AU4479889A - Renin-inhibiting urea derivatives of dipeptides, a process for the preparation thereof, agents containing these, and the use thereof - Google Patents

Renin-inhibiting urea derivatives of dipeptides, a process for the preparation thereof, agents containing these, and the use thereof

Info

Publication number
AU4479889A
AU4479889A AU44798/89A AU4479889A AU4479889A AU 4479889 A AU4479889 A AU 4479889A AU 44798/89 A AU44798/89 A AU 44798/89A AU 4479889 A AU4479889 A AU 4479889A AU 4479889 A AU4479889 A AU 4479889A
Authority
AU
Australia
Prior art keywords
dipeptides
renin
preparation
urea derivatives
agents containing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
AU44798/89A
Other versions
AU616071B2 (en
Inventor
Wolfgang Ruger
Dieter Ruppert
Bernward Scholkens
Hansjorg Urbach
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Publication of AU4479889A publication Critical patent/AU4479889A/en
Application granted granted Critical
Publication of AU616071B2 publication Critical patent/AU616071B2/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU44798/89A 1988-11-19 1989-11-17 Renin-inhibiting urea derivatives of dipeptides, a process for the preparation thereof, agents containing these, and the use thereof Expired - Fee Related AU616071B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3839126 1988-11-19
DE3839126A DE3839126A1 (en) 1988-11-19 1988-11-19 RENIN-INHIBITING UREA DERIVATIVES OF DIPEPTIDES, METHOD FOR THE PRODUCTION THEREOF, THESE AGENTS AND THEIR USE

Publications (2)

Publication Number Publication Date
AU4479889A true AU4479889A (en) 1990-08-09
AU616071B2 AU616071B2 (en) 1991-10-17

Family

ID=6367476

Family Applications (1)

Application Number Title Priority Date Filing Date
AU44798/89A Expired - Fee Related AU616071B2 (en) 1988-11-19 1989-11-17 Renin-inhibiting urea derivatives of dipeptides, a process for the preparation thereof, agents containing these, and the use thereof

Country Status (12)

Country Link
EP (1) EP0370382A3 (en)
JP (1) JPH02180898A (en)
KR (1) KR900007868A (en)
AU (1) AU616071B2 (en)
DE (1) DE3839126A1 (en)
DK (1) DK579089A (en)
FI (1) FI895462A0 (en)
HU (1) HU203771B (en)
IL (1) IL92348A0 (en)
NO (1) NO894569L (en)
PT (1) PT92330A (en)
ZA (1) ZA898784B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU630386B2 (en) * 1988-12-09 1992-10-29 Hoechst Aktiengesellschaft Enzyme-inhibiting urea derivatives of dipeptides, a process for the preparation thereof, agents containing these, and the use thereof

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4014421A1 (en) * 1990-05-05 1991-11-07 Merck Patent Gmbh AMINOSAEUREDERIVATE
US8940726B2 (en) 2012-12-21 2015-01-27 Epizyme, Inc. PRMT5 inhibitors and uses thereof
US9604930B2 (en) 2012-12-21 2017-03-28 Epizyme, Inc. Tetrahydro- and dihydro-isoquinoline PRMT5 inhibitors and uses thereof
EP2935240A1 (en) 2012-12-21 2015-10-28 Epizyme, Inc. Prmt5 inhibitors and uses thereof
US10118918B2 (en) 2012-12-21 2018-11-06 Epizyme, Inc. PRMT5 inhibitors and uses thereof
WO2014100716A1 (en) 2012-12-21 2014-06-26 Epizyme, Inc. Prmt5 inhibitors and uses thereof
CA2953572A1 (en) 2014-08-04 2016-02-11 Epizyme, Inc. Prmt5 inhibitors and uses thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA87563B (en) * 1986-02-03 1987-09-30 Squibb & Sons Inc N-heterocyclic alcohol renin inhibitors
DE3627877A1 (en) * 1986-07-30 1988-02-04 Hoechst Ag RENINE-INHIBITING DI- AND TRIPEPTIDES, METHOD FOR THE PRODUCTION THEREOF, THESE AGENTS AND THEIR USE
GB8707412D0 (en) * 1987-03-27 1987-04-29 Fujisawa Pharmaceutical Co Peptide compounds
DE3841520A1 (en) * 1988-12-09 1990-06-13 Hoechst Ag ENZYME-INFRINGING DERIVATIVES OF DIPEPTIDES, METHOD FOR THE PRODUCTION THEREOF, METHODS CONTAINING THEM AND THEIR USE

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU630386B2 (en) * 1988-12-09 1992-10-29 Hoechst Aktiengesellschaft Enzyme-inhibiting urea derivatives of dipeptides, a process for the preparation thereof, agents containing these, and the use thereof

Also Published As

Publication number Publication date
DE3839126A1 (en) 1990-05-23
IL92348A0 (en) 1990-07-26
ZA898784B (en) 1990-08-29
DK579089A (en) 1990-05-20
EP0370382A2 (en) 1990-05-30
PT92330A (en) 1990-05-31
NO894569D0 (en) 1989-11-16
AU616071B2 (en) 1991-10-17
KR900007868A (en) 1990-06-02
JPH02180898A (en) 1990-07-13
HU203771B (en) 1991-09-30
DK579089D0 (en) 1989-11-17
HU895948D0 (en) 1990-02-28
HUT53122A (en) 1990-09-28
NO894569L (en) 1990-05-21
EP0370382A3 (en) 1991-04-10
FI895462A0 (en) 1989-11-16

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