AU4291897A - Imidazoles with serotonin receptor binding activity - Google Patents

Imidazoles with serotonin receptor binding activity

Info

Publication number
AU4291897A
AU4291897A AU42918/97A AU4291897A AU4291897A AU 4291897 A AU4291897 A AU 4291897A AU 42918/97 A AU42918/97 A AU 42918/97A AU 4291897 A AU4291897 A AU 4291897A AU 4291897 A AU4291897 A AU 4291897A
Authority
AU
Australia
Prior art keywords
imidazoles
binding activity
receptor binding
serotonin receptor
serotonin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU42918/97A
Inventor
Richard A Glennon
Ho Law
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Allelix Biopharmaceuticals Inc
Virginia Commonwealth University
Original Assignee
Allelix Biopharmaceuticals Inc
Virginia Commonwealth University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Allelix Biopharmaceuticals Inc, Virginia Commonwealth University filed Critical Allelix Biopharmaceuticals Inc
Publication of AU4291897A publication Critical patent/AU4291897A/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4174—Arylalkylimidazoles, e.g. oxymetazolin, naphazoline, miconazole
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU42918/97A 1996-09-19 1997-09-17 Imidazoles with serotonin receptor binding activity Abandoned AU4291897A (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US71579296A 1996-09-19 1996-09-19
US08715792 1996-09-19
US08821297 1997-03-20
US08/821,297 US5969137A (en) 1996-09-19 1997-03-20 Benzylamidine derivatives with serotonin receptor binding activity
PCT/CA1997/000680 WO1998012183A1 (en) 1996-09-19 1997-09-17 Imidazoles with serotonin receptor binding activity

Publications (1)

Publication Number Publication Date
AU4291897A true AU4291897A (en) 1998-04-14

Family

ID=27109419

Family Applications (1)

Application Number Title Priority Date Filing Date
AU42918/97A Abandoned AU4291897A (en) 1996-09-19 1997-09-17 Imidazoles with serotonin receptor binding activity

Country Status (3)

Country Link
US (2) US5969137A (en)
AU (1) AU4291897A (en)
WO (1) WO1998012183A1 (en)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009524617A (en) * 2006-01-27 2009-07-02 エフ．ホフマン−ラ ロシュ アーゲー Use of substituted 2-imidazole or imidazoline derivatives
JP2008063306A (en) * 2006-09-11 2008-03-21 Japan Enviro Chemicals Ltd Method for producing imidazole compound
KR101176699B1 (en) 2006-10-19 2012-08-23 에프. 호프만-라 로슈 아게 Aminomethyl-4-imidazoles
KR101172940B1 (en) * 2006-10-19 2012-08-10 에프. 호프만-라 로슈 아게 Aminomethyl-2-imidazoles with affinity with the trace amine associated receptors
ATE533755T1 (en) 2006-11-02 2011-12-15 Hoffmann La Roche SUBSTITUTED 2-IMIDAZOLES AS MODULATORS OF RECEPTORS ASSOCIATED WITH TRACE AMINES
RU2456281C2 (en) 2006-11-16 2012-07-20 Ф. Хоффманн-Ля Рош Аг Substituted 4-imidazoles, method for preparing and using them
BRPI0720047A2 (en) 2006-12-13 2013-12-24 Hoffmann La Roche 2-IMMEDAZOLE AS BINDERS FOR TRACE AMINE RECEIVERS (TAAR)
US20080146523A1 (en) 2006-12-18 2008-06-19 Guido Galley Imidazole derivatives
CA2675221C (en) 2007-02-02 2016-02-23 F. Hoffmann-La Roche Ag Novel 2-aminooxazolines as taar1 ligands
KR101222412B1 (en) 2007-02-15 2013-01-15 에프. 호프만-라 로슈 아게 2-aminooxazolines as taar1 ligands
WO2009003868A2 (en) 2007-07-02 2009-01-08 F. Hoffmann-La Roche Ag 2 -imidazolines having a good affinity to the trace amine associated receptors (taars)
CA2691704A1 (en) 2007-07-03 2009-01-08 F. Hoffmann-La Roche Ag 4-imidazolines and their use as antidepressants
BRPI0813837A2 (en) 2007-07-27 2015-01-06 Hoffmann La Roche 2-AZETIDINAMETANOAMINES and 2-PYROLIDINAMETANOAMINES as TAAR LEADERS
JP5341084B2 (en) 2007-08-03 2013-11-13 エフ．ホフマン−ラ ロシュ アーゲー Pyridinecarboxamide and benzamide derivatives as TAAR1 ligands
US8242153B2 (en) 2008-07-24 2012-08-14 Hoffmann-La Roche Inc. 4,5-dihydro-oxazol-2YL derivatives
US8354441B2 (en) 2009-11-11 2013-01-15 Hoffmann-La Roche Inc. Oxazoline derivatives
US9452980B2 (en) 2009-12-22 2016-09-27 Hoffmann-La Roche Inc. Substituted benzamides
CN101928247B (en) * 2010-09-19 2012-05-09 武汉武药科技有限公司 Method for synthesizing xylometazoline hydrochloride compound
AU2017234042B2 (en) 2016-03-17 2020-11-19 F. Hoffmann-La Roche Ag 5-ethyl-4-methyl-pyrazole-3-carboxamide derivative having activity as agonist of TAAR

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2868802A (en) * 1959-01-13 Nxchj
NL286080A (en) * 1961-11-30
HU193592B (en) * 1984-01-25 1987-11-30 Glaxo Group Ltd Process for producing tetrahydro-carbazolone derivatives
GB8623819D0 (en) * 1986-10-03 1986-11-05 Glaxo Group Ltd Heterocyclic compounds
CA2104873C (en) * 1991-02-26 2000-05-23 James N. Campbell Compositions and methods of treatment of sympathetically maintained pain

Also Published As

Publication number Publication date
WO1998012183A1 (en) 1998-03-26
US5969137A (en) 1999-10-19
US6048862A (en) 2000-04-11

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