AU3747178A - Substituted-1-thienyl and furyl-2,3,4,5-tetrahydro-14-3 benzazepine derivatives - Google Patents

Substituted-1-thienyl and furyl-2,3,4,5-tetrahydro-14-3 benzazepine derivatives

Info

Publication number
AU3747178A
AU3747178A AU37471/78A AU3747178A AU3747178A AU 3747178 A AU3747178 A AU 3747178A AU 37471/78 A AU37471/78 A AU 37471/78A AU 3747178 A AU3747178 A AU 3747178A AU 3747178 A AU3747178 A AU 3747178A
Authority
AU
Australia
Prior art keywords
furyl
tetrahydro
thienyl
substituted
benzazepine derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
AU37471/78A
Other versions
AU515236B2 (en
Inventor
K. G. and Yim N. C. F Holden
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GlaxoSmithKline LLC
Original Assignee
SmithKline Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SmithKline Corp filed Critical SmithKline Corp
Priority to AU37471/78A priority Critical patent/AU515236B2/en
Priority to NL7807819A priority patent/NL7807819A/en
Publication of AU3747178A publication Critical patent/AU3747178A/en
Application granted granted Critical
Publication of AU515236B2 publication Critical patent/AU515236B2/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/52—Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/10—Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU37471/78A 1978-06-26 1978-06-26 Substituted-1-thienyl and furyl-2,3,4,5-tetrahydro-14-3 benzazepine derivatives Expired AU515236B2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU37471/78A AU515236B2 (en) 1978-06-26 1978-06-26 Substituted-1-thienyl and furyl-2,3,4,5-tetrahydro-14-3 benzazepine derivatives
NL7807819A NL7807819A (en) 1978-06-26 1978-07-21 Pharmaceutically active benzazepine cpds. - specifically, substd. 1-thienyl and furyl-2,34,5-tetra:hydro-1H-3-benzazepine(s)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AU37471/78A AU515236B2 (en) 1978-06-26 1978-06-26 Substituted-1-thienyl and furyl-2,3,4,5-tetrahydro-14-3 benzazepine derivatives
NL7807819A NL7807819A (en) 1978-06-26 1978-07-21 Pharmaceutically active benzazepine cpds. - specifically, substd. 1-thienyl and furyl-2,34,5-tetra:hydro-1H-3-benzazepine(s)

Publications (2)

Publication Number Publication Date
AU3747178A true AU3747178A (en) 1980-01-03
AU515236B2 AU515236B2 (en) 1981-03-26

Family

ID=25623985

Family Applications (1)

Application Number Title Priority Date Filing Date
AU37471/78A Expired AU515236B2 (en) 1978-06-26 1978-06-26 Substituted-1-thienyl and furyl-2,3,4,5-tetrahydro-14-3 benzazepine derivatives

Country Status (2)

Country Link
AU (1) AU515236B2 (en)
NL (1) NL7807819A (en)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999045013A1 (en) * 1998-03-06 1999-09-10 Novo Nordisk A/S 4,5,6,7-TETRAHYDRO-THIENO[3,2-c]PYRIDINE DERIVATIVES
US6953787B2 (en) 2002-04-12 2005-10-11 Arena Pharmaceuticals, Inc. 5HT2C receptor modulators
CN1805938B (en) 2003-06-17 2010-06-16 艾尼纳制药公司 Benzazepine derivatives useful for the treatment of 5HT2C receptor associated diseases
EP2332919A3 (en) 2003-06-17 2011-10-19 Arena Pharmaceuticals, Inc. Processes for preparing 3-benzazepines
DK1838677T3 (en) 2004-12-21 2010-01-11 Arena Pharm Inc Crystalline forms of (R) -8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride
CN102627607A (en) 2004-12-23 2012-08-08 艾尼纳制药公司 5HT2c receptor modulator compositions and methods of use
CA2646044A1 (en) 2006-04-03 2007-10-25 Arena Pharmaceuticals, Inc. Processes for the preparation of 8-chloro-1-methyl-2,3,4,5-tetrahydro-1h-3-benzazepine and intermediates related thereto
WO2008070111A2 (en) 2006-12-05 2008-06-12 Arena Pharmaceuticals, Inc. Processes for preparing (r)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1h-3-benzazepine and intermediates thereof
EP2288585A1 (en) 2008-03-04 2011-03-02 Arena Pharmaceuticals, Inc. Processes for the preparation of intermediates related to the 5-ht2c agonist (r)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1h-3-benzazepine
WO2010148207A2 (en) 2009-06-18 2010-12-23 Arena Pharmaceuticals, Inc. Processes for the preparation of 5-ht2c receptor agonists
US9045431B2 (en) 2010-06-02 2015-06-02 Arena Pharmaceuticals, Inc. Processes for the preparation of 5-HT2C receptor agonists
SG10201506874UA (en) 2010-09-01 2015-10-29 Arena Pharm Inc Modified-release dosage forms of 5-ht2c agonists useful for weight management
US9365521B2 (en) 2010-09-01 2016-06-14 Arena Pharmaceuticals, Inc. Non-hygroscopic salts of 5-HT2C agonists
JP2013539470A (en) 2010-09-01 2013-10-24 アリーナ ファーマシューティカルズ， インコーポレイテッド Salt of lorcaserine and optically active acid
KR20180094131A (en) 2010-09-01 2018-08-22 에자이 알앤드디 매니지먼트 가부시키가이샤 Administration of lorcaserin to individuals with renal impairment
MX2015004532A (en) 2012-10-09 2016-01-20 Arena Pharm Inc Method of weight management.

Also Published As

Publication number Publication date
AU515236B2 (en) 1981-03-26
NL7807819A (en) 1980-01-23

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