AU4239089A - New 1,4-dihydropyridinederivative, namely (-)-2-{(2- aminoethoxy) ethoxy)-4-(2,3-dichlorophenyl)-3- ethoxycarbonyl-50methoxycarbonyl-6-methyl}-1,4- dihydropyridine, process for preparing it and pharmaceutical compositions containing it - Google Patents

New 1,4-dihydropyridinederivative, namely (-)-2-{(2- aminoethoxy) ethoxy)-4-(2,3-dichlorophenyl)-3- ethoxycarbonyl-50methoxycarbonyl-6-methyl}-1,4- dihydropyridine, process for preparing it and pharmaceutical compositions containing it

Info

Publication number
AU4239089A
AU4239089A AU42390/89A AU4239089A AU4239089A AU 4239089 A AU4239089 A AU 4239089A AU 42390/89 A AU42390/89 A AU 42390/89A AU 4239089 A AU4239089 A AU 4239089A AU 4239089 A AU4239089 A AU 4239089A
Authority
AU
Australia
Prior art keywords
methyl
aminoethoxy
dichlorophenyl
ethoxy
dihydropyridine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
AU42390/89A
Other versions
AU619049B2 (en
Inventor
Yves-Michel Gargouil
Jean-Louis Peglion
Jean-Paul Vilaine
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ADIR SARL
Original Assignee
ADIR SARL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ADIR SARL filed Critical ADIR SARL
Publication of AU4239089A publication Critical patent/AU4239089A/en
Application granted granted Critical
Publication of AU619049B2 publication Critical patent/AU619049B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Rheumatology (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)

Abstract

(-)2{[2-(2-Aminoethoxy)ethoxy]methyl}-4-(2,3-dichlorophenyl)-3-etho xycarbonyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyridine compound of formula I <IMAGE> and its addition salts with a pharmaceutically acceptable inorganic or organic acid. Medication.
AU42390/89A 1989-07-04 1989-09-29 New 1,4-dihydropyridinederivative, namely (-)-2-{(2- aminoethoxy) ethoxy)-4-(2,3-dichlorophenyl)-3- ethoxycarbonyl-50methoxycarbonyl-6-methyl}-1,4- dihydropyridine, process for preparing it and pharmaceutical compositions containing it Ceased AU619049B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR8908920A FR2649395B1 (en) 1989-07-04 1989-07-04 NEW DERIVATIVE OF 1,4-DIHYDRO PYRIDINE NAMED (-) I1(((2-AMINO ETHOXY)-2 ETHOXY) METHYLI1) -2 (2,3-DICHLORO-PHENYL)-4 ETHOXYCARBONYL-3 METHOXYCARBONYL -5 METHYL-6 DIHYDRO-1,4 PYRIDINE, ITS PREPARATION PROCESS AND THE COMPOSITIONS WHICH CONTAIN IT
FR8908920 1989-07-04

Publications (2)

Publication Number Publication Date
AU4239089A true AU4239089A (en) 1991-01-10
AU619049B2 AU619049B2 (en) 1992-01-16

Family

ID=9383413

Family Applications (1)

Application Number Title Priority Date Filing Date
AU42390/89A Ceased AU619049B2 (en) 1989-07-04 1989-09-29 New 1,4-dihydropyridinederivative, namely (-)-2-{(2- aminoethoxy) ethoxy)-4-(2,3-dichlorophenyl)-3- ethoxycarbonyl-50methoxycarbonyl-6-methyl}-1,4- dihydropyridine, process for preparing it and pharmaceutical compositions containing it

Country Status (14)

Country Link
EP (1) EP0406502B1 (en)
JP (1) JPH0720934B2 (en)
AT (1) ATE122340T1 (en)
AU (1) AU619049B2 (en)
CA (1) CA1327582C (en)
DE (1) DE68922605T2 (en)
DK (1) DK478989A (en)
ES (1) ES2074472T3 (en)
FR (1) FR2649395B1 (en)
IE (1) IE67059B1 (en)
NZ (1) NZ230854A (en)
OA (1) OA09136A (en)
PT (1) PT91869B (en)
ZA (1) ZA897349B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU618444B2 (en) * 1989-09-20 1991-12-19 Adir Et Compagnie New process for separating optical isomers of 1,4-dihydropyridine derivatives

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2686879B1 (en) * 1992-02-05 1994-03-18 Adir Cie NOVEL 1,4-DIHYDROPYRIDINE COMPOUNDS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.
DE4444864A1 (en) * 1994-12-16 1996-06-20 Bayer Ag Use of 5-acyl-1,4-dihydropyridines

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK161312C (en) * 1982-03-11 1991-12-09 Pfizer CHANGES FOR THE PREPARATION FOR THE PREPARATION OF 2-Amino-CO-Methyl-4-Methyl-4-Methyl-4-Methyl-4-Methyl-4-Methyl-4-Methyl-2-D-Hydroxy
FR2602231B1 (en) * 1986-08-04 1988-10-28 Adir NOVEL 1,4-DIHYDRO PYRIDINE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU618444B2 (en) * 1989-09-20 1991-12-19 Adir Et Compagnie New process for separating optical isomers of 1,4-dihydropyridine derivatives

Also Published As

Publication number Publication date
PT91869B (en) 1995-07-18
EP0406502A1 (en) 1991-01-09
ES2074472T3 (en) 1995-09-16
ZA897349B (en) 1990-09-26
JPH0344371A (en) 1991-02-26
IE67059B1 (en) 1996-02-21
DE68922605D1 (en) 1995-06-14
IE893103A1 (en) 1991-01-16
ATE122340T1 (en) 1995-05-15
DK478989D0 (en) 1989-09-28
PT91869A (en) 1991-03-20
FR2649395A1 (en) 1991-01-11
FR2649395B1 (en) 1992-11-06
AU619049B2 (en) 1992-01-16
NZ230854A (en) 1991-02-26
CA1327582C (en) 1994-03-08
JPH0720934B2 (en) 1995-03-08
DK478989A (en) 1991-01-05
DE68922605T2 (en) 1996-01-04
EP0406502B1 (en) 1995-05-10
OA09136A (en) 1991-10-31

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