transgenic animals deficient in gas6 function and their use Abandoned AU5077100A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP99201859 1999-06-10
EP99201859 1999-06-10
PCT/EP2000/005318 WO2000076309A2 (fr) 1999-06-10 2000-06-08 Animaux transgeniques non-humains deficients en fonction 'gas6' (growth arrest-specific gene 6) et leur utilisation

Publications (1)

Publication Number Publication Date
AU5077100A true AU5077100A (en) 2001-01-02

Family

ID=8240301

Family Applications (1)

Application Number Title Priority Date Filing Date
AU50771/00A Abandoned AU5077100A (en) 1999-06-10 2000-06-08 Non-human transgenic animals deficient in gas6 function and their use

Country Status (3)

Country Link
EP (1) EP1185635A2 (fr)
AU (1) AU5077100A (fr)
WO (1) WO2000076309A2 (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2001260214A1 (en) * 2000-04-13 2001-10-30 D. Collen Research Foudation Vzw Use of inhibition of a gas6 function or of a gas6 receptor for preventing and treating a cardiovascular disease
EP1199081A1 (fr) * 2000-10-20 2002-04-24 Vlaams Interuniversitair Instituut voor Biotechnologie Inhibition de la fonction de gas6 (growth arrest-specific gene) ou du récepteur de gas6 pour le traitement des maladies thromboemboliques
GB2374870A (en) * 2001-01-26 2002-10-30 Thromb X Nv Use of genetically modified multicellular animals in the identification of drug target proteins
DE10130657A1 (de) * 2001-06-27 2003-01-16 Axaron Bioscience Ag Neues endothetial exprimiertes Protein und seine Verwendung
EP1382969A1 (fr) 2002-07-17 2004-01-21 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Diagnostic et traitement de l'invasion des cellules cancéreuses
EP1563094A4 (fr) * 2002-10-29 2007-04-25 Rigel Pharmaceuticals Inc Modulateurs de l'angiogenese et de la tumorigenese
RU2490632C1 (ru) * 2012-05-17 2013-08-20 Государственное Бюджетное Образовательное Учреждение Высшего Профессионального Образования "Красноярский Государственный Медицинский Университет Имени Профессора В.Ф. Войно-Ясенецкого Министерства Здравоохранения И Социального Развития Российской Федерации" Способ моделирования дисфункции эндотелия in vitro
GB201506411D0 (en) 2015-04-15 2015-05-27 Bergenbio As Humanized anti-axl antibodies
CN110536703A (zh) 2017-04-20 2019-12-03 Adc治疗有限公司 使用抗axl抗体-药物缀合物的组合疗法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH1179A (ja) * 1997-06-09 1999-01-06 Shionogi & Co Ltd Ｇａｓ６遺伝子改変マウス

Also Published As

Publication number Publication date
WO2000076309A2 (fr) 2000-12-21
EP1185635A2 (fr) 2002-03-13
WO2000076309A3 (fr) 2001-04-19

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Legal Events

Date Code Title Description
MK6 Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase