AU4015497A - Thiazole derivatives useful as selective inhibitors of pde-iv - Google Patents

Thiazole derivatives useful as selective inhibitors of pde-iv

Info

Publication number
AU4015497A
AU4015497A AU40154/97A AU4015497A AU4015497A AU 4015497 A AU4015497 A AU 4015497A AU 40154/97 A AU40154/97 A AU 40154/97A AU 4015497 A AU4015497 A AU 4015497A AU 4015497 A AU4015497 A AU 4015497A
Authority
AU
Australia
Prior art keywords
pde
selective inhibitors
derivatives useful
thiazole derivatives
thiazole
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU40154/97A
Inventor
Hermann Amschler
Thomas Bar
Rolf Beume
Hildegard Boss
Dieter Flockerzi
Beate Gutterer
Dietrich Hafner
Armin Hatzelmann
Hans-Peter Kley
Thomas Martin
Ulrich Thibaut
Wolf-Rudiger Ulrich
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda GmbH
Original Assignee
Byk Gulden Lomberg Chemische Fabrik GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Byk Gulden Lomberg Chemische Fabrik GmbH filed Critical Byk Gulden Lomberg Chemische Fabrik GmbH
Publication of AU4015497A publication Critical patent/AU4015497A/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/24—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/26—Radicals substituted by sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/30—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU40154/97A 1996-08-26 1997-08-13 Thiazole derivatives useful as selective inhibitors of pde-iv Abandoned AU4015497A (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
DE19634408 1996-08-26
DE19634408 1996-08-26
EP96113739 1996-08-28
EP96113739 1996-08-28
PCT/EP1997/004422 WO1998008830A1 (en) 1996-08-26 1997-08-13 Thiazole derivatives useful as selective inhibitors of pde-iv

Publications (1)

Publication Number Publication Date
AU4015497A true AU4015497A (en) 1998-03-19

Family

ID=26028744

Family Applications (1)

Application Number Title Priority Date Filing Date
AU40154/97A Abandoned AU4015497A (en) 1996-08-26 1997-08-13 Thiazole derivatives useful as selective inhibitors of pde-iv

Country Status (2)

Country Link
AU (1) AU4015497A (en)
WO (1) WO1998008830A1 (en)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU4394799A (en) 1998-07-01 2000-01-24 Takeda Chemical Industries Ltd. Retinoid-associated receptor regulators
JP2000281664A (en) * 1999-03-30 2000-10-10 Otsuka Pharmaceut Co Ltd Thiazole derivative
KR100701904B1 (en) 1999-08-21 2007-04-02 알타나 파마 아게 Synergistic combination of pde inhibitors and beta 2 adrenoceptor agonist
WO2002040449A1 (en) * 2000-11-14 2002-05-23 Altana Pharma Ag Dihydroisoquinolines as novel phosphodiesterase inhibitors
ATE440096T1 (en) 2000-12-08 2009-09-15 Takeda Pharmaceutical SUBSTITUTED THIAZOLE DERIVATIVES WITH 3-PYRIDYL GROUPS, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE
KR100566709B1 (en) * 2001-07-24 2006-04-03 오쓰까 세이야꾸 가부시키가이샤 Use of thiazole derivatives for the manufacture of a medicament for the treatment of chronic obstructive pulmonary disease
PL210475B1 (en) 2001-08-13 2012-01-31 Janssen Pharmaceutica Nv 2,4,5-trisubstituted thiazolyl derivatives ant their antiinflammatory activity
CN102816130B (en) 2004-05-17 2015-05-06 大塚制药株式会社 Thiazole compound and use thereof
KR20080066938A (en) * 2005-10-07 2008-07-17 깃세이 야쿠힌 고교 가부시키가이샤 Nitrogenated heterocyclic compound and pharmaceutical composition comprising the same
SI1954684T1 (en) 2005-11-15 2014-07-31 Otsuka Pharmaceutical Co., Ltd. Oxazole compound and pharmaceutical composition
CN104054719B (en) 2007-08-13 2016-09-28 孟山都技术有限责任公司 For controlling compositions and the method for nematicide
WO2011112828A1 (en) 2010-03-12 2011-09-15 Omeros Corporation Pde10 inhibitors and related compositions and methods
NZ716462A (en) 2014-04-28 2017-11-24 Omeros Corp Optically active pde10 inhibitor
NZ716494A (en) 2014-04-28 2017-07-28 Omeros Corp Processes and intermediates for the preparation of a pde10 inhibitor
MX2017008090A (en) * 2014-12-19 2017-12-04 Galderma Res & Dev Novel compounds, synthesis method thereof and use of same in medicine and in cosmetics.
CA2980801A1 (en) 2015-04-24 2016-10-27 Omeros Corporation Pde10 inhibitors and related compositions and methods
WO2017079678A1 (en) 2015-11-04 2017-05-11 Omeros Corporation Solid state forms of a pde10 inhibitor

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ257955A (en) * 1992-12-02 1996-05-28 Pfizer Catechol diethers pharmaceutical compositions

Also Published As

Publication number Publication date
WO1998008830A1 (en) 1998-03-05

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